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Volumn 10, Issue 1, 2013, Pages 1-18

The intriguing options of multispecific antibody formats for treatment of cancer

Author keywords

Antibody formats; Cytokine delivery; Death receptors; HER signaling; Inhibition of angiogenesis; Recruitment of immune effector cells; Review.

Indexed keywords

ANTINEOPLASTIC AGENT; CD28 ANTIGEN; CYTOKINE; DEATH RECEPTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LAPATINIB; MM 111; PROTEIN TYROSINE KINASE; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 84875032564     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (42)

References (132)
  • 1
    • 77956690413 scopus 로고    scopus 로고
    • Biopharmaceutical benchmarks 2010
    • Walsh G: Biopharmaceutical benchmarks 2010. Nat Biotechnol 28: 917-924, 2010.
    • (2010) Nat Biotechnol , vol.28 , pp. 917-924
    • Walsh, G.1
  • 2
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • Weiner LM, Surana R and Wang S: Monoclonal antibodies: Versatile platforms for cancer immunotherapy. Nat Rev Immunol 10: 317-327, 2010.
    • (2010) Nat Rev Immunol , vol.10 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 3
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • Adams GP and Weiner LM: Monoclonal antibody therapy of cancer. Nat Biotechnol 23: 1147-1157, 2005.
    • (2005) Nat Biotechnol , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 4
    • 34548580969 scopus 로고    scopus 로고
    • Anti-cd40 agonist antibodies: Preclinical and clinical experience
    • Khalil M and Vonderheide RH: Anti-CD40 agonist antibodies: Preclinical and clinical experience. Update Cancer Ther 2: 61-65, 2007.
    • (2007) Update Cancer Ther , vol.2 , pp. 61-65
    • Khalil, M.1    Vonderheide, R.H.2
  • 5
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by ctla-4 blockade
    • Leach DR, Krummel MF and Allison JP: Enhancement of antitumor immunity by CTLA-4 blockade. Science 271: 1734-1736, 1996.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 6
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell 144: 646-674, 2011.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
    • Colotta F, Allavena P, Sica A, Garlanda C and Mantovani A: Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability. Carcinogenesis 30: 1073-1081, 2009.
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 8
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of vegf signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G and Hanahan D: Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8: 299-309, 2005.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 9
    • 79955515280 scopus 로고    scopus 로고
    • Resistance to her2-directed antibodies and tyrosine kinase inhibitors: Mechanisms and clinical implications
    • Garrett JT and Arteaga CL: Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: Mechanisms and clinical implications. Cancer Biol Ther 11: 793-800, 2011.
    • (2011) Cancer Biol Ther , vol.11 , pp. 793-800
    • Garrett, J.T.1    Arteaga, C.L.2
  • 10
    • 0031059402 scopus 로고    scopus 로고
    • Design and production of novel tetravalent bispecific antibodies
    • Coloma MJ and Morrison SL: Design and production of novel tetravalent bispecific antibodies. Nat Biotechnol 15: 159-163, 1997.
    • (1997) Nat Biotechnol , vol.15 , pp. 159-163
    • Coloma, M.J.1    Morrison, S.L.2
  • 15
    • 78049233650 scopus 로고    scopus 로고
    • A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor a and osteopontin
    • Kou G, Shi J, Chen L, Zhang D, Hou S, Zhao L, Fang C, Zheng L, Zhang X, Liang P, Zhang X, Li B and Guo Y: A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin. Cancer Lett 299: 130-136, 2010.
    • (2010) Cancer Lett , vol.299 , pp. 130-136
    • Kou, G.1    Shi, J.2    Chen, L.3    Zhang, D.4    Hou, S.5    Zhao, L.6    Fang, C.7    Zheng, L.8    Zhang, X.9    Liang, P.10    Zhang, X.11    Li, B.12    Guo, Y.13
  • 16
    • 77950787098 scopus 로고    scopus 로고
    • Alternative antibody formats
    • Kontermann RE: Alternative antibody formats. Curr Opin Mol Ther 12: 176-183, 2010.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 176-183
    • Kontermann, R.E.1
  • 20
    • 0029946383 scopus 로고    scopus 로고
    • Knobs-into-holes engineering of antibody ch3 domains for heavy chain heterodimerization
    • Ridgway JB, Presta LG and Carter P: 'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization. Protein Eng 9: 617-621, 1996.
