Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo

International Journal of Oncology

Volumn 35, Issue 1, 2009, Pages 167-173

  Heinze, Emil ^a,b   Baldwin, Scott ^c   Chan, Grace ^a   Hansen, James ^a   Song, Jason ^a   Clements, Douglas ^a   Aragon, Robert ^c   Nishimura, Robert ^a   Reeves, Mark ^c   Weisbart, Richard ^a  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b OLIVE VIEW UCLA MEDICAL CENTER   (United States)

^c Jerry L Pettis Memorial VA Medical Center   (United States)

Author keywords

Antibodies; Apoptosis; Cytotoxicity; Gene regulation; Transcription factors

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3E10; PROTEIN P17; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL DEATH; CELL STRAIN MCF 7; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; OVARY CANCER; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN FRAGMENTS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; OVARIAN NEOPLASMS; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 67649446813     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000325     Document Type: Article

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