The functional role of intramuscular interstitial cells of Cajal in the stomach

Journal of Smooth Muscle Research

Volumn 47, Issue 2, 2011, Pages 47-53

  Kito, Yoshihiko ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Intramuscular interstitial cells of Cajal; Neurotransmission; Slow waves; Spontaneous transient depolarization; Unitary potential

Indexed keywords

STEM CELL FACTOR RECEPTOR;

ANIMAL; CELL MEMBRANE POTENTIAL; GASTROINTESTINAL MOTILITY; GENETICS; INNERVATION; INTERSTITIAL CELL OF CAJAL; PHYSIOLOGY; REVIEW; SMOOTH MUSCLE; STOMACH; STOMACH ANTRUM; STOMACH FUNDUS; SYNAPTIC TRANSMISSION;

ANIMALS; GASTRIC FUNDUS; GASTROINTESTINAL MOTILITY; INTERSTITIAL CELLS OF CAJAL; MEMBRANE POTENTIALS; MUSCLE, SMOOTH; PROTO-ONCOGENE PROTEINS C-KIT; PYLORIC ANTRUM; STOMACH; SYNAPTIC TRANSMISSION;

EID: 80051564138     PISSN: 09168737     EISSN: None     Source Type: Journal    
DOI: 10.1540/jsmr.47.47     Document Type: Review

References (33)