    • (1996) Protein Eng , vol.9 , pp. 617-621
    • Ridgway, J.B.1    Presta, L.G.2    Carter, P.3
  • 21
    • 77954628740 scopus 로고    scopus 로고
    • Seedbodies: Fusion proteins based on strand-exchange engineered domain (seed) ch3 heterodimers in an fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies
    • Davis JH, Aperlo C, Li Y, Kurosawa E, Lan Y, Lo KM and Huston JS: SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies. Protein Eng Des Sel 23: 195-202, 2010.
    • (2010) Protein Eng Des Sel , vol.23 , pp. 195-202
    • Davis, J.H.1    Aperlo, C.2    Li, Y.3    Kurosawa, E.4    Lan, Y.5    Lo, K.M.6    Huston, J.S.7
  • 26
    • 84858416256 scopus 로고    scopus 로고
    • Antibody-based immunotherapy of cancer
    • Weiner LM, Murray JC and Shuptrine CW: Antibody-based immunotherapy of cancer. Cell 148: 1081-1084, 2012.
    • (2012) Cell , vol.148 , pp. 1081-1084
    • Weiner, L.M.1    Murray, J.C.2    Shuptrine, C.W.3
  • 27
    • 36549022608 scopus 로고    scopus 로고
    • A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein g
    • Stork R, Mler D and Kontermann RE: A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G. Protein Eng Des Sel 20: 569-576, 2007.
    • (2007) Protein Eng Des Sel , vol.20 , pp. 569-576
    • Stork, R.1    Mler, D.2    Kontermann, R.E.3
  • 28
    • 34250361507 scopus 로고    scopus 로고
    • Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin
    • Mler D, Karle A, Meissburger B, Hig I, Stork R and Kontermann RE: Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin. J Biol Chem 282: 12650-12660, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 12650-12660
    • Mler, D.1    Karle, A.2    Meissburger, B.3    Hig, I.4    Stork, R.5    Kontermann, R.E.6
  • 29
    • 0037124466 scopus 로고    scopus 로고
    • Pegylated antibodies and antibody fragments for improved therapy: A review
    • Chapman AP: PEGylated antibodies and antibody fragments for improved therapy: A review. Adv Drug Deliv Rev 54: 531-545, 2002.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 531-545
    • Chapman, A.P.1
  • 32
    • 10244230493 scopus 로고    scopus 로고
    • Recombinant bispecific antibodies for the targeting of adenoviruses to cea-expressing tumour cells: A comparative analysis of bacterially expressed single-chain diabody and tandem scfv
    • Korn T, Nettelbeck DM, Vkel T, Mler R and Kontermann RE: Recombinant bispecific antibodies for the targeting of adenoviruses to CEA-expressing tumour cells: A comparative analysis of bacterially expressed single-chain diabody and tandem scFv. J Gene Med 6: 642-651, 2004.
    • (2004) J Gene Med , vol.6 , pp. 642-651
    • Korn, T.1    Nettelbeck, D.M.2    Vkel, T.3    Mler, R.4    Kontermann, R.E.5
  • 34
    • 33646477258 scopus 로고    scopus 로고
    • Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting
    • Rossi EA, Goldenberg DM, Cardillo TM, McBride WJ, Sharkey RM and Chang CH: Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting. Proc Natl Acad Sci USA 103: 6841-6846, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6841-6846
    • Rossi, E.A.1    Goldenberg, D.M.2    Cardillo, T.M.3    McBride, W.J.4    Sharkey, R.M.5    Chang, C.H.6
  • 36
    • 34248382009 scopus 로고    scopus 로고
    • Bispecific antibodies: Molecules that enable novel therapeutic strategies
    • Fischer N and Ler O: Bispecific antibodies: molecules that enable novel therapeutic strategies. Pathobiology 74: 3-14, 2007.
    • (2007) Pathobiology , vol.74 , pp. 3-14
    • Fischer, N.1    Ler, O.2
  • 37
    • 0031034123 scopus 로고    scopus 로고
    • Cd28-mediated induction of proliferation in resting t-cells in vitro and in vivo without engagement of the t-cell receptor: Evidence for functionally distinct forms of cd28
    • Tacke M, Hanke G, Hanke T and Hig T: CD28-mediated induction of proliferation in resting T-cells in vitro and in vivo without engagement of the T-cell receptor: Evidence for functionally distinct forms of CD28. Eur J Immunol 27: 239-247, 1997.
