메뉴 건너뛰기




Volumn 28, Issue 38, 2009, Pages 3412-3422

Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells

Author keywords

Angiogenesis; HUVEC; Osteopontin; Signal pathway; VEGF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOPONTIN; OSTEOPONTIN ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR 2;

EID: 70349439129     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.189     Document Type: Article
Times cited : (276)

References (33)
  • 1
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E. (1995). Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1: 1024-1028.
    • (1995) Nat Med , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'Er, J.4    Stone, J.5    Keshet, E.6
  • 2
    • 0028824336 scopus 로고
    • Inhibition of tumor growth and metastasis by an immunoneutraliz-ing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121
    • Asano M, Yukita A, Matsumoto T, Kondo S, Suzuki H. (1995). Inhibition of tumor growth and metastasis by an immunoneutraliz-ing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121. Cancer Res 55: 5296-5301.
    • (1995) Cancer Res , vol.55 , pp. 5296-5301
    • Asano, M.1    Yukita, A.2    Matsumoto, T.3    Kondo, S.4    Suzuki, H.5
  • 3
    • 0033582285 scopus 로고    scopus 로고
    • Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kB activation
    • Beraud C, Henzel WJ, Baeuerle PA. (1999). Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kB activation. Proc Natl Acad Sci USA 96: 429-434.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 429-434
    • Beraud, C.1    Henzel, W.J.2    Baeuerle, P.A.3
  • 4
    • 0036494109 scopus 로고    scopus 로고
    • Effects of SP50 a novel, potent antiestrogen, on breast cancer cells and in xenograft models
    • Brady H, Desai S, Gayo-Fung LM, Khammungkhune S, McKie JA et al. (2002). Effects of SP50 a novel, potent antiestrogen, on breast cancer cells and in xenograft models. Cancer Res 62: 1439-1442.
    • (2002) Cancer Res , vol.62 , pp. 1439-1442
    • Brady, H.1    Desai, S.2    Gayo-Fung, L.M.3    Khammungkhune, S.4    McKie, J.A.5
  • 5
    • 48049124106 scopus 로고    scopus 로고
    • A novel functional motif of osteopontin for human lymphocyte migration and survival
    • Cao Z, Dai J, Fan K, Wang H, Ji G, Li B et al. (2008). A novel functional motif of osteopontin for human lymphocyte migration and survival. Mol Immunol 45: 3683-3692.
    • (2008) Mol Immunol , vol.45 , pp. 3683-3692
    • Cao, Z.1    Dai, J.2    Fan, K.3    Wang, H.4    Ji, G.5    Li, B.6
  • 6
    • 39149110606 scopus 로고    scopus 로고
    • Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms
    • Chakraborty G, Jain S, Kundu GC. (2008). Osteopontin promotes vascular endothelial growth factor-dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms. Cancer Res 68: 152-161.
    • (2008) Cancer Res , vol.68 , pp. 152-161
    • Chakraborty, G.1    Jain, S.2    Kundu, G.C.3
  • 7
    • 0042709227 scopus 로고    scopus 로고
    • Osteopontin stimulates cell motility and nuclear factor kB- mediated secretion of urokinase type plasminogen activator through phosphatidylino-sitol 3-Kinase/Akt signaling pathways in breast cancer cells
    • Das R, Mahabeleshwar GH, Kundu GC. (2003). Osteopontin stimulates cell motility and nuclear factor kB- mediated secretion of urokinase type plasminogen activator through phosphatidylino-sitol 3-Kinase/Akt signaling pathways in breast cancer cells. J Biol Chem 278: 28593-28606.
    • (2003) J Biol Chem , vol.278 , pp. 28593-28606
    • Das, R.1    Mahabeleshwar, G.H.2    Kundu, G.C.3
  • 8
    • 0028071229 scopus 로고
    • Overcoming obstacles to metastasis-defenses against host defenses: Osteopontin (OPN) as a shield against attack by cytotoxic host cells
    • Denhardt DT, Chambers AF. (1994). Overcoming obstacles to metastasis-defenses against host defenses: Osteopontin (OPN) as a shield against attack by cytotoxic host cells. J Cell Biochem 56: 48-51.
    • (1994) J Cell Biochem , vol.56 , pp. 48-51
    • Denhardt, D.T.1    Chambers, A.F.2
  • 9
    • 0030390037 scopus 로고    scopus 로고
    • Oncogene-initiated aberrant signaling engenders the metastatic phenotype: Synergistic transcription factor interactions are targets for cancer therapy
