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Volumn 68, Issue 6, 2009, Pages 830-843

Obesity treatment: Novel peripheral targets

Author keywords

Amylin; Cholecystokinin; Ghrelin; Glucagon like peptide 1; Obesity; Oxyntomodulin; Pancreatic polypeptide; Peptide YY

Indexed keywords

ALBIGLUTIDE; AMYLIN; ANTIOBESITY AGENT; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR AGONIST; CHOLECYSTOKININ RECEPTOR STIMULATING AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GHRELIN; GHRELIN RECEPTOR ANTAGONIST; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HORMONE RECEPTOR STIMULATING AGENT; LEPTIN RECEPTOR AGONIST; LIRAGLUTIDE; METFORMIN; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PEPTIDE YY; PEPTIDE YY [3-36]; PRAMLINTIDE; SULFONYLUREA DERIVATIVE; TASPOGLUTIDE; UNCLASSIFIED DRUG; VICTOZA;

EID: 70849085551     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2009.03522.x     Document Type: Review
Times cited : (59)

References (210)
  • 2
    • 0842302386 scopus 로고    scopus 로고
    • Overweight and obesity mortality trends in Canada, 1985-2000
    • Katzmarzyk PT, Ardern CI. Overweight and obesity mortality trends in Canada, 1985-2000. Can J Public Health 2004 95 : 16 20.
    • (2004) Can J Public Health , vol.95 , pp. 16-20
    • Katzmarzyk, P.T.1    Ardern, C.I.2
  • 3
    • 0037048669 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2000
    • Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002 288 : 1723 7.
    • (2002) JAMA , vol.288 , pp. 1723-1727
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Johnson, C.L.4
  • 4
    • 0141865826 scopus 로고    scopus 로고
    • AIHW Cat. No. PHE 24. Canberra: Australian Institute of Health and Welfare
    • de Looper M, Bhatia K. Australian Health Trends 2001. AIHW Cat. No. PHE 24. Canberra : Australian Institute of Health and Welfare, 2001.
    • (2001) Australian Health Trends 2001.
    • De Looper, M.1    Bhatia, K.2
  • 5
    • 0003968789 scopus 로고    scopus 로고
    • National Audit Office. Report by the Comptroller and Auditor General. London: The Stationery Office
    • National Audit Office. Tackling obesity in England. Report by the Comptroller and Auditor General. London : The Stationery Office, 2001.
    • (2001) Tackling Obesity in England.
  • 6
    • 62849107573 scopus 로고    scopus 로고
    • Body-mass index and cause-specific mortality in 900 000 adults: Collaborative analyses of 57 prospective studies
    • Prospective Studies Collaboration
    • Prospective Studies Collaboration, Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, Qizilbash N, Collins R, Peto R. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009 373 : 1083 96.
    • (2009) Lancet , vol.373 , pp. 1083-1096
    • Whitlock, G.1    Lewington, S.2    Sherliker, P.3    Clarke, R.4    Emberson, J.5    Halsey, J.6    Qizilbash, N.7    Collins, R.8    Peto, R.9
  • 7
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature 2000 404 : 635 43.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 8
    • 0028917432 scopus 로고
    • Weight gain as a risk factor for clinical diabetes mellitus in women
    • Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 1995 122 : 481 6.
    • (1995) Ann Intern Med , vol.122 , pp. 481-486
    • Colditz, G.A.1    Willett, W.C.2    Rotnitzky, A.3    Manson, J.E.4
  • 9
    • 11244331742 scopus 로고    scopus 로고
    • Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: A randomized trial
    • Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 2005 293 : 43 53.
    • (2005) JAMA , vol.293 , pp. 43-53
    • Dansinger, M.L.1    Gleason, J.A.2    Griffith, J.L.3    Selker, H.P.4    Schaefer, E.J.5
  • 10
    • 33845874637 scopus 로고    scopus 로고
    • Drug treatments for obesity: Orlistat, sibutramine, and rimonabant
    • Padwal RS, Majumdar SR. Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet 2007 369 : 71 7.
    • (2007) Lancet , vol.369 , pp. 71-77
    • Padwal, R.S.1    Majumdar, S.R.2
  • 13
    • 33646878552 scopus 로고    scopus 로고
    • A case-controlled matched-pair cohort study of laparoscopic Roux-en-Y gastric bypass and Lap-Band patients in a single US center with three-year follow-up
    • Cottam DR, Atkinson J, Anderson A, Grace B, Fisher B. A case-controlled matched-pair cohort study of laparoscopic Roux-en-Y gastric bypass and Lap-Band patients in a single US center with three-year follow-up. Obes Surg 2006 16 : 534 40.
    • (2006) Obes Surg , vol.16 , pp. 534-540
    • Cottam, D.R.1    Atkinson, J.2    Anderson, A.3    Grace, B.4    Fisher, B.5
  • 14
    • 33746036883 scopus 로고    scopus 로고
    • Laparoscopic gastric bypass is superior to adjustable gastric band in super morbidly obese patients: A prospective, comparative analysis
    • Bowne WB, Julliard K, Castro AE, Shah P, Morgenthal CB, Ferzli GS. Laparoscopic gastric bypass is superior to adjustable gastric band in super morbidly obese patients: a prospective, comparative analysis. Arch Surg 2006 141 : 683 9.
    • (2006) Arch Surg , vol.141 , pp. 683-689
    • Bowne, W.B.1    Julliard, K.2    Castro, A.E.3    Shah, P.4    Morgenthal, C.B.5    Ferzli, G.S.6
  • 19
    • 0026514389 scopus 로고
    • Human gut hormone profiles in patients with short bowel syndrome
    • Andrews NJ, Irving MH. Human gut hormone profiles in patients with short bowel syndrome. Dig Dis Sci 1992 37 : 729 32.
    • (1992) Dig Dis Sci , vol.37 , pp. 729-732
    • Andrews, N.J.1    Irving, M.H.2
  • 20
    • 0021849270 scopus 로고
    • Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry
    • Varndell IM, Bishop AE, Sikri KL, Uttenthal LO, Bloom SR, Polak JM. Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry. J Histochem Cytochem 1985 33 : 1080 6.
    • (1985) J Histochem Cytochem , vol.33 , pp. 1080-1086
    • Varndell, I.M.1    Bishop, A.E.2    Sikri, K.L.3    Uttenthal, L.O.4    Bloom, S.R.5    Polak, J.M.6
  • 23
    • 0032982267 scopus 로고    scopus 로고
    • Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion
    • Rocca AS, Brubaker PL. Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion. Endocrinology 1999 140 : 1687 94.
    • (1999) Endocrinology , vol.140 , pp. 1687-1694
    • Rocca, A.S.1    Brubaker, P.L.2
  • 24
    • 0028838030 scopus 로고
    • Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients
    • Herrmann C, Göke R, Richter G, Fehmann HC, Arnold R, Göke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion 1995 56 : 117 26.
