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Volumn 40, Issue 11, 2010, Pages 2969-2975

The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity

Author keywords

Dendritic cells; Macrophages; Myeloid derived suppressor cells; Neutrophils

Indexed keywords

ARGININE; CD11B ANTIGEN; CYTOKINE; NITRIC OXIDE; PROSTAGLANDIN E2;

EID: 78649586268     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040895     Document Type: Review
Times cited : (476)

References (56)
  • 1
    • 23444456772 scopus 로고    scopus 로고
    • Regulation of immune responses by L-arginine metabolism
    • Bronte, V. and Zanovello, P., Regulation of immune responses by L-arginine metabolism. Nat. Rev. Immunol. 2005. 5: 641-654
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 641-654
    • Bronte, V.1    Zanovello, P.2
  • 2
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich, D. I. and Nagaraj, S., Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 2009. 9: 162-174.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 3
    • 41149148269 scopus 로고    scopus 로고
    • Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives
    • Rodriguez, P. C. and Ochoa, A. C., Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol. Rev. 2008. 222: 180-191.
    • (2008) Immunol. Rev , vol.222 , pp. 180-191
    • Rodriguez, P.C.1    Ochoa, A.C.2
  • 5
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • Serafini, P., Mgebroff, S., Noonan, K. and Borrello, I., Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res. 2008. 68: 5439-5449.
    • (2008) Cancer Res , vol.68 , pp. 5439-5449
    • Serafini, P.1    Mgebroff, S.2    Noonan, K.3    Borrello, I.4
  • 6
    • 31544446571 scopus 로고    scopus 로고
    • Gr-1+CD115+immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    • Huang, B., Pan, P. Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M. and Chen, S. H., Gr-1+CD115+immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res. 2006. 66: 1123-1131.
    • (2006) Cancer Res , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.Y.2    Li, Q.3    Sato, A.I.4    Levy, D.E.5    Bromberg, J.6    Divino, C.M.7    Chen, S.H.8
  • 7
    • 75149179545 scopus 로고    scopus 로고
    • Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer
    • Pan, P. Y., Ma, G., Weber, K. J., Ozao-Choy, J., Wang, G., Yin, B., Divino, C. M. and Chen, S. H., Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer. Cancer Res. 2010. 70: 99-108.
    • (2010) Cancer Res , vol.70 , pp. 99-108
    • Pan, P.Y.1    Ma, G.2    Weber, K.J.3    Ozao-Choy, J.4    Wang, G.5    Yin, B.6    Divino, C.M.7    Chen, S.H.8
  • 8
    • 37349100945 scopus 로고    scopus 로고
    • Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+myeloid cells that promote metastasis
    • Yang, L., Huang, J., Ren, X., Gorska, A. E., Chytil, A., Aakre, M., Carbone, D. P. et al., Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+myeloid cells that promote metastasis. Cancer Cell 2008. 13: 23-35.
    • (2008) Cancer Cell , vol.13 , pp. 23-35
    • Yang, L.1    Huang, J.2    Ren, X.3    Gorska, A.E.4    Chytil, A.5    Aakre, M.6    Carbone, D.P.7
  • 9
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloidderived suppressor cells induce anergy of NK cells through membranebound TGF-beta 1
    • Li, H., Han, Y., Guo, Q., Zhang, M. and Cao, X., Cancer-expanded myeloidderived suppressor cells induce anergy of NK cells through membranebound TGF-beta 1. J. Immunol. 2009. 182: 240-249.
    • (2009) J. Immunol , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3    Zhang, M.4    Cao, X.5
  • 10
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • Srivastava, M. K., Sinha, P., Clements, V. K., Rodriguez, P. and Ostrand-Rosenberg, S., Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res. 2010. 70: 68-77.
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3    Rodriguez, P.4    Ostrand-Rosenberg, S.5
  • 11
    • 70249140303 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+and CD8+T cells
    • Hanson, E. M., Clements, V. K., Sinha, P., Ilkovitch, D. and Ostrand-Rosenberg, S., Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+and CD8+T cells. J. Immunol. 2009. 183: 937-944.
