HIF-1α is up-regulated in activated mast cells by a process that involves calcineurin and NFAT

Journal of Immunology

Volumn 181, Issue 3, 2008, Pages 1665-1672

  Walczak Drzewiecka, Aurelia ^a   Ratajewski, Marcin ^a   Wagner, Waldemar ^a   Dastych, Jaroslaw ^a  

^a INSTITUTE OF MEDICAL BIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; CYCLOSPORIN A; DACTINOMYCIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IONOMYCIN; MESSENGER RNA; SUBSTANCE P; TACROLIMUS; TRANSCRIPTION FACTOR NFAT;

ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; HYPOXIA INDUCIBLE FACTOR 1ALPHA GENE; MAST CELL; MUTAGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL LINE; DNA RESPONSIVE ELEMENT; GENETICS; IMMUNOLOGY; METABOLISM; PROMOTER REGION;

ANIMALS; CALCINEURIN; CELL LINE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAST CELLS; NFATC TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; UP-REGULATION;

EID: 49649118801     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.3.1665     Document Type: Article

References (45)

1. Mekori, Y. A., and D. D. Metcalfe. 2000. Mast cells in innate immunity. Immunol. Rev. 173: 131-140.
2. Nilsson G, C. J., and D. D. Metcalfe. 1999. Mast cells and basophils. In Inflammation: Basic Principles and Clinical Correlates. J. I. Gallin and R. Snyder, eds. Lippincott-Raven Publications, Philadelphia, pp. 97-117.
3. Taylor, M. L., and D. D. Metcalfe. 2001. Mast cells in allergy and host defense. Allergy Asthma Proc. 22: 115-119.
4. Malaviya, R., T. Ikeda, E. Ross, and S. N. Abraham. 1996. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α. Nature 381: 77-80.
5. Nutman, T. B. 1993. Mast cells and their role in parasitic helminth infection. In The Mast Cell in Health and Disease. M. A. Kaliner and D. D. Metcalfe, eds. Marcel Dekker, New York, pp. 669-686.
6. Maurer, M., J. Wedemeyer, M. Metz, A. M. Piliponsky, K. Weller, D. Chatterjea, D. E. Clouthier, M. M. Yanagisawa, M. Tsai, and S. J. Galli. 2004. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 432: 512-516.
7. Norrby, K., A. Jakobsson, and J. Sorbo. 1986. Mast-cell-mediated angiogenesis: a novel experimental model using the rat mesentery. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 52: 195-206.
8. Nishikori, Y., E. Kakizoe, Y. Kobayashi, K. Shimoura, H. Okunishi, and S. Dekio. 1998. Skin mast cell promotion of matrix remodeling in burn wound healing in mice: relevance of chymase. Arch. Dermatol. Res. 290: 553-560.
9. Koshino, T., Y. Arai, Y. Miyamoto, Y. Sano, M. Itami, S. Teshima, K. Hirai, T. Takaishi, K. Ito, and Y. Morita. 1996. Airway basophil and mast cell density in patients with bronchial asthma: relationship to bronchial hyperresponsiveness. J. Asthma 33: 89-95.
10. Kassel, O., F. de Blay, C. Duvernelle, C. Olgart, D. Israel-Biet, P. Krieger, L. Moreau, C. Muller, G. Pauli, and N. Frossard. 2001. Local increase in the number of mast cells and expression of nerve growth factor in the bronchus of asthmatic patients after repeated inhalation of allergen at low-dose. Clin. Exp. Allergy 31: 1432-1440.
11. Mican, J. M., and D. D. Metcalfe. 1990. Arthritis and mast cell activation. J. Allergy Clin. Immunol. 86: 677-683.
12. Yano, H., M. Kinuta, H. Tateishi, Y. Nakano, S. Matsui, T. Monden, J. Okamura, M. Sakai, and S. Okamoto. 1999. Mast cell infiltration around gastric cancer cells correlates with tumor angiogenesis and metastasis. Gastric Cancer 2: 26-32.
13. Ch'ng, S., R. A. Wallis, L. Yuan, P. F. Davis, and S. T. Tan. 2006. Mast cells and cutaneous malignancies. Mod. Pathol. 19: 149-159.
14. Wright, J. L. 2001. Diseases of the small airways. Lung 179: 375-396.
15. Levick, J. R. 1990. Hypoxia and acidosis in chronic inflammatory arthritis; relation to vascular supply and dynamic effusion pressure. J. Rheumatol. 17: 579-582.
16. Hockel, M., and P. Vaupel. 2001. Biological consequences of tumor hypoxia. Semin. Oncol. 28: 36-41.
17. Steiner, D. R., N. C. Gonzalez, and J. G. Wood. 2003. Mast cells mediate the microvascular inflammatory response to systemic hypoxia. J. Appl. Physiol. 94: 325-334.
18. Jeong, H. J., H. S. Chung, B. R. Lee, S. J. Kim, S. J. Yoo, S. H. Hong, and H. M. Kim. 2003. Expression of proinflammatory cytokines via HIF-1α and NF-κB activation on desferrioxamine-stimulated HMC-1 cells. Biochem. Biophys. Res. Commun. 306: 805-811.
19. Zhang, Q., C. K. Oh, D. V. Messadi, H. S. Duong, A. P. Kelly, C. Soo, L. Wang, and A. D. Le. 2006. Hypoxia-induced HIF-1 α accumulation is augmented in a coculture of keloid fibroblast and human mast cells: involvement of ERK1/2 and PI-3K/Akt. Exp. Cell Res. 312: 145-155.
