메뉴 건너뛰기




Volumn 13, Issue 3, 2013, Pages 247-257

TRP channels as targets for therapeutic intervention in obesity: Focus on TRPV1 and TRPM5

Author keywords

Drug targets; Obesity; TRP channels

Indexed keywords

CAPSAICIN; CAPSAICIN DERIVATIVE; CAPSIATE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; LORCASERIN; PIPERINE; RIMONABANT; SIBUTRAMINE; TETRAHYDROLIPSTATIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; VANILLOID RECEPTOR 1;

EID: 84876698097     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/15680266113139990089     Document Type: Article
Times cited : (20)

References (156)
  • 1
    • 84876733134 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention, Last accessed October 10
    • Centers for Disease Control and Prevention http://www.cdc.gov/obesity/data/adult.html. Last accessed October 10, 2012.
    • (2012)
  • 2
    • 74549140993 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2008
    • Flegal, K.M.; Carroll, M.D.; Ogden, C.L.; Curtin, L.R. Prevalence and trends in obesity among US adults, 1999-2008. JAMA., 2010, 303(3), 235-241.
    • (2010) JAMA , vol.303 , Issue.3 , pp. 235-241
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Curtin, L.R.4
  • 3
    • 74549159752 scopus 로고    scopus 로고
    • Prevalence of high body mass index in US children and adolescents, 2007-2008
    • Ogden, C.L.; Carroll, M.D.; Curtin, L.R.; Lamb, M.M.; Flegal, K.M. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA., 2010, 303(3), 242-249.
    • (2010) JAMA , vol.303 , Issue.3 , pp. 242-249
    • Ogden, C.L.1    Carroll, M.D.2    Curtin, L.R.3    Lamb, M.M.4    Flegal, K.M.5
  • 4
    • 84856848766 scopus 로고    scopus 로고
    • Childhood obesity: A life-long health risk
    • Barton, M. Childhood obesity: a life-long health risk. Acta. Pharmacol. Sin., 2012, 33(2), 189-193.
    • (2012) Acta. Pharmacol. Sin , vol.33 , Issue.2 , pp. 189-193
    • Barton, M.1
  • 5
    • 84855692008 scopus 로고    scopus 로고
    • Childhood obesity and risk of the adult metabolic syndrome: A systematic review
    • Lloyd, L.J.; Langley-Evans, S.C.; McMullen, S. Childhood obesity and risk of the adult metabolic syndrome: a systematic review. Int. J. Obes. (Lond)., 2012, 36(1), 1-11.
    • (2012) Int. J. Obes. (Lond) , vol.36 , Issue.1 , pp. 1-11
    • Lloyd, L.J.1    Langley-Evans, S.C.2    McMullen, S.3
  • 9
    • 57749204131 scopus 로고    scopus 로고
    • Cost-effectiveness of pharmacological anti-obesity treatments: A systematic review
    • Neovius, M.; Narbro, K. Cost-effectiveness of pharmacological anti-obesity treatments: a systematic review. Int. J. Obes. (Lond)., 2008, 32(12), 1752-1763.
    • (2008) Int. J. Obes. (Lond) , vol.32 , Issue.12 , pp. 1752-1763
    • Neovius, M.1    Narbro, K.2
  • 10
    • 56849099017 scopus 로고    scopus 로고
    • Central and peripheral regulation of food intake and physical activity: Pathways and genes
    • Lenard, N.R.; Berthoud, H.R. Central and peripheral regulation of food intake and physical activity: pathways and genes. Obesity. (Silver. Spring)., 2008, 16. Suppl. 3, S11-22.
    • (2008) Obesity. (Silver. Spring) , vol.16 , Issue.SUPPL. 3 , pp. 11-22
    • Lenard, N.R.1    Berthoud, H.R.2
  • 12
    • 80054901454 scopus 로고    scopus 로고
    • Increased portion sizes from energy-dense foods affect total energy intake at eating occasions in US children and adolescents: Patterns and trends by age group and sociodemographic characteristics, 1977-2006
    • Piernas, C.; Popkin, B.M. Increased portion sizes from energy-dense foods affect total energy intake at eating occasions in US children and adolescents: patterns and trends by age group and sociodemographic characteristics, 1977-2006. Am. J. Clin. Nutr., 2011, 94(5), 1324-1332.
    • (2011) Am. J. Clin. Nutr , vol.94 , Issue.5 , pp. 1324-1332
    • Piernas, C.1    Popkin, B.M.2
  • 13
    • 0036585028 scopus 로고    scopus 로고
    • Trends in energy intake in U.S. between 1977 and 1996: Similar shifts seen across age groups
    • Nielsen, S.J.; Siega-Riz, A.M.; Popkin, B.M. Trends in energy intake in U.S. between 1977 and 1996: similar shifts seen across age groups. Obes. Res., 2002, 10(5), 370-378.
    • (2002) Obes. Res , vol.10 , Issue.5 , pp. 370-378
    • Nielsen, S.J.1    Siega-Riz, A.M.2    Popkin, B.M.3
  • 14
    • 75149188238 scopus 로고    scopus 로고
    • Characterizing the obesogenic environment: The state of the evidence with directions for future research
    • Kirk, S.F.; Penney, T.L.; McHugh, T.L. Characterizing the obesogenic environment: the state of the evidence with directions for future research. Obes. Rev., 2010, 11(2), 109-117.
    • (2010) Obes. Rev , vol.11 , Issue.2 , pp. 109-117
    • Kirk, S.F.1    Penney, T.L.2    McHugh, T.L.3
  • 15
    • 84859622440 scopus 로고    scopus 로고
    • Physical activity, sedentary behavior, and childhood obesity: A review of cross-sectional studies
    • Prentice-Dunn, H.; Prentice-Dunn, S. Physical activity, sedentary behavior, and childhood obesity: a review of cross-sectional studies. Psychol. Health. Med., 2012, 17(3), 255-273.
    • (2012) Psychol. Health. Med , vol.17 , Issue.3 , pp. 255-273
    • Prentice-Dunn, H.1    Prentice-Dunn, S.2
  • 16
    • 33644990006 scopus 로고    scopus 로고
    • Physical activity and sedentary behavior: A review of longitudinal studies of weight and adiposity in youth
    • Must, A.; Tybor, D.J. Physical activity and sedentary behavior: a review of longitudinal studies of weight and adiposity in youth. Int. J. Obes. (Lond)., 2005, 29. Suppl. 2, S84-96.
    • (2005) Int. J. Obes. (Lond) , vol.29 , Issue.SUPPL. 2 , pp. 84-96
    • Must, A.1    Tybor, D.J.2
  • 17
    • 49449088260 scopus 로고    scopus 로고
    • Physical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals
    • Westerterp, K.R.; Speakman, J.R. Physical activity energy expenditure has not declined since the 1980s and matches energy expenditures of wild mammals. Int. J. Obes. (Lond)., 2008, 32(8), 1256-1263.
    • (2008) Int. J. Obes. (Lond) , vol.32 , Issue.8 , pp. 1256-1263
    • Westerterp, K.R.1    Speakman, J.R.2
  • 19
    • 40749142726 scopus 로고    scopus 로고
    • A role for sweet taste: Calorie predictive relations in energy regulation by rats
    • Swithers, S.E.; Davidson, T.L. A role for sweet taste: calorie predictive relations in energy regulation by rats. Behav. Neurosci., 2008, 122(1), 161-173.
