A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G

Protein Engineering, Design and Selection

Volumn 20, Issue 11, 2007, Pages 569-576

  Stork, Roland ^a   Müller, Dafne ^a   Kontermann, Roland E ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Albumin binding domain; Bispecific antibody; Effector cells; Pharmacokinetics; Tri functional antibody

Indexed keywords

ANTIBODIES; ANTIGENS; BACTERIA; PHARMACOKINETICS; RATS;

ALBUMIN; ALBUMIN-BINDING DOMAIN; DIABODY; EFFECTOR CELLS; THERAPEUTICS;

PROTEINS;

ALBUMIN; ANTIBODY; BISPECIFIC ANTIBODY; HYBRID PROTEIN; INTERLEUKIN 2; PROTEIN G;

ANTIGEN BINDING; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG BINDING; DRUG HALF LIFE; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; T LYMPHOCYTE; THERMOSTABILITY;

ALBUMINS; ANIMALS; ANTIBODIES; ANTIGENS; BACTERIAL PROTEINS; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES;

MAMMALIA; MUS;

EID: 36549022608     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzm061     Document Type: Article

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