    • (1997) Eur J Immunol , vol.27 , pp. 239-247
    • Tacke, M.1    Hanke, G.2    Hanke, T.3    Hig, T.4
  • 38
    • 58249122185 scopus 로고    scopus 로고
    • A bispecific single-chain antibody that mediates target cell-restricted, supra-agonistic cd28 stimulation and killing of lymphoma cells
    • Otz T, Grosse-Hovest L, Hofmann M, Rammensee HG and Jung G: A bispecific single-chain antibody that mediates target cell-restricted, supra-agonistic CD28 stimulation and killing of lymphoma cells. Leukemia 23: 71-77, 2009.
    • (2009) Leukemia , vol.23 , pp. 71-77
    • Otz, T.1    Grosse-Hovest, L.2    Hofmann, M.3    Rammensee, H.G.4    Jung, G.5
  • 39
    • 0038297196 scopus 로고    scopus 로고
    • A recombinant bispecific single-chain antibody induces targeted supra-agonistic cd28-stimulation and tumor cell killing
    • Grosse-Hovest L, Hartlapp I, Marwan W, Brem G, Rammensee HG and Jung G: A recombinant bispecific single-chain antibody induces targeted, supra-agonistic CD28-stimulation and tumor cell killing. Eur J Immunol 33: 1334-1340, 2003.
    • (2003) Eur J Immunol , vol.33 , pp. 1334-1340
    • Grosse-Hovest, L.1    Hartlapp, I.2    Marwan, W.3    Brem, G.4    Rammensee, H.G.5    Jung, G.6
  • 41
    • 27144451130 scopus 로고    scopus 로고
    • Supra agonistic, bispecific singlechain antibody purified from the serum of cloned, transgenic cows induces t-cell-mediated killing of glioblastoma cells in vitro and in vivo
    • Grosse-Hovest L, Wick W, Minoia R, Weller M, Rammensee HG, Brem G and Jung G: Supra agonistic, bispecific singlechain antibody purified from the serum of cloned, transgenic cows induces T-cell-mediated killing of glioblastoma cells in vitro and in vivo. Int J Cancer 117: 1060-1064, 2005.
    • (2005) Int J Cancer , vol.117 , pp. 1060-1064
    • Grosse-Hovest, L.1    Wick, W.2    Minoia, R.3    Weller, M.4    Rammensee, H.G.5    Brem, G.6    Jung, G.7
  • 43
    • 0029063312 scopus 로고
    • Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies
    • Lindhofer H, Mocikat R, Steipe B and Thierfelder S: Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. J Immunol 155: 219-225, 1995.
    • (1995) J Immunol , vol.155 , pp. 219-225
    • Lindhofer, H.1    Mocikat, R.2    Steipe, B.3    Thierfelder, S.4
  • 44
    • 0034051390 scopus 로고    scopus 로고
    • The fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and nk cells and induces direct phagocytosis of tumour cells
    • Zeidler R, Mysliwietz J, Csady M, Walz A, Ziegler I, Schmitt B, Wollenberg B and Lindhofer H: The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells. Br J Cancer 83: 261-266, 2000.
    • (2000) Br J Cancer , vol.83 , pp. 261-266
    • Zeidler, R.1    Mysliwietz, J.2    Csady, M.3    Walz, A.4    Ziegler, I.5    Schmitt, B.6    Wollenberg, B.7    Lindhofer, H.8
  • 46
    • 66249126868 scopus 로고    scopus 로고
    • The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2
    • Jer M, Schoberth A, Ruf P, Hess J and Lindhofer H: The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2. Cancer Res 69: 4270-4276, 2009.
    • (2009) Cancer Res , vol.69 , pp. 4270-4276
    • Jer, M.1    Schoberth, A.2    Ruf, P.3    Hess, J.4    Lindhofer, H.5
  • 47
    • 47249143734 scopus 로고    scopus 로고
    • Bi20 (fbta05), a novel trifunctional bispecific antibody (anti-cd20 anti-cd3), mediates efficient killing of b-cell lymphoma cells even with very low cd20 expression levels
    • Stanglmaier M, Faltin M, Ruf P, Bodenhausen A, Schrer P and Lindhofer H: Bi20 (FBTA05), a novel trifunctional bispecific antibody (anti-CD20 anti-CD3), mediates efficient killing of B-cell lymphoma cells even with very low CD20 expression levels. Int J Cancer 123: 1181-1189, 2008.
    • (2008) Int J Cancer , vol.123 , pp. 1181-1189
    • Stanglmaier, M.1    Faltin, M.2    Ruf, P.3    Bodenhausen, A.4    Schrer, P.5    Lindhofer, H.6
  • 48
    • 0347915678 scopus 로고    scopus 로고
    • Two new trifunctional antibodies for the therapy of human malignant melanoma
    • Ruf P, Jer M, Ellwart J, Wosch S, Kusterer E and Lindhofer H: Two new trifunctional antibodies for the therapy of human malignant melanoma. Int J Cancer 108: 725-732, 2004.