    • (2008) Behav. Neurosci , vol.122 , Issue.1 , pp. 161-173
    • Swithers, S.E.1    Davidson, T.L.2
  • 20
    • 67949100464 scopus 로고    scopus 로고
    • General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats
    • Swithers, S.E.; Baker, C.R.; Davidson, T.L. General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats. Behav. Neurosci., 2009, 123(4), 772-780.
    • (2009) Behav. Neurosci , vol.123 , Issue.4 , pp. 772-780
    • Swithers, S.E.1    Baker, C.R.2    Davidson, T.L.3
  • 21
    • 77949789393 scopus 로고    scopus 로고
    • High-intensity sweeteners and energy balance
    • Swithers, S.E.; Martin, A.A.; Davidson, T.L. High-intensity sweeteners and energy balance. Physiol. Behav., 2010, 100(1), 55-62.
    • (2010) Physiol. Behav , vol.100 , Issue.1 , pp. 55-62
    • Swithers, S.E.1    Martin, A.A.2    Davidson, T.L.3
  • 22
    • 0025366823 scopus 로고
    • Effects of aspartame and sucrose on hunger and energy intake in humans
    • Mattes, R. Effects of aspartame and sucrose on hunger and energy intake in humans. Physiol. Behav., 1990, 47(6), 1037-1044.
    • (1990) Physiol. Behav , vol.47 , Issue.6 , pp. 1037-1044
    • Mattes, R.1
  • 23
    • 80051776224 scopus 로고    scopus 로고
    • Physical activity and weight control: Conflicting findings
    • Cook, C.M.; Schoeller, D.A. Physical activity and weight control: conflicting findings. Curr. Opin. Clin. Nutr. Metab. Care., 2011, 14(5), 419-424.
    • (2011) Curr. Opin. Clin. Nutr. Metab. Care , vol.14 , Issue.5 , pp. 419-424
    • Cook, C.M.1    Schoeller, D.A.2
  • 24
    • 84872109705 scopus 로고    scopus 로고
    • A review of late-stage CNS drug candidates for the treatment of obesity
    • Heal, D.J.; Gosden, J.; Smith, S.L. A review of late-stage CNS drug candidates for the treatment of obesity. Int. J. Obes. (Lond)., 2013. 37(1), 107-117.
    • (2013) Int. J. Obes. (Lond) , vol.37 , Issue.1 , pp. 107-117
    • Heal, D.J.1    Gosden, J.2    Smith, S.L.3
  • 25
    • 81155154245 scopus 로고    scopus 로고
    • Serotonergic anti-obesity agents: Past experience and future prospects
    • Halford, J.C.; Boyland, E.J.; Lawton, C.L.; Blundell, J.E.; Harrold, J.A. Serotonergic anti-obesity agents: past experience and future prospects. Drugs., 2011, 71(17), 2247-2255.
    • (2011) Drugs , vol.71 , Issue.17 , pp. 2247-2255
    • Halford, J.C.1    Boyland, E.J.2    Lawton, C.L.3    Blundell, J.E.4    Harrold, J.A.5
  • 26
    • 84856348064 scopus 로고    scopus 로고
    • Central and peripheral cannabinoid receptors as therapeutic targets in the control of food intake and body weight
    • Engeli, S. Central and peripheral cannabinoid receptors as therapeutic targets in the control of food intake and body weight. Handb. Exp. Pharmacol., 2012(209), 357-381.
    • (2012) Handb. Exp. Pharmacol , vol.209 , pp. 357-381
    • Engeli, S.1
  • 27
    • 33646859222 scopus 로고    scopus 로고
    • Central nervous system biogenic amine targets for control of appetite and energy expenditure
    • Nelson, D.L.; Gehlert, D.R. Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine., 2006, 29(1), 49-60.
    • (2006) Endocrine , vol.29 , Issue.1 , pp. 49-60
    • Nelson, D.L.1    Gehlert, D.R.2
  • 28
    • 84860163107 scopus 로고    scopus 로고
    • Anti-obesity drugs: A review about their effects and their safety
    • Derosa, G.; Maffioli, P. Anti-obesity drugs: a review about their effects and their safety. Expert. Opin. Drug. Saf., 2012, 11(3), 459-471.
    • (2012) Expert. Opin. Drug. Saf , vol.11 , Issue.3 , pp. 459-471
    • Derosa, G.1    Maffioli, P.2
  • 30
    • 78751644062 scopus 로고    scopus 로고
    • TRP channels and their implications in metabolic diseases
    • Zhu, Z.; Luo, Z.; Ma, S.; Liu, D. TRP channels and their implications in metabolic diseases. Pflugers. Arch., 2011, 461(2), 211-223.
    • (2011) Pflugers. Arch , vol.461 , Issue.2 , pp. 211-223
    • Zhu, Z.1    Luo, Z.2    Ma, S.3    Liu, D.4
  • 31
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • Caterina, M.J.; Schumacher, M.A.; Tominaga, M.; Rosen, T.A.; Levine, J.D.; Julius, D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature., 1997, 389(6653), 816-824.
    • (1997) Nature , vol.389 , Issue.6653 , pp. 816-824
    • Caterina, M.J.1    Schumacher, M.A.2    Tominaga, M.3    Rosen, T.A.4    Levine, J.D.5    Julius, D.6
  • 33
    • 0344873175 scopus 로고    scopus 로고
    • Anandamide and vanilloid TRPV1 receptors
    • Ross, R.A. Anandamide and vanilloid TRPV1 receptors. Br. J. Pharmacol., 2003, 140(5), 790-801.
    • (2003) Br. J. Pharmacol , vol.140 , Issue.5 , pp. 790-801
    • Ross, R.A.1
  • 34
    • 4644266613 scopus 로고    scopus 로고
    • The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology
    • Nagy, I.; Santha, P.; Jancso, G.; Urban, L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur. J. Pharmacol., 2004, 500(1-3), 351-369.
    • (2004) Eur. J. Pharmacol , vol.500 , Issue.1-3 , pp. 351-369
    • Nagy, I.1    Santha, P.2    Jancso, G.3    Urban, L.4
  • 35
    • 39449102203 scopus 로고    scopus 로고
    • Peripheral TRPV1 receptors as targets for drug development: New molecules and mechanisms
    • Gunthorpe, M.J.; Szallasi, A. Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms. Curr. Pharm. Des., 2008, 14(1), 32-41.
    • (2008) Curr. Pharm. Des , vol.14 , Issue.1 , pp. 32-41
    • Gunthorpe, M.J.1    Szallasi, A.2
  • 37
    • 57549118558 scopus 로고    scopus 로고
    • The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor
    • Holzer, P. The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br. J. Pharmacol., 2008, 155(8), 1145-1162.
    • (2008) Br. J. Pharmacol , vol.155 , Issue.8 , pp. 1145-1162
    • Holzer, P.1
  • 38
    • 34248138496 scopus 로고    scopus 로고
    • The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
    • Szallasi, A.; Cortright, D.N.; Blum, C.A.; Eid, S.R. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat. Rev. Drug. Discov., 2007, 6(5), 357-372.
    • (2007) Nat. Rev. Drug. Discov , vol.6 , Issue.5 , pp. 357-372
    • Szallasi, A.1    Cortright, D.N.2    Blum, C.A.3    Eid, S.R.4
  • 39
    • 79959808567 scopus 로고    scopus 로고
    • TRPV1: A therapy target that attracts the pharmaceutical interests
    • Xia, R.; Dekermendjian, K.; Lullau, E.; Dekker, N. TRPV1: a therapy target that attracts the pharmaceutical interests. Adv. Exp. Med. Biol., 2011, 704, 637-665.