    • Denhardt DT. (1996). Oncogene-initiated aberrant signaling engenders the metastatic phenotype: synergistic transcription factor interactions are targets for cancer therapy. Crit Rev Oncog 7: 261-291.
    • (1996) Crit Rev Oncog , vol.7 , pp. 261-291
    • Denhardt, D.T.1
  • 10
    • 0035021027 scopus 로고    scopus 로고
    • Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival
    • Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS. (2001). Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 107: 1055-1061.
    • (2001) J Clin Invest , vol.107 , pp. 1055-1061
    • Denhardt, D.T.1    Noda, M.2    O'Regan, A.W.3    Pavlin, D.4    Berman, J.S.5
  • 11
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • Folkman J, Watson K, Ingber D, Hanahan D. (1989). Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339: 58-61.
    • (1989) Nature , vol.339 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 12
    • 0032515047 scopus 로고    scopus 로고
    • 0-kinase/Akt signal transduction pathway: Requirement for Flk-1/KDR activation
    • Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V et al. (1998). Vascular endothelial growth factor regulates endothe-lial cell survival through the phosphatidylinositol 30-kinase/Akt signal transduction pathway: requirement for Flk-1/KDR activation. J Biol Chem 273: 30336-30343.
    • (1998) J Biol Chem , vol.273 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3    Yan, M.4    Keyt, B.A.5    Dixit, V.6
  • 13
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 14
    • 33746114248 scopus 로고    scopus 로고
    • The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C alpha/ c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis
    • Jain S, Chakraborty G, Kundu GC. (2006). The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C alpha/ c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis. Cancer Res 66: 6638-6648.
    • (2006) Cancer Res , vol.66 , pp. 6638-6648
    • Jain, S.1    Chakraborty, G.2    Kundu, G.C.3
  • 15
    • 0036789313 scopus 로고    scopus 로고
    • The role of fibroblast growth factors in vascular development
    • Javerzat S, Auguste P, Bikfalvi A. (2002). The role of fibroblast growth factors in vascular development. Trends Mol Med 8: 483-489.
    • (2002) Trends Mol Med , vol.8 , pp. 483-489
    • Javerzat, S.1    Auguste, P.2    Bikfalvi, A.3
  • 18
    • 33845666847 scopus 로고    scopus 로고
    • The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia
    • Kilic E, Kilic U, Wang Y, Bassetti CL, Marti HH, Hermann DM. (2006). The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J 20: 1185-1187.
    • (2006) FASEB J , vol.20 , pp. 1185-1187
    • Kilic, E.1    Kilic, U.2    Wang, Y.3    Bassetti, C.L.4    Marti, H.H.5    Hermann, D.M.6
  • 19
    • 0032926320 scopus 로고    scopus 로고
    • Angiopoietin-1 is an apoptosis survival factor for endothelial cells
    • Kwak HJ, So JN, Lee SJ, Kim I, Koh GY. (1999). Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS Lett 448: 249-253.
    • (1999) FEBS Lett , vol.448 , pp. 249-253
    • Kwak, H.J.1    So, J.N.2    Lee, S.J.3    Kim, I.4    Koh, G.Y.5
  • 20
    • 14644394929 scopus 로고    scopus 로고
    • Cell responses to FGFR3 signaling: Growth, differentiation and apoptosis
    • L'Hote CG, Knowles MA. (2005). Cell responses to FGFR3 signaling: growth, differentiation and apoptosis. Exp Cell Res 304: 417-431.
    • (2005) Exp Cell Res , vol.304 , pp. 417-431
    • L'Hote, C.G.1    Knowles, M.A.2
  • 21
    • 27844595938 scopus 로고    scopus 로고
    • Id1 gene transfer confers angiogenic property on fully differentiated endothelial cells and contributes to therapeutic angiogenesis
    • Nishiyama K, Takaji K, Kataoka K, Kurihara Y, Yoshimura M, Kato A et al. (2005). Id1 gene transfer confers angiogenic property on fully differentiated endothelial cells and contributes to therapeutic angiogenesis. Circulation 112: 2840-2850.
    • (2005) Circulation , vol.112 , pp. 2840-2850
    • Nishiyama, K.1    Takaji, K.2    Kataoka, K.3    Kurihara, Y.4    Yoshimura, M.5    Kato, A.6
  • 22
    • 0034646644 scopus 로고    scopus 로고
    • Akt/Protein kinase B upregulates Bcl-2 expression through cAMP-response element-binding protein
    • Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE et al. (2000). Akt/Protein kinase B upregulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 275: 10761-10766.
    • (2000) J Biol Chem , vol.275 , pp. 10761-10766
    • Pugazhenthi, S.1    Nesterova, A.2    Sable, C.3    Heidenreich, K.A.4    Boxer, L.M.5    Heasley, L.E.6
  • 23
    • 2942511574 scopus 로고    scopus 로고
    • Role of osteopontin in tumor progression
    • Rittling SR, Chambers AF. (2004). Role of osteopontin in tumor progression. Br J Cancer 90: 1877-1881.
    • (2004) Br J Cancer , vol.90 , pp. 1877-1881
    • Rittling, S.R.1    Chambers, A.F.2
  • 24
    • 0029999603 scopus 로고    scopus 로고
    • Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin
    • Senger DR, Ledbetter SR, Claffey KP, Papadopoulos-Sergiou A, Peruzzi CA, Detmar M. (1996). Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. Am J Pathol 149: 293-305.
    • (1996) Am J Pathol , vol.149 , pp. 293-305
    • Senger, D.R.1    Ledbetter, S.R.2    Claffey, K.P.3    Papadopoulos-Sergiou, A.4    Peruzzi, C.A.5    Detmar, M.6
  • 25
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • DOI 10.1161/01.RES.0000022200.71892.9F
    • Shiojima I, Walsh K. (2002). Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 90: 1243-1250. (Pubitemid 34787405)
    • (2002) Circulation Research , vol.90 , Issue.12 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 27
    • 0035477472 scopus 로고    scopus 로고
    • In vivo intracellular signaling as a marker of antiangiogenic activity
    • Solorzano CC, Jung YD, Bucana CD et al. (2001). In vivo intracellular signaling as a marker of antiangiogenic activity. Cancer Res 61: 7048-7051.
    • (2001) Cancer Res , vol.61 , pp. 7048-7051
    • Solorzano, C.C.1    Jung, Y.D.2    Bucana, C.D.3
  • 28
    • 7044264360 scopus 로고    scopus 로고
    • Role of osteopontin in adhesion, migration, cell survival and bone remodeling
    • Standal T, Borset M, Sundan A. (2004). Role of osteopontin in adhesion, migration, cell survival and bone remodeling. Exp Oncol 26: 179-184.
    • (2004) Exp Oncol , vol.26 , pp. 179-184
    • Standal, T.1    Borset, M.2    Sundan, A.3
  • 29
    • 0037799253 scopus 로고    scopus 로고
    • PTEN regulates RANKL-and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility
    • Toshifumi S, Ulises A, Hruska KA. (2003). PTEN regulates RANKL-and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility. J Biol Chem 278: 5001-5008.
    • (2003) J Biol Chem , vol.278 , pp. 5001-5008
    • Toshifumi, S.1    Ulises, A.2    Hruska, K.A.3
  • 30
    • 35648970587 scopus 로고    scopus 로고
    • Osteopontin over-expression in breast cancer: Knowledge gained and possible implications for clinical management
    • Tuck AB, Chambers AF, Allan AL. (2007). Osteopontin over-expression in breast cancer: knowledge gained and possible implications for clinical management. J Cell Biochem 102: 859-868.
    • (2007) J Cell Biochem , vol.102 , pp. 859-868
    • Tuck, A.B.1    Chambers, A.F.2    Allan, A.L.3
  • 31
    • 0029127219 scopus 로고
    • Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors
    • Weidner N. (1995). Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 36: 169-180.
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 169-180
    • Weidner, N.1
  • 32
    • 0034681392 scopus 로고    scopus 로고
    • Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation
    • Wu LW, Mayo LD, Dunbar JD, Kessler KM, Baerwald MR, Jaffe EA et al. (2000). Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation. J Biol Chem 18: 275:5096-275:5103.
    • (2000) J Biol Chem , vol.18 , pp. 275
    • Wu, L.W.1    Mayo, L.D.2    Dunbar, J.D.3    Kessler, K.M.4    Baerwald, M.R.5    Jaffe, E.A.6
  • 33
    • 20144389023 scopus 로고    scopus 로고
    • Role of osteopontin in amplification and perpetuation of rheumatoid synovitis
    • Xu G, Nie H, Li N, Ni L, Xu R, Hong J et al. (2005). Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J Clin Invest 115: 1060-1067.
    • (2005) J Clin Invest , vol.115 , pp. 1060-1067
    • Xu, G.1    Nie, H.2    Li, N.3    Ni, L.4    Xu, R.5    Hong, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.