    • (2009) J. Immunol , vol.183 , pp. 937-944
    • Hanson, E.M.1    Clements, V.K.2    Sinha, P.3    Ilkovitch, D.4    Ostrand-Rosenberg, S.5
  • 12
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: linking inflammation and cancer
    • Ostrand-Rosenberg, S. and Sinha, P., Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 2009. 182: 4499-4506.
    • (2009) J. Immunol , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 13
    • 34848887822 scopus 로고    scopus 로고
    • Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy
    • Talmadge, J. E., Pathways mediating the expansion and immunosuppressive activity of myeloid-derived suppressor cells and their relevance to cancer therapy. Clin Cancer Res 2007. 13: 5243-5248.
    • (2007) Clin Cancer Res , vol.13 , pp. 5243-5248
    • Talmadge, J.E.1
  • 14
    • 60349113226 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: a novel therapeutic target
    • Ko, J. S., Bukowski, R. M. and Fincke, J. H., Myeloid-derived suppressor cells: a novel therapeutic target. Curr. Oncol. Rep. 2009. 11: 87-93.
    • (2009) Curr. Oncol. Rep , vol.11 , pp. 87-93
    • Ko, J.S.1    Bukowski, R.M.2    Fincke, J.H.3
  • 15
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • Yang, L., DeBusk, L., Fukuda, K., Fingleton, B., Green-Jarvis, B., Shyr, Y., Matrisian, L. et al., Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 2004. 6: 409-421.
    • (2004) Cancer Cell , vol.6 , pp. 409-421
    • Yang, L.1    DeBusk, L.2    Fukuda, K.3    Fingleton, B.4    Green-Jarvis, B.5    Shyr, Y.6    Matrisian, L.7
  • 16
    • 77949900433 scopus 로고    scopus 로고
    • Targeting distinct tumorinfiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
    • Priceman, S. J., Sung, J. L., Shaposhnik, Z., Burton, J. B., Torres-Collado, A. X., Moughon, D. L., Johnson, M. et al., Targeting distinct tumorinfiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood 2010. 115: 1461-1471.
    • (2010) Blood , vol.115 , pp. 1461-1471
    • Priceman, S.J.1    Sung, J.L.2    Shaposhnik, Z.3    Burton, J.B.4    Torres-Collado, A.X.5    Moughon, D.L.6    Johnson, M.7
  • 17
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b(+)Gr1(+) myeloid cells
    • Shojaei, F., Wu, X., Malik, A. K., Zhong, C., Baldwin, M. E., Schanz, S., Fuh, G. et al., Tumor refractoriness to anti-VEGF treatment is mediated by CD11b(+)Gr1(+) myeloid cells. Nat. Biotechnol. 2007. 25: 911-920.
    • (2007) Nat. Biotechnol , vol.25 , pp. 911-920
    • Shojaei, F.1    Wu, X.2    Malik, A.K.3    Zhong, C.4    Baldwin, M.E.5    Schanz, S.6    Fuh, G.7
  • 18
    • 0032533478 scopus 로고    scopus 로고
    • Apoptotic death of CD8+T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells
    • Bronte, V., Wang, M., Overwijk, W., Surman, D., Pericle, F., Rosenberg, S. A. and Restifo, N. P., Apoptotic death of CD8+T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. J. Immunol. 1998. 161: 5313-5320.
    • (1998) J. Immunol , vol.161 , pp. 5313-5320
    • Bronte, V.1    Wang, M.2    Overwijk, W.3    Surman, D.4    Pericle, F.5    Rosenberg, S.A.6    Restifo, N.P.7
  • 19
    • 0032400862 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
    • Gabrilovich, D., Ishida, T., Oyama, T., Ran, S., Kravtsov, V., Nadaf, S. and Carbone, D. P., Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 1998. 92: 4150-4166.
