Simultaneous Blockade of Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor Signaling Pathways in Cancer Cells with a Fully Human Recombinant Bispecific Antibody

Journal of Biological Chemistry

Volumn 279, Issue 4, 2004, Pages 2856-2865

  Lu, Dan ^a   Zhang, Haifan ^a   Ludwig, Dale ^a   Persaud, Anita ^a   Jimenez, Xenia ^a   Burtrum, Douglas ^a   Balderes, Paul ^a   Liu, Meilin ^a   Bohlen, Peter ^a   Witte, Larry ^a   Zhu, Zhenping ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; BIOASSAY; BIOCHEMISTRY; CELL CULTURE; CHEMICAL BONDS; CROSSLINKING; ENZYME KINETICS; GROWTH KINETICS; IMMUNOLOGY;

BIOCHEMICAL PATHWAYS; IMMUNOSORBENTS; TUMORIGENESIS;

TUMORS;

BISPECIFIC ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; PROTEIN KINASE B; SOMATOMEDIN RECEPTOR;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL KILLING; CROSS LINKING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE TARGETING; GROWTH INHIBITION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PHAGE DISPLAY; PRIORITY JOURNAL; RECEPTOR BLOCKING; TUMOR GROWTH;

ANTIBODIES, BISPECIFIC; CELL DIVISION; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, SOMATOMEDIN; SIGNAL TRANSDUCTION;

EID: 9144256621     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310132200     Document Type: Article

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