Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5 -/- mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 11, 2010, Pages 5208-5213

  Colsoul, Barbara ^a   Schraenen, Anica ^b   Lemaire, Katleen ^b   Quintens, Roel ^b   Van Lommel, Leentje ^b   Segal, Andrei ^a   Owsianik, Grzegorz ^a   Talavera, Karel ^a   Voets, Thomas ^a   Margolskee, Robert F ^c   Kokrashvili, Zaza ^c   Gilon, Patrick ^d   Nilius, Bernd ^a   Schuit, Frans C ^b   Vennekensa, Rudi ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Ca2+ signaling; Insulin release; Pancreatic cells; Transient receptor potential ion channels | glucose sensing

Indexed keywords

CALCIUM; CATION CHANNEL; GLUCOSE; INSULIN; MONOVALENT CATION; PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; CORRELATIONAL STUDY; ELECTROPHYSIOLOGY; GLUCOSE TOLERANCE; IMAGING; IMMUNOFLUORESCENCE; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CALCIUM SIGNALING; CATIONS; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; INTRACELLULAR SPACE; ION CHANNEL GATING; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; MICE; PHENOTYPE; TRPM CATION CHANNELS;

MUS;

EID: 77950450361     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0913107107     Document Type: Article

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