    • (2011) Adv. Exp. Med. Biol , vol.704 , pp. 637-665
    • Xia, R.1    Dekermendjian, K.2    Lullau, E.3    Dekker, N.4
  • 40
    • 77955802570 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid-1 antagonists: A survey of recent patent literature
    • Voight, E.A.; Kort, M.E. Transient receptor potential vanilloid-1 antagonists: a survey of recent patent literature. Expert. Opin. Ther. Pat., 2010, 20(9), 1107-1122.
    • (2010) Expert. Opin. Ther. Pat , vol.20 , Issue.9 , pp. 1107-1122
    • Voight, E.A.1    Kort, M.E.2
  • 42
    • 0030444564 scopus 로고    scopus 로고
    • The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglandin F2alpha
    • Miller, C.W.; Casimir, D.A.; Ntambi, J.M. The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglandin F2alpha. Endocrinology., 1996, 137(12), 5641-5650.
    • (1996) Endocrinology , vol.137 , Issue.12 , pp. 5641-5650
    • Miller, C.W.1    Casimir, D.A.2    Ntambi, J.M.3
  • 43
    • 84859884294 scopus 로고    scopus 로고
    • Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARgamma activity in 3T3-L1 cells
    • Park, U.H.; Jeong, H.S.; Jo, E.Y.; Park, T.; Yoon, S.K.; Kim, E.J.; Jeong, J.C.; Um, S.J. Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARgamma activity in 3T3-L1 cells. J. Agric. Food. Chem., 2012, 60(15), 3853-3860.
    • (2012) J. Agric. Food. Chem , vol.60 , Issue.15 , pp. 3853-3860
    • Park, U.H.1    Jeong, H.S.2    Jo, E.Y.3    Park, T.4    Yoon, S.K.5    Kim, E.J.6    Jeong, J.C.7    Um, S.J.8
  • 44
    • 44749085444 scopus 로고    scopus 로고
    • TRPV1-null mice are protected from diet-induced obesity
    • Motter, A.L.; Ahern, G.P. TRPV1-null mice are protected from diet-induced obesity. FEBS. Lett., 2008, 582(15), 2257-2262.
    • (2008) FEBS. Lett , vol.582 , Issue.15 , pp. 2257-2262
    • Motter, A.L.1    Ahern, G.P.2
  • 46
    • 80052102101 scopus 로고    scopus 로고
    • Hyperactive when young, hypoactive and overweight when aged: Connecting the dots in the story about locomotor activity, body mass, and aging in Trpv1 knockout mice
    • Wanner, S.P.; Garami, A.; Romanovsky, A.A. Hyperactive when young, hypoactive and overweight when aged: connecting the dots in the story about locomotor activity, body mass, and aging in Trpv1 knockout mice. Aging. (Albany. NY)., 2011, 3(4), 450-454.
    • (2011) Aging. (Albany. NY) , vol.3 , Issue.4 , pp. 450-454
    • Wanner, S.P.1    Garami, A.2    Romanovsky, A.A.3
  • 47
    • 77950221998 scopus 로고    scopus 로고
    • Human brown adipose tissue
    • Enerback, S. Human brown adipose tissue. Cell. Metab., 2010, 11(4), 248-252.
    • (2010) Cell. Metab , vol.11 , Issue.4 , pp. 248-252
    • Enerback, S.1
  • 48
    • 78449291034 scopus 로고    scopus 로고
    • Brown fat thermogenesis and body weight regulation in mice: Relevance to humans
    • Kozak, L.P.; Koza, R.A.; Anunciado-Koza, R. Brown fat thermogenesis and body weight regulation in mice: relevance to humans. Int. J. Obes. (Lond)., 2010, 34. Suppl. 1, S23-27.
    • (2010) Int. J. Obes. (Lond) , vol.34 , Issue.SUPPL. 1 , pp. 23-27
    • Kozak, L.P.1    Koza, R.A.2    Anunciado-Koza, R.3
  • 49
    • 0026527890 scopus 로고
    • Long-term decrease in body fat and in brown adipose tissue in capsaicin-desensitized rats
    • Cui, J.; Himms-Hagen, J. Long-term decrease in body fat and in brown adipose tissue in capsaicin-desensitized rats. Am. J. Physiol., 1992, 262(4 Pt 2), R568-573.
    • (1992) Am. J. Physiol , vol.262 , Issue.4 Pt 2 , pp. 568-573
    • Cui, J.1    Himms-Hagen, J.2
  • 50
    • 0029331457 scopus 로고
    • Resistance to aging-associated obesity in capsaicin-desensitized rats one year after treatment
    • Melnyk, A.; Himms-Hagen, J. Resistance to aging-associated obesity in capsaicin-desensitized rats one year after treatment. Obes. Res., 1995, 3(4), 337-344.
    • (1995) Obes. Res , vol.3 , Issue.4 , pp. 337-344
    • Melnyk, A.1    Himms-Hagen, J.2
  • 51
    • 0032431616 scopus 로고    scopus 로고
    • Temperature-and capsaicin-sensitive nerve fibers in brown adipose tissue attenuate thermogenesis in the rat
    • Osaka, T.; Kobayashi, A.; Namba, Y.; Ezaki, O.; Inoue, S.; Kimura, S.; Lee, T.H. Temperature-and capsaicin-sensitive nerve fibers in brown adipose tissue attenuate thermogenesis in the rat. Pflugers. Arch., 1998, 437(1), 36-42.
    • (1998) Pflugers. Arch , vol.437 , Issue.1 , pp. 36-42
    • Osaka, T.1    Kobayashi, A.2    Namba, Y.3    Ezaki, O.4    Inoue, S.5    Kimura, S.6    Lee, T.H.7
  • 52
    • 0032293345 scopus 로고    scopus 로고
    • TH-, NPY-, SP-, and CGRP-immunoreactive nerves in interscapular brown adipose tissue of adult rats acclimated at different temperatures: An immunohistochemical study
    • De Matteis, R.; Ricquier, D.; Cinti, S. TH-, NPY-, SP-, and CGRP-immunoreactive nerves in interscapular brown adipose tissue of adult rats acclimated at different temperatures: an immunohistochemical study. J. Neurocytol., 1998, 27(12), 877-886.
    • (1998) J. Neurocytol , vol.27 , Issue.12 , pp. 877-886
    • de Matteis, R.1    Ricquier, D.2    Cinti, S.3
  • 53
    • 2442598415 scopus 로고    scopus 로고
    • Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice
    • Petho, G.; Izydorczyk, I.; Reeh, P.W. Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice. Pain., 2004, 109(3), 284-290.
    • (2004) Pain , vol.109 , Issue.3 , pp. 284-290
    • Petho, G.1    Izydorczyk, I.2    Reeh, P.W.3
  • 55
    • 29644448140 scopus 로고    scopus 로고
    • Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats
    • Gram, D.X.; Hansen, A.J.; Wilken, M.; Elm, T.; Svendsen, O.; Carr, R.D.; Ahren, B.; Brand, C.L. Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur. J. Endocrinol., 2005, 153(6), 963-969.