    • (1995) Digestion , vol.56 , pp. 117-126
    • Herrmann, C.1    Göke, R.2    Richter, G.3    Fehmann, H.C.4    Arnold, R.5    Göke, B.6
  • 25
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 1987 2 : 1300 4.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 26
    • 0026775150 scopus 로고
    • Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1
    • Thorens B. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 1992 89 : 8641 5.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8641-8645
    • Thorens, B.1
  • 27
    • 0027393644 scopus 로고
    • The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37)
    • Lu M, Wheeler MB, Leng XH, Boyd AE III. The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37). Endocrinology 1993 132 : 94 100.
    • (1993) Endocrinology , vol.132 , pp. 94-100
    • Lu, M.1    Wheeler, M.B.2    Leng, X.H.3    Boyd, III.A.E.4
  • 28
    • 0028900758 scopus 로고
    • Tissue-specific expression of the human receptor for glucagon-like peptide-I: Brain, heart and pancreatic forms have the same deduced amino acid sequences
    • Wei Y, Mojsov S. Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett 1995 358 : 219 24.
    • (1995) FEBS Lett , vol.358 , pp. 219-224
    • Wei, Y.1    Mojsov, S.2
  • 29
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfetti R, Zhou J, Doyle ME, Egan JM. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000 141 : 4600 5.
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 30
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: Effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients
    • Willms B, Werner J, Holst JJ, Ørskov C, Creutzfeldt W, Nauck MA. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 1996 81 : 327 32.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 327-332
    • Willms, B.1    Werner, J.2    Holst, J.J.3    Ørskov, C.4    Creutzfeldt, W.5    Nauck, M.A.6
  • 31
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus
    • Gutniak M, Ørskov C, Holst JJ, Ahrén B, Efendic S. Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med 1992 326 : 1316 22.
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Ørskov, C.2    Holst, J.J.3    Ahrén, B.4    Efendic, S.5
  • 32
    • 0035516188 scopus 로고    scopus 로고
    • Systemic Administration of the Long-Acting GLP-1 Derivative NN2211 Induces Lasting and Reversible Weight Loss in Both Normal and Obese Rats
    • Larsen PJ, Fledelius C, Knudsen LB, Tang-Christensen M. Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats. Diabetes 2001 50 : 2530 9. (Pubitemid 33642771)
    • (2001) Diabetes , vol.50 , Issue.7-12 , pp. 2530-2539
    • Larsen, P.J.1    Fledelius, C.2    Knudsen, L.B.3    Tang-Christensen, M.4
  • 35
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest. 1998 101 : 515 20.
    • (1998) J Clin Invest. , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 36
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 2002 359 : 824 30.
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 37
    • 18144381593 scopus 로고    scopus 로고
    • The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JRC, Ghatei MA, Bloom SR. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 2005 1044 : 127 31.
    • (2005) Brain Res , vol.1044 , pp. 127-131
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3    Sajedi, A.4    Smith, K.L.5    Parkinson, J.R.C.6    Ghatei, M.A.7    Bloom, S.R.8
  • 38
    • 0030765810 scopus 로고    scopus 로고
    • Comparison of Fos induced in rat brain by GLP-1 and amylin
    • Rowland NE, Crews EC, Gentry RM. Comparison of Fos induced in rat brain by GLP-1 and amylin. Regul Pept 1997 71 : 171 4.
    • (1997) Regul Pept , vol.71 , pp. 171-174
    • Rowland, N.E.1    Crews, E.C.2    Gentry, R.M.3
  • 39
    • 0030967436 scopus 로고    scopus 로고
    • Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    • Larsen PJ, Tang-Christensen M, Jessop DS. Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 1997 138 : 4445 55.
    • (1997) Endocrinology , vol.138 , pp. 4445-4455
    • Larsen, P.J.1    Tang-Christensen, M.2    Jessop, D.S.3
  • 40
    • 0141736850 scopus 로고    scopus 로고
    • Short-term food restriction and refeeding alter expression of genes likely involved in brain glucosensing
    • Zhou J, Roane DS, Xi X, Bogacka I, Li B, Ryan DH, Martin RJ. Short-term food restriction and refeeding alter expression of genes likely involved in brain glucosensing. Exp Biol Med 2003 228 : 943 50.
    • (2003) Exp Biol Med , vol.228 , pp. 943-950
    • Zhou, J.1    Roane, D.S.2    Xi, X.3    Bogacka, I.4    Li, B.5    Ryan, D.H.6    Martin, R.J.7
  • 42
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993 214 : 829 35.
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 43
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 1995 136 : 3585 96.
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 44
    • 33644819643 scopus 로고    scopus 로고
    • Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs
    • Simonsen L, Holst JJ, Deacon CF. Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs. Diabetologia 2006 49 : 706 12.
    • (2006) Diabetologia , vol.49 , pp. 706-712
    • Simonsen, L.1    Holst, J.J.2    Deacon, C.F.3
  • 45
    • 0038363953 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV
    • de Meester I, Lambeir AM, Proost P, Scharpé S. Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIV. Adv Exp Med Biol 2003 524 : 3 17.
    • (2003) Adv Exp Med Biol , vol.524 , pp. 3-17
    • De Meester, I.1    Lambeir, A.M.2    Proost, P.3    Scharpé, S.4
  • 46
    • 0036235563 scopus 로고    scopus 로고
    • Endoproteolysis by isolated membrane peptidases reveal metabolic stability of glucagon-like peptide-1 analogs, exendins-3 and -4
    • Thum A, Hupe-Sodmann K, Göke R, Voigt K, Göke B, McGregor GP. Endoproteolysis by isolated membrane peptidases reveal metabolic stability of glucagon-like peptide-1 analogs, exendins-3 and -4. Exp Clin Endocrinol Diabetes 2002 110 : 113 8.
    • (2002) Exp Clin Endocrinol Diabetes , vol.110 , pp. 113-118
    • Thum, A.1    Hupe-Sodmann, K.2    Göke, R.3    Voigt, K.4    Göke, B.5    McGregor, G.P.6
  • 47
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
    • Eng J, Kleinman WA, Singh L, Singh G, Raufman JP. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 1992 267 : 7402 5.
    • (1992) J Biol Chem , vol.267 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 48
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D, Porter L. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008 372 : 1240 50.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3    Kendall, D.M.4    Trautmann, M.5    Zhuang, D.6    Porter, L.7
  • 49
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
    • Kim D, MacConell L, Zhuang D, Kothare PA, Trautmann M, Fineman M, Taylor K. Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care 2007 30 : 1487 93.
