Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing

Protein Engineering, Design and Selection

Volumn 25, Issue 10, 2012, Pages 571-580

  Metz, Silke ^a   Panke, Christian ^a   Haas, Alexander K ^a   Schanzer, Jürgen ^a   Lau, Wilma ^a   Croasdale, Rebecca ^a   Hoffmann, Eike ^a   Schneider, Britta ^a   Auer, Johannes ^a   Gassner, Christian ^a   Bossenmaier, Birgit ^a   Umana, Pablo ^b   Sustmann, Claudio ^a   Brinkmann, Ulrich ^a  

^a ROCHE INNOVATION CENTER MUNICH   (Germany)

^b Roche Glycart AG   (Switzerland)

Author keywords

antibody engineering; bispecific antibodies; disulfide stabilization; protease activation

Indexed keywords

ANTIBODY ENGINEERING; BINDING MOLECULES; C-TERMINUS; DISULFIDE BONDS; HEAVY CHAIN; HETERODIMERIZATION; MAMMALIAN CELLS; METALLOPROTEASES; MULTIPLE APPLICATIONS; PROTEASE ACTIVATION; PROTEOLYTIC PROCESSING; RECOGNITION SEQUENCE; STERIC HINDRANCES; TARGET TISSUES;

ANTIGENS; COVALENT BONDS; ENZYME ACTIVITY; MOLECULES; TISSUE;

ANTIBODIES;

BISPECIFIC ANTIBODY; FURIN; IMMUNOGLOBULIN G;

ANTIBODY COMBINING SITE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIMERIZATION; GENE MUTATION; HEAVY CHAIN; HUMAN; HUMAN CELL; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PURIFICATION;

ANTIBODIES, BISPECIFIC; BINDING SITES, ANTIBODY; CELL LINE; DISULFIDES; GENE EXPRESSION; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PEPTIDE HYDROLASES; PROTEIN ENGINEERING; PROTEOLYSIS; RECEPTOR, ERBB-3; RECOMBINANT PROTEINS; SINGLE-CHAIN ANTIBODIES; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

MAMMALIA;

EID: 84866980918     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs064     Document Type: Article

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