메뉴 건너뛰기




Volumn 132, Issue 12, 2013, Pages 2721-2729

Hypoxia-inducible factors as key regulators of tumor inflammation

Author keywords

cancer inflammation; HIF; hypoxia

Indexed keywords

HYPOXIA INDUCIBLE FACTOR;

EID: 84876134353     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27901     Document Type: Review
Times cited : (61)

References (145)
  • 1
    • 61849104559 scopus 로고    scopus 로고
    • Air and fire - Carl Wilhelm Scheele, Torbern Bergman, the Royal Society of Sciences and the discovery of oxygen in Uppsala in the year 1772
    • Sundelof LO,. Air and fire-Carl Wilhelm Scheele, Torbern Bergman, the Royal Society of Sciences and the discovery of oxygen in Uppsala in the year 1772. Adv Exp Med Biol 2009; 645: 1-6.
    • (2009) Adv Exp Med Biol , vol.645 , pp. 1-6
    • Sundelof, L.O.1
  • 2
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray LH, Conger AD, Ebert M, et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953; 26: 638-48.
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3
  • 3
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH, Gray LH,. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955; 9: 539-49.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 4
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM, Wilson WR,. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 2004; 4: 437-47.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 5
    • 0034161989 scopus 로고    scopus 로고
    • Heterogeneity of angiogenesis and blood vessel maturation in human tumors: Implications for antiangiogenic tumor therapies
    • Eberhard A, Kahlert S, Goede V, et al. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res 2000; 60: 1388-93.
    • (2000) Cancer Res , vol.60 , pp. 1388-1393
    • Eberhard, A.1    Kahlert, S.2    Goede, V.3
  • 6
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • Morikawa S, Baluk P, Kaidoh T, et al. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 2002; 160: 985-1000.
    • (2002) Am J Pathol , vol.160 , pp. 985-1000
    • Morikawa, S.1    Baluk, P.2    Kaidoh, T.3
  • 7
    • 0037105721 scopus 로고    scopus 로고
    • Significance of blood vessel leakiness in cancer
    • McDonald DM, Baluk P,. Significance of blood vessel leakiness in cancer. Cancer Res 2002; 62: 5381-5.
    • (2002) Cancer Res , vol.62 , pp. 5381-5385
    • McDonald, D.M.1    Baluk, P.2
  • 8
    • 0032565578 scopus 로고    scopus 로고
    • Mutagenesis induced by the tumor microenvironment
    • Yuan J, Glazer PM,. Mutagenesis induced by the tumor microenvironment. Mutat Res 1998; 400: 439-46.
    • (1998) Mutat Res , vol.400 , pp. 439-446
    • Yuan, J.1    Glazer, P.M.2
  • 9
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996; 379: 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 10
    • 77954563464 scopus 로고    scopus 로고
    • Hypoxia, inflammation, and the tumor microenvironment in metastatic disease
    • Finger EC, Giaccia AJ,. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev 2010; 29: 285-93.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 285-293
    • Finger, E.C.1    Giaccia, A.J.2
  • 11
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • Vaupel P, Mayer A,. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 2007; 26: 225-39.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 12
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • Dewhirst MW, Cao Y, Moeller B,. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 2008; 8: 425-37.
    • (2008) Nat Rev Cancer , vol.8 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 13
    • 39749172398 scopus 로고    scopus 로고
    • Tumor hypoxia in cancer therapy
    • Brown JM,. Tumor hypoxia in cancer therapy. Methods Enzymol 2007; 435: 297-321.
    • (2007) Methods Enzymol , vol.435 , pp. 297-321
    • Brown, J.M.1
  • 14
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow RG, Hill RP,. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008; 8: 180-92.
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 15
    • 0010992283 scopus 로고    scopus 로고
    • Conventional cancer therapy: Promise broken or promise delayed?
    • Tannock IF,. Conventional cancer therapy: promise broken or promise delayed? Lancet 1998; 351 (Suppl 2): SII9-SI16.
    • (1998) Lancet , vol.351 , Issue.SUPPL. 2
    • Tannock, I.F.1
  • 17
    • 26444466467 scopus 로고    scopus 로고
    • Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
    • Nordsmark M, Bentzen SM, Rudat V, et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005; 77: 18-24.
    • (2005) Radiother Oncol , vol.77 , pp. 18-24
    • Nordsmark, M.1    Bentzen, S.M.2    Rudat, V.3
  • 18
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC,. The impact of O2 availability on human cancer. Nat Rev Cancer 2008; 8: 967-75.
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 19
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O,. On the origin of cancer cells. Science 1956; 123: 309-14.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 20
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J,. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 21
    • 4444287238 scopus 로고    scopus 로고
    • Hypoxia and defective apoptosis drive genomic instability and tumorigenesis
    • Nelson DA, Tan T-T, Rabson AB, et al. Hypoxia and defective apoptosis drive genomic instability and tumorigenesis. Genes Dev 2004; 18: 2095-107.