    • (2007) Diabetes Care , vol.30 , pp. 1487-1493
    • Kim, D.1    MacConell, L.2    Zhuang, D.3    Kothare, P.A.4    Trautmann, M.5    Fineman, M.6    Taylor, K.7
  • 50
    • 33748471110 scopus 로고    scopus 로고
    • Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus
    • Ratner RE, Maggs D, Nielsen LL, Stonehouse AH, Poon T, Zhang B, Bicsak TA, Brodows RG, Kim DD. Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus. Diabetes Obes Metab 2006 8 : 419 28.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 419-428
    • Ratner, R.E.1    Maggs, D.2    Nielsen, L.L.3    Stonehouse, A.H.4    Poon, T.5    Zhang, B.6    Bicsak, T.A.7    Brodows, R.G.8    Kim, D.D.9
  • 51
    • 33749364478 scopus 로고    scopus 로고
    • Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin
    • Riddle MC, Henry RR, Poon TH, Zhang B, Mac SM, Holcombe JH, Kim DD, Maggs DG. Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin. Diabetes Metab Res Rev 2006 22 : 483 91.
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 483-491
    • Riddle, M.C.1    Henry, R.R.2    Poon, T.H.3    Zhang, B.4    Mac, S.M.5    Holcombe, J.H.6    Kim, D.D.7    Maggs, D.G.8
  • 52
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004 27 : 2628 35.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 53
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (Exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (Exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005 28 : 1092 100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • Defronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 54
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, Zhuang D, Kim DD, Fineman MS, Baron AD. Effects of exenatide (Exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005 28 : 1083 91.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6    Baron, A.D.7
  • 55
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: A randomized trial
    • Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG. Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med 2005 143 : 559 69.
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.J.1    Van Gaal, L.F.2    Johns, D.3    Mihm, M.J.4    Widel, M.H.5    Brodows, R.G.6
  • 56
    • 33646354927 scopus 로고    scopus 로고
    • Exenatide (exendin-4)-induced pancreatitis: A case report
    • Denker PS, Dimarco PE. Exenatide (exendin-4)-induced pancreatitis: a case report. Diabetes Care 2006 29 : 471.
    • (2006) Diabetes Care , vol.29 , pp. 471
    • Denker, P.S.1    Dimarco, P.E.2
  • 57
    • 42949089442 scopus 로고    scopus 로고
    • Exenatide and rare adverse events
    • Ahmad SR, Swann J. Exenatide and rare adverse events. N Engl J Med 2008 358 : 1970 1.
    • (2008) N Engl J Med , vol.358 , pp. 1970-1971
    • Ahmad, S.R.1    Swann, J.2
  • 58
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold CK. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin 2009 25 : 1019 27.
    • (2009) Curr Med Res Opin , vol.25 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold, C.K.3
  • 59
    • 47549095688 scopus 로고    scopus 로고
    • Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome
    • Elkind-Hirsch K, Marrioneaux O, Bhushan M, Vernor D, Bhushan R. Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2008 93 : 2670 8.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2670-2678
    • Elkind-Hirsch, K.1    Marrioneaux, O.2    Bhushan, M.3    Vernor, D.4    Bhushan, R.5
  • 60
    • 57649232757 scopus 로고    scopus 로고
    • Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue
    • Russell-Jones D. Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue. Mol Cell Endocrinol 2009 297 : 137 40.
    • (2009) Mol Cell Endocrinol , vol.297 , pp. 137-140
    • Russell-Jones, D.1
  • 61
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, Shah NS, Tankova T, Mitha IH, Zdravkovic M, Düring M, Matthews DR. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care 2009 32 : 84 90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3    Shah, N.S.4    Tankova, T.5    Mitha, I.H.6    Zdravkovic, M.7    Düring, M.8    Matthews, D.R.9
  • 62
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, Lewin A, Schwartz S, Raskin P, Hale PM, Zdravkovic M, Blonde L. Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care 2009 32 : 1224 30.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3    Lewin, A.4    Schwartz, S.5    Raskin, P.6    Hale, P.M.7    Zdravkovic, M.8    Blonde, L.9
  • 64
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brändle M, Bebakar WM, Kamaruddin NA, Strand J, Zdravkovic M, Le Thi TD, Colagiuri S. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 2009 26 : 268 78.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3    Bebakar, W.M.4    Kamaruddin, N.A.5    Strand, J.6    Zdravkovic, M.7    Le Thi, T.D.8    Colagiuri, S.9
  • 65
    • 67649523294 scopus 로고    scopus 로고
    • Treatment with the human once-weekly GLP-1 analogue taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes mellitus inadequately controlled with metformin alone: A double-blind placebo-controlled study
    • Nauck MA, Ratner RE, Kapitza C, Berria R, Boldrin M, Balena R. Treatment with the human once-weekly GLP-1 analogue taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes mellitus inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care 2009 32 : 1237 43.
    • (2009) Diabetes Care , vol.32 , pp. 1237-1243
    • Nauck, M.A.1    Ratner, R.E.2    Kapitza, C.3    Berria, R.4    Boldrin, M.5    Balena, R.6
  • 66
    • 57349168543 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes
    • Matthews JE, Stewart MW, De Boever EH, Dobbins RL, Hodge RJ, Walker SE, Holland MC, Bush MA. Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes. J Clin Endocrinol Metab 2008 93 : 4810 7.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4810-4817
    • Matthews, J.E.1    Stewart, M.W.2    De Boever, E.H.3    Dobbins, R.L.4    Hodge, R.J.5    Walker, S.E.6    Holland, M.C.7    Bush, M.A.8
  • 67
    • 0023008693 scopus 로고
    • Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
    • Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 1986 261 : 11880 9.
    • (1986) J Biol Chem , vol.261 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3    Ravazzola, M.4    Orci, L.5    Habener, J.F.6
  • 68
    • 0020509994 scopus 로고
    • Molecular forms of human enteroglucagon in tissue and plasma: Plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract
    • Ghatei MA, Uttenthal LO, Christofides ND, Bryant MG, Bloom SR. Molecular forms of human enteroglucagon in tissue and plasma: plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract. J Clin Endocrinol Metab 1983 57 : 488 95.
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 488-495
    • Ghatei, M.A.1    Uttenthal, L.O.2    Christofides, N.D.3    Bryant, M.G.4    Bloom, S.R.5
  • 69
    • 0026718211 scopus 로고
    • Oxyntomodulin-like immunoreactivity: Diurnal profile of a new potential enterogastrone
    • Le QA, Kervran A, Blache P, Ciurana AJ, Bataille D. Oxyntomodulin-like immunoreactivity: diurnal profile of a new potential enterogastrone. J Clin Endocrinol Metab 1992 74 : 1405 9.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 1405-1409
    • Le, Q.A.1    Kervran, A.2    Blache, P.3    Ciurana, A.J.4    Bataille, D.5
  • 70
    • 0024442006 scopus 로고
    • Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions
    • Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ. Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions. Dig Dis Sci 1989 34 : 1411 9.
