The tail wagging the dog: Insights into catalysis in R67 dihydrofolate reductase

Biochemistry

Volumn 49, Issue 42, 2010, Pages 9078-9088

  Kamath, Ganesh ^a   Howell, Elizabeth E ^b   Agarwal, Pratul K ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; CATALYSIS; COMPLEXATION; ENZYME KINETICS; ENZYMES; PROTEIN FOLDING;

ACTIVE SITE; BULK SOLVENTS; COFACTORS; COMPUTATIONAL APPROACH; COMPUTATIONAL RESULTS; DIHYDROFOLATE; HOMOTETRAMERS; HYDRIDE TRANSFERS; HYDRIDE-TRANSFER REACTION; ION PAIRS; ION-PAIR INTERACTIONS; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATES; PROTEIN FOLDS; R67 DIHYDROFOLATE REDUCTASE; TRANSITION STATE;

AMIDES;

DIHYDROFOLATE REDUCTASE; NICOTINAMIDE; PTERIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; ESCHERICHIA COLI PROTEIN; MUTANT PROTEIN;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; PLASMID; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENETICS; METABOLISM; PROTEIN QUATERNARY STRUCTURE; R FACTOR; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

CANIS FAMILIARIS;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PROTEIN STRUCTURE, QUATERNARY; R FACTORS; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

EID: 77958091882     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1007222     Document Type: Article

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