    • (2004) Genes Dev , vol.18 , pp. 2095-2107
    • Nelson, D.A.1    Tan, T.-T.2    Rabson, A.B.3
  • 22
    • 48349111944 scopus 로고    scopus 로고
    • Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression
    • Fang JS, Gillies RD, Gatenby RA,. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol 2008; 18: 330-7.
    • (2008) Semin Cancer Biol , vol.18 , pp. 330-337
    • Fang, J.S.1    Gillies, R.D.2    Gatenby, R.A.3
  • 23
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • Semenza GL,. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 2012; 33: 207-14.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 24
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar AJ, Wong WJ, Simon MC,. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 2010; 40: 294-309.
    • (2010) Mol Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 25
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • Goldberg MA, Dunning SP, Bunn HF,. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 1988; 242: 1412-15.
    • (1988) Science , vol.242 , pp. 1412-1415
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 26
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92: 5510-14.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3
  • 27
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL,. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995; 270: 1230-7.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 28
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL,. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992; 12: 5447-54.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 29
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza GL,. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 2004; 19: 176-82.
    • (2004) Physiology (Bethesda) , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 30
    • 0035969508 scopus 로고    scopus 로고
    • Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
    • Makino Y, Cao R, Svensson K, et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001; 414: 550-4.
    • (2001) Nature , vol.414 , pp. 550-554
    • Makino, Y.1    Cao, R.2    Svensson, K.3
  • 31
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando D, Peet DJ, Gorman JJ, et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 2002; 16: 1466-71.
    • (2002) Genes Dev , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3
  • 32
    • 0036391915 scopus 로고    scopus 로고
    • Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors
    • Oehme F, Ellinghaus P, Kolkhof P, et al. Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. Biochem Biophys Res Commun 2002; 296: 343-9.
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 343-349
    • Oehme, F.1    Ellinghaus, P.2    Kolkhof, P.3
  • 33
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
    • Berra E, Benizri E, Ginouves A, et al. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 2003; 22: 4082-90.
    • (2003) EMBO J , vol.22 , pp. 4082-4090
    • Berra, E.1    Benizri, E.2    Ginouves, A.3
  • 34
    • 33750976389 scopus 로고    scopus 로고
    • Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2
    • Takeda K, Ho VC, Takeda H, et al. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol 2006; 26: 8336-46.
    • (2006) Mol Cell Biol , vol.26 , pp. 8336-8346
    • Takeda, K.1    Ho, V.C.2    Takeda, H.3
  • 35
    • 42449163874 scopus 로고    scopus 로고
    • Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
    • Minamishima YA, Moslehi J, Bardeesy N, et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 2008; 111: 3236-44.
    • (2008) Blood , vol.111 , pp. 3236-3244
    • Minamishima, Y.A.1    Moslehi, J.2    Bardeesy, N.3
  • 36
    • 80455122752 scopus 로고    scopus 로고
    • Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
    • Takeda Y, Costa S, Delamarre E, et al. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature 2011; 479: 122-6.
    • (2011) Nature , vol.479 , pp. 122-126
    • Takeda, Y.1    Costa, S.2    Delamarre, E.3
  • 37
    • 40949090791 scopus 로고    scopus 로고
    • Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
    • Takeda K, Aguila HL, Parikh NS, et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood 2008; 111: 3229-35.
    • (2008) Blood , vol.111 , pp. 3229-3235
    • Takeda, K.1    Aguila, H.L.2    Parikh, N.S.3
  • 38
    • 79955518026 scopus 로고    scopus 로고
    • Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFbeta
    • Klotzsche-von Ameln A, Muschter A, Mamlouk S, et al. Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFbeta. Cancer Res 2011; 71: 3306-16.
    • (2011) Cancer Res , vol.71 , pp. 3306-3316
    • Klotzsche-Von Ameln, A.1    Muschter, A.2    Mamlouk, S.3
  • 39
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone M, Dettori D, Leite de Oliveira, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009; 136: 839-51.
    • (2009) Cell , vol.136 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    De Oliveira, L.3
  • 40
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL,. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 41
    • 84655161946 scopus 로고    scopus 로고
    • HIF1a and HIF2a: Sibling rivalry in hypoxic tumour growth and progression
    • Keith B, Johnson RS, Simon MC,. HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2012; 12: 9-22.
    • (2012) Nat Rev Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 42
    • 83755178199 scopus 로고    scopus 로고
    • Stabilisation and knockdown of HIF - Two distinct ways comparably important in radiotherapy
    • Stroefer Mf, Mareike, Jelkmann W, et al. Stabilisation and knockdown of HIF-two distinct ways comparably important in radiotherapy. Cell Physiol Biochem 2011; 28: 805-12.
    • (2011) Cell Physiol Biochem , vol.28 , pp. 805-812
    • Stroefer, M.1    Mareike2    Jelkmann, W.3
  • 43
    • 65649138377 scopus 로고    scopus 로고
    • Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment
    • Chan DA, Kawahara TLA, Sutphin PD, et al. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 2009; 15: 527-38.