    • (2005) Eur. J. Endocrinol , vol.153 , Issue.6 , pp. 963-969
    • Gram, D.X.1    Hansen, A.J.2    Wilken, M.3    Elm, T.4    Svendsen, O.5    Carr, R.D.6    Ahren, B.7    Brand, C.L.8
  • 56
    • 33947596710 scopus 로고    scopus 로고
    • Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells
    • Hsu, C.L.; Yen, G.C. Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. J. Agric. Food. Chem., 2007, 55(5), 1730-1736.
    • (2007) J. Agric. Food. Chem , vol.55 , Issue.5 , pp. 1730-1736
    • Hsu, C.L.1    Yen, G.C.2
  • 57
    • 79955032433 scopus 로고    scopus 로고
    • Brown fat biology and thermogenesis
    • Richard, D.; Picard, F. Brown fat biology and thermogenesis. Front. Biosci., 2011, 16, 1233-1260.
    • (2011) Front. Biosci , vol.16 , pp. 1233-1260
    • Richard, D.1    Picard, F.2
  • 59
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): Transcriptional coactivator and metabolic regulator
    • Puigserver, P.; Spiegelman, B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev., 2003, 24(1), 78-90.
    • (2003) Endocr. Rev , vol.24 , Issue.1 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 61
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
    • Wenz, T.; Rossi, S.G.; Rotundo, R.L.; Spiegelman, B.M.; Moraes, C.T. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc. Natl. Acad. Sci. U. S. A., 2009, 106(48), 20405-20410.
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , Issue.48 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3    Spiegelman, B.M.4    Moraes, C.T.5
  • 63
    • 0023879210 scopus 로고
    • Effect of capsaicin pretreatment on capsaicin-induced catecholamine secretion from the adrenal medulla in rats
    • Watanabe, T.; Kawada, T.; Iwai, K. Effect of capsaicin pretreatment on capsaicin-induced catecholamine secretion from the adrenal medulla in rats. Proc. Soc. Exp. Biol. Med., 1988, 187(3), 370-374.
    • (1988) Proc. Soc. Exp. Biol. Med , vol.187 , Issue.3 , pp. 370-374
    • Watanabe, T.1    Kawada, T.2    Iwai, K.3
  • 64
    • 0028158942 scopus 로고
    • Effects of capsaicin analogs on adrenal catecholamine secretion in rats
    • Watanabe, T.; Kawada, T.; Kato, T.; Harada, T.; Iwai, K. Effects of capsaicin analogs on adrenal catecholamine secretion in rats. Life. Sci., 1994, 54(5), 369-374.
    • (1994) Life. Sci , vol.54 , Issue.5 , pp. 369-374
    • Watanabe, T.1    Kawada, T.2    Kato, T.3    Harada, T.4    Iwai, K.5
  • 65
    • 0023008170 scopus 로고
    • Capsaicin-induced beta-adrenergic action on energy metabolism in rats: Influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization
    • Kawada, T.; Watanabe, T.; Takaishi, T.; Tanaka, T.; Iwai, K. Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc. Soc. Exp. Biol. Med., 1986, 183(2), 250-256.
    • (1986) Proc. Soc. Exp. Biol. Med , vol.183 , Issue.2 , pp. 250-256
    • Kawada, T.1    Watanabe, T.2    Takaishi, T.3    Tanaka, T.4    Iwai, K.5
  • 66
    • 0021351360 scopus 로고
    • Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats
    • Kawada, T.; Suzuki, T.; Takahashi, M.; Iwai, K. Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. Toxicol. Appl. Pharmacol., 1984, 72(3), 449-456.
    • (1984) Toxicol. Appl. Pharmacol , vol.72 , Issue.3 , pp. 449-456
    • Kawada, T.1    Suzuki, T.2    Takahashi, M.3    Iwai, K.4
  • 67
    • 0025073928 scopus 로고
    • Absorption and metabolism of capsaicinoids following intragastric administration in rats
    • Donnerer, J.; Amann, R.; Schuligoi, R.; Lembeck, F. Absorption and metabolism of capsaicinoids following intragastric administration in rats. Naunyn. Schmiedebergs. Arch. Pharmacol., 1990, 342(3), 357-361.
    • (1990) Naunyn. Schmiedebergs. Arch. Pharmacol , vol.342 , Issue.3 , pp. 357-361
    • Donnerer, J.1    Amann, R.2    Schuligoi, R.3    Lembeck, F.4
  • 69
    • 33847189521 scopus 로고    scopus 로고
    • Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids)
    • Inoue, N.; Matsunaga, Y.; Satoh, H.; Takahashi, M. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci. Biotechnol. Biochem., 2007, 71(2), 380-389.
    • (2007) Biosci. Biotechnol. Biochem , vol.71 , Issue.2 , pp. 380-389
    • Inoue, N.1    Matsunaga, Y.2    Satoh, H.3    Takahashi, M.4
  • 71
    • 58149394253 scopus 로고    scopus 로고
    • Effects of novel capsinoid treatment on fatness and energy metabolism in humans: Possible pharmacogenetic implications
    • Snitker, S.; Fujishima, Y.; Shen, H.; Ott, S.; Pi-Sunyer, X.; Furuhata, Y.; Sato, H.; Takahashi, M. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am. J. Clin. Nutr., 2009, 89(1), 45-50.
    • (2009) Am. J. Clin. Nutr , vol.89 , Issue.1 , pp. 45-50
    • Snitker, S.1    Fujishima, Y.2    Shen, H.3    Ott, S.4    Pi-Sunyer, X.5    Furuhata, Y.6    Sato, H.7    Takahashi, M.8
  • 72
    • 84859046511 scopus 로고    scopus 로고
    • Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans
    • Yoneshiro, T.; Aita, S.; Kawai, Y.; Iwanaga, T.; Saito, M. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am. J. Clin. Nutr., 2012, 95(4), 845-850.
    • (2012) Am. J. Clin. Nutr , vol.95 , Issue.4 , pp. 845-850
    • Yoneshiro, T.1    Aita, S.2    Kawai, Y.3    Iwanaga, T.4    Saito, M.5
  • 73
    • 75549089629 scopus 로고    scopus 로고
    • Effect of capsinoids on energy metabolism in human subjects
    • Galgani, J.E.; Ryan, D.H.; Ravussin, E. Effect of capsinoids on energy metabolism in human subjects. Br. J. Nutr., 2010, 103(1), 38-42.
    • (2010) Br. J. Nutr , vol.103 , Issue.1 , pp. 38-42
    • Galgani, J.E.1    Ryan, D.H.2    Ravussin, E.3
  • 74
    • 78149271512 scopus 로고    scopus 로고
    • Effect of dihydrocapsiate on resting metabolic rate in humans
    • Galgani, J.E.; Ravussin, E. Effect of dihydrocapsiate on resting metabolic rate in humans. Am. J. Clin. Nutr., 2010, 92(5), 1089-1093.
    • (2010) Am. J. Clin. Nutr , vol.92 , Issue.5 , pp. 1089-1093
    • Galgani, J.E.1    Ravussin, E.2
  • 75
    • 84855904085 scopus 로고    scopus 로고
    • The effects of capsaicin and capsiate on energy balance: Critical review and meta-analyses of studies in humans
    • Ludy, M.J.; Moore, G.E.; Mattes, R.D. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem. Senses., 2012, 37(2), 103-121.
