Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase

Biochemistry

Volumn 47, Issue 8, 2008, Pages 2559-2564

  Ghanem, Mahmoud ^a   Li, Lei ^a   Wing, Corin ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYST ACTIVITY; ISOTOPES; THERMODYNAMICS;

CATALYTIC SITES; CRYSTALLOGRAPHIC PACKING;

ENZYME ACTIVITY;

ARGININE DERIVATIVE; GUANOSINE; HISTIDINE DERIVATIVE; LYSINE DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DEPHOSPHORYLATION; ENZYME STRUCTURE; HUMAN; INHIBITION KINETICS; MUTATION; NONHUMAN; PARAMETER; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

ADENOSINE; ANIMALS; CATTLE; ENZYME ACTIVATION; HUMANS; HYDROLYSIS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; PYRROLIDINES; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; THERMODYNAMICS; TRANSITION TEMPERATURE;

BOVINAE;

EID: 39749171162     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702132e     Document Type: Article

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