    • (1989) Dig Dis Sci , vol.34 , pp. 1411-1419
    • Schjoldager, B.1    Mortensen, P.E.2    Myhre, J.3    Christiansen, J.4    Holst, J.J.5
  • 71
    • 0023442944 scopus 로고
    • The effect of oxyntomodulin (glucagon-37) and glucagon on exocrine pancreatic secretion in the conscious rat
    • Biedzinski TM, Bataille D, Devaux MA, Sarles H. The effect of oxyntomodulin (glucagon-37) and glucagon on exocrine pancreatic secretion in the conscious rat. Peptides 1987 8 : 967 72.
    • (1987) Peptides , vol.8 , pp. 967-972
    • Biedzinski, T.M.1    Bataille, D.2    Devaux, M.A.3    Sarles, H.4
  • 72
    • 0019983555 scopus 로고
    • Oxyntomodulin (glucagon-37 or bioactive enteroglucagon): A potent inhibitor of pentagastrin-stimulated acid secretion in rats
    • Dubrasquet M, Bataille D, Gespach C. Oxyntomodulin (glucagon-37 or bioactive enteroglucagon): a potent inhibitor of pentagastrin-stimulated acid secretion in rats. Biosci Rep 1982 2 : 391 5.
    • (1982) Biosci Rep , vol.2 , pp. 391-395
    • Dubrasquet, M.1    Bataille, D.2    Gespach, C.3
  • 73
    • 0019527355 scopus 로고
    • Enteroglucagon': A specific effect on gastric glands isolated from the rat fundus. Evidence for an 'oxyntomodulin' action
    • Bataille D, Gespach C, Coudray AM, Rosselin G Enteroglucagon': a specific effect on gastric glands isolated from the rat fundus. Evidence for an 'oxyntomodulin' action. Biosci Rep 1981 1 : 151 5.
    • (1981) Biosci Rep , vol.1 , pp. 151-151
    • Bataille, D.1    Gespach, C.2    Coudray, A.M.3    Rosselin, G.4
  • 74
    • 4143116741 scopus 로고    scopus 로고
    • Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    • Baggio LL, Huang Q, Brown TJ, Drucker DJ. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 2004 127 : 546 58.
    • (2004) Gastroenterology , vol.127 , pp. 546-558
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 76
    • 0036889316 scopus 로고    scopus 로고
    • Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats
    • Dakin CL, Small CJ, Park AJ, Seth A, Ghatei MA, Bloom SR. Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats. Am J Physiol Endocrinol Metab 2002 283 : E1173 7.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Dakin, C.L.1    Small, C.J.2    Park, A.J.3    Seth, A.4    Ghatei, M.A.5    Bloom, S.R.6
  • 80
    • 33749339257 scopus 로고    scopus 로고
    • Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial
    • Wynne K, Park AJ, Small CJ, Meeran K, Ghatei MA, Frost GS, Bloom SR. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial. Int J Obes (Lond) 2006 30 : 1729 36.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 1729-1736
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Meeran, K.4    Ghatei, M.A.5    Frost, G.S.6    Bloom, S.R.7
  • 81
    • 0020377971 scopus 로고
    • Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide
    • DOI 10.1016/0014-5793(82)80709-6
    • Bataille D, Tatemoto K, Gespach C, Jornvall H, Rosselin G, Mutt V. Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide. FEBS Lett 1982 146 : 79 86. (Pubitemid 13254172)
    • (1982) FEBS Letters , vol.146 , Issue.1 , pp. 79-86
    • Bataille, D.1    Tatemoto, K.2    Gespach, C.3
  • 82
    • 0020596734 scopus 로고
    • Hamster preproglucagon contains the sequence of glucagon and two related peptides
    • Bell GI, Santerre RF, Mullenbach GT. Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 1983 302 : 716 8.
    • (1983) Nature , vol.302 , pp. 716-718
    • Bell, G.I.1    Santerre, R.F.2    Mullenbach, G.T.3
  • 83
  • 85
    • 57749169279 scopus 로고    scopus 로고
    • Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI)
    • Parkinson JRC, Chaudhri OB, Kuo YT, Field BCT, Herlihy AH, Dhillo WS, Ghatei MA, Bloom SR, Bell JD. Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI). NeuroImage 2009 44 : 1022 31.
    • (2009) NeuroImage , vol.44 , pp. 1022-1031
    • Parkinson, J.R.C.1    Chaudhri, O.B.2    Kuo, Y.T.3    Field, B.C.T.4    Herlihy, A.H.5    Dhillo, W.S.6    Ghatei, M.A.7    Bloom, S.R.8    Bell, J.D.9
  • 91
    • 33745841347 scopus 로고    scopus 로고
    • The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR
    • Nygaard R, Nielbo S, Schwartz TW, Poulsen FM. The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR. Biochem 2006 45 : 8350 7.
    • (2006) Biochem , vol.45 , pp. 8350-8357
    • Nygaard, R.1    Nielbo, S.2    Schwartz, T.W.3    Poulsen, F.M.4
  • 92
    • 0028173653 scopus 로고
    • Two molecular forms of peptide YY (PYY) are abundant in human blood: Characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36
    • Grandt D, Schimiczek M, Beglinger C, Layer P, Goebell H, Eysselein VE, Reeve JR Jr. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36. Regul Pept 1994 51 : 151 9.
    • (1994) Regul Pept , vol.51 , pp. 151-159
    • Grandt, D.1    Schimiczek, M.2    Beglinger, C.3    Layer, P.4    Goebell, H.5    Eysselein, V.E.6    Reeve, Jr.J.R.7
  • 94
    • 0027494070 scopus 로고
    • Proteolytic processing of neuropeptide y and peptide YY by dipeptidyl peptidase IV
    • Mentlein R, Dahms P, Grandt D, Kruger R. Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV. Regul Pept 1993 49 : 133 44.
    • (1993) Regul Pept , vol.49 , pp. 133-144
    • Mentlein, R.1    Dahms, P.2    Grandt, D.3    Kruger, R.4
  • 95
    • 0022392297 scopus 로고
    • Peptide YY (PYY), a potent orexigenic agent
    • DOI 10.1016/0006-8993(85)91490-8
    • Morley JE, Levine AS, Grace M, Kneip J. Peptide YY (PYY), a potent orexigenic agent. Brain Res 1985 341 : 200 3. (Pubitemid 15246340)
    • (1985) Brain Research , vol.341 , Issue.1 , pp. 200-203
    • Morley, J.E.1    Levine, A.S.2    Grace, M.3    Kneip, J.4
  • 96
    • 36949012499 scopus 로고    scopus 로고
    • Distribution of peripherally injected peptide YY ([125I] PYY (3-36)) and pancreatic polypeptide ([125I] hPP) in the CNS: Enrichment in the area postrema
    • Dumont Y, Moyse E, Fournier A, Quirion R. Distribution of peripherally injected peptide YY ([125I] PYY (3-36)) and pancreatic polypeptide ([125I] hPP) in the CNS: enrichment in the area postrema. J Mol Neurosci 2007 33 : 294 304.