    • (2009) Cancer Cell , vol.15 , pp. 527-538
    • Chan, D.A.1    Kawahara, T.L.A.2    Sutphin, P.D.3
  • 44
    • 75149150805 scopus 로고    scopus 로고
    • Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity
    • Xue J, Li X, Jiao S, et al. Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity. Gastroenterology 2010; 138: 606-15.
    • (2010) Gastroenterology , vol.138 , pp. 606-615
    • Xue, J.1    Li, X.2    Jiao, S.3
  • 45
    • 84856778101 scopus 로고    scopus 로고
    • Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer
    • Su Y, Loos M, Giese N, et al. Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer. Cancer 2012; 118: 960-72.
    • (2012) Cancer , vol.118 , pp. 960-972
    • Su, Y.1    Loos, M.2    Giese, N.3
  • 46
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty TD, Coussens LM,. Tumor stroma and regulation of cancer development. Annu Rev Pathol 2006; 1: 119-50.
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 47
    • 33746069082 scopus 로고    scopus 로고
    • In memoriam of Rudolf virchow: A historical retrospective including aspects of inflammation, infection and neoplasia
    • Schmidt A, Weber OF,. In memoriam of Rudolf virchow: a historical retrospective including aspects of inflammation, infection and neoplasia. Contrib Microbiol 2006; 13: 1-15.
    • (2006) Contrib Microbiol , vol.13 , pp. 1-15
    • Schmidt, A.1    Weber, O.F.2
  • 48
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
    • Colotta F, Allavena P, Sica A, et al. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009; 30: 1073-81.
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3
  • 49
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA,. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 50
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature 2008; 454: 436-44.
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3
  • 53
    • 26844576749 scopus 로고    scopus 로고
    • Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
    • Borrello MG, Alberti L, Fischer A, et al. Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene. Proc Natl Acad Sci USA 2005; 102: 14825-30.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14825-14830
    • Borrello, M.G.1    Alberti, L.2    Fischer, A.3
  • 54
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M,. Immunity, inflammation, and cancer. Cell 2010; 140: 883-99.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 55
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C, Giannoudis A, Lewis CE,. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004; 104: 2224-34.
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 56
    • 0034650329 scopus 로고    scopus 로고
    • Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma
    • Sica A, Saccani A, Bottazzi B, et al. Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol 2000; 164: 733-8.
    • (2000) J Immunol , vol.164 , pp. 733-738
    • Sica, A.1    Saccani, A.2    Bottazzi, B.3
  • 57
    • 2942620525 scopus 로고    scopus 로고
    • Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages
    • Bosco MC, Reffo G, Puppo M, et al. Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages. Cell Immunol 2004; 228: 1-7.
    • (2004) Cell Immunol , vol.228 , pp. 1-7
    • Bosco, M.C.1    Reffo, G.2    Puppo, M.3
  • 58
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF,. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986; 315: 1650-9.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 59
    • 0346753956 scopus 로고    scopus 로고
    • Natural killer cell-mediated basal and interferon-enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions
    • Fink T, Ebbesen P, Koppelhus U, et al. Natural killer cell-mediated basal and interferon-enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions. Scand J Immunol 2003; 58: 607-12.
    • (2003) Scand J Immunol , vol.58 , pp. 607-612
    • Fink, T.1    Ebbesen, P.2    Koppelhus, U.3
  • 60
    • 0028199166 scopus 로고
    • Tumour-associated leucocytes: Friends or foes in breast carcinoma
    • O'Sullivan C, Lewis CE,. Tumour-associated leucocytes: friends or foes in breast carcinoma. J Pathol 1994; 172: 229-35.
    • (1994) J Pathol , vol.172 , pp. 229-235
    • O'Sullivan, C.1    Lewis, C.E.2
  • 61
    • 0034266661 scopus 로고    scopus 로고
    • Tumor associated macrophages in human prostate cancer: Relation to clinicopathological variables and survival
    • Lissbrant IF, Stattin P, Wikstrom P, et al. Tumor associated macrophages in human prostate cancer: relation to clinicopathological variables and survival. Int J Oncol 2000; 17: 445-51.
    • (2000) Int J Oncol , vol.17 , pp. 445-451
    • Lissbrant, I.F.1    Stattin, P.2    Wikstrom, P.3
  • 62
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C, Muthana M, Coffelt SB, et al. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer 2008; 8: 618-31.
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3
  • 63
    • 0031975315 scopus 로고    scopus 로고
    • Neutrophil alveolitis in bronchioloalveolar carcinoma: Induction by tumor-derived interleukin-8 and relation to clinical outcome
    • Bellocq A, Antoine M, Flahault A, et al. Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome. Am J Pathol 1998; 152: 83-92.
    • (1998) Am J Pathol , vol.152 , pp. 83-92
    • Bellocq, A.1    Antoine, M.2    Flahault, A.3
  • 64
    • 36849010167 scopus 로고    scopus 로고
    • Adaptive immunity maintains occult cancer in an equilibrium state
    • Koebel CM, Vermi W, Swann JB, et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 2007; 450: 903-7.
