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Volumn 6, Issue 1, 2011, Pages

Hypoxia potentiates glioma-mediated immunosuppression

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; VASCULOTROPIN; WP 1066; WP 744; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 79251620102     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016195     Document Type: Article
Times cited : (175)

References (58)
  • 1
    • 76049114698 scopus 로고    scopus 로고
    • Immunobiological characterization of cancer stem cells isolated from glioblastoma patients
    • Di Tomaso T, Mazzoleni S, Wang E, Sovena G, Clavenna D, et al. (2010) Immunobiological characterization of cancer stem cells isolated from glioblastoma patients. Clin Cancer Res 16: 800-813.
    • (2010) Clin Cancer Res , vol.16 , pp. 800-813
    • di Tomaso, T.1    Mazzoleni, S.2    Wang, E.3    Sovena, G.4    Clavenna, D.5
  • 2
    • 73949096430 scopus 로고    scopus 로고
    • Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway
    • Wei J, Barr J, Kong LY, Wang Y, Wu A, et al. Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol Cancer Ther 9: 67-78.
    • Mol Cancer Ther , vol.9 , pp. 67-78
    • Wei, J.1    Barr, J.2    Kong, L.Y.3    Wang, Y.4    Wu, A.5
  • 3
    • 74549187948 scopus 로고    scopus 로고
    • Glioma-associated cancerinitiating cells induce immunosuppression
    • Wei J, Barr J, Kong LY, Wang Y, Wu A, et al. Glioma-associated cancerinitiating cells induce immunosuppression. Clin Cancer Res 16: 461-473.
    • Clin Cancer Res , vol.16 , pp. 461-473
    • Wei, J.1    Barr, J.2    Kong, L.Y.3    Wang, Y.4    Wu, A.5
  • 4
    • 79251637895 scopus 로고    scopus 로고
    • Glioma cancer stem cells induce immunosuppressive macrophages/microglia
    • Wu A, Wei J, Kong LY, Wang Y, Priebe W, et al. Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol.
    • Neuro Oncol
    • Wu, A.1    Wei, J.2    Kong, L.Y.3    Wang, Y.4    Priebe, W.5
  • 5
    • 71549119185 scopus 로고    scopus 로고
    • Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells
    • Brown CE, Starr R, Martinez C, Aguilar B, D'Apuzzo M, et al. (2009) Recognition and killing of brain tumor stem-like initiating cells by CD8+ cytolytic T cells. Cancer Res 69: 8886-8893.
    • (2009) Cancer Res , vol.69 , pp. 8886-8893
    • Brown, C.E.1    Starr, R.2    Martinez, C.3    Aguilar, B.4    D'Apuzzo, M.5
  • 6
    • 33751297619 scopus 로고    scopus 로고
    • Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas
    • Pellegatta S, Poliani PL, Corno D, Menghi F, Ghielmetti F, et al. (2006) Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas. Cancer Res 66: 10247-10252.
    • (2006) Cancer Res , vol.66 , pp. 10247-10252
    • Pellegatta, S.1    Poliani, P.L.2    Corno, D.3    Menghi, F.4    Ghielmetti, F.5
  • 7
    • 69249149701 scopus 로고    scopus 로고
    • Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens
    • Xu Q, Liu G, Yuan X, Xu M, Wang H, et al. (2009) Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens. Stem Cells 27: 1734-1740.
    • (2009) Stem Cells , vol.27 , pp. 1734-1740
    • Xu, Q.1    Liu, G.2    Yuan, X.3    Xu, M.4    Wang, H.5
  • 8
    • 65249131228 scopus 로고    scopus 로고
    • Brain tumor hypoxia: Tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
    • Jensen RL (2009) Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J Neurooncol 92: 317-335.
    • (2009) J Neurooncol , vol.92 , pp. 317-335
    • Jensen, R.L.1
  • 9
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1a in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • 485-480
    • Carmeliet P, Dor Y, Herbert J-M, Fukumuras D, Brusselmans K, et al. (1998) Role of HIF-1a in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394: 485-480.
    • (1998) Nature , vol.394
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.-M.3    Fukumuras, D.4    Brusselmans, K.5
  • 10
    • 55249095393 scopus 로고    scopus 로고
    • Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha
    • Ben-Shoshan J, Maysel-Auslender S, Mor A, Keren G, George J (2008) Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol 38: 2412-2418.