    • (2007) J Mol Neurosci , vol.33 , pp. 294-304
    • Dumont, Y.1    Moyse, E.2    Fournier, A.3    Quirion, R.4
  • 98
    • 18044365777 scopus 로고    scopus 로고
    • Blockade of the neuropeptide y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake
    • Abbott CR, Small CJ, Kennedy AR, Neary NM, Sajedi A, Ghatei MA, Bloom SR. Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake. Brain Res 2005 1043 : 139 44.
    • (2005) Brain Res , vol.1043 , pp. 139-144
    • Abbott, C.R.1    Small, C.J.2    Kennedy, A.R.3    Neary, N.M.4    Sajedi, A.5    Ghatei, M.A.6    Bloom, S.R.7
  • 99
    • 23844554610 scopus 로고    scopus 로고
    • Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice
    • Talsania T, Anini Y, Siu S, Drucker DJ, Brubaker PL. Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice. Endocrinology 2005 146 : 3748 56.
    • (2005) Endocrinology , vol.146 , pp. 3748-3756
    • Talsania, T.1    Anini, Y.2    Siu, S.3    Drucker, D.J.4    Brubaker, P.L.5
  • 100
    • 0028096125 scopus 로고
    • Cholecystokinin and neuropeptide y receptors on single rabbit vagal afferent ganglion neurons: Site of prejunctional modulation of visceral sensory neurons
    • Ghilardi JR, Allen CJ, Vigna SR, McVey DC, Mantyh PW. Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: site of prejunctional modulation of visceral sensory neurons. Brain Res 1994 633 : 33 40.
    • (1994) Brain Res , vol.633 , pp. 33-40
    • Ghilardi, J.R.1    Allen, C.J.2    Vigna, S.R.3    McVey, D.C.4    Mantyh, P.W.5
  • 109
    • 12344332415 scopus 로고    scopus 로고
    • Intravenous infusion of peptide YY(3-36) potently inhibits food intake in rats
    • Chelikani PK, Haver AC, Reidelberger RD. Intravenous infusion of peptide YY(3-36) potently inhibits food intake in rats. Endocrinology 2005 146 : 879 88.
    • (2005) Endocrinology , vol.146 , pp. 879-888
    • Chelikani, P.K.1    Haver, A.C.2    Reidelberger, R.D.3
  • 111
    • 33751066788 scopus 로고    scopus 로고
    • Effects of peripheral administration of PYY3-36 on feed intake and plasma acyl-ghrelin levels in pigs
    • Ito T, Thidarmyint H, Murata T, Inoue H, Neyra RM, Kuwayama H. Effects of peripheral administration of PYY3-36 on feed intake and plasma acyl-ghrelin levels in pigs. J Endocrinol 2006 191 : 113 9.
    • (2006) J Endocrinol , vol.191 , pp. 113-119
    • Ito, T.1    Thidarmyint, H.2    Murata, T.3    Inoue, H.4    Neyra, R.M.5    Kuwayama, H.6
  • 113
    • 41649099750 scopus 로고    scopus 로고
    • Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake
    • Le Roux CW, Borg CM, Murphy KG, Vincent RP, Ghatei MA, Bloom SR. Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake. Ann Clin Biochem 2008 45 : 93 5.
    • (2008) Ann Clin Biochem , vol.45 , pp. 93-95
    • Le Roux, C.W.1    Borg, C.M.2    Murphy, K.G.3    Vincent, R.P.4    Ghatei, M.A.5    Bloom, S.R.6
  • 114
    • 3442879939 scopus 로고    scopus 로고
    • Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin
    • Martin NM, Small CJ, Sajedi A, Patterson M, Ghatei MA, Bloom SR. Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY(3-36) but resistant to ghrelin. Int J Obes Relat Metab Disord 2004 28 : 886 93.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 886-893
    • Martin, N.M.1    Small, C.J.2    Sajedi, A.3    Patterson, M.4    Ghatei, M.A.5    Bloom, S.R.6
  • 117
    • 36348948599 scopus 로고    scopus 로고
    • Combination therapy with amylin and peptide YY[3-36] in obese rodents: Anorexigenic synergy and weight loss additivity
    • Roth JD, Coffey T, Jodka CM, Maier H, Athanacio JR, Mack CM, Weyer C, Parkes DG. Combination therapy with amylin and peptide YY[3-36] in obese rodents: anorexigenic synergy and weight loss additivity. Endocrinology 2007 148 : 6054 61.
    • (2007) Endocrinology , vol.148 , pp. 6054-6061
    • Roth, J.D.1    Coffey, T.2    Jodka, C.M.3    Maier, H.4    Athanacio, J.R.5    MacK, C.M.6    Weyer, C.7    Parkes, D.G.8
  • 119
    • 34447646115 scopus 로고    scopus 로고
    • Intermittent intraperitoneal infusion of peptide YY(3-36) reduces daily food intake and adiposity in obese rats
    • Chelikani PK, Haver AC, Reidelberger RD. Intermittent intraperitoneal infusion of peptide YY(3-36) reduces daily food intake and adiposity in obese rats. Am J Physiol Regul Integr Comp Physiol 2007 293 : R39 46.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293
    • Chelikani, P.K.1    Haver, A.C.2    Reidelberger, R.D.3
  • 120
    • 31544480051 scopus 로고    scopus 로고
    • PYY[3-36] administration decreases the respiratory quotient and reduces adiposity in diet-induced obese mice
    • Adams SH, Lei C, Jodka CM, Nikoulina SE, Hoyt JA, Gedulin B, Mack CM, Kendall ES. PYY[3-36] administration decreases the respiratory quotient and reduces adiposity in diet-induced obese mice. J Nutr 2006 136 : 195 201.