    • (2007) Nature , vol.450 , pp. 903-907
    • Koebel, C.M.1    Vermi, W.2    Swann, J.B.3
  • 65
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: From immunosurveillance to tumor escape
    • Dunn GP, Bruce AT, Ikeda H, et al. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002; 3: 991-8.
    • (2002) Nat Immunol , vol.3 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3
  • 66
    • 84858793263 scopus 로고    scopus 로고
    • Ovarian cancer progression is controlled by phenotypic changes in dendritic cells
    • Scarlett UK, Rutkowski MR, Rauwerdink AM, et al. Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. J Exp Med 2012; 209: 495-506.
    • (2012) J Exp Med , vol.209 , pp. 495-506
    • Scarlett, U.K.1    Rutkowski, M.R.2    Rauwerdink, A.M.3
  • 67
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A,. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7: 211-17.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 68
    • 0030785819 scopus 로고    scopus 로고
    • The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine
    • Blay J, White TD, Hoskin DW,. The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Cancer Res 1997; 57: 2602-5.
    • (1997) Cancer Res , vol.57 , pp. 2602-2605
    • Blay, J.1    White, T.D.2    Hoskin, D.W.3
  • 69
    • 79251620102 scopus 로고    scopus 로고
    • Hypoxia potentiates glioma-mediated immunosuppression
    • Wei J, Wu A, Kong L-Y, et al. Hypoxia potentiates glioma-mediated immunosuppression. PLoS One 2011; 6: e16195.
    • (2011) PLoS One , vol.6
    • Wei, J.1    Wu, A.2    Kong, L.-Y.3
  • 70
    • 84255170452 scopus 로고    scopus 로고
    • Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: Role of nitric oxide
    • Barsoum IB, Hamilton TK, Li X, Cotechini T, Miles EA, Siemens DR, Graham CH,. Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide. Cancer Res 2011; 71: 7433-41.
    • (2011) Cancer Res , vol.71 , pp. 7433-7441
    • Barsoum, I.B.1    Hamilton, T.K.2    Li, X.3    Cotechini, T.4    Miles, E.A.5    Siemens, D.R.6    Graham, C.H.7
  • 71
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002; 23: 549-55.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3
  • 72
    • 77950944395 scopus 로고    scopus 로고
    • Macrophages, innate immunity and cancer: Balance, tolerance, and diversity
    • Mantovani A, Sica A,. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr Opin Immunol 2010; 22: 231-7.
    • (2010) Curr Opin Immunol , vol.22 , pp. 231-237
    • Mantovani, A.1    Sica, A.2
  • 73
    • 24044461733 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: Implications for tumor progression and anti-cancer therapies
    • Lewis C, Murdoch C,. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 2005; 167: 627-35.
    • (2005) Am J Pathol , vol.167 , pp. 627-635
    • Lewis, C.1    Murdoch, C.2
  • 74
    • 77957808350 scopus 로고    scopus 로고
    • Knockout of HIF-1alpha in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
    • Werno C, Menrad H, Weigert A, et al. Knockout of HIF-1alpha in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses. Carcinogenesis 2010; 31: 1863-72.
    • (2010) Carcinogenesis , vol.31 , pp. 1863-1872
    • Werno, C.1    Menrad, H.2    Weigert, A.3
  • 75
    • 67651160649 scopus 로고    scopus 로고
    • CD4(+) T-cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo DG, Barreto JB, Andreu P, et al. CD4(+) T-cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009; 16: 91-102.
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • Denardo, D.G.1    Barreto, J.B.2    Andreu, P.3
  • 76
    • 77957350018 scopus 로고    scopus 로고
    • Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
    • Doedens AL, Stockmann C, Rubinstein MP, et al. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res 2010; 70: 7465-75.
    • (2010) Cancer Res , vol.70 , pp. 7465-7475
    • Doedens, A.L.1    Stockmann, C.2    Rubinstein, M.P.3
  • 77
    • 77649177217 scopus 로고    scopus 로고
    • Differential activation and antagonistic function of HIF-alpha isoforms in macrophages are essential for NO homeostasis
    • Takeda N, O'Dea EL, Doedens A, et al. Differential activation and antagonistic function of HIF-alpha isoforms in macrophages are essential for NO homeostasis. Genes Dev 2010; 24: 491-501.
    • (2010) Genes Dev , vol.24 , pp. 491-501
    • Takeda, N.1    O'Dea, E.L.2    Doedens, A.3
  • 78
    • 0037223170 scopus 로고    scopus 로고
    • IL-4-induced arginase 1 suppresses alloreactive T-cells in tumor-bearing mice
    • Bronte V, Serafini P, De Santo, et al. IL-4-induced arginase 1 suppresses alloreactive T-cells in tumor-bearing mice. J Immunol 2003; 170: 270-8.