    • (2004) Int J Cancer , vol.108 , pp. 725-732
    • Ruf, P.1    Jer, M.2    Ellwart, J.3    Wosch, S.4    Kusterer, E.5    Lindhofer, H.6
  • 49
    • 0035889129 scopus 로고    scopus 로고
    • Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody
    • Ruf P and Lindhofer H: Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody. Blood 98: 2526-2534, 2001.
    • (2001) Blood , vol.98 , pp. 2526-2534
    • Ruf, P.1    Lindhofer, H.2
  • 51
    • 62549086034 scopus 로고    scopus 로고
    • Immunotherapy of recurrent b-cell malignancies after allo-sct with bi20 (fbta05), a trifunctional anti-cd3 anti-cd20 antibody and donor lymphocyte infusion
    • Buhmann R, Simoes B, Stanglmaier M, Yang T, Faltin M, Bund D, Lindhofer H and Kolb HJ: Immunotherapy of recurrent B-cell malignancies after allo-SCT with Bi20 (FBTA05), a trifunctional anti-CD3 anti-CD20 antibody and donor lymphocyte infusion. Bone Marrow Transplant 43: 383-397, 2009.
    • (2009) Bone Marrow Transplant , vol.43 , pp. 383-397
    • Buhmann, R.1    Simoes, B.2    Stanglmaier, M.3    Yang, T.4    Faltin, M.5    Bund, D.6    Lindhofer, H.7    Kolb, H.J.8
  • 52
    • 58849085569 scopus 로고    scopus 로고
    • Bite: Teaching antibodies to engage t-cells for cancer therapy
    • Baeuerle PA, Kufer P and Bargou R: BiTE: Teaching antibodies to engage T-cells for cancer therapy. Curr Opin Mol Ther 11: 22-30, 2009.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 22-30
    • Baeuerle, P.A.1    Kufer, P.2    Bargou, R.3
  • 54
    • 67449156132 scopus 로고    scopus 로고
    • Bispecific t-cell engaging antibodies for cancer therapy
    • Baeuerle PA and Reinhardt C: Bispecific T-cell engaging antibodies for cancer therapy. Cancer Res 69: 4941-4944, 2009.
    • (2009) Cancer Res , vol.69 , pp. 4941-4944
    • Baeuerle, P.A.1    Reinhardt, C.2
  • 55
    • 0029148633 scopus 로고
    • A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity
    • Mack M, Riethmler G and Kufer P: A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc Natl Acad Sci USA 92: 7021-7025, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7021-7025
    • Mack, M.1    Riethmler, G.2    Kufer, P.3
  • 57
    • 28944434529 scopus 로고    scopus 로고
    • Induction of regular cytolytic t cell synapses by bispecific single-chain antibody constructs on mhc class i-negative tumor cells. Mol immunol 43: 763-771, 2006. 58 hoffmann p, hofmeister r, brischwein k, brandl c, crommer s, bargou r, itin c, prang n and baeuerle pa: Serial killing of tumor cells by cytotoxic t cells redirected with a cd19-/cd3-bispecific single-chain antibody construct
    • Offner S, Hofmeister R, Romaniuk A, Kufer P and Baeuerle PA: Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells. Mol Immunol 43: 763-771, 2006. 58 Hoffmann P, Hofmeister R, Brischwein K, Brandl C, Crommer S, Bargou R, Itin C, Prang N and Baeuerle PA: Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct. Int J Cancer 115: 98-104, 2005.
    • (2005) Int J Cancer , vol.115 , pp. 98-104
    • Offner, S.1    Hofmeister, R.2    Romaniuk, A.3    Kufer, P.4    Baeuerle, P.A.5
  • 60
    • 0037446782 scopus 로고    scopus 로고
    • T-cell co-stimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human b-cell lymphoma xenografts by a cd19-/cd3-bispecific single-chain antibody construct
    • Dreier T, Baeuerle PA, Fichtner I, Gr M, Schlereth B, Lorenczewski G, Kufer P, Lutterbe R, Riethmler G, Gjorstrup P and Bargou RC: T-Cell co-stimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B-cell lymphoma xenografts by a CD19-/CD3-bispecific single-chain antibody construct. J Immunol 170: 4397-4402, 2003.