    • (2006) J Nutr , vol.136 , pp. 195-201
    • Adams, S.H.1    Lei, C.2    Jodka, C.M.3    Nikoulina, S.E.4    Hoyt, J.A.5    Gedulin, B.6    MacK, C.M.7    Kendall, E.S.8
  • 124
    • 29044450310 scopus 로고    scopus 로고
    • Lower mean weight after 14 days intravenous administration peptide YY3-36 (PYY3-36) in rabbits
    • Sileno AP, Brandt GC, Spann BM, Quay SC. Lower mean weight after 14 days intravenous administration peptide YY3-36 (PYY3-36) in rabbits. Int J Obes (Lond) 2006 30 : 68 72.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 68-72
    • Sileno, A.P.1    Brandt, G.C.2    Spann, B.M.3    Quay, S.C.4
  • 125
    • 32544444153 scopus 로고    scopus 로고
    • The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat
    • Abbott CR, Small CJ, Sajedi A, Smith KL, Parkinson JR, Broadhead LL, Ghatei MA, Bloom SR. The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat. Int J Obes (Lond) 2006 30 : 288 92.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 288-292
    • Abbott, C.R.1    Small, C.J.2    Sajedi, A.3    Smith, K.L.4    Parkinson, J.R.5    Broadhead, L.L.6    Ghatei, M.A.7    Bloom, S.R.8
  • 128
    • 0021905218 scopus 로고
    • Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction
    • Liddle RA, Goldfine ID, Rosen MS, Taplitz RA, Williams JA. Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest 1985 75 : 1144 52.
    • (1985) J Clin Invest , vol.75 , pp. 1144-1152
    • Liddle, R.A.1    Goldfine, I.D.2    Rosen, M.S.3    Taplitz, R.A.4    Williams, J.A.5
  • 129
    • 0035145814 scopus 로고    scopus 로고
    • The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33
    • Rehfeld JF, Sun G, Christensen T, Hillingsø JG. The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33. J Clin Endocrinol Metab 2001 86 : 251 8.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 251-258
    • Rehfeld, J.F.1    Sun, G.2    Christensen, T.3    Hillingsø, J.G.4
  • 130
    • 0019829945 scopus 로고
    • Neuropeptides in the gut: Quantification and characterization of cholecystokinin octapeptide-, bombesin- and vasoactive intestinal polypeptide-like immunoreactivities in the myenteric plexus of the guinea-pig small institute
    • Hutchison JB, Dimaline R, Dockray GJ. Neuropeptides in the gut: quantification and characterization of cholecystokinin octapeptide-, bombesin- and vasoactive intestinal polypeptide-like immunoreactivities in the myenteric plexus of the guinea-pig small institute. Peptides 1981 2 : 23 30.
    • (1981) Peptides , vol.2 , pp. 23-30
    • Hutchison, J.B.1    Dimaline, R.2    Dockray, G.J.3
  • 131
    • 84879282584 scopus 로고
    • Regional distributions of somatostatin and cholecystokinin-like immunoreactivities in rat and bovine brain
    • Barden N, Merand Y, Rouleau D, Moore S, Dockray GJ, Dupont A. Regional distributions of somatostatin and cholecystokinin-like immunoreactivities in rat and bovine brain. Peptides 1981 2 : 299 302.
    • (1981) Peptides , vol.2 , pp. 299-302
    • Barden, N.1    Merand, Y.2    Rouleau, D.3    Moore, S.4    Dockray, G.J.5    Dupont, A.6
  • 134
    • 33644841711 scopus 로고    scopus 로고
    • Cholecystokinin and gastrin receptors
    • Dufresne M, Seva C, Fourmy D. Cholecystokinin and gastrin receptors. Physiol Rev 2006 86 : 805 47.
    • (2006) Physiol Rev , vol.86 , pp. 805-847
    • Dufresne, M.1    Seva, C.2    Fourmy, D.3
  • 136
    • 0013590165 scopus 로고
    • Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin
    • Ritter RC, Ladenheim EE. Capsaicin pretreatment attenuates suppression of food intake by cholecystokinin. Am J Physiol 1985 248 : R501 4.
    • (1985) Am J Physiol , vol.248
    • Ritter, R.C.1    Ladenheim, E.E.2
  • 137
    • 0021808614 scopus 로고
    • Abrogation of peripheral cholecystokinin-satiety in the capsaicin treated rat
    • MacLean DB. Abrogation of peripheral cholecystokinin-satiety in the capsaicin treated rat. Regul Pept 1985 11 : 321 33.
    • (1985) Regul Pept , vol.11 , pp. 321-333
    • MacLean, D.B.1
  • 138
    • 0026544562 scopus 로고
    • Effects of selective CCK receptor agonists on food intake after central or peripheral administration in rats
    • Asin KE, Gore PA Jr., Bednarz L, Holladay M, Nadzan AM. Effects of selective CCK receptor agonists on food intake after central or peripheral administration in rats. Brain Res 1992 571 : 169 74.
    • (1992) Brain Res , vol.571 , pp. 169-174
    • Asin, K.E.1    Gore, Jr.P.A.2    Bednarz, L.3    Holladay, M.4    Nadzan, A.M.5
  • 139
    • 0030985882 scopus 로고    scopus 로고
    • Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin
    • Moran TH, Baldessarini AR, Salorio CF, Lowery T, Schwartz GJ. Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin. Am J Physiol 1997 272 : R1245 51.
    • (1997) Am J Physiol , vol.272
    • Moran, T.H.1    Baldessarini, A.R.2    Salorio, C.F.3    Lowery, T.4    Schwartz, G.J.5
  • 140
  • 141
    • 0020380007 scopus 로고
    • C-terminal octapeptide of cholecystokinin decreases food intake in obese men
    • Pi-Sunyer X, Kissileff HR, Thornton J, Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in obese men. Physiol Behav 1982 29 : 627 30.
    • (1982) Physiol Behav , vol.29 , pp. 627-630
    • Pi-Sunyer, X.1    Kissileff, H.R.2    Thornton, J.3    Smith, G.P.4
  • 142
  • 144
    • 0028836552 scopus 로고
    • Satiety effects of a physiological dose of cholecystokinin in humans
    • Lieverse RJ, Jansen JB, Masclee AA, Lamers CB. Satiety effects of a physiological dose of cholecystokinin in humans. Gut 1995 36 : 176 9.
    • (1995) Gut , vol.36 , pp. 176-179
    • Lieverse, R.J.1    Jansen, J.B.2    Masclee, A.A.3    Lamers, C.B.4
  • 146
    • 0020522487 scopus 로고
    • Rapid development of tolerance to the behavioural actions of cholecystokinin
    • Crawley JN, Beinfeld MC. Rapid development of tolerance to the behavioural actions of cholecystokinin. Nature 1983 302 : 703 6.
    • (1983) Nature , vol.302 , pp. 703-706
    • Crawley, J.N.1    Beinfeld, M.C.2
  • 147
    • 0021433344 scopus 로고
    • Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats
    • West DB, Fey D, Woods SC. Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 1984 246 : R776 87.
    • (1984) Am J Physiol , vol.246
    • West, D.B.1    Fey, D.2    Woods, S.C.3
  • 148
    • 0036088537 scopus 로고    scopus 로고
    • Daily CCK injection enhances reduction of body weight by chronic intracerebroventricular leptin infusion
    • Matson CA, Reid DF, Ritter RC. Daily CCK injection enhances reduction of body weight by chronic intracerebroventricular leptin infusion. Am J Physiol Regul Integr Comp Physiol 2002 282 : R1368 73.