    • (2003) J Immunol , vol.170 , pp. 270-278
    • Bronte, V.1    Serafini, P.2    De Santo3
  • 79
    • 33847307112 scopus 로고    scopus 로고
    • Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2
    • Berchner-Pfannschmidt U, Yamac H, Trinidad B, et al. Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2. J Biol Chem 2007; 282: 1788-96.
    • (2007) J Biol Chem , vol.282 , pp. 1788-1796
    • Berchner-Pfannschmidt, U.1    Yamac, H.2    Trinidad, B.3
  • 80
    • 0038207007 scopus 로고    scopus 로고
    • Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase
    • Ellies LG, Fishman M, Hardison J, et al. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer 2003; 106: 1-7.
    • (2003) Int J Cancer , vol.106 , pp. 1-7
    • Ellies, L.G.1    Fishman, M.2    Hardison, J.3
  • 81
    • 84860703232 scopus 로고    scopus 로고
    • Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia
    • Niecknig H, Tug S, Reyes BD, et al. Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic Res 2012; 46: 705-17.
    • (2012) Free Radic Res , vol.46 , pp. 705-717
    • Niecknig, H.1    Tug, S.2    Reyes, B.D.3
  • 82
    • 24144444133 scopus 로고    scopus 로고
    • Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
    • Brunelle JK, Bell EL, Quesada NM, et al. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab 2005; 1: 409-14.
    • (2005) Cell Metab , vol.1 , pp. 409-414
    • Brunelle, J.K.1    Bell, E.L.2    Quesada, N.M.3
  • 83
    • 24144493814 scopus 로고    scopus 로고
    • Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    • Guzy RD, Hoyos B, Robin E, et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 2005; 1: 401-8.
    • (2005) Cell Metab , vol.1 , pp. 401-408
    • Guzy, R.D.1    Hoyos, B.2    Robin, E.3
  • 84
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157: 411-21.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 85
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu CJ, Wang LY, Chodosh LA, et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003; 23: 9361-74.
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3
  • 86
    • 43149084780 scopus 로고    scopus 로고
    • Prognostic significance of HIF-2alpha expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy
    • Kawanaka T, Kubo A, Ikushima H, et al. Prognostic significance of HIF-2alpha expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy. J Med Invest 2008; 55: 78-86.
    • (2008) J Med Invest , vol.55 , pp. 78-86
    • Kawanaka, T.1    Kubo, A.2    Ikushima, H.3
  • 87
    • 77955295091 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
    • Imtiyaz HZ, Williams EP, Hickey MM, et al. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest 2010; 120: 2699-714.
    • (2010) J Clin Invest , vol.120 , pp. 2699-2714
    • Imtiyaz, H.Z.1    Williams, E.P.2    Hickey, M.M.3
  • 88
    • 0037423948 scopus 로고    scopus 로고
    • HIF-1alpha is essential for myeloid cell-mediated inflammation
    • Cramer T, Yamanishi Y, Clausen BE, et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003; 112: 645-57.
    • (2003) Cell , vol.112 , pp. 645-657
    • Cramer, T.1    Yamanishi, Y.2    Clausen, B.E.3
  • 89
    • 22144492953 scopus 로고    scopus 로고
    • HIF-1alpha expression regulates the bactericidal capacity of phagocytes
    • Peyssonnaux C, Datta V, Cramer T, et al. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest 2005; 115: 1806-15.
    • (2005) J Clin Invest , vol.115 , pp. 1806-1815
    • Peyssonnaux, C.1    Datta, V.2    Cramer, T.3
  • 90
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran V, Ikeda H, Bruce AT, et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001; 410: 1107-11.
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3
  • 91
    • 0035872423 scopus 로고    scopus 로고
    • Prognostic significance of activated CD8(+) T-cell infiltrations within esophageal carcinomas
    • Schumacher K, Haensch W, Röefzaad C, Schlag PM,. Prognostic significance of activated CD8(+) T-cell infiltrations within esophageal carcinomas. Cancer Res 2001; 61: 3932-6.
    • (2001) Cancer Res , vol.61 , pp. 3932-3936
    • Schumacher, K.1    Haensch, W.2    Röefzaad, C.3    Schlag, P.M.4
  • 92
  • 93
    • 24344436369 scopus 로고    scopus 로고
    • Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
    • Willimsky G, Blankenstein T,. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature 2005; 437: 141-6.
    • (2005) Nature , vol.437 , pp. 141-146
    • Willimsky, G.1    Blankenstein, T.2
  • 94
    • 0034663561 scopus 로고    scopus 로고
    • Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts
    • Thornton RD, Lane P, Borghaei RC, et al. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem J 2000; 350 (Part 1): 307-12.
    • (2000) Biochem J , vol.350 , Issue.PART 1 , pp. 307-312
    • Thornton, R.D.1    Lane, P.2    Borghaei, R.C.3
  • 95
    • 20444429440 scopus 로고    scopus 로고
    • TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T-cells
    • Nakamura H, Makino Y, Okamoto K, et al. TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T-cells. J Immunol 2005; 174: 7592-9.