    • (2012) Chem. Senses , vol.37 , Issue.2 , pp. 103-121
    • Ludy, M.J.1    Moore, G.E.2    Mattes, R.D.3
  • 76
    • 16644368877 scopus 로고    scopus 로고
    • Alterations of gastrointestinal motility in obesity
    • Xing, J.; Chen, J.D. Alterations of gastrointestinal motility in obesity. Obes. Res., 2004, 12(11), 1723-1732.
    • (2004) Obes. Res , vol.12 , Issue.11 , pp. 1723-1732
    • Xing, J.1    Chen, J.D.2
  • 77
    • 80054837074 scopus 로고    scopus 로고
    • The effects of weight loss strategies on gastric emptying and appetite control
    • Horner, K.M.; Byrne, N.M.; Cleghorn, G.J.; Naslund, E.; King, N.A. The effects of weight loss strategies on gastric emptying and appetite control. Obes. Rev., 2011, 12(11), 935-951.
    • (2011) Obes. Rev , vol.12 , Issue.11 , pp. 935-951
    • Horner, K.M.1    Byrne, N.M.2    Cleghorn, G.J.3    Naslund, E.4    King, N.A.5
  • 78
    • 0033374725 scopus 로고    scopus 로고
    • Capsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoic acid breath test
    • Debreceni, A.; Abdel-Salam, O.M.; Figler, M.; Juricskay, I.; Szolcsanyi, J.; Mozsik, G. Capsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoic acid breath test. J. Physiol. Paris., 1999, 93(5), 455-460.
    • (1999) J. Physiol. Paris , vol.93 , Issue.5 , pp. 455-460
    • Debreceni, A.1    Abdel-Salam, O.M.2    Figler, M.3    Juricskay, I.4    Szolcsanyi, J.5    Mozsik, G.6
  • 79
    • 0031778305 scopus 로고    scopus 로고
    • Effect of capsaicin-containing red pepper sauce suspension on upper gastrointestinal motility in healthy volunteers
    • Gonzalez, R.; Dunkel, R.; Koletzko, B.; Schusdziarra, V.; Allescher, H.D. Effect of capsaicin-containing red pepper sauce suspension on upper gastrointestinal motility in healthy volunteers. Dig. Dis. Sci., 1998, 43(6), 1165-1171.
    • (1998) Dig. Dis. Sci , vol.43 , Issue.6 , pp. 1165-1171
    • Gonzalez, R.1    Dunkel, R.2    Koletzko, B.3    Schusdziarra, V.4    Allescher, H.D.5
  • 83
    • 77954496073 scopus 로고    scopus 로고
    • Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells
    • Huang, Y.A.; Roper, S.D. Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells. J. Physiol., 2010, 588(Pt 13), 2343-2350.
    • (2010) J. Physiol , vol.588 , Issue.Pt 13 , pp. 2343-2350
    • Huang, Y.A.1    Roper, S.D.2
  • 85
    • 61649093046 scopus 로고    scopus 로고
    • TRPM5-expressing microvillous cells in the main olfactory epithelium
    • Lin, W.; Ezekwe, E.A. Jr.; Zhao, Z.; Liman, E.R.; Restrepo, D. TRPM5-expressing microvillous cells in the main olfactory epithelium. BMC. Neurosci., 2008, 9, 114.
    • (2008) BMC. Neurosci , vol.9 , pp. 114
    • Lin, W.1    Ezekwe Jr., E.A.2    Zhao, Z.3    Liman, E.R.4    Restrepo, D.5
  • 86
    • 84859341984 scopus 로고    scopus 로고
    • Second-order input to the medial amygdala from olfactory sensory neurons expressing the transduction channel TRPM5
    • Thompson, J.A.; Salcedo, E.; Restrepo, D.; Finger, T.E. Second-order input to the medial amygdala from olfactory sensory neurons expressing the transduction channel TRPM5. J. Comp. Neurol., 2012, 520(8), 1819-1830.
    • (2012) J. Comp. Neurol , vol.520 , Issue.8 , pp. 1819-1830
    • Thompson, J.A.1    Salcedo, E.2    Restrepo, D.3    Finger, T.E.4
  • 87
    • 67650948294 scopus 로고    scopus 로고
    • Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5
    • 606 e591-592
    • Kokrashvili, Z.; Rodriguez, D.; Yevshayeva, V.; Zhou, H.; Margolskee, R.F.; Mosinger, B. Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5. Gastroenterology., 2009, 137(2), 598-606, 606 e591-592.
    • (2009) Gastroenterology , vol.137 , Issue.2 , pp. 598-606
    • Kokrashvili, Z.1    Rodriguez, D.2    Yevshayeva, V.3    Zhou, H.4    Margolskee, R.F.5    Mosinger, B.6
  • 88
    • 48249128056 scopus 로고    scopus 로고
    • Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells
    • Bezencon, C.; Furholz, A.; Raymond, F.; Mansourian, R.; Metairon, S.; Le Coutre, J.; Damak, S. Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells. J. Comp. Neurol., 2008, 509(5), 514-525.
    • (2008) J. Comp. Neurol , vol.509 , Issue.5 , pp. 514-525
    • Bezencon, C.1    Furholz, A.2    Raymond, F.3    Mansourian, R.4    Metairon, S.5    Le Coutre, J.6    Damak, S.7
  • 91
    • 34247568273 scopus 로고    scopus 로고
    • The pharmacology and signaling of bitter, sweet, and umami taste sensing
    • Palmer, R.K. The pharmacology and signaling of bitter, sweet, and umami taste sensing. Mol. Interv., 2007, 7(2), 87-98.
    • (2007) Mol. Interv , vol.7 , Issue.2 , pp. 87-98
    • Palmer, R.K.1
  • 92
    • 0037423367 scopus 로고    scopus 로고
    • Coding of sweet, bitter, and umami tastes: Different receptor cells sharing similar signaling pathways
    • Zhang, Y.; Hoon, M.A.; Chandrashekar, J.; Mueller, K.L.; Cook, B.; Wu, D.; Zuker, C.S.; Ryba, N.J. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell., 2003, 112(3), 293-301.
    • (2003) Cell , vol.112 , Issue.3 , pp. 293-301
    • Zhang, Y.1    Hoon, M.A.2    Chandrashekar, J.3    Mueller, K.L.4    Cook, B.5    Wu, D.6    Zuker, C.S.7    Ryba, N.J.8
  • 94
    • 79960397923 scopus 로고    scopus 로고
    • Accumulating evidence supports a taste component for free fatty acids in humans
    • Mattes, R.D. Accumulating evidence supports a taste component for free fatty acids in humans. Physiol. Behav., 2011, 104(4), 624-631.
    • (2011) Physiol. Behav , vol.104 , Issue.4 , pp. 624-631
    • Mattes, R.D.1
  • 95
    • 83455250388 scopus 로고    scopus 로고
    • TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1
    • Shah, B.P.; Liu, P.; Yu, T.; Hansen, D.R.; Gilbertson, T.A. TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. Am. J. Physiol. Cell. Physiol., 2012, 302(1), C210-219.
    • (2012) Am. J. Physiol. Cell. Physiol , vol.302 , Issue.1 , pp. 210-219
    • Shah, B.P.1    Liu, P.2    Yu, T.3    Hansen, D.R.4    Gilbertson, T.A.5
  • 97
    • 84905565906 scopus 로고    scopus 로고
    • Functional characterization of the human sweet receptor: High-throughput screening assay development and structural function relation
    • D.K. Weerasinghe and G.E. DuBois (Ed.)