1. Agaimy, A., Wunsch,P.H., Hofstaedter, F., Blaszyk, H., Rummele, P., Gaumann, A., Dietmaier, W. and Hartmann, A. (2007). Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations. Am. J. Surg. Pathol. 31: 113-120.
2. Arakawa, T., Uno, H., Fukuda, T., Higuchi, K., Kobayashi, K. and Kuroki, T. (1997). New aspects of gastric adaptive relaxation, reflex after food intake for more food: involvement of capsaicin-sensitive sensory nerves and nitric oxide. J. Smooth Muscle Res. 33: 81-88.
3. Bayguinov, P.O., Hennig, G.W. and Smith, T.K. (2010). Ca2+ imaging of activity in ICC-MY during local mucosal reflexes and the colonic migrating motor complex in the murine large intestine. J. Physiol. (Lond.). 588: 4453-4474.
4. Beckett, E.A., Bayguinov, Y.R., Sanders, K.M., Ward, S.M. and Hirst, G.D. (2004). Properties of unitary potentials generated by intramuscular interstitial cells of Cajal in the murine and guinea-pig gastric fundus. J. Physiol. (Lond.). 559: 259-269.
5. Beckett, E.A., Takeda, Y., Yanase, H., Sanders, K.M. and Ward, S.M. (2005). Synaptic specializations exist between enteric motor nerves and interstitial cells of Cajal in the murine stomach. J. Comp. Neurol. 493: 193-206.
6. Burns, A.J., Lomax, A.E., Torihashi, S., Sanders, K.M. and Ward, S.M. (1996). Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc. Natl. Acad. Sci. USA 93: 12008- 12013.
7. Dickens, E.J., Edwards, F.R. and Hirst, G.D. (2000). Vagal inhibition in the antral region of guinea pig stomach. Am. J. Physiol. 279: G388-G399.
8. Dickens, E.J., Edwards, F.R. and Hirst, G.D. (2001). Selective knockout of intramuscular interstitial cells reveals their role in the generation of slow waves in mouse stomach. J. Physiol. (Lond.). 531: 827- 833.
9. Edwards, F.R., Hirst, G.D. and Suzuki, H. (1999). Unitary nature of regenerative potentials recorded from circular smooth muscle of guinea-pig antrum. J. Physiol. (Lond.). 519: 235-250.
10. Epperson, A., Halton, W.J., Callaghan, B., Doherty, P., Walker, R.L., Sanders, K.M., Ward, S.M. and Horowitz, B. (2000). Molecular markers expressed in cultured and freshly isolated interstitial cells of Cajal. Am. J. Physiol. 279: C529-C539.
11. 2+ transients in guinea pig coronary artery. J. Physiol. (Lond.). 504: 47-55.
12. Hashitani, H., Garcia-Londono, A.P., Hirst, G.D. and Edwards, F.R. (2005). Atypical slow waves generated in gastric corpus provide dominant pacemaker activity in guinea pig stomach. J. Physiol. (Lond.). 569: 459-465.
13. Hirota, S. and Isozaki, K. (2006). Pathology of gastrointestinal stromal tumors. Pathol. Int. 56: 1-9.
14. Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., Muhammad Tunio, G., Matsuzawa, Y., Kanakura, Y., Shinomura, Y. and Kitamura, Y. (1998).Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279: 577-580.
15. Hirst, G.D., Beckett, E.A., Sanders, K.M. and Ward, S.M. (2002). Regional variation in contribution of myenteric and intramuscular interstitial cells of Cajal to generation of slow waves in mouse gastric antrum. J. Physiol. (Lond.). 540: 1003-1012.
16. Hirst, G.D. and Edwards, F.R. (2006). Electrical events underlying organized myogenic contractions of the guinea pig stomach. J. Physiol. (Lond.). 576: 659-665.
17. Huizinga, J.D., Liu, L.W., Fitzpatrick, A., White, E., Gill, S., Wang, X.Y., Zarate, N., Krebs, I., Choi, C., Starret, T., Dixit, D. and Ye, J. (2008). Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation. Am. J. Physiol. 294: G589-G594.
18. Kito, Y., Sanders, K.M., Ward, S.M. and Suzuki, H. (2009). Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus. Am. J. Physiol. 297: G814-G824.
19. Komori, K. and Suzuki, H. (1986). Distribution and properties of excitatory and inhibitory junction potentials in circular muscle of the guinea-pig stomach. J. Physiol. (Lond.). 370: 339-355.
20. Komuro, T. (2006). Structure and organization of interstitial cells of Cajal in the gastrointestinal tract. J. Physiol. (Lond.). 576: 653-658.
21. Sanders, K.M. (1996). A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterol. 111: 492-515.
22. Sanders, K.M., Ordog, T., Koh, S.D., Torihashi, S. and Ward, S.M. (1999). Development and plasticity of interstitial cells of Cajal. Neurogastroenterol. Motil. 11: 311-338.
23. Seki, K. and Komuro, T. (2002). Distribution of interstitial cells of Cajal and gap junction protein, CX 43 in the stomach of wild-type and W/WV mutant mice. Anat. Embryol. 206: 57-65.
24. Suzuki, H. and Hirst, G.D. (1999). Regenerative potentials evoked in circular smooth muscle of the antral region of guinea-pig stomach. J. Physiol. (Lond.). 517: 563-573.
25. Suzuki, H., Takano, H., Yamamoto, Y., Komuro, T., Saito, M., Kato, K. and Mikoshiba, K. (2000). Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor. J. Physiol. (Lond.). 525: 105-111.
26. Suzuki, H., Ward, S.M., Bayguinov, Y.R., Edwards, F.R. and Hirst, G.D. (2003). Involvement of intramuscular interstitial cells in nitrergic inhibition in the mouse gastric antrum. J. Physiol. (Lond.). 546: 751-763.
27. Szurszewski, J.H. (1981). Electrical basis for gastrointestinal motility. In Physiology of the Gastrointestinal Tract, ed. Johnson R, pp. 1435-1465. Raven Press, New York.
28. Thuneberg, L. (1982). Interstitial cells of Cajal: intestinal pacemaker cells? Adv. Anat. Embryol. Cell. Biol. 71: 1-130.
29. Wang, X.Y., Sanders, K.M. and Ward, S.M. (1999). Intimate relationship between interstitial cells of Cajal and enteric nerves in guinea-pig small intestine. Cell Tissue Res. 295: 247-256.
30. Ward, S.M. and Sanders, K.M. (2001). Interstitial cells of Cajal: primary targets of enteric motor innervation. Anat. Rec. 262: 125-135.
31. Ward, S.M. and Sanders, K.M. (2006). Involvement of intramuscular interstitial cells of Cajal in neuroeffector transmission in the gastrointestinal tract. J. Physiol. (Lond.). 576: 675-682.
32. Xue, L., Fukuta, H., Yamamoto, Y. and Suzuki, H. (1996). Properties of junction potentials in gastric smooth muscle of the rat. Jpn. J. Physiol. 46: 123-130.
33. Zhang, Y., Carmichael, S.A., Wang, X.Y., Huizinga, J.D. and Paterson, W.G. (2009). Neurotransmission in lower esophageal sphincter of W/Wv mutant mice. Am. J. Physiol. 298: G14-G24.