    • (2008) Eur J Immunol , vol.38 , pp. 2412-2418
    • Ben-Shoshan, J.1    Maysel-Auslender, S.2    Mor, A.3    Keren, G.4    George, J.5
  • 11
    • 18844444774 scopus 로고    scopus 로고
    • HIF-1a, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    • Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, et al. (2005) HIF-1a, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 24: 3110-3120.
    • (2005) Oncogene , vol.24 , pp. 3110-3120
    • Gray, M.J.1    Zhang, J.2    Ellis, L.M.3    Semenza, G.L.4    Evans, D.B.5
  • 12
    • 23444449093 scopus 로고    scopus 로고
    • STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells
    • Jung JE, Lee HG, Cho IH, Chung DH, Yoon S-H, et al. (2005) STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J 19: 1296-1298.
    • (2005) FASEB J , vol.19 , pp. 1296-1298
    • Jung, J.E.1    Lee, H.G.2    Cho, I.H.3    Chung, D.H.4    Yoon, S.-H.5
  • 13
    • 70350558753 scopus 로고    scopus 로고
    • Physiology and therapeutics of vascular endothelial growth factor in tumor immunosuppression
    • Johnson B, Osada T, Clay T, Lyerly H, Morse M (2009) Physiology and therapeutics of vascular endothelial growth factor in tumor immunosuppression. Curr Mol Med 9: 702-707.
    • (2009) Curr Mol Med , vol.9 , pp. 702-707
    • Johnson, B.1    Osada, T.2    Clay, T.3    Lyerly, H.4    Morse, M.5
  • 14
    • 34047131797 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and immunosuppression in cancer: Current knowledge and potential for new therapy
    • Johnson BF, Clay TM, Hobeika, Kim Lyerly HK, Morse MA (2007) Vascular endothelial growth factor and immunosuppression in cancer: current knowledge and potential for new therapy. Expert Opin Biol Ther 7: 449-460.
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 449-460
    • Johnson, B.F.1    Clay, T.M.2    Hobeika3    Kim Lyerly, H.K.4    Morse, M.A.5
  • 15
    • 67649966553 scopus 로고    scopus 로고
    • Sitespecific anti-tumor immunity: Differences in DC function, TGF-beta production and numbers of intratumoral Foxp3+ Treg
    • Biollaz G, Bernasconi L, Cretton C, Puntener U, Frei K, et al. (2009) Sitespecific anti-tumor immunity: differences in DC function, TGF-beta production and numbers of intratumoral Foxp3+ Treg. Eur J Immunol 39: 1323-1333.
    • (2009) Eur J Immunol , vol.39 , pp. 1323-1333
    • Biollaz, G.1    Bernasconi, L.2    Cretton, C.3    Puntener, U.4    Frei, K.5
  • 16
    • 75749136051 scopus 로고    scopus 로고
    • TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients
    • Crane CA, Han SJ, Barry JJ, Ahn BJ, Lanier LL, et al. TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients. Neuro Oncol 12: 7-13.
    • Neuro Oncol , vol.12 , pp. 7-13
    • Crane, C.A.1    Han, S.J.2    Barry, J.J.3    Ahn, B.J.4    Lanier, L.L.5
  • 17
    • 0028972556 scopus 로고
    • TGF-beta enhances macrophage ability to produce IL-10 in normal and tumorbearing mice
    • Maeda H, Kuwahara H, Ichimura Y, Ohtsuki M, Kurakata S, et al. (1995) TGF-beta enhances macrophage ability to produce IL-10 in normal and tumorbearing mice. J Immunol 155: 4926-4932.
    • (1995) J Immunol , vol.155 , pp. 4926-4932
    • Maeda, H.1    Kuwahara, H.2    Ichimura, Y.3    Ohtsuki, M.4    Kurakata, S.5
  • 18
    • 52049100352 scopus 로고    scopus 로고
    • Modulation of tumor associated macrophages in solid tumors
    • Lucas T, Abraham D, Aharinejad S (2008) Modulation of tumor associated macrophages in solid tumors. Front Biosci 13: 5580-5588.
    • (2008) Front Biosci , vol.13 , pp. 5580-5588
    • Lucas, T.1    Abraham, D.2    Aharinejad, S.3
  • 19
    • 7444254061 scopus 로고    scopus 로고
    • CSF-1 regulation of the wandering macrophage: Complexity in action
    • Pixley FJ, Stanley ER (2004) CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol 14: 628-638.