    • (1998) Blood , vol.92 , pp. 4150-4166
    • Gabrilovich, D.1    Ishida, T.2    Oyama, T.3    Ran, S.4    Kravtsov, V.5    Nadaf, S.6    Carbone, D.P.7
  • 20
    • 0035164478 scopus 로고    scopus 로고
    • Increased production of immature myeloid cells in cancer patients. A mechanism of immunosuppression in cancer
    • Almand, B., Clark, J. I., Nikitina, E., English, N. R., Knight, S. C., Carbone, D. P. and Gabrilovich, D. I., Increased production of immature myeloid cells in cancer patients. A mechanism of immunosuppression in cancer. J. Immunol. 2001. 166: 678-689.
    • (2001) J. Immunol , vol.166 , pp. 678-689
    • Almand, B.1    Clark, J.I.2    Nikitina, E.3    English, N.R.4    Knight, S.C.5    Carbone, D.P.6    Gabrilovich, D.I.7
  • 21
    • 20244367914 scopus 로고    scopus 로고
    • Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion
    • Zea, A. H., Rodriguez, P. C., Atkins, M. B., Hernandez, C., Signoretti, S., Zabaleta, J., McDermott, D. et al., Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res. 2005. 65: 3044-3048.
    • (2005) Cancer Res , vol.65 , pp. 3044-3048
    • Zea, A.H.1    Rodriguez, P.C.2    Atkins, M.B.3    Hernandez, C.4    Signoretti, S.5    Zabaleta, J.6    McDermott, D.7
  • 22
    • 0035874990 scopus 로고    scopus 로고
    • Activated granulocytes and granulocytederived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients
    • Schmielau, J. and Finn, O. J., Activated granulocytes and granulocytederived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res. 2001. 61: 4756-4760.
    • (2001) Cancer Res , vol.61 , pp. 4756-4760
    • Schmielau, J.1    Finn, O.J.2
  • 24
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearingmice
    • Youn, J. I., Nagaraj, S., Collazo, M. and Gabrilovich, D. I., Subsets of myeloid-derived suppressor cells in tumor-bearingmice. J. Immunol. 2008. 181: 5791-5802.
    • (2008) J. Immunol , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 25
    • 0027272534 scopus 로고
    • Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family
    • Fleming, T. J., Fleming, M. L. and Malek, T. R., Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 1993. 151: 2399-2408.
    • (1993) J. Immunol , vol.151 , pp. 2399-2408
    • Fleming, T.J.1    Fleming, M.L.2    Malek, T.R.3
  • 27
    • 73249125588 scopus 로고    scopus 로고
    • Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloidderived suppressor cell activity in BM cells
    • Ribechini, E., Leenen, P. J. and Lutz, M. B., Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloidderived suppressor cell activity in BM cells. Eur. J. Immunol. 2009. 39: 3538-3551.
    • (2009) Eur. J. Immunol , vol.39 , pp. 3538-3551
    • Ribechini, E.1    Leenen, P.J.2    Lutz, M.B.3
  • 28
    • 74249101123 scopus 로고    scopus 로고
    • Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GMCSF
    • Dolcetti, L., Peranzoni, E., Ugel, S., Marigo, I., Fernandez Gomez, A., Mesa, C., Geilich, M. et al., Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GMCSF. Eur. J. Immunol. 2010. 40: 22-35.
    • (2010) Eur. J. Immunol , vol.40 , pp. 22-35
    • Dolcetti, L.1    Peranzoni, E.2    Ugel, S.3    Marigo, I.4    Fernandez Gomez, A.5    Mesa, C.6    Geilich, M.7
  • 29
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • Ko, J. S., Zea, A. H., Rini, B. I., Ireland, J. L., Elson, P., Cohen, P., Golshayan, A. et al., Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 2009. 15: 2148-2157.
    • (2009) Clin. Cancer Res , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3    Ireland, J.L.4    Elson, P.5    Cohen, P.6    Golshayan, A.7
  • 30
    • 60549088732 scopus 로고    scopus 로고
    • Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    • Rodriguez, P. C., Ernstoff, M. S., Hernandez, C., Atkins, M., Zabaleta, J., Sierra, R. and Ochoa, A. C., Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 2009. 69: 1553-1560.