    • Li X. and Servant, G. 2008, Functional characterization of the human sweet receptor: high-throughput screening assay development and structural function relation, D.K. Weerasinghe and G.E. DuBois (Ed.), American Chemical Society, 979, 368.
    • (2008) American Chemical Society
    • Li, X.1    Servant, G.2
  • 99
    • 77957261430 scopus 로고    scopus 로고
    • The T1R2/T1R3 sweet receptor and TRPM5 ion channel taste targets with therapeutic potential
    • Sprous, D.; Palmer, K.R. The T1R2/T1R3 sweet receptor and TRPM5 ion channel taste targets with therapeutic potential. Prog. Mol. Biol. Transl. Sci., 2010, 91, 151-208.
    • (2010) Prog. Mol. Biol. Transl. Sci , vol.91 , pp. 151-208
    • Sprous, D.1    Palmer, K.R.2
  • 101
    • 84857426294 scopus 로고    scopus 로고
    • Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
    • Kyriazis, G.A.; Soundarapandian, M.M.; Tyrberg, B. Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc. Natl. Acad. Sci. U. S. A., 2012, 109(8), E524-532.
    • (2012) Proc. Natl. Acad. Sci. U. S. A , vol.109 , Issue.8 , pp. 524-532
    • Kyriazis, G.A.1    Soundarapandian, M.M.2    Tyrberg, B.3
  • 103
    • 84857772149 scopus 로고    scopus 로고
    • The structure and function of the glucagon-like peptide-1 receptor and its ligands
    • Donnelly, D. The structure and function of the glucagon-like peptide-1 receptor and its ligands. Br. J. Pharmacol., 2012, 166(1), 27-41.
    • (2012) Br. J. Pharmacol , vol.166 , Issue.1 , pp. 27-41
    • Donnelly, D.1
  • 104
    • 0032871230 scopus 로고    scopus 로고
    • GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans
    • Naslund, E.; Bogefors, J.; Skogar, S.; Gryback, P.; Jacobsson, H.; Holst, J.J.; Hellstrom, P.M. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am. J. Physiol., 1999, 277(3 Pt 2), R910-916.
    • (1999) Am. J. Physiol , vol.277 , Issue.3 Pt 2 , pp. 910-916
    • Naslund, E.1    Bogefors, J.2    Skogar, S.3    Gryback, P.4    Jacobsson, H.5    Holst, J.J.6    Hellstrom, P.M.7
  • 105
    • 84855680846 scopus 로고    scopus 로고
    • Clinical efficacy and safety of once-weekly glucagon-like peptide-1 agonists in development for treatment of type 2 diabetes mellitus in adults
    • Tzefos, M.; Harris, K.; Brackett, A. Clinical efficacy and safety of once-weekly glucagon-like peptide-1 agonists in development for treatment of type 2 diabetes mellitus in adults. Ann. Pharmacother., 2012, 46(1), 68-78.
    • (2012) Ann. Pharmacother , vol.46 , Issue.1 , pp. 68-78
    • Tzefos, M.1    Harris, K.2    Brackett, A.3
  • 106
    • 0032100186 scopus 로고    scopus 로고
    • Intracerebroventricular glucagon-like peptide-1 (7-36) amide inhibits sham feeding in rats without eliciting satiety
    • Asarian, L.; Corp, E.S.; Hrupka, B.; Geary, N. Intracerebroventricular glucagon-like peptide-1 (7-36) amide inhibits sham feeding in rats without eliciting satiety. Physiol. Behav., 1998, 64(3), 367-372.
    • (1998) Physiol. Behav , vol.64 , Issue.3 , pp. 367-372
    • Asarian, L.1    Corp, E.S.2    Hrupka, B.3    Geary, N.4
  • 107
    • 19344375318 scopus 로고    scopus 로고
    • Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats
    • Chelikani, P.K.; Haver, A.C.; Reidelberger, R.D. Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2005, 288(6), R1695-1706.
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.288 , Issue.6 , pp. 1695-1706
    • Chelikani, P.K.1    Haver, A.C.2    Reidelberger, R.D.3
  • 108
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint, A.; Raben, A.; Astrup, A.; Holst, J.J. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J. Clin. Invest., 1998, 101(3), 515-520.
    • (1998) J. Clin. Invest , vol.101 , Issue.3 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 110
    • 33750628142 scopus 로고    scopus 로고
    • The role of oxyntomodulin and peptide tyrosine-tyrosine (PYY) in appetite control
    • Wynne, K.; Bloom, S.R. The role of oxyntomodulin and peptide tyrosine-tyrosine (PYY) in appetite control. Nat. Clin. Pract. Endocrinol. Metab., 2006, 2(11), 612-620.
    • (2006) Nat. Clin. Pract. Endocrinol. Metab , vol.2 , Issue.11 , pp. 612-620
    • Wynne, K.1    Bloom, S.R.2
  • 112
    • 34547446564 scopus 로고    scopus 로고
    • TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells
    • Kaske, S.; Krasteva, G.; Konig, P.; Kummer, W.; Hofmann, T.; Gudermann, T.; Chubanov, V. TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells. BMC. Neurosci., 2007, 8, 49.
    • (2007) BMC. Neurosci , vol.8 , pp. 49
    • Kaske, S.1    Krasteva, G.2    Konig, P.3    Kummer, W.4    Hofmann, T.5    Gudermann, T.6    Chubanov, V.7
  • 113
    • 77949266522 scopus 로고    scopus 로고
    • T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach
    • Hass, N.; Schwarzenbacher, K.; Breer, H. T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach. Cell. Tissue. Res., 2010, 339(3), 493-504.
    • (2010) Cell. Tissue. Res , vol.339 , Issue.3 , pp. 493-504
    • Hass, N.1    Schwarzenbacher, K.2    Breer, H.3
  • 114
    • 33845865790 scopus 로고    scopus 로고
    • Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells
    • Bezencon, C.; Le Coutre, J.; Damak, S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem. Senses., 2007, 32(1), 41-49.
    • (2007) Chem. Senses , vol.32 , Issue.1 , pp. 41-49
    • Bezencon, C.1    Le Coutre, J.2    Damak, S.3
  • 116
    • 0029009813 scopus 로고
    • Changes in patients' taste acuity after Roux-en-Y gastric bypass for clinically severe obesity
    • Burge, J.C.; Schaumburg, J.Z.; Choban, P.S.; DiSilvestro, R.A.; Flancbaum, L. Changes in patients' taste acuity after Roux-en-Y gastric bypass for clinically severe obesity. J. Am. Diet. Assoc., 1995, 95(6), 666-670.
    • (1995) J. Am. Diet. Assoc , vol.95 , Issue.6 , pp. 666-670
    • Burge, J.C.1    Schaumburg, J.Z.2    Choban, P.S.3    Disilvestro, R.A.4    Flancbaum, L.5
  • 119
    • 84861204401 scopus 로고    scopus 로고
    • A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice
    • Eddy, M.C.; Eschle, B.K.; Peterson, D.; Lauras, N.; Margolskee, R.F.; Delay, E.R. A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice. Chem. Senses., 2012, 37(5), 391-401.
    • (2012) Chem. Senses , vol.37 , Issue.5 , pp. 391-401
    • Eddy, M.C.1    Eschle, B.K.2    Peterson, D.3    Lauras, N.4    Margolskee, R.F.5    Delay, E.R.6
  • 120
    • 35148868260 scopus 로고    scopus 로고
    • Fat and carbohydrate preferences in mice: The contribution of alpha-gustducin and Trpm5 taste-signaling proteins
    • Sclafani, A.; Zukerman, S.; Glendinning, J.I.; Margolskee, R.F. Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007, 293(4), R1504-1513.