    • (2005) J Immunol , vol.174 , pp. 7592-7599
    • Nakamura, H.1    Makino, Y.2    Okamoto, K.3
  • 96
    • 0035966119 scopus 로고    scopus 로고
    • Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes
    • Lukashev D, Caldwell C, Ohta A, et al. Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 alpha in activated T lymphocytes. J Biol Chem 2001; 276: 48754-63.
    • (2001) J Biol Chem , vol.276 , pp. 48754-48763
    • Lukashev, D.1    Caldwell, C.2    Ohta, A.3
  • 97
    • 0030916245 scopus 로고    scopus 로고
    • The mouse gene for hypoxia-inducible factor-1alpha - Genomic organization, expression and characterization of an alternative first exon and 5′ flanking sequence
    • Wenger RH, Rolfs A, Kvietikova I, et al. The mouse gene for hypoxia-inducible factor-1alpha-genomic organization, expression and characterization of an alternative first exon and 5′ flanking sequence. Eur J Biochem/FEBS 1997; 246: 155-65.
    • (1997) Eur J Biochem/FEBS , vol.246 , pp. 155-165
    • Wenger, R.H.1    Rolfs, A.2    Kvietikova, I.3
  • 98
    • 33749512970 scopus 로고    scopus 로고
    • Cutting edge: Hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
    • Lukashev D, Klebanov B, Kojima H, et al. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J Immunol 2006; 177: 4962-5.
    • (2006) J Immunol , vol.177 , pp. 4962-4965
    • Lukashev, D.1    Klebanov, B.2    Kojima, H.3
  • 99
    • 34547120458 scopus 로고    scopus 로고
    • Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues
    • Lukashev D, Ohta A, Sitkovsky M,. Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues. Cancer Metastasis Rev 2007; 26: 273-9.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 273-279
    • Lukashev, D.1    Ohta, A.2    Sitkovsky, M.3
  • 100
    • 75149118269 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor 1alpha in T-cells as a negative regulator in development of vascular remodeling
    • Kurobe H, Urata M, Ueno M, et al. Role of hypoxia-inducible factor 1alpha in T-cells as a negative regulator in development of vascular remodeling. Arterioscler Thromb Vasc Biol 2010; 30: 210-17.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 210-217
    • Kurobe, H.1    Urata, M.2    Ueno, M.3
  • 101
    • 34547655923 scopus 로고    scopus 로고
    • A unique subset of CD4+CD25highFoxp3+ T-cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment
    • Strauss L, Bergmann C, Szczepanski M, et al. A unique subset of CD4+CD25highFoxp3+ T-cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment. Clin Cancer Res 2007; 13: 4345-54.
    • (2007) Clin Cancer Res , vol.13 , pp. 4345-4354
    • Strauss, L.1    Bergmann, C.2    Szczepanski, M.3
  • 102
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene A, Peng X, Hagemann IS, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 2011; 475: 226-30.
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3
  • 103
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    • Dang EV, Barbi J, Yang H-Y, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 2011; 146: 772-84.
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1    Barbi, J.2    Yang, H.-Y.3
  • 104
    • 78649586268 scopus 로고    scopus 로고
    • The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity
    • Youn J-I, Gabrilovich DI,. The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity. Eur J Immunol 2010; 40: 2969-75.
    • (2010) Eur J Immunol , vol.40 , pp. 2969-2975
    • Youn, J.-I.1    Gabrilovich, D.I.2
  • 105
    • 79952794385 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: A double-edged sword?
    • Pastula A, Marcinkiewicz J,. Myeloid-derived suppressor cells: a double-edged sword? Int J Exp Pathol 2011; 92: 73-8.
    • (2011) Int J Exp Pathol , vol.92 , pp. 73-78
    • Pastula, A.1    Marcinkiewicz, J.2
  • 106
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S,. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009; 9: 162-74.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 107
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica A, Bronte V,. Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest 2007; 117: 1155-66.
    • (2007) J Clin Invest , vol.117 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 108
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero CM, Salem ML, Nishimura MI, et al. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother 2009; 58: 49-59.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3
  • 109
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1a regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, Condamine T, Lu L, et al. HIF-1a regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 2010; 207: 2439-53.
    • (2010) J Exp Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3
  • 110
    • 44449117540 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function
    • Jantsch J, Chakravortty D, Turza N, et al. Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function. J Immunol 2008; 180: 4697-705.
    • (2008) J Immunol , vol.180 , pp. 4697-4705
    • Jantsch, J.1    Chakravortty, D.2    Turza, N.3
  • 112
    • 84859070461 scopus 로고    scopus 로고
    • Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 masT-cells and basophils
    • Sumbayev VV, Yasinska I, Oniku AE, et al. Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 masT-cells and basophils. PLoS One 2012; 7: e34259.