    • (2004) Trends Cell Biol , vol.14 , pp. 628-638
    • Pixley, F.J.1    Stanley, E.R.2
  • 20
    • 22544457887 scopus 로고    scopus 로고
    • Impact of Tumor-Derived CCL2 on Macrophage Effector Function
    • Brault MS, Kurt RA (2005) Impact of Tumor-Derived CCL2 on Macrophage Effector Function. J Biomed Biotechnol 2005: 37-43.
    • (2005) J Biomed Biotechnol , vol.2005 , pp. 37-43
    • Brault, M.S.1    Kurt, R.A.2
  • 21
    • 2342526003 scopus 로고    scopus 로고
    • CCL2 (monocyte chemoattractant protein-1) and cancer
    • Conti I, Rollins BJ (2004) CCL2 (monocyte chemoattractant protein-1) and cancer. Semin Cancer Biol 14: 149-154.
    • (2004) Semin Cancer Biol , vol.14 , pp. 149-154
    • Conti, I.1    Rollins, B.J.2
  • 23
    • 52049118288 scopus 로고    scopus 로고
    • Tumor-associated galectin-3 modulates the function of tumor-reactive T cells
    • Peng W, Wang HY, Miyahara Y, Peng G, Wang RF (2008) Tumor-associated galectin-3 modulates the function of tumor-reactive T cells. Cancer Res 68: 7228-7236.
    • (2008) Cancer Res , vol.68 , pp. 7228-7236
    • Peng, W.1    Wang, H.Y.2    Miyahara, Y.3    Peng, G.4    Wang, R.F.5
  • 24
    • 33745685879 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway
    • Carroll VA, Ashcroft M (2006) Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway. Cancer Res 66: 6264-6270.
    • (2006) Cancer Res , vol.66 , pp. 6264-6270
    • Carroll, V.A.1    Ashcroft, M.2
  • 25
    • 42949153257 scopus 로고    scopus 로고
    • Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
    • Knowles HJ, Athanasou NA (2008) Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF. J Pathol 215: 56-66.
    • (2008) J Pathol , vol.215 , pp. 56-66
    • Knowles, H.J.1    Athanasou, N.A.2
  • 26
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in amouse model of breast cancer
    • Lin EY, Li JF, Gnalovskiy L, Deng Y, Zhu L, et al. (2006) Macrophages regulate the angiogenic switch in amouse model of breast cancer. Cancer Res 66: 11238-11246.
    • (2006) Cancer Res , vol.66 , pp. 11238-11246
    • Lin, E.Y.1    Li, J.F.2    Gnalovskiy, L.3    Deng, Y.4    Zhu, L.5
  • 27
    • 59349094663 scopus 로고    scopus 로고
    • Expression of HIF-1, galectin-3, cox-2 and Wilms tumor-1 protein in multiple schwannomas of the conus medullaris
    • Sarwat AM, Al-Salam S (2009) Expression of HIF-1, galectin-3, cox-2 and Wilms tumor-1 protein in multiple schwannomas of the conus medullaris. J Neurooncol 92: 111-115.
    • (2009) J Neurooncol , vol.92 , pp. 111-115
    • Sarwat, A.M.1    Al-Salam, S.2
  • 28
    • 33749262441 scopus 로고    scopus 로고
    • Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12
    • Tabatabai G, Frank B, Mohle R, Weller M, Wick W (2006) Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12. Brain 129: 2426-2435.
    • (2006) Brain , vol.129 , pp. 2426-2435
    • Tabatabai, G.1    Frank, B.2    Mohle, R.3    Weller, M.4    Wick, W.5
  • 29
    • 0032481383 scopus 로고    scopus 로고
    • IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and independent pathways
    • O'Farrell AM, Liu Y, Moore KW, Mui AL (1998) IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and independent pathways. EMBO J 17: 1006-1018.
    • (1998) EMBO J , vol.17 , pp. 1006-1018
    • O'Farrell, A.M.1    Liu, Y.2    Moore, K.W.3    Mui, A.L.4
  • 30
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, et al. (2006) Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 12: 1314-1321.
    • (2006) Nat Med , vol.12 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3    Wei, S.4    Zhang, S.5
  • 31
    • 33748532939 scopus 로고    scopus 로고
    • The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
    • Hussain SF, Yang D, Suki D, Aldape K, Grimm E, et al. (2006) The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol 8: 261-279.