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.293 , Issue.4 , pp. 1504-1513
    • Sclafani, A.1    Zukerman, S.2    Glendinning, J.I.3    Margolskee, R.F.4
  • 122
    • 79961088401 scopus 로고    scopus 로고
    • Cell signaling mechanisms of gustatory perception of lipids: Can the taste cells be the target of anti-obesity agents
    • Dramane, G.; Akpona, S.; Simonin, A.M.; Besnard, P.; Khan, N.A. Cell signaling mechanisms of gustatory perception of lipids: can the taste cells be the target of anti-obesity agents? Curr. Med. Chem., 2011, 18(22), 3417-3422.
    • (2011) Curr. Med. Chem , vol.18 , Issue.22 , pp. 3417-3422
    • Dramane, G.1    Akpona, S.2    Simonin, A.M.3    Besnard, P.4    Khan, N.A.5
  • 123
    • 33748439003 scopus 로고    scopus 로고
    • Intake of sugar-sweetened beverages and weight gain: A systematic review
    • Malik, V.S.; Schulze, M.B.; Hu, F.B. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am. J. Clin. Nutr., 2006, 84(2), 274-288.
    • (2006) Am. J. Clin. Nutr , vol.84 , Issue.2 , pp. 274-288
    • Malik, V.S.1    Schulze, M.B.2    Hu, F.B.3
  • 125
    • 70349243429 scopus 로고    scopus 로고
    • Natural addiction: A behavioral and circuit model based on sugar addiction in rats
    • Hoebel, B.G.; Avena, N.M.; Bocarsly, M.E.; Rada, P. Natural addiction: a behavioral and circuit model based on sugar addiction in rats. J. Addict. Med., 2009, 3(1), 33-41.
    • (2009) J. Addict. Med , vol.3 , Issue.1 , pp. 33-41
    • Hoebel, B.G.1    Avena, N.M.2    Bocarsly, M.E.3    Rada, P.4
  • 126
    • 63549107662 scopus 로고    scopus 로고
    • Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity
    • Geiger, B.M.; Haburcak, M.; Avena, N.M.; Moyer, M.C.; Hoebel, B.G.; Pothos, E.N. Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity. Neuroscience., 2009, 159(4), 1193-1199.
    • (2009) Neuroscience , vol.159 , Issue.4 , pp. 1193-1199
    • Geiger, B.M.1    Haburcak, M.2    Avena, N.M.3    Moyer, M.C.4    Hoebel, B.G.5    Pothos, E.N.6
  • 127
    • 79951699573 scopus 로고    scopus 로고
    • Reward mechanisms in obesity: New insights and future directions
    • Kenny, P.J. Reward mechanisms in obesity: new insights and future directions. Neuron., 2011, 69(4), 664-679.
    • (2011) Neuron , vol.69 , Issue.4 , pp. 664-679
    • Kenny, P.J.1
  • 128
    • 79958296324 scopus 로고    scopus 로고
    • Transient receptor potential channel type M5 is essential for fat taste
    • Liu, P.; Shah, B.P.; Croasdell, S.; Gilbertson, T.A. Transient receptor potential channel type M5 is essential for fat taste. J. Neurosci., 2011, 31(23), 8634-8642.
    • (2011) J. Neurosci , vol.31 , Issue.23 , pp. 8634-8642
    • Liu, P.1    Shah, B.P.2    Croasdell, S.3    Gilbertson, T.A.4
  • 129
    • 23244464783 scopus 로고    scopus 로고
    • Taste disorders in acute stroke: A prospective observational study on taste disorders in 102 stroke patients
    • Heckmann, J.G.; Stossel, C.; Lang, C.J.; Neundorfer, B.; Tomandl, B.; Hummel, T. Taste disorders in acute stroke: a prospective observational study on taste disorders in 102 stroke patients. Stroke., 2005, 36(8), 1690-1694.
    • (2005) Stroke , vol.36 , Issue.8 , pp. 1690-1694
    • Heckmann, J.G.1    Stossel, C.2    Lang, C.J.3    Neundorfer, B.4    Tomandl, B.5    Hummel, T.6
  • 131
    • 0031812769 scopus 로고    scopus 로고
    • Biology of taste buds and the clinical problem of taste loss
    • Nelson, G.M. Biology of taste buds and the clinical problem of taste loss. Anat. Rec., 1998, 253(3), 70-78.
    • (1998) Anat. Rec , vol.253 , Issue.3 , pp. 70-78
    • Nelson, G.M.1
  • 132
    • 0033923362 scopus 로고    scopus 로고
    • Taste and smell perception affect appetite and immunity in the elderly
    • Schiffman, S.S.; Graham, B.G. Taste and smell perception affect appetite and immunity in the elderly. Eur. J. Clin. Nutr., 2000, 54. Suppl. 3, S54-63.
    • (2000) Eur. J. Clin. Nutr , vol.54 , Issue.SUPPL. 3 , pp. 54-63
    • Schiffman, S.S.1    Graham, B.G.2
  • 134
    • 0346786141 scopus 로고    scopus 로고
    • Weight reduction due to stroke-induced dysgeusia
    • Finsterer, J.; Stollberger, C.; Kopsa, W. Weight reduction due to stroke-induced dysgeusia. Eur. Neurol., 2004, 51(1), 47-49.
    • (2004) Eur. Neurol , vol.51 , Issue.1 , pp. 47-49
    • Finsterer, J.1    Stollberger, C.2    Kopsa, W.3
  • 135
    • 0037045835 scopus 로고    scopus 로고
    • Loss of taste is loss of weight
    • Woschnagg, H.; Stollberger, C.; Finsterer, J. Loss of taste is loss of weight. Lancet., 2002, 359(9309), 891.
    • (2002) Lancet , vol.359 , Issue.9309 , pp. 891
    • Woschnagg, H.1    Stollberger, C.2    Finsterer, J.3
  • 138
    • 0043267987 scopus 로고    scopus 로고
    • Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    • Watanabe, H.; Vriens, J.; Prenen, J.; Droogmans, G.; Voets, T.; Nilius, B. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature., 2003, 424(6947), 434-438.
    • (2003) Nature , vol.424 , Issue.6947 , pp. 434-438
    • Watanabe, H.1    Vriens, J.2    Prenen, J.3    Droogmans, G.4    Voets, T.5    Nilius, B.6
  • 139
    • 77955305225 scopus 로고    scopus 로고
    • The vanilloid transient receptor potential channel TRPV4: From structure to disease
    • Everaerts, W.; Nilius, B.; Owsianik, G. The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog. Biophys. Mol. Biol., 2010, 103(1), 2-17.
    • (2010) Prog. Biophys. Mol. Biol , vol.103 , Issue.1 , pp. 2-17
    • Everaerts, W.1    Nilius, B.2    Owsianik, G.3
  • 140
    • 84859613211 scopus 로고    scopus 로고
    • TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity
    • Kusudo, T.; Wang, Z.; Mizuno, A.; Suzuki, M.; Yamashita, H. TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity. J. Appl. Physiol., 2012, 112(7), 1223-1232.