    • (2003) J Immunol , vol.170 , pp. 4397-4402
    • Dreier, T.1    Baeuerle, P.A.2    Fichtner, I.3    Gr, M.4    Schlereth, B.5    Lorenczewski, G.6    Kufer, P.7    Lutterbe, R.8    Riethmler, G.9    Gjorstrup, P.10    Bargou, R.C.11
  • 65
    • 84863650195 scopus 로고    scopus 로고
    • Recruit-tandabs: Harnessing the immune system to kill cancer cells
    • McAleese F and Eser M: RECRUIT-TandAbs: harnessing the immune system to kill cancer cells. Future Oncol 8: 687-695, 2012.
    • (2012) Future Oncol , vol.8 , pp. 687-695
    • McAleese, F.1    Eser, M.2
  • 66
    • 0034662632 scopus 로고    scopus 로고
    • Cure of burkitt's lymphoma in severe combined immunodeficiency mice by t cells, tetravalent cd3 cd19 tandem diabody, and cd28 costimulation
    • Cochlovius B, Kipriyanov SM, Stassar MJ, Schuhmacher J, Benner A, Moldenhauer G and Little M: Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 CD19 tandem diabody, and CD28 costimulation. Cancer Res 60: 4336-4341, 2000.
    • (2000) Cancer Res , vol.60 , pp. 4336-4341
    • Cochlovius, B.1    Kipriyanov, S.M.2    Stassar, M.J.3    Schuhmacher, J.4    Benner, A.5    Moldenhauer, G.6    Little, M.7
  • 67
    • 78049395507 scopus 로고    scopus 로고
    • Multiple signaling pathways induced by hexavalent monospecific anti-cd20 and hexavalent bispecific anti-cd20cd22 humanized antibodies correlate with enhanced toxicity to b-cell lymphomas and leukemias
    • Gupta P, Goldenberg DM, Rossi EA and Chang CH: Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias. Blood 116: 3258-3267, 2010.
    • (2010) Blood , vol.116 , pp. 3258-3267
    • Gupta, P.1    Goldenberg, D.M.2    Rossi, E.A.3    Chang, C.H.4
  • 68
    • 84860332847 scopus 로고    scopus 로고
    • Dual-targeting immunotherapy of lymphoma: Potent cytotoxicity of anti-cd20cd74 bispecific antibodies in mantle cell and other lymphomas
    • Gupta P, Goldenberg DM, Rossi EA, Cardillo TM, Byrd JC, Muthusamy N, Furman RR and Chang CH: Dual-targeting immunotherapy of lymphoma: Potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas. Blood 119: 3767-3778, 2012.
    • (2012) Blood , vol.119 , pp. 3767-3778
    • Gupta, P.1    Goldenberg, D.M.2    Rossi, E.A.3    Cardillo, T.M.4    Byrd, J.C.5    Muthusamy, N.6    Furman, R.R.7    Chang, C.H.8
  • 69
    • 85041366220 scopus 로고    scopus 로고
    • Engineering a cd123cd3 bispecific scfv immunofusion for the treatment of leukemia and elimination of leukemia stem cells. Protein eng des sel 25: 561-569, 2012 71 bowles ja and weiner gj: Cd16 polymorphisms and nk activation induced by monoclonal antibody-coated target cells
    • Kuo SR, Wong L and Liu JS: Engineering a CD123CD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells. Protein Eng Des Sel 25: 561-569, 2012 71 Bowles JA and Weiner GJ: CD16 polymorphisms and NK activation induced by monoclonal antibody-coated target cells. J Immunol Methods 304: 88-99, 2005.
    • (2005) J Immunol Methods , vol.304 , pp. 88-99
    • Kuo, S.R.1    Wong, L.2    Liu, J.S.3
  • 71
    • 0028101333 scopus 로고
    • A novel membrane antigen selectively expressed on terminally differentiated human b-cells
    • Goto T, Kennel SJ, Abe M, Takishita M, Kosaka M, Solomon A and Saito S: A novel membrane antigen selectively expressed on terminally differentiated human B-cells. Blood 84: 1922-1930, 1994.
    • (1994) Blood , vol.84 , pp. 1922-1930
    • Goto, T.1    Kennel, S.J.2    Abe, M.3    Takishita, M.4    Kosaka, M.5    Solomon, A.6    Saito, S.7
  • 77
    • 0022382737 scopus 로고
    • Recombinant human tumor necrosis factor-alpha: Effects on proliferation of normal and transformed cells in vitro
    • Sugarman BJ, Aggarwal BB, Hass PE, Figari IS, Palladino MA Jr. and Shepard HM: Recombinant human tumor necrosis factor-alpha: Effects on proliferation of normal and transformed cells in vitro. Science 230: 943-945, 1985.