    • (2006) Neuro Oncol , vol.8 , pp. 261-279
    • Hussain, S.F.1    Yang, D.2    Suki, D.3    Aldape, K.4    Grimm, E.5
  • 33
    • 0031709864 scopus 로고    scopus 로고
    • Tumor-induced immune dysfunction: The macrophage connection
    • Elgert KD, Alleva DG, Mullins DW (1998) Tumor-induced immune dysfunction: the macrophage connection. J Leukoc Biol 64: 275-290.
    • (1998) J Leukoc Biol , vol.64 , pp. 275-290
    • Elgert, K.D.1    Alleva, D.G.2    Mullins, D.W.3
  • 34
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4: 71-78.
    • (2004) Nat Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 36
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-induced factors, stem cells, and cancer
    • Keith B, Simon MC (2007) Hypoxia-induced factors, stem cells, and cancer. Cell 129: 465-472.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 37
    • 70449687092 scopus 로고    scopus 로고
    • Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1a
    • Soeda A, Park M, Lee D, Mintz A, Androutsellis-Theotokis A, et al. (2009) Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1a. Oncogene 28: 3949-3959.
    • (2009) Oncogene , vol.28 , pp. 3949-3959
    • Soeda, A.1    Park, M.2    Lee, D.3    Mintz, A.4    Androutsellis-Theotokis, A.5
  • 38
    • 34247154498 scopus 로고    scopus 로고
    • A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
    • Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, et al. (2007) A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 26: 2435-2444.
    • (2007) Oncogene , vol.26 , pp. 2435-2444
    • Iwamaru, A.1    Szymanski, S.2    Iwado, E.3    Aoki, H.4    Yokoyama, T.5
  • 39
    • 0035570755 scopus 로고    scopus 로고
    • WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity
    • Estrov FS, H.M. K, Harris D, Van Q, Fokt I, et al. (2001) WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity. Anticancer Res 21: 3777-3784.
    • (2001) Anticancer Res , vol.21 , pp. 3777-3784
    • Estrov, F.S.H.M.K.1    Harris, D.2    van, Q.3    Fokt, I.4
  • 40
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • Lee K, D.Z. Q, Rey S, Wei H, Liu JO, et al. (2009) Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci U S A 106: 2353-2358.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2353-2358
    • Lee, K.D.Z.Q.1    Rey, S.2    Wei, H.3    Liu, J.O.4
  • 41
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, et al. (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444: 756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5
  • 42
    • 35448979864 scopus 로고    scopus 로고
    • A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients
    • Hussain SF, Kong L-Y, Jordan J, Conrad C, Madden T, et al. (2007) A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res 67: 9630-9636.
    • (2007) Cancer Res , vol.67 , pp. 9630-9636
    • Hussain, S.F.1    Kong, L.-Y.2    Jordan, J.3    Conrad, C.4    Madden, T.5
  • 43
    • 53249094201 scopus 로고    scopus 로고
    • A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells
    • Kong LY, Abou-Ghazal MK, Wei J, Chakraborty A, Sun W, et al. (2008) A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. Clin Cancer Res 14: 5759-5768.
    • (2008) Clin Cancer Res , vol.14 , pp. 5759-5768
    • Kong, L.Y.1    Abou-Ghazal, M.K.2    Wei, J.3    Chakraborty, A.4    Sun, W.5
  • 44
    • 61349158530 scopus 로고    scopus 로고
    • T regulatory cells: Hypoxia-adenosinergic suppression and re-direction of the immune response
    • Sitkovsky M (2009) T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response. Trends in Immunology 30: 102-108.
    • (2009) Trends in Immunology , vol.30 , pp. 102-108
    • Sitkovsky, M.1
  • 45
    • 0035924320 scopus 로고    scopus 로고
    • Role of G-protein coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
    • Ohta A, Sitkovsky M (2001) Role of G-protein coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414: 916-920.
    • (2001) Nature , vol.414 , pp. 916-920
    • Ohta, A.1    Sitkovsky, M.2
  • 46
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • Leek RD, Landers RJ, Harris AL, Lewis CE (1999) Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br J Cancer 79: 991.
    • (1999) Br J Cancer , vol.79 , pp. 991
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3    Lewis, C.E.4
  • 47
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C, Giannoudis A, Lewis CE (2004) Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104: 2224.