    • (2002) Am J Physiol Regul Integr Comp Physiol , vol.282
    • Matson, C.A.1    Reid, D.F.2    Ritter, R.C.3
  • 149
    • 41549102091 scopus 로고    scopus 로고
    • Leptin-mediated hypothalamic pathway of cholecystokinin (CCK-8) to regulate body weight in free-feeding rats
    • Merino B, Cano V, Guzman R, Somoza B, Ruiz-Gayo M. Leptin-mediated hypothalamic pathway of cholecystokinin (CCK-8) to regulate body weight in free-feeding rats. Endocrinology 2008 149 : 1994 2000.
    • (2008) Endocrinology , vol.149 , pp. 1994-2000
    • Merino, B.1    Cano, V.2    Guzman, R.3    Somoza, B.4    Ruiz-Gayo, M.5
  • 150
    • 0020584172 scopus 로고
    • Conformational flexibility in a small globular hormone: X-ray analysis of avian pancreatic polypeptide at 0.98-Å resolution
    • Glover I, Haneef I, Pitts J, Wood S, Moss D, Tickle I, Blundell T. Conformational flexibility in a small globular hormone: x-ray analysis of avian pancreatic polypeptide at 0.98-Å resolution. Biopolymers 1983 22 : 293 304.
    • (1983) Biopolymers , vol.22 , pp. 293-304
    • Glover, I.1    Haneef, I.2    Pitts, J.3    Wood, S.4    Moss, D.5    Tickle, I.6    Blundell, T.7
  • 152
    • 0016615670 scopus 로고
    • Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells
    • Larsson LI, Sundler F, Håkanson R. Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells. Cell Tissue Res 1975 156 : 167 71.
    • (1975) Cell Tissue Res , vol.156 , pp. 167-171
    • Larsson, L.I.1    Sundler, F.2    Håkanson, R.3
  • 153
    • 0019276487 scopus 로고
    • Human pancreatic polypeptide: Studies of fasting and postprandial plasma concentrations
    • Track NS, McLeod RS, Mee AV. Human pancreatic polypeptide: studies of fasting and postprandial plasma concentrations. Can J Physiol Pharmacol 1980 58 : 1484 9.
    • (1980) Can J Physiol Pharmacol , vol.58 , pp. 1484-1489
    • Track, N.S.1    McLeod, R.S.2    Mee, A.V.3
  • 155
    • 0037338622 scopus 로고    scopus 로고
    • Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes
    • Berglund MM, Hipskind PA, Gehlert DR. Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes. Exp Biol Med (Maywood) 2003 228 : 217 44.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 217-244
    • Berglund, M.M.1    Hipskind, P.A.2    Gehlert, D.R.3
  • 156
    • 0033383202 scopus 로고    scopus 로고
    • Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice
    • Asakawa A, Inui A, Ueno N, Fujimiya M, Fujino MA, Kasuga M. Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice. Peptides 1999 20 : 1445 8.
    • (1999) Peptides , vol.20 , pp. 1445-1448
    • Asakawa, A.1    Inui, A.2    Ueno, N.3    Fujimiya, M.4    Fujino, M.A.5    Kasuga, M.6
  • 158
    • 0021248888 scopus 로고
    • Neuropeptide y and human pancreatic polypeptide stimulate feeding behavior in rats
    • Clark JT, Kalra PS, Crowley WR, Kalra SP. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 1984 115 : 427 9.
    • (1984) Endocrinology , vol.115 , pp. 427-429
    • Clark, J.T.1    Kalra, P.S.2    Crowley, W.R.3    Kalra, S.P.4
  • 160
    • 0017723085 scopus 로고
    • Pancreatic polypeptide: A possible role in the regulation of food intake in the mouse. Hypothesis
    • Malaisse-Lagae F, Carpentier JL, Patel YC, Malaisse WJ, Orci L. Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse. Hypothesis. Experientia 1977 33 : 915 7.
    • (1977) Experientia , vol.33 , pp. 915-917
    • Malaisse-Lagae, F.1    Carpentier, J.L.2    Patel, Y.C.3    Malaisse, W.J.4    Orci, L.5
  • 161
    • 0025012383 scopus 로고
    • Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain
    • Whitcomb DC, Taylor IL, Vigna SR. Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain. Am J Physiol 1990 259 : G687 91.
    • (1990) Am J Physiol , vol.259
    • Whitcomb, D.C.1    Taylor, I.L.2    Vigna, S.R.3
  • 162
    • 0017659621 scopus 로고
    • The ability of pancreatic polypeptides (APP and BPP) to return to normal the hyperglycaemia, hyperinsulinaemia and weight gain of New Zealand obese mice
    • Gates RJ, Lazarus NR. The ability of pancreatic polypeptides (APP and BPP) to return to normal the hyperglycaemia, hyperinsulinaemia and weight gain of New Zealand obese mice. Horm Res 1977 8 : 189 202.
    • (1977) Horm Res , vol.8 , pp. 189-202
    • Gates, R.J.1    Lazarus, N.R.2
  • 164
    • 0019735952 scopus 로고
    • Blunted pancreatic polypeptide responses in children with obesity of Prader-Willi syndrome
    • Zipf WB, O'Dorisio TM, Cataland S, Sotos J. Blunted pancreatic polypeptide responses in children with obesity of Prader-Willi syndrome. J Clin Endocrinol Metab 1981 52 : 1264 6.
    • (1981) J Clin Endocrinol Metab , vol.52 , pp. 1264-1266
    • Zipf, W.B.1    O'Dorisio, T.M.2    Cataland, S.3    Sotos, J.4
  • 165
    • 0021048887 scopus 로고
    • Pancreatic polypeptide responses to protein meal challenges in obese but otherwise normal children and obese children with Prader-Willi syndrome
    • Zipf WB, O'Dorisio TM, Cataland S, Dixon K. Pancreatic polypeptide responses to protein meal challenges in obese but otherwise normal children and obese children with Prader-Willi syndrome. J Clin Endocrinol Metab 1983 57 : 1074 80.
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 1074-1080
    • Zipf, W.B.1    O'Dorisio, T.M.2    Cataland, S.3    Dixon, K.4
  • 166
    • 0025125869 scopus 로고
    • Short-term infusion of pancreatic polypeptide: Effect on children with Prader-Willi syndrome
    • Zipf WB, O'Dorisio TM, Berntson GG. Short-term infusion of pancreatic polypeptide: effect on children with Prader-Willi syndrome. Am J Clin Nutr 1990 51 : 162 6.