    • (2009) Cancer Res , vol.69 , pp. 1553-1560
    • Rodriguez, P.C.1    Ernstoff, M.S.2    Hernandez, C.3    Atkins, M.4    Zabaleta, J.5    Sierra, R.6    Ochoa, A.C.7
  • 32
    • 77955561020 scopus 로고    scopus 로고
    • Subsets, expansion and activation of myeloid-derived suppressor cells
    • Ribechini, E., Greifenberg, V., Sandwick, S. and Lutz, M. B., Subsets, expansion and activation of myeloid-derived suppressor cells. Med. Microbiol. Immunol. 2010. 199: 273-281.
    • (2010) Med. Microbiol. Immunol , vol.199 , pp. 273-281
    • Ribechini, E.1    Greifenberg, V.2    Sandwick, S.3    Lutz, M.B.4
  • 33
    • 33749425534 scopus 로고    scopus 로고
    • Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+T cells
    • Gallina, G., Dolcetti, L., Serafini, P., De Santo, C., Marigo, I., Colombo, M. P., Basso, G. et al., Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+T cells. J. Clin. Invest. 2006. 116: 2777-2790.
    • (2006) J. Clin. Invest , vol.116 , pp. 2777-2790
    • Gallina, G.1    Dolcetti, L.2    Serafini, P.3    De Santo, C.4    Marigo, I.5    Colombo, M.P.6    Basso, G.7
  • 34
    • 33746115391 scopus 로고    scopus 로고
    • CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-+1CD11b+myeloid cells
    • Yang, R., Cai, Z., Zhang, Y., Yutzy, W. H. t., Roby, K. F. and Roden, R. B., CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-+1CD11b+myeloid cells. Cancer Res. 2006. 66: 6807-6815.
    • (2006) Cancer Res , vol.66 , pp. 6807-6815
    • Yang, R.1    Cai, Z.2    Zhang, Y.3    Yutzy, W.H.T.4    Roby, K.F.5    Roden, R.B.6
  • 35
    • 34447118098 scopus 로고    scopus 로고
    • Altered recognition of antigen is a novel mechanism of CD8+T cell tolerance in cancer
    • Nagaraj, S., Gupta, K., Pisarev, V., Kinarsky, L., Sherman, S., Kang, L., Herber, D. et al., Altered recognition of antigen is a novel mechanism of CD8+T cell tolerance in cancer. Nat. Med. 2007. 13: 828-835.
    • (2007) Nat. Med , vol.13 , pp. 828-835
    • Nagaraj, S.1    Gupta, K.2    Pisarev, V.3    Kinarsky, L.4    Sherman, S.5    Kang, L.6    Herber, D.7
  • 36
    • 58949086448 scopus 로고    scopus 로고
    • Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
    • Nausch, N., Galani, I. E., Schlecker, E. and Cerwenka, A., Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells. Blood 2008. 112: 4080-4089.
    • (2008) Blood , vol.112 , pp. 4080-4089
    • Nausch, N.1    Galani, I.E.2    Schlecker, E.3    Cerwenka, A.4
  • 37
    • 37049011210 scopus 로고    scopus 로고
    • Suppression of proximal T cell receptor signaling and lytic function in CD8+tumor-infiltrating T cells
    • Monu, N. and Frey, A. B., Suppression of proximal T cell receptor signaling and lytic function in CD8+tumor-infiltrating T cells. Cancer Res. 2007. 67: 11447-11454.
    • (2007) Cancer Res , vol.67 , pp. 11447-11454
    • Monu, N.1    Frey, A.B.2
  • 38
    • 34548125294 scopus 로고    scopus 로고
    • Treatment of cancer patients with VEGF-Trap overcomes defects in DC differentiation but is insufficient to improve antigen-specific immune responses
    • Fricke, I., Mirza, N., Dupont, J., Lockhart, G., Jackson, A., Lee, J.-H., Sosman, J. A. and Gabrilovich, D. I., Treatment of cancer patients with VEGF-Trap overcomes defects in DC differentiation but is insufficient to improve antigen-specific immune responses. Clin. Cancer Res. 2007. 13: 4840-4848.