    • (2004) Blood , vol.104 , pp. 2224
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 48
    • 0030944928 scopus 로고    scopus 로고
    • Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines
    • Negus RP, Stamp GW, Hadley J, Balkwill FR (1997) Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. Am J Pathol 150: 1723.
    • (1997) Am J Pathol , vol.150 , pp. 1723
    • Negus, R.P.1    Stamp, G.W.2    Hadley, J.3    Balkwill, F.R.4
  • 49
    • 0036740130 scopus 로고    scopus 로고
    • Endothelin-2 is a macrophage chemoattractant: Implications for macrophage distribution in tumors
    • Grimshaw MJ, Wilson JL, Balkwill FR (2002) Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol 32: 2393.
    • (2002) Eur J Immunol , vol.32 , pp. 2393
    • Grimshaw, M.J.1    Wilson, J.L.2    Balkwill, F.R.3
  • 50
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon B, Sozzani S, Zhou D, Welch HA, Mantovani A, et al. (1996) Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87: 3336.
    • (1996) Blood , vol.87 , pp. 3336
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3    Welch, H.A.4    Mantovani, A.5
  • 51
    • 64849087205 scopus 로고    scopus 로고
    • Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor
    • Acosta-Iborra B, Elorza A, Olazabal IM, Martin-Cofreces NB, Martin-Puig S, et al. (2009) Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor. J Immunol 182: 3155-3164.
    • (2009) J Immunol , vol.182 , pp. 3155-3164
    • Acosta-Iborra, B.1    Elorza, A.2    Olazabal, I.M.3    Martin-Cofreces, N.B.4    Martin-Puig, S.5
  • 52
    • 36248996487 scopus 로고    scopus 로고
    • Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1alpha-dependent manner
    • Anand RJ, Gribar SC, Li J, Kohler JW, Branca MF, et al. (2007) Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1alpha-dependent manner. J Leukoc Biol 82: 1257-1265.
    • (2007) J Leukoc Biol , vol.82 , pp. 1257-1265
    • Anand, R.J.1    Gribar, S.C.2    Li, J.3    Kohler, J.W.4    Branca, M.F.5
  • 53
    • 77951611536 scopus 로고    scopus 로고
    • Macrophage activity in response to steady-state oxygen and hydrogen peroxide concentration-biomed 2010
    • Owegi HO, Egot-Lemaire S, Waite LR, Waite GN (2010) Macrophage activity in response to steady-state oxygen and hydrogen peroxide concentration-biomed 2010. Biomed Sci Instrum 46: 57-62.
    • (2010) Biomed Sci Instrum , vol.46 , pp. 57-62
    • Owegi, H.O.1    Egot-Lemaire, S.2    Waite, L.R.3    Waite, G.N.4
  • 54
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica A, Bronte V (2007) Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest 117: 1155-1166.
    • (2007) J Clin Invest , vol.117 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 55
    • 2542432162 scopus 로고    scopus 로고
    • Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors
    • Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, et al. (2004) Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol 22: 657-682.
    • (2004) Annu Rev Immunol , vol.22 , pp. 657-682
    • Sitkovsky, M.V.1    Lukashev, D.2    Apasov, S.3    Kojima, H.4    Koshiba, M.5
  • 56
    • 27744472334 scopus 로고    scopus 로고
    • Macrophage migration and gene expression in response to tumore hypoxia
    • Murdoch C, Lewis CE (2005) Macrophage migration and gene expression in response to tumore hypoxia. Int J Cancer 117: 701-708.
    • (2005) Int J Cancer , vol.117 , pp. 701-708
    • Murdoch, C.1    Lewis, C.E.2
  • 57
    • 35748975652 scopus 로고    scopus 로고
    • Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy
    • Jordan JT, Sun WH, Hussain SF, DeAngulo G, Prabhu SS, et al. (2008) Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy. Cancer Immunol Immunother 57: 123-131.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 123-131
    • Jordan, J.T.1    Sun, W.H.2    Hussain, S.F.3    De Angulo, G.4    Prabhu, S.S.5
  • 58
    • 34249701932 scopus 로고    scopus 로고
    • ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells
    • Bodor J, Fehervari Z, Diamond B, Sakaguchi S (2007) ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells. Eur J Immunol 37: 884-895.
    • (2007) Eur J Immunol , vol.37 , pp. 884-895
    • Bodor, J.1    Fehervari, Z.2    Diamond, B.3    Sakaguchi, S.4


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