    • (1985) Science , vol.230 , pp. 943-945
    • Sugarman, B.J.1    Aggarwal, B.B.2    Hass, P.E.3    Figari, I.S.4    Palladino Jr., M.A.5    Shepard, H.M.6
  • 79
    • 0040887215 scopus 로고    scopus 로고
    • Evidence for the involvement of endothelial cell integrin alphavbeta3 in the disruption of the tumor vasculature induced by tnf and ifn-gamma. Nat med 4: 408-414, 1998. 82 robert b, mach jp, mani jc, ychou m, folli s, artus jc and pelegrin a: Cytokine targeting in tumors using a bispecific antibody directed against carcinoembryonic antigen and tumor necrosis factor alpha
    • Rgg C, Yilmaz A, Bieler G, Bamat J, Chaubert P and Lejeune FJ: Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma. Nat Med 4: 408-414, 1998. 82 Robert B, Mach JP, Mani JC, Ychou M, Folli S, Artus JC and Pelegrin A: Cytokine targeting in tumors using a bispecific antibody directed against carcinoembryonic antigen and tumor necrosis factor alpha. Cancer Res 56: 4758-4765, 1996.
    • (1996) Cancer Res , vol.56 , pp. 4758-4765
    • Rgg, C.1    Yilmaz, A.2    Bieler, G.3    Bamat, J.4    Chaubert, P.5    Lejeune, F.J.6
  • 80
    • 0024582830 scopus 로고
    • Oxidative damage in murine tumor cells treated in vitro by recombinant human tumor necrosis factor
    • Zimmerman RJ, Chan A and Leadon SA: Oxidative damage in murine tumor cells treated in vitro by recombinant human tumor necrosis factor. Cancer Res 49: 1644-1648, 1989.
    • (1989) Cancer Res , vol.49 , pp. 1644-1648
    • Zimmerman, R.J.1    Chan, A.2    Leadon, S.A.3
  • 84
    • 0035266408 scopus 로고    scopus 로고
    • Target cell-restricted triggering of the cd95 (apo-1fas) death receptor with bispecific antibody fragments
    • Jung G, Grosse-Hovest L, Krammer PH and Rammensee HG: Target cell-restricted triggering of the CD95 (APO-1/Fas) death receptor with bispecific antibody fragments. Cancer Res 61: 1846-1848, 2001.
    • (2001) Cancer Res , vol.61 , pp. 1846-1848
    • Jung, G.1    Grosse-Hovest, L.2    Krammer, P.H.3    Rammensee, H.G.4
  • 85
    • 39449129555 scopus 로고    scopus 로고
    • Construction of optimized bispecific antibodies for selective activation of the death receptor cd95
    • Herrmann T, Grosse-Hovest L, Otz T, Krammer PH, Rammensee HG and Jung G: Construction of optimized bispecific antibodies for selective activation of the death receptor CD95. Cancer Res 68: 1221-1227, 2008.
    • (2008) Cancer Res , vol.68 , pp. 1221-1227
    • Herrmann, T.1    Grosse-Hovest, L.2    Otz, T.3    Krammer, P.H.4    Rammensee, H.G.5    Jung, G.6
  • 90
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the her-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A and McGuire WL: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182, 1987.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 92
    • 0042307325 scopus 로고    scopus 로고
    • The erbb2/erbb3 heterodimer functions as an oncogenic unit: Erbb2 requires erbb3 to drive breast tumor cell proliferation
    • Holbro T, Beerli RR, Maurer F, Koziczak M, Barbas CF 3rd and Hynes NE: The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci USA 100: 8933-8938, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3    Koziczak, M.4    Barbas III, C.F.5    Hynes, N.E.6
  • 95
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • Holliger P and Hudson PJ: Engineered antibody fragments and the rise of single domains. Nat Biotechnol 23: 1126-1136, 2005.
    • (2005) Nat Biotechnol , vol.23 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 96
    • 30544449081 scopus 로고    scopus 로고
    • A quantitative protein interaction network for the erbb receptors using protein microarrays
    • Jones RB, Gordus A, Krall JA and MacBeath G: A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 439: 168-174, 2006.
    • (2006) Nature , vol.439 , pp. 168-174
    • Jones, R.B.1    Gordus, A.2    Krall, J.A.3    MacBeath, G.4
  • 97
    • 0034600849 scopus 로고    scopus 로고
    • The erbb signaling network: Receptor heterodimerization in development and cancer
    • Olayioye MA, Neve RM, Lane HA and Hynes NE: The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J 19: 3159-3167, 2000.
