A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity

Journal of Biological Chemistry

Volumn 280, Issue 20, 2005, Pages 19665-19672

  Lu, Dan ^a   Zhang, Haifan ^a   Koo, Henry ^a   Tonra, James ^a   Balderes, Paul ^a   Prewett, Marie ^a   Corcoran, Eric ^a   Mangalampalli, Venkata ^a   Bassi, Rajiv ^a   Anselma, Deborah ^a   Patel, Dipa ^a   Kang, Xiaoqiang ^a   Ludwig, Dale L ^a   Hicklin, Daniel J ^a   Bohlen, Peter ^a   Witte, Larry ^a   Zhu, Zhenping ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; CYTOLOGY; GENETIC ENGINEERING; GROWTH KINETICS; INSULIN; PROTEINS; TOXICITY; TUMORS;

BIOLOGICAL PROPERTIES; EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR); INSULIN-LIKE GROWTH FACTOR RECEPTOR (IGFR); TUMORIGENESIS;

ANTIBODIES;

ANTIBODY IMC 11F8; ANTIBODY IMC A12; BISPECIFIC ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN G ANTIBODY; RECOMBINANT ANTIBODY; SOMATOMEDIN RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER; CANCER INHIBITION; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG TARGETING; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERNALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; TUMOR CELL; TUMOR XENOGRAFT; ANIMAL; BIOSYNTHESIS; CANCER TRANSPLANTATION; CHEMISTRY; EXPERIMENTAL NEOPLASM; GENETICS; IMMUNOLOGY; METABOLISM; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FEMALE; HUMANS; IMMUNOGLOBULIN G; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, SOMATOMEDIN; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 21244441508     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500815200     Document Type: Article

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