    • (2012) PLoS One , vol.7
    • Sumbayev, V.V.1    Yasinska, I.2    Oniku, A.E.3
  • 113
    • 49649118801 scopus 로고    scopus 로고
    • HIF-1alpha is up-regulated in activated masT-cells by a process that involves calcineurin and NFAT
    • Walczak-Drzewiecka A, Ratajewski M, Wagner W, et al. HIF-1alpha is up-regulated in activated masT-cells by a process that involves calcineurin and NFAT. J Immunol 2008; 181: 1665-72.
    • (2008) J Immunol , vol.181 , pp. 1665-1672
    • Walczak-Drzewiecka, A.1    Ratajewski, M.2    Wagner, W.3
  • 114
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • Palucka K, Banchereau J,. Cancer immunotherapy via dendritic cells. Nat Rev Cancer 2012; 12: 265-77.
    • (2012) Nat Rev Cancer , vol.12 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 115
    • 19944432390 scopus 로고    scopus 로고
    • Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity
    • Walmsley SR, Print C, Farahi N, et al. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med 2005; 201: 105-15.
    • (2005) J Exp Med , vol.201 , pp. 105-115
    • Walmsley, S.R.1    Print, C.2    Farahi, N.3
  • 116
    • 33845321931 scopus 로고    scopus 로고
    • Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
    • Cummins EP, Berra E, Comerford KM, et al. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci USA 2006; 103: 18154-9.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18154-18159
    • Cummins, E.P.1    Berra, E.2    Comerford, K.M.3
  • 117
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW,. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006; 66: 605-12.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 118
    • 0345118952 scopus 로고    scopus 로고
    • Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis
    • White JR, Harris RA, Lee SR, et al. Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis. Genomics 2004; 83: 1-8.
    • (2004) Genomics , vol.83 , pp. 1-8
    • White, J.R.1    Harris, R.A.2    Lee, S.R.3
  • 119
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW,. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4: 71-8.
    • (2004) Nat Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 120
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian B-Z, Pollard JW,. Macrophage diversity enhances tumor progression and metastasis. Cell 2010; 141: 39-51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.-Z.1    Pollard, J.W.2
  • 121
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • Lin EY, Li J-F, Gnatovskiy L, et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 2006; 66: 11238-46.
    • (2006) Cancer Res , vol.66 , pp. 11238-11246
    • Lin, E.Y.1    Li, J.-F.2    Gnatovskiy, L.3
  • 122
    • 57649112725 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
    • Stockmann C, Doedens A, Weidemann A, et al. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 2008; 456: 814-18.
    • (2008) Nature , vol.456 , pp. 814-818
    • Stockmann, C.1    Doedens, A.2    Weidemann, A.3
  • 123
    • 80051946936 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2a regulates GM-CSF-derived soluble vascular endothelial growth factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesis
    • Roda JM, Sumner LA, Evans R, et al. Hypoxia-inducible factor-2a regulates GM-CSF-derived soluble vascular endothelial growth factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesis. J Immunol 2011; 187: 1970-6.
    • (2011) J Immunol , vol.187 , pp. 1970-1976
    • Roda, J.M.1    Sumner, L.A.2    Evans, R.3
  • 124
    • 0036493984 scopus 로고    scopus 로고
    • Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer
    • Leek RD, Talks KL, Pezzella F, et al. Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. Cancer Res 2002; 62: 1326-9.
    • (2002) Cancer Res , vol.62 , pp. 1326-1329
    • Leek, R.D.1    Talks, K.L.2    Pezzella, F.3
  • 125
    • 13944252559 scopus 로고    scopus 로고
    • Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma
    • Petrella BL, Lohi J, Brinckerhoff CE,. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005; 24: 1043-52.
    • (2005) Oncogene , vol.24 , pp. 1043-1052
    • Petrella, B.L.1    Lohi, J.2    Brinckerhoff, C.E.3
  • 126
    • 0141425768 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression in human macrophages: Implications for ischemic tissues and hypoxia-regulated gene therapy
    • Burke B, Giannoudis A, Corke KP, et al. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol 2003; 163: 1233-43.
    • (2003) Am J Pathol , vol.163 , pp. 1233-1243
    • Burke, B.1    Giannoudis, A.2    Corke, K.P.3
  • 127
    • 0037036679 scopus 로고    scopus 로고
    • Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice
    • Huang S, Van Arsdall M, Tedjarati S, et al. Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice. J Natl Cancer Inst 2002; 94: 1134-42.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1134-1142
    • Huang, S.1    Van Arsdall, M.2    Tedjarati, S.3
  • 128
    • 34249979533 scopus 로고    scopus 로고
    • Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
    • Venneri MA, De Palma, Michele, et al. Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 2007; 109: 5276-85.
    • (2007) Blood , vol.109 , pp. 5276-5285
    • Venneri, M.A.1    De Palma2    Michele3
  • 129
    • 34249791475 scopus 로고    scopus 로고
    • Expression of Tie-2 by human monocytes and their responses to angiopoietin-2
    • Murdoch C, Tazzyman S, Webster S, et al. Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J Immunol 2007; 178: 7405-11.