    • (2000) EMBO J , vol.19 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3    Hynes, N.E.4
  • 98
    • 62849118728 scopus 로고    scopus 로고
    • Selection and characterization of affibody ligands to the transcription factor c-jun
    • Lundberg E, Brismar H and Grlund T: Selection and characterization of Affibody ligands to the transcription factor c-Jun. Biotechnol Appl Biochem 52: 17-27, 2009.
    • (2009) Biotechnol Appl Biochem , vol.52 , pp. 17-27
    • Lundberg, E.1    Brismar, H.2    Grlund, T.3
  • 100
    • 9144256621 scopus 로고    scopus 로고
    • Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody
    • Lu D, Zhang H, Ludwig D, Persaud A, Jimenez X, Burtrum D, Balderes P, Liu M, Bohlen P, Witte L and Zhu Z: Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody. J Biol Chem 279: 2856-2865, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 2856-2865
    • Lu, D.1    Zhang, H.2    Ludwig, D.3    Persaud, A.4    Jimenez, X.5    Burtrum, D.6    Balderes, P.7    Liu, M.8    Bohlen, P.9    Witte, L.10    Zhu, Z.11
  • 105
    • 84863787049 scopus 로고    scopus 로고
    • Human monoclonal antibodies targeting nonoverlapping epitopes on insulin-like growth factor ii as a novel type of candidate cancer therapeutics. Mol cancer ther 11: 1400-1410, 2012. 109 childs sg: The pathogenesis of systemic lupus erythematosus
    • Chen W, Feng Y, Zhao Q, Zhu Z and Dimitrov DS: Human monoclonal antibodies targeting nonoverlapping epitopes on insulin-like growth factor II as a novel type of candidate cancer therapeutics. Mol Cancer Ther 11: 1400-1410, 2012. 109 Childs SG: The pathogenesis of systemic lupus erythematosus. Orthop Nurs 25: 140-145, 2006.
    • (2006) Orthop Nurs , vol.25 , pp. 140-145
    • Chen, W.1    Feng, Y.2    Zhao, Q.3    Zhu, Z.4    Dimitrov, D.S.5
  • 106
    • 0037699954 scopus 로고    scopus 로고
    • The biology of vegf and its receptors
    • Ferrara N, Gerber HP and LeCouter J: The biology of VEGF and its receptors. Nat Med 9: 669-676, 2003.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 107
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS: Tumor angiogenesis. N Engl J Med 358: 2039-2049, 2008.
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 108
    • 0035476882 scopus 로고    scopus 로고
    • Complete inhibition of vascular endothelial growth factor (vegf) activities with a bifunctional diabody directed against both vegf kinase receptors, fms-like tyrosine kinase receptor and kinase insert domain-containing receptor
    • Lu D, Jimenez X, Zhang H, Wu Y, Bohlen P, Witte L and Zhu Z: Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF kinase receptors, FMS-like tyrosine kinase receptor and kinase insert domain-containing receptor. Cancer Res 61: 7002-7008, 2001.
    • (2001) Cancer Res , vol.61 , pp. 7002-7008
    • Lu, D.1    Jimenez, X.2    Zhang, H.3    Wu, Y.4    Bohlen, P.5    Witte, L.6    Zhu, Z.7
  • 109
    • 0027131418 scopus 로고
    • Osteopontin: A protein with diverse functions
    • Denhardt DT and Guo X: Osteopontin: A protein with diverse functions. FASEB J 7: 1475-1482, 1993.
    • (1993) FASEB J , vol.7 , pp. 1475-1482
    • Denhardt, D.T.1    Guo, X.2
  • 111
    • 78049233650 scopus 로고    scopus 로고
    • A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor a and osteopontin
    • Kou G, Shi J, Chen L, Zhang D, Hou S, Zhao L, Fang C, Zheng L, Zhang X, Liang P, Zhang X, Li B and Guo Y: A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin. Cancer Lett 299: 130-136, 2010.
