Connecting protein conformational dynamics with catalytic function as illustrated in dihydrofolate reductase

Biochemistry

Volumn 52, Issue 12, 2013, Pages 2036-2049

  Fan, Yao ^a   Cembran, Alessandro ^a   Ma, Shuhua ^a,b   Gao, Jiali ^a  

^a University of Minnesota   (United States)

^b TOWSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL RESULTS; CONFORMATIONAL DYNAMICS; DIHYDROFOLATE REDUCTASE; DONOR-ACCEPTOR DISTANCE; KINETIC ISOTOPE EFFECTS; MOLECULAR DYNAMICS SIMULATIONS; QUANTUM MECHANICS/MOLECULAR MECHANICS; TEMPERATURE DEPENDENCE;

HYDROGEN BONDS; ISOTOPES; MOLECULAR DYNAMICS; MOLECULAR MODELING;

CATALYSIS;

DIHYDROFOLATE REDUCTASE;

ARTICLE; CATALYST; CONTROLLED STUDY; ENTHALPY; ENTROPY; ENZYME ACTIVATION; HYDROGEN BOND; MICHAELIS CONSTANT; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTUM MECHANICS; TEMPERATURE DEPENDENCE;

AMINO ACID SUBSTITUTION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN CONFORMATION; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84875675509     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301559q     Document Type: Article

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