    • (2007) J Immunol , vol.178 , pp. 7405-7411
    • Murdoch, C.1    Tazzyman, S.2    Webster, S.3
  • 130
    • 84857466801 scopus 로고    scopus 로고
    • HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFbeta activation
    • Klotzsche-von Ameln A, Muschter A, Heimesaat MM, et al. HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFbeta activation. Cancer Biol Ther 2012; 13: 216-23.
    • (2012) Cancer Biol Ther , vol.13 , pp. 216-223
    • Klotzsche-Von Ameln, A.1    Muschter, A.2    Heimesaat, M.M.3
  • 131
    • 33846044750 scopus 로고    scopus 로고
    • Bone marrow cells in the 'pre-metastatic niche': Within bone and beyond
    • Kaplan RN, Psaila B, Lyden D,. Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer Metastasis Rev 2006; 25: 521-9.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 521-529
    • Kaplan, R.N.1    Psaila, B.2    Lyden, D.3
  • 132
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH, et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 2009; 4: e6562.
    • (2009) PLoS One , vol.4
    • Qian, B.1    Deng, Y.2    Im, J.H.3
  • 133
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang N, Wang L, Esko J, et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004; 6: 485-95.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3
  • 134
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • Pennacchietti S, Michieli P, Galluzzo M, et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003; 3: 347-61.
    • (2003) Cancer Cell , vol.3 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3
  • 135
    • 0035399174 scopus 로고    scopus 로고
    • Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells
    • Canning MT, Postovit LM, Clarke SH, et al. Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells. Exp Cell Res 2001; 267: 88-94.
    • (2001) Exp Cell Res , vol.267 , pp. 88-94
    • Canning, M.T.1    Postovit, L.M.2    Clarke, S.H.3
  • 136
    • 80053645045 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
    • Wong CC-L, Gilkes DM, Zhang H, et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci USA 2011; 108: 16369-74.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16369-16374
    • Wong, C.-L.1    Gilkes, D.M.2    Zhang, H.3
  • 137
    • 0036007293 scopus 로고    scopus 로고
    • Expression of HIF-1alpha by human macrophages: Implications for the use of macrophages in hypoxia-regulated cancer gene therapy
    • Burke B, Tang N, Corke KP, et al. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J Pathol 2002; 196: 204-12.
    • (2002) J Pathol , vol.196 , pp. 204-212
    • Burke, B.1    Tang, N.2    Corke, K.P.3
  • 138
    • 33947302545 scopus 로고    scopus 로고
    • Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner
    • Miyoshi A, Kitajima Y, Ide T, et al. Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner. Int J Oncol 2006; 29: 1533-9.
    • (2006) Int J Oncol , vol.29 , pp. 1533-1539
    • Miyoshi, A.1    Kitajima, Y.2    Ide, T.3
  • 139
    • 0036740130 scopus 로고    scopus 로고
    • Endothelin-2 is a macrophage chemoattractant: Implications for macrophage distribution in tumors
    • Grimshaw MJ, Wilson JL, Balkwill FR,. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol 2002; 32: 2393-400.
    • (2002) Eur J Immunol , vol.32 , pp. 2393-2400
    • Grimshaw, M.J.1    Wilson, J.L.2    Balkwill, F.R.3
  • 140
    • 80052274543 scopus 로고    scopus 로고
    • Transcriptional upregulation of MT2-MMP in response to hypoxia is promoted by HIF-1 in cancer cells
    • Zhu S, Zhou Y, Wang L, et al. Transcriptional upregulation of MT2-MMP in response to hypoxia is promoted by HIF-1 in cancer cells. Mol Carcinog 2011; 50: 770-80.
    • (2011) Mol Carcinog , vol.50 , pp. 770-780
    • Zhu, S.1    Zhou, Y.2    Wang, L.3
  • 141
    • 77953183739 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction
    • Yang S, Kim J, Ryu J-H, et al. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 2010; 16: 687-93.
    • (2010) Nat Med , vol.16 , pp. 687-693
    • Yang, S.1    Kim, J.2    Ryu, J.-H.3
  • 142
    • 70249099576 scopus 로고    scopus 로고
    • Interdependence of hypoxic and innate immune responses
    • Nizet V, Johnson RS,. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 2009; 9: 609-17.
    • (2009) Nat Rev Immunol , vol.9 , pp. 609-617
    • Nizet, V.1    Johnson, R.S.2
  • 144
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas SK, Mantovani A,. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol 2010; 11: 889-96.
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 145
    • 84855817522 scopus 로고    scopus 로고
    • Immunology in the clinic review series; Focus on cancer: Tumour-associated macrophages: Undisputed stars of the inflammatory tumour microenvironment
    • Allavena P, Mantovani A,. Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment. Clin Exp Immunol 2012; 167: 195-205.
    • (2012) Clin Exp Immunol , vol.167 , pp. 195-205
    • Allavena, P.1    Mantovani, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.