    • (1990) Am J Clin Nutr , vol.51 , pp. 162-166
    • Zipf, W.B.1    O'Dorisio, T.M.2    Berntson, G.G.3
  • 167
  • 173
    • 0025950606 scopus 로고
    • Co-secretion of amylin and insulin from cultured islet beta-cells: Modulation by nutrient secretagogues, islet hormones and hypoglycemic agents
    • Moore CX, Cooper GJ. Co-secretion of amylin and insulin from cultured islet beta-cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents. Biochem Biophys Res Commun 1991 179 : 1 9.
    • (1991) Biochem Biophys Res Commun , vol.179 , pp. 1-9
    • Moore, C.X.1    Cooper, G.J.2
  • 177
    • 0029913870 scopus 로고    scopus 로고
    • Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7-36) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake
    • Young AA, Gedulin BR, Rink TJ. Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7-36) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake. Metabolism 1996 45 : 1 3.
    • (1996) Metabolism , vol.45 , pp. 1-3
    • Young, A.A.1    Gedulin, B.R.2    Rink, T.J.3
  • 179
    • 0032005144 scopus 로고    scopus 로고
    • Lesion of the area postrema/nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats
    • Lutz TA, Senn M, Althaus J, Del Prete E, Ehrensperger F, Scharrer E. Lesion of the area postrema/nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats. Peptides 1998 19 : 309 17.
    • (1998) Peptides , vol.19 , pp. 309-317
    • Lutz, T.A.1    Senn, M.2    Althaus, J.3    Del Prete, E.4    Ehrensperger, F.5    Scharrer, E.6
  • 180
    • 0035658654 scopus 로고    scopus 로고
    • Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP
    • Riediger T, Schmid HA, Lutz T, Simon E. Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP. Am J Physiol Regul Integr Comp Physiol 2001 281 : R1833 43.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.281
    • Riediger, T.1    Schmid, H.A.2    Lutz, T.3    Simon, E.4
  • 181
    • 0036548068 scopus 로고    scopus 로고
    • A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes
    • Whitehouse F, Kruger DF, Fineman M, Shen L, Ruggles JA, Maggs DG, Weyer C, Kolterman OG. A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes. Diabetes Care 2002 25 : 724 30.
    • (2002) Diabetes Care , vol.25 , pp. 724-730
    • Whitehouse, F.1    Kruger, D.F.2    Fineman, M.3    Shen, L.4    Ruggles, J.A.5    Maggs, D.G.6    Weyer, C.7    Kolterman, O.G.8
  • 182
    • 0042167233 scopus 로고    scopus 로고
    • Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: A 1-year randomized controlled trial
    • Hollander PA, Levy P, Fineman MS, Maggs DG, Shen LZ, Strobel SA, Weyer C, Kolterman OG. Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: a 1-year randomized controlled trial. Diabetes Care 2003 26 : 784 90.
    • (2003) Diabetes Care , vol.26 , pp. 784-790
    • Hollander, P.A.1    Levy, P.2    Fineman, M.S.3    Maggs, D.G.4    Shen, L.Z.5    Strobel, S.A.6    Weyer, C.7    Kolterman, O.G.8
  • 183
    • 8144228619 scopus 로고    scopus 로고
    • Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: A 1-year, randomized controlled trial
    • Ratner RE, Dickey R, Fineman M, Maggs DG, Shen L, Strobel SA, Weyer C, Kolterman OG. Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: a 1-year, randomized controlled trial. Diabet Med 2004 21 : 1204 12.
    • (2004) Diabet Med , vol.21 , pp. 1204-1212
    • Ratner, R.E.1    Dickey, R.2    Fineman, M.3    Maggs, D.G.4    Shen, L.5    Strobel, S.A.6    Weyer, C.7    Kolterman, O.G.8
  • 184
    • 33747763918 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial assessing pramlintide treatment in the setting of intensive insulin therapy in type 1 diabetes
    • Edelman S, Garg S, Frias J, Maggs D, Wang Y, Zhang B, Strobel S, Lutz K, Kolterman O. A double-blind, placebo-controlled trial assessing pramlintide treatment in the setting of intensive insulin therapy in type 1 diabetes. Diabetes Care 2006 29 : 2189 95.
    • (2006) Diabetes Care , vol.29 , pp. 2189-2195
    • Edelman, S.1    Garg, S.2    Frias, J.3    Maggs, D.4    Wang, Y.5    Zhang, B.6    Strobel, S.7    Lutz, K.8    Kolterman, O.9
  • 185
    • 56149124659 scopus 로고    scopus 로고
    • Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity
    • Smith SR, Aronne LJ, Burns CM, Kesty NC, Halseth AE, Weyer C. Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity. Diabetes Care 2008 31 : 1816 23.
    • (2008) Diabetes Care , vol.31 , pp. 1816-1823
    • Smith, S.R.1    Aronne, L.J.2    Burns, C.M.3    Kesty, N.C.4    Halseth, A.E.5    Weyer, C.6
  • 187
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999 402 : 656 60.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 188
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000 141 : 4255 61.
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 191
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000 407 : 908 13.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 195
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor - Identification of a potent inverse agonist
    • Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW. High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist. Mol Endocrinol 2003 17 : 2201 10.
    • (2003) Mol Endocrinol , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 196
  • 197
    • 7644219561 scopus 로고    scopus 로고
    • Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats
    • DOI 10.1016/j.lfs.2004.09.001, PII S0024320504008306
    • Beck B, Richy S, Stricker-Krongrad A. Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. Life Sci 2004 76 : 473 8. (Pubitemid 39458314)
    • (2004) Life Sciences , vol.76 , Issue.4 , pp. 473-478
    • Beck, B.1    Richy, S.2    Stricker-Krongrad, A.3
  • 202
    • 34347329282 scopus 로고    scopus 로고
    • Active immunization against ghrelin decreases weight gain and alters plasma concentrations of growth hormone in growing pigs
    • Vizcarra JA, Kirby JD, Kim SK, Galyean ML. Active immunization against ghrelin decreases weight gain and alters plasma concentrations of growth hormone in growing pigs. Domest Anim Endocrinol 2007 33 : 176 89.
    • (2007) Domest Anim Endocrinol , vol.33 , pp. 176-189
    • Vizcarra, J.A.1    Kirby, J.D.2    Kim, S.K.3    Galyean, M.L.4
  • 203
  • 208
    • 0031768644 scopus 로고    scopus 로고
    • Untangling the effects of hunger, anxiety, and nausea on energy intake during intravenous cholecystokinin octapeptide (CCK-8) infusion
    • Greenough A, Cole G, Lewis J, Lockton A, Blundell J. Untangling the effects of hunger, anxiety, and nausea on energy intake during intravenous cholecystokinin octapeptide (CCK-8) infusion. Physiol Behav 1998 65 : 303 10.
    • (1998) Physiol Behav , vol.65 , pp. 303-310
    • Greenough, A.1    Cole, G.2    Lewis, J.3    Lockton, A.4    Blundell, J.5


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