Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

Neuron

Volumn 74, Issue 3, 2012, Pages 467-474

  Bakker, Arnold ^a   Krauss, Gregory L ^b   Albert, Marilyn S ^b   Speck, Caroline L ^c   Jones, Lauren R ^c   Stark, Craig E ^d,e   Yassa, Michael A ^c   Bassett, Susan S ^a   Shelton, Amy L ^c   Gallagher, Michela ^c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETIRACETAM;

AGED; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HIPPOCAMPUS; HUMAN; LOW DRUG DOSE; MALE; MEMORY CONSOLIDATION; MILD COGNITIVE IMPAIRMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TASK PERFORMANCE; TREATMENT DURATION; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; AMNESIA; BRAIN MAPPING; CASE-CONTROL STUDIES; CHOICE BEHAVIOR; DOUBLE-BLIND METHOD; FEMALE; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; NOOTROPIC AGENTS; OXYGEN; PHOTIC STIMULATION; PIRACETAM; STATISTICS AS TOPIC;

EID: 84860659903     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2012.03.023     Document Type: Article

References (39)

1. Andrews-Zwilling Y., Bien-Ly N., Xu Q., Li G., Bernardo A., Yoon S.Y., Zwilling D., Yan T.X., Chen L., Huang Y. Apolipoprotein E4 cause age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J. Neurosci. 2010, 41:13707-13717.
2. Bakker A., Kirwan C.B., Miller M., Stark C.E. Pattern separation in the human hippocampal CA3 and dentate gyrus. Science 2008, 319:1640-1642.
3. Benton A.L. Revised Visual Retention Test 4th 1974, Psychological Corporation, New York.
4. Bero A.W., Yan P., Roh J.H., Cirrito J.R., Stewart F.R., Raichle M.E., Lee J.M., Holtzman D.M. Neuronal activity regulates the regional vulnerability to amyloid-β deposition. Nat. Neurosci. 2011, 14:750-756.
5. Bookheimer S.Y., Strojwas M.H., Cohen M.S., Saunders A.M., Pericak-Vance M.A., Mazziotta J.C., Small G.W. Patterns of brain activation in people at risk for Alzheimer's disease. N. Engl. J. Med. 2000, 343:450-456.
6. Buschke H., Fuld P.A. Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 1974, 24:1019-1025.
7. Celone K.A., Calhoun V.D., Dickerson B.C., Atri A., Chua E.F., Miller S.L., DePeau K., Rentz D.M., Selkoe D.J., Blacker D., et al. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. J. Neurosci. 2006, 26:10222-10231.
8. Cox R.W. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput. Biomed. Res. 1996, 29:162-173.
9. Dennis N.A., Browndyke J.N., Stokes J., Need A., Burke J.R., Welsh-Bohmer K.A., Cabeza R. Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers. Alzheimers Dement. 2010, 6:303-311.
10. Dickerson B.C., Salat D.H., Bates J.F., Atiya M., Killiany R.J., Greve D.N., Dale A.M., Stern C.E., Blacker D., Albert M.S., Sperling R.A. Medial temporal lobe function and structure in mild cognitive impairment. Ann. Neurol. 2004, 56:27-35.
11. Dickerson B.C., Salat D.H., Greve D.N., Chua E.F., Rand-Giovannetti E., Rentz D.M., Bertram L., Mullin K., Tanzi R.E., Blacker D., et al. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology 2005, 65:404-411.
12. Ewers M., Sperling R.A., Klunk W.E., Weiner M.W., Hampel H. Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia. Trends Neurosci. 2011, 34:430-442.
13. Filippini N., MacIntosh B.J., Hough M.G., Goodwin G.M., Frisoni G.B., Smith S.M., Matthews P.M., Beckmann C.F., Mackay C.E. Distinct patterns of brain activity in young carriers of the APOE-ε4 allele. Proc. Natl. Acad. Sci. USA 2009, 106:7209-7214.
14. Gallagher M., Koh M.T. Episodic memory on the path to Alzheimer's disease. Curr. Opin. Neurobiol. 2011, 21:929-934.
15. Hämäläinen A., Pihlajamäki M., Tanila H., Hänninen T., Niskanen E., Tervo S., Karjalainen P.A., Vanninen R.L., Soininen H. Increased fMRI responses during encoding in mild cognitive impairment. Neurobiol. Aging 2007, 28:1889-1903.
16. Kirwan C.B., Stark C.E. Overcoming interference: an fMRI investigation of pattern separation in the medial temporal lobe. Learn. Mem. 2007, 14:625-633.
17. Kirwan C.B., Jones C.K., Miller M.I., Stark C.E.L. High-resolution fMRI investigation of the medial temporal lobe. Hum. Brain Mapp. 2007, