Stabilisation and knockdown of HIF - Two distinct ways comparably important in radiotherapy

Cellular Physiology and Biochemistry

Volumn 28, Issue 5, 2011, Pages 805-812

  Ströfer, Mareike ^a   Jelkmann, Wolfgang ^a   Metzen, Eric ^b   Brockmeier, Ulf ^b   Dunst, Jürgen ^a   Depping, Reinhard ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Cancer; HIF; Hypoxia; Radiotherapy; Stabiliser

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA;

ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CELL HYPOXIA; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIOSENSITIVITY; SURVIVAL;

EID: 83755178199     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000335794     Document Type: Article

References (34)

1. Dewhirst MW, Cao Y, Moeller B: Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer 2008;8:425-437. (Pubitemid 351744964)
2. Semenza GL: Hypoxia and cancer. Cancer Metastasis Rev 2007;26:223-224. (Pubitemid 47101662)
3. Harris AL: Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47. (Pubitemid 37328806)
4. Vaupel P, Harrison L: Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist 2004;9:4-9. (Pubitemid 39658340)
5. Semenza GL: Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda ) 2009;24:97-106.
6. Dewhirst MW: Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res 2009;172:653-665.
7. Overgaard J, Eriksen JG, Nordsmark M, Alsner J, Horsman MR: Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. Lancet Oncol 2005;6:757-764. (Pubitemid 41430716)
8. Brown JM: Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies. Mol Med Today 2000;6:157-162. (Pubitemid 30171366)
9. Osinsky S, Zavelevich M, Vaupel P: Tumor hypoxia and malignant progression. Exp Oncol 2009;31:80-86.
10. Vaupel P, Mayer A, Hockel M: Tumor hypoxia and malignant progression. Methods Enzymol 2004;381:335-354. (Pubitemid 38401518)
11. Vaupel P, Dunst J, Engert A, Fandrey J, Feyer P, Freund M, Jelkmann W: Effects of recombinant human erythropoietin (rHuEPO) on tumor control in patients with cancer-induced anemia. Onkologie 2005;28:216-221. (Pubitemid 41094492)
12. Brokers N, Le-Huu S, Vogel S, Hagos Y, Katschinski DM, Kleinschmidt M: Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes. Cancer Sci 2010;101:129-136.
13. Palayoor ST, Burgos MA, Shoaibi A, Tofilon PJ, Coleman CN: Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxiainducible factors by loss of von Hippel-Lindau tumor suppressor gene function. Clin Cancer Res 2004;10:4158-4164. (Pubitemid 38812496)
14. Vordermark D, Katzer A, Baier K, Kraft P, Flentje M: Cell type-specific association of hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein accumulation and radiobiologic tumor hypoxia. Int J Radiat Oncol Biol Phys 2004;58:1242-1250. (Pubitemid 38314810)
15. Zou Y, Cheng C, Omura-Minamisawa M, Kang Y, Hara T, Guan X, Inoue T: The suppression of hypoxia-inducible factor and vascular endothelial growth factor by siRNA does not affect the radiation sensitivity of multicellular tumor spheroids. J Radiat Res (Tokyo ) 2010;51:47-55.
16. Moeller BJ, Cao Y, Li CY, Dewhirst MW: Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004;5:429-441. (Pubitemid 38610245)
17. Hsieh CH, Lee CH, Liang JA, Yu CY, Shyu WC: Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity. Oncol Rep 2010;24:1629-1636.
18. Kessler J, Hahnel A, Wichmann H, Rot S, Kappler M, Bache M, Vordermark D: HIF-1alpha inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer 2010;10:605.
19. Staab A, Fleischer M, Loeffler J, Said HM, Katzer A, Plathow C, Einsele H, Flentje M, Vordermark D: Small interfering RNA targeting HIF-1alpha reduces hypoxiadependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. Strahlenther Onkol 2011;187:252-259.
20. Schwartz DL, Bankson JA, Lemos RJ, Lai SY, Thittai AK, He Y, Hostetter G, Demeure MJ, Von HD, Powis G: Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer. Mol Cancer Ther 2010;9:2057-2067.
21. Aebersold DM, Burri P, Beer KT, Laissue J, Djonov V, Greiner RH, Semenza GL: Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001;61:2911-2916. (Pubitemid 32691934)
22. Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI: Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 2002;95:1055-1063. (Pubitemid 34925357)
23. Gordan JD, Bertout JA, Hu CJ, Diehl JA, Simon MC: HIF-2alpha promotes hypoxic cell proliferation by enhancing cmyc transcriptional activity. Cancer Cell 2007;11:335-347. (Pubitemid 46518312)
24. Wiesener MS, Jurgensen JS, Rosenberger C, Scholze CK, Horstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA, Pugh CW, Ratcliffe PJ, Bachmann S, Maxwell PH, Eckardt KU: Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J 2003;17:271-273.
25. Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC: Differential roles of hypoxiainducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003;23:9361-9374. (Pubitemid 37499822)
26. Warnecke C, Zaborowska Z, Kurreck J, Erdmann VA, Frei U, Wiesener M, Eckardt KU: Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J 2004;18:1462-1464. (Pubitemid 39561615)
27. Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B: HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev 2006;20:557-570. (Pubitemid 43345322)
28. Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC: Differential roles of hypoxiainducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 2003;23:9361-9374. (Pubitemid 37499822)
29. Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, Peet DJ: Cellspecific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J Biol Chem 2006;281:22575-22585.
30. Jones EL, Prosnitz LR, Dewhirst MW, Marcom PK, Hardenbergh PH, Marks LB, Brizel DM, Vujaskovic Z: Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer. Clin Cancer Res 2004;10:4287-4293. (Pubitemid 38878865)
31. Zhang L, Subarsky P, Hill RP: Hypoxiaregulated p53 and its effect on radiosensitivity in cancer cells. Int J Radiat Biol 2007;83:443-456. (Pubitemid 46854838)
32. Semenza GL: Intratumoral hypoxia, radiation resistance, and HIF-1. Cancer Cell 2004;5:405-406. (Pubitemid 38610240)
33. Michiels C, Minet E, Mottet D, Raes M: Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes. Free Radic Biol Med 2002;33:1231-1242. (Pubitemid 35246591)
34. Bernhardt WM, Wiesener MS, Scigalla P, Chou J, Schmieder RE, Gunzler V, Eckardt KU: Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol 2010;21:2151-2156.