Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

Journal of Neurochemistry

Volumn 124, Issue 6, 2013, Pages 880-893

  Pierce, Anson ^a,b   Podlutskaya, Natalia ^a   Halloran, Jonathan J ^a   Hussong, Stacy A ^a   Lin, Pei Yi ^a,b   Burbank, Raquel ^a   Hart, Matthew J ^a,c   Galvan, Veronica ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c University of Texas Health Science Center   (United States)

Author keywords

Alzheimer's disease; chaperones; heat shock factor 1; proteostasis; rapamycin; TOR

Indexed keywords

ALPHA CRYSTALLIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA CRYSTALLIN; CHAPERONE; HEAT SHOCK TRANSCRIPTION FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE COURSE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MEMORY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; REAL TIME POLYMERASE CHAIN REACTION; SPATIAL LEARNING; TRANSGENIC MOUSE; UPREGULATION;

ALZHEIMER DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; SIROLIMUS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; UP-REGULATION;

MUS;

EID: 84874678862     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12080     Document Type: Article

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