    • (2010) Cancer Lett , vol.299 , pp. 130-136
    • Kou, G.1    Shi, J.2    Chen, L.3    Zhang, D.4    Hou, S.5    Zhao, L.6    Fang, C.7    Zheng, L.8    Zhang, X.9    Liang, P.10    Zhang, X.11    Li, B.12    Guo, Y.13
  • 112
    • 2942670180 scopus 로고    scopus 로고
    • Pdgf receptors mediators of autocrine tumor growth and regulators of tumor vasculature and stroma
    • Ostman A: PDGF receptors mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev 15: 275-286, 2004.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 275-286
    • Ostman, A.1
  • 114
    • 33744964246 scopus 로고    scopus 로고
    • Single variable domain-igg fusion. A novel recombinant approach to fc domain-containing bispecific antibodies
    • Shen J, Vil MD, Jimenez X, Iacolina M, Zhang H and Zhu Z: Single variable domain-IgG fusion. A novel recombinant approach to Fc domain-containing bispecific antibodies. J Biol Chem 281: 10706-10714, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 10706-10714
    • Shen, J.1    Vil, M.D.2    Jimenez, X.3    Iacolina, M.4    Zhang, H.5    Zhu, Z.6
  • 119
    • 0030240078 scopus 로고    scopus 로고
    • Mechanisms of cellular penetration and nuclear localization of an anti-double-strand dna autoantibody
    • Zack DJ, Stempniak M, Wong AL, Taylor C and Weisbart RH: Mechanisms of cellular penetration and nuclear localization of an anti-double-strand DNA autoantibody. J Immunol 157: 2082-2088, 1996.
    • (1996) J Immunol , vol.157 , pp. 2082-2088
    • Zack, D.J.1    Stempniak, M.2    Wong, A.L.3    Taylor, C.4    Weisbart, R.H.5
  • 120
    • 0032191311 scopus 로고    scopus 로고
    • An autoantibody is modified for use as a delivery system to target the cell nucleus: Therapeutic implications
    • Weisbart RH, Stempniak M, Harris S, Zack DJ and Ferreri K: An autoantibody is modified for use as a delivery system to target the cell nucleus: Therapeutic implications. J Autoimmun 11: 539-546, 1998.
    • (1998) J Autoimmun , vol.11 , pp. 539-546
    • Weisbart, R.H.1    Stempniak, M.2    Harris, S.3    Zack, D.J.4    Ferreri, K.5
  • 123
    • 0005382256 scopus 로고    scopus 로고
    • Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain fv fragments
    • Caron de Fromentel C, Gruel N, Venot C, Debussche L, Conseiller E, Dureil C, Teillaud JL, Tocque B and Bracco L: Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments. Oncogene 18: 551-557, 1999.
    • (1999) Oncogene , vol.18 , pp. 551-557
    • Caron De Fromentel, C.1    Gruel, N.2    Venot, C.3    Debussche, L.4    Conseiller, E.5    Dureil, C.6    Teillaud, J.L.7    Tocque, B.8    Bracco, L.9
  • 124
    • 11844277240 scopus 로고    scopus 로고
    • Construction and expression of a bispecific single-chain antibody that penetrates mutant p53 colon cancer cells and binds p53
    • Weisbart RH, Wakelin R, Chan G, Miller CW and Koeffler PH: Construction and expression of a bispecific single-chain antibody that penetrates mutant p53 colon cancer cells and binds p53. Int J Oncol 25: 1113-1118, 2004.
    • (2004) Int J Oncol , vol.25 , pp. 1113-1118
    • Weisbart, R.H.1    Wakelin, R.2    Chan, G.3    Miller, C.W.4    Koeffler, P.H.5
  • 125
    • 33845901313 scopus 로고    scopus 로고
    • Mdm2 inhibitors for cancer therapy
    • Vassilev LT: MDM2 inhibitors for cancer therapy. Trends Mol Med 13: 23-31, 2007.
    • (2007) Trends Mol Med , vol.13 , pp. 23-31
    • Vassilev, L.T.1
  • 128
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM: The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12: 252-264, 2012.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 130
    • 0035909785 scopus 로고    scopus 로고
    • Construction of a bispecific single chain antibody for recruitment of cytotoxic tcells to the tumour stroma associated antigen fibroblast activation protein
    • Wst T, Moosmayer D and Pfizenmaier K: Construction of a bispecific single chain antibody for recruitment of cytotoxic Tcells to the tumour stroma associated antigen fibroblast activation protein. J Biotechnol 92: 159-168, 2001.
    • (2001) J Biotechnol , vol.92 , pp. 159-168
    • Wst, T.1    Moosmayer, D.2    Pfizenmaier, K.3
  • 132
    • 77953879099 scopus 로고    scopus 로고
    • Accelrys Software Inc. Release 3.1 . San Diego: Accelrys Software Inc
    • Accelrys Software Inc., Discovery Studio Modeling Environment, Release 3.1 . San Diego: Accelrys Software Inc., 2007.
    • (2007) Discovery Studio Modeling Environment


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