Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers

Neurobiology of Aging

Volumn 31, Issue 6, 2010, Pages 1055-1058

  Wu, Yanjue ^a,d   Cao, Zhiming ^a   Klein, William L ^c   Luo, Yuan ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

A oligomers Alzheimer's disease; C. elegans; Heat shock

Indexed keywords

AMYLOID BETA PROTEIN; CHAPERONE; OLIGOMER; SMALL HEAT SHOCK PROTEIN; SMALL HEAT SHOCK PROTEIN 16.2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; HEAT SHOCK RESPONSE; IN VIVO STUDY; NEUROPROTECTION; NEUROTOXICITY; NON INVASIVE PROCEDURE; NONHUMAN; OLIGOMERIZATION; PARALYSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; TRANSGENIC ORGANISM; UPREGULATION;

AGING; AMYLOID BETA-PROTEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIOXIDANTS; BEHAVIOR, ANIMAL; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; HOT TEMPERATURE; HUMANS; HYDROGEN PEROXIDE; MOLECULAR WEIGHT; PARALYSIS; PEPTIDE FRAGMENTS; PHYTOTHERAPY; PLANT EXTRACTS; TIME FACTORS;

EID: 77951975674     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.07.013     Document Type: Article

References (18)

1. Boyd-Kimball D., Poon H.F., Lynn B.C., Cai J., Pierce W.M., Klein J.B., Ferguson J., Link C.D., Butterfield D.A. Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta (1-42): implications for Alzheimer's disease. Neurobiol. Aging 2006, 27(9):1239-1249.
2. Cohen E., Bieschke J., Perciavalle R.M., Kelly J.W., Dillin A. Opposing activities protect against age-onset proteotoxicity. Science 2006, 313(5793):1604-1610.
3. Fonte V., Kapulkin V., Taft A., Fluet A., Friedman D., Link C.D. Interaction of intracellular beta amyloid peptide with chaperone proteins. Proc. Natl. Acad. Sci. USA 2002, 99:9439-9444.
4. Fonte V., Kipp D.R., Yerg J., Merin D., Forrestal M., Wagner E., Roberts C.M., Link C.D. Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein. J. Biol. Chem. 2008, 283(2):784-791.
5. Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297(5580):353-356.
6. Herbst M., Wanker E.E. Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation: a possible therapeutic strategy. Neurodegener. Dis. 2007, 4:254-260.
7. Hinault M.P., Ben-Zvi A., Goloubinoff P. Chaperones and proteases: cellular fold-controlling factors of proteins in neurodegenerative diseases and aging. J. Mol. Neurosci. 2006, 30:249.
8. Hsu A.L., Murphy C.T., Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 2003, 300(5622):1142-1145.
9. Klein W.L., Krafft G.A., Finch C.E. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?. Trends Neurosci. 2001, 24(4):219-224.
10. Lambert M.P., Velasco P.T., Chang L., Viola K.L., Fernandez S., Lacor P.N., Khuon D., Gong Y., Bigio E.H., Shaw P., De Felice F.G., Krafft G.A., Klein W.L. Monoclonal antibodies that target pathological assemblies of Abeta. J. Neurochem. 2007, 100(1):23-35.
11. Link C.D. Invertebrate models of Alzheimer's disease. Genes Brain Behav. 2005, 4(3):147-156.
12. Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 2004, 430:631-639.
13. Morimoto R.I., Santoro M.G. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nat. Biotechnol. 1998, 16(9):833-838.
14. Prahlad V., Cornelius T., Morimoto R.I. Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 2008, 320(5877):811-814.
15. Smith J.V., Luo Y. Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761. J. Alzheimers Dis. 2003, 5(4):287-300.
16. Steinkraus K.A., Smith E.D., Davis C., Carr D., Pendergrass W.R., Sutphin G.L., Kennedy B.K., Kaeberlein M. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 2008.
17. Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416(6880):535-539.
18. Wu Y., Wu Z., Butko P., Christen Y., Lambert M.P., Klein W.L., Link C.D., Luo Y. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J. Neurosci. 2006, 26(50):13102-13113.