    • (2007) Clin. Cancer Res , vol.13 , pp. 4840-4848
    • Fricke, I.1    Mirza, N.2    Dupont, J.3    Lockhart, G.4    Jackson, A.5    Lee, J.-H.6    Sosman, J.A.7    Gabrilovich, D.I.8
  • 39
    • 77950579005 scopus 로고    scopus 로고
    • Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells
    • Zhou, Z., French, D. L., Ma, G., Eisenstein, S., Chen, Y., Divino, C. M., Keller, G. et al., Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells. Stem Cells 2010. 28: 620-632.
    • (2010) Stem Cells , vol.28 , pp. 620-632
    • Zhou, Z.1    French, D.L.2    Ma, G.3    Eisenstein, S.4    Chen, Y.5    Divino, C.M.6    Keller, G.7
  • 40
    • 70350536358 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell activation by combined LPS and IFN-gamma treatment impairs DC development
    • Greifenberg, V., Ribechini, E., Rossner, S. and Lutz, M. B., Myeloid-derived suppressor cell activation by combined LPS and IFN-gamma treatment impairs DC development. Eur. J. Immunol. 2009. 39: 2865-2876.
    • (2009) Eur. J. Immunol , vol.39 , pp. 2865-2876
    • Greifenberg, V.1    Ribechini, E.2    Rossner, S.3    Lutz, M.B.4
  • 42
  • 43
    • 77956205298 scopus 로고    scopus 로고
    • is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice
    • Haile, L. A., Gamrekelashvili, J., Manns, M. P., Korangy, F. and Greten, T. F., CD49d is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice. J. Immunol. 2010. 185: 203-210.
    • (2010) J. Immunol , vol.185 , pp. 203-210
    • Haile, L.A.1    Gamrekelashvili, J.2    Manns, M.P.3    Korangy, F.4    Greten, T.F.5
  • 44
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M. and Ley, K., Development of monocytes, macrophages, and dendritic cells. Science 2010. 327: 656-661.
    • (2010) Science , vol.327 , pp. 656-661
    • Geissmann, F.1    Manz, M.G.2    Jung, S.3    Sieweke, M.H.4    Merad, M.5    Ley, K.6
  • 45
    • 65049084189 scopus 로고    scopus 로고
    • Tumorassociated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    • Mantovani, A., Sica, A., Allavena, P., Garlanda, C. and Locati, M., Tumorassociated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum. Immunol. 2009. 70: 325-330.
    • (2009) Hum. Immunol , vol.70 , pp. 325-330
    • Mantovani, A.1    Sica, A.2    Allavena, P.3    Garlanda, C.4    Locati, M.5
  • 46
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica, A. and Bronte, V., Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 2007. 117: 1155-1166.
    • (2007) J. Clin. Invest , vol.117 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 47
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani, A., Sozzani, S., Locati, M., Allavena, P. and Sica, A., Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002. 23: 549-555.
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 48
    • 4744349398 scopus 로고    scopus 로고
    • Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases
    • Quinn, M. T. and Gauss, K. A., Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases. J. Leukoc. Biol. 2004. 76: 760-781.
    • (2004) J. Leukoc. Biol , vol.76 , pp. 760-781
    • Quinn, M.T.1    Gauss, K.A.2
  • 49
    • 77953914366 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor
    • Marigo, I., Bosio, E., Solito, S., Mesa, C., Fernandez, A., Dolcetti, L., Ugel, S. et al., Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 2010. 32: 790-802.
    • (2010) Immunity , vol.32 , pp. 790-802
    • Marigo, I.1    Bosio, E.2    Solito, S.3    Mesa, C.4    Fernandez, A.5    Dolcetti, L.6    Ugel, S.7
  • 50
    • 77956920766 scopus 로고    scopus 로고
    • Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells
    • Lechner, M. G., Liebertz, D. J. and Epstein, A. L., Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J. Immunol. 2010. 185: 2273-2284.