20. Semenza, G. L. 2000. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88: 1474-1480.
21. Seagroves, T. N., H. E. Ryan, H. Lu, B. G. Wouters, M. Knapp, P. Thibault, K. Laderoute, and R. S. Johnson. 2001. Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol. Cell. Biol. 21: 3436-3444.
22. Hon, W. C., M. I. Wilson, K. Harlos, T. D. Claridge, C. J. Schofield, C. W. Pugh, P. H. Maxwell, P. J. Ratcliffe, D. I. Stuart, and E. Y. Jones. 2002. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL. Nature 417: 975-978.
23. Frede, S., C. Stockmann, P. Freitag, and J. Fandrey. 2006. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB. Biochem. J. 396: 517-527.
24. Butterfield, J. H., D. Weiler, G. Dewald, and G. J. Gleich. 1988. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk. Res. 12: 345-355.
25. Kirshenbaum, A. S., C. Akin, Y. Wu, M. Rottem, J. P. Goff, M. A. Beaven, V. K. Rao, and D. D. Metcalfe. 2003. Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcεRI or FcγRI. Leuk. Res. 27: 677-682.
26. Walczak-Drzewiecka, A., J. Wyczolkowska, and J. Dastych. 2005. c-Jun N-terminal kinase is involved in mercuric ions-mediated interleukin-4 secretion in mast cells. Int. Arch. Allergy Immunol. 136: 181-190.
27. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475-1489.
28. Semenza, G. L., and G. L. Wang. 1992. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12: 5447-5454.
29. Vandesompele, J., K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe, and F. Speleman. 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3: 0034.1-0034.11.
30. Lukashev, D., C. Caldwell, A. Ohta, P. Chen, and M. Sitkovsky. 2001. Differential regulation of two alternatively spliced isoforms of hypoxia-inducible factor-1 α in activated T lymphocytes. J. Biol. Chem. 276: 48754-48763.
31. Ratajewski, M., G. Bartosz, and L. Pulaski. 2006. Expression of the human ABCC6 gene is induced by retinoids through the retinoid X receptor. Biochem. Biophys. Res. Commun. 350: 1082-1087.
32. Waleev, T., D. Shtokalo, T. Konovalova, N. Voss, E. Cheremushkin, P. Stegmaier, O. Kel-Margoulis, E. Wingender, and A. Kel. 2006. Composite module analyst: identification of transcription factor binding site combinations using genetic algorithm. Nucleic Acids Res. 34: W541-W545.
33. Cartharius, K., K. Frech, K. Grote, B. Klocke, M. Haltmeier, A. Klingenhoff, M. Frisch, M. Bayerlein, and T. Werner. 2005. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21: 2933-2942.
34. D'Angelo, G., E. Duplan, P. Vigne, and C. Frelin. 2003. Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1α pro-564 hydroxylation. J. Biol. Chem. 278: 15406-15411.
35. Lawrence, M. C., H. S. Bhatt, and R. A. Easom. 2002. NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1. Diabetes 51: 691-698.
36. Mottet, D., G. Michel, P. Renard, N. Ninane, M. Raes, and C. Michiels. 2003. Role of ERK and calcium in the hypoxia-induced activation of HIF-1. J. Cell. Physiol. 194: 30-44.
37. Mottet, D., G. Michel, P. Renard, N. Ninane, M. Raes, and C. Michiels. 2002. ERK and calcium in activation of HIF-1. Ann. NY Acad. Sci. 973: 448-453.
38. Kim, K. E., Y. J. Jung, E. J. Yeo, Y. S. Chun, and J. W. Park. 2006. FK506: an immunosuppressive agent preserving HIF-1 activity. Immunopharmacol. Immunotoxicol. 28: 609-620.
39. Zee, E. D., S. Schomberg, and T. C. Carpenter. 2006. Hypoxia upregulates lung microvascular neurokinin-1 receptor expression. Am. J. Physiol. 291: L102-L110.
40. Goldman, G., R. Welbourn, J. M. Klausner, L. Kobzik, C. R. Valeri, D. Shepro, and H. B. Hechtman. 1992. Mast cells and leukotrienes mediate neutrophil sequestration and lung edema after remote ischemia in rodents. Surgery 112: 578-586.
41. Koulmann, N., V. Novel-Chaté, A. Peinnequin, R. Chapot, B. Serrurier, N. Simler, H. Richard, R. Ventura-Clapier, and X. Bigard. 2006. Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy. Am. J. Respir. Crit. Care Med. 174: 699-705.
42. McCaffrey, P. G., A. E. Goldfeld, and A. Rao. 1994. The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-α gene transcription. J. Biol. Chem. 269: 30445-30450.
43. Clipstone, N. A., and G. R. Crabtree. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357: 695-697.
44. Crabtree, G. R., and E. N. Olson. 2002. NFAT signaling: choreographing the social lives of cells. Cell 109:S67-S79.
45. Fruman, D. A., B. E. Bierer, J. E. Benes, S. J. Burakoff, K. F. Austen, and H. R. Katz. 1995. The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. J. Immunol. 154: 1846-1851.