    • (2012) J. Appl. Physiol , vol.112 , Issue.7 , pp. 1223-1232
    • Kusudo, T.1    Wang, Z.2    Mizuno, A.3    Suzuki, M.4    Yamashita, H.5
  • 142
    • 70349771967 scopus 로고    scopus 로고
    • Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes
    • Phan, M.N.; Leddy, H.A.; Votta, B.J.; Kumar, S.; Levy, D.S.; Lipshutz, D.B.; Lee, S.H.; Liedtke, W.; Guilak, F. Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis. Rheum., 2009, 60(10), 3028-3037.
    • (2009) Arthritis. Rheum , vol.60 , Issue.10 , pp. 3028-3037
    • Phan, M.N.1    Leddy, H.A.2    Votta, B.J.3    Kumar, S.4    Levy, D.S.5    Lipshutz, D.B.6    Lee, S.H.7    Liedtke, W.8    Guilak, F.9
  • 143
    • 55049139230 scopus 로고    scopus 로고
    • TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion
    • Iwasaki, Y.; Tanabe, M.; Kobata, K.; Watanabe, T. TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion. Biosci. Biotechnol. Biochem., 2008, 72(10), 2608-2614.
    • (2008) Biosci. Biotechnol. Biochem , vol.72 , Issue.10 , pp. 2608-2614
    • Iwasaki, Y.1    Tanabe, M.2    Kobata, K.3    Watanabe, T.4
  • 144
    • 67049154139 scopus 로고    scopus 로고
    • Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice
    • Masamoto, Y.; Kawabata, F.; Fushiki, T. Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. Biosci. Biotechnol. Biochem., 2009, 73(5), 1021-1027.
    • (2009) Biosci. Biotechnol. Biochem , vol.73 , Issue.5 , pp. 1021-1027
    • Masamoto, Y.1    Kawabata, F.2    Fushiki, T.3
  • 145
    • 84862150176 scopus 로고    scopus 로고
    • Ingestion of Cinnamaldehyde, a TRPA1 Agonist, Reduces Visceral Fats in Mice Fed a High-Fat and High-Sucrose Diet
    • Tamura, Y.; Iwasaki, Y.; Narukawa, M.; Watanabe, T. Ingestion of Cinnamaldehyde, a TRPA1 Agonist, Reduces Visceral Fats in Mice Fed a High-Fat and High-Sucrose Diet. J. Nutr. Sci. Vitaminol. (Tokyo)., 2012, 58(1), 9-13.
    • (2012) J. Nutr. Sci. Vitaminol. (Tokyo) , vol.58 , Issue.1 , pp. 9-13
    • Tamura, Y.1    Iwasaki, Y.2    Narukawa, M.3    Watanabe, T.4
  • 147
    • 73349119703 scopus 로고    scopus 로고
    • TRPA1 agonists delay gastric emptying in rats through serotonergic pathways. Naunyn. Schmiedebergs
    • Doihara, H.; Nozawa, K.; Kawabata-Shoda, E.; Kojima, R.; Yokoyama, T.; Ito, H. TRPA1 agonists delay gastric emptying in rats through serotonergic pathways. Naunyn. Schmiedebergs. Arch. Pharmacol., 2009, 380(4), 353-357.
    • (2009) Arch. Pharmacol , vol.380 , Issue.4 , pp. 353-357
    • Doihara, H.1    Nozawa, K.2    Kawabata-Shoda, E.3    Kojima, R.4    Yokoyama, T.5    Ito, H.6
  • 148
    • 68549136483 scopus 로고    scopus 로고
    • Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs
    • Doihara, H.; Nozawa, K.; Kawabata-Shoda, E.; Kojima, R.; Yokoyama, T.; Ito, H. Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs. Eur. J. Pharmacol., 2009, 617(1-3), 124-129.
    • (2009) Eur. J. Pharmacol , vol.617 , Issue.1-3 , pp. 124-129
    • Doihara, H.1    Nozawa, K.2    Kawabata-Shoda, E.3    Kojima, R.4    Yokoyama, T.5    Ito, H.6
  • 151
    • 58749091111 scopus 로고    scopus 로고
    • Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system
    • Liu, S.; Qu, M.H.; Ren, W.; Hu, H.Z.; Gao, N.; Wang, G.D.; Wang, X.Y.; Fei, G.; Zuo, F.; Xia, Y.; Wood, J.D. Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system. J. Comp. Neurol., 2008, 511(6), 847-862.
    • (2008) J. Comp. Neurol , vol.511 , Issue.6 , pp. 847-862
    • Liu, S.1    Qu, M.H.2    Ren, W.3    Hu, H.Z.4    Gao, N.5    Wang, G.D.6    Wang, X.Y.7    Fei, G.8    Zuo, F.9    Xia, Y.10    Wood, J.D.11
  • 152
    • 0037166343 scopus 로고    scopus 로고
    • Calcium oscillation linked to pacemaking of interstitial cells of Cajal: Requirement of calcium influx and localization of TRP4 in caveolae
    • Torihashi, S.; Fujimoto, T.; Trost, C.; Nakayama, S. Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolae. J. Biol. Chem., 2002, 277(21), 19191-19197.
    • (2002) J. Biol. Chem , vol.277 , Issue.21 , pp. 19191-19197
    • Torihashi, S.1    Fujimoto, T.2    Trost, C.3    Nakayama, S.4
  • 153
    • 0036888986 scopus 로고    scopus 로고
    • TRPC4 currents have properties similar to the pacemaker current in interstitial cells of Cajal
    • Walker, R.L.; Koh, S.D.; Sergeant, G.P.; Sanders, K.M.; Horowitz, B. TRPC4 currents have properties similar to the pacemaker current in interstitial cells of Cajal. Am. J. Physiol. Cell. Physiol., 2002, 283(6), C1637-1645.
    • (2002) Am. J. Physiol. Cell. Physiol , vol.283 , Issue.6 , pp. 1637-1645
    • Walker, R.L.1    Koh, S.D.2    Sergeant, G.P.3    Sanders, K.M.4    Horowitz, B.5
  • 154
    • 80051564138 scopus 로고    scopus 로고
    • The functional role of intramuscular interstitial cells of Cajal in the stomach
    • Kito, Y. The functional role of intramuscular interstitial cells of Cajal in the stomach. J. Smooth. Muscle. Res., 2011, 47(2), 47-53.
    • (2011) J. Smooth. Muscle. Res , vol.47 , Issue.2 , pp. 47-53
    • Kito, Y.1
  • 155
    • 33646695456 scopus 로고    scopus 로고
    • The relationship of TRP channels to the pacemaker activity of interstitial cells of Cajal in the gastrointestinal tract
    • Kim, B.J.; So, I.; Kim, K.W. The relationship of TRP channels to the pacemaker activity of interstitial cells of Cajal in the gastrointestinal tract. J. Smooth. Muscle. Res., 2006, 42(1), 1-7.
    • (2006) J. Smooth. Muscle. Res , vol.42 , Issue.1 , pp. 1-7
    • Kim, B.J.1    So, I.2    Kim, K.W.3
  • 156
    • 0141755156 scopus 로고    scopus 로고
    • Formation of novel TRPC channels by complex subunit interactions in embryonic brain
    • Strubing, C.; Krapivinsky, G.; Krapivinsky, L.; Clapham, D.E. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem., 2003, 278(40), 39014-39019.
    • (2003) J. Biol. Chem , vol.278 , Issue.40 , pp. 39014-39019
    • Strubing, C.1    Krapivinsky, G.2    Krapivinsky, L.3    Clapham, D.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.