    • (2010) J. Immunol , vol.185 , pp. 2273-2284
    • Lechner, M.G.1    Liebertz, D.J.2    Epstein, A.L.3
  • 51
    • 77958166370 scopus 로고    scopus 로고
    • TLR4/MyD88-induced CD11b(+)Gr-1 (int)F4/80(+) non-migratory myeloid cells suppress Th2 effector function in the lung
    • Arora, M., Poe, S. L., Oriss, T. B., Krishnamoorthy, N., Yarlagadda, M., Wenzel, S. E., Billiar, T. R. et al., TLR4/MyD88-induced CD11b(+)Gr-1 (int)F4/80(+) non-migratory myeloid cells suppress Th2 effector function in the lung. Mucosal Immunol. 2010. 3: 578-593.
    • (2010) Mucosal Immunol , vol.3 , pp. 578-593
    • Arora, M.1    Poe, S.L.2    Oriss, T.B.3    Krishnamoorthy, N.4    Yarlagadda, M.5    Wenzel, S.E.6    Billiar, T.R.7
  • 52
    • 0842325789 scopus 로고    scopus 로고
    • Role of immature myeloid Gr-1+cells in the development of antitumor immunity
    • Li, Q., Pan, P. Y., Gu, P., Xu, D. and Chen, S. H., Role of immature myeloid Gr-1+cells in the development of antitumor immunity. Cancer Res. 2004. 64: 1130-1139.
    • (2004) Cancer Res , vol.64 , pp. 1130-1139
    • Li, Q.1    Pan, P.Y.2    Gu, P.3    Xu, D.4    Chen, S.H.5
  • 53
    • 66749149867 scopus 로고    scopus 로고
    • Potential differentiation of tumor bearing mouse CD11b+Gr-1+immature myeloid cells into both suppressor macrophages and immunostimulatory dendritic cells
    • Narita, Y., Wakita, D., Ohkur, T., Chamoto, K. and Nishimura, T., Potential differentiation of tumor bearing mouse CD11b+Gr-1+immature myeloid cells into both suppressor macrophages and immunostimulatory dendritic cells. Biomed. Res. 2009. 30: 7-15.
    • (2009) Biomed. Res , vol.30 , pp. 7-15
    • Narita, Y.1    Wakita, D.2    Ohkur, T.3    Chamoto, K.4    Nishimura, T.5
  • 54
    • 17044366637 scopus 로고    scopus 로고
    • STAT1 signaling regulates tumorassociated macrophage-mediated T cell deletion
    • Kusmartsev, S. and Gabrilovich, D., STAT1 signaling regulates tumorassociated macrophage-mediated T cell deletion. J. Immunol. 2005. 174: 4880-4891.
    • (2005) J. Immunol , vol.174 , pp. 4880-4891
    • Kusmartsev, S.1    Gabrilovich, D.2
  • 55
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1α regulates function and differentiation of myeloidderived suppressor cells in the tumor microenvironment
    • Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I. et al., HIF-1α regulates function and differentiation of myeloidderived suppressor cells in the tumor microenvironment. J. Exp. Med. 2010. 207: 2439-2453.
    • (2010) J. Exp. Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3    Cotter, M.J.4    Youn, J.-I.5    Cheng, P.6    Cho, H.-I.7
  • 56
    • 46949094641 scopus 로고    scopus 로고
    • Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics
    • Umemura, N., Saio, M., Suwa, T., Kitoh, Y., Bai, J., Nonaka, K., Ouyang, G. F. et al., Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics. J. Leukoc. Biol. 2008. 83: 1136-1144.
    • (2008) J. Leukoc. Biol , vol.83 , pp. 1136-1144
    • Umemura, N.1    Saio, M.2    Suwa, T.3    Kitoh, Y.4    Bai, J.5    Nonaka, K.6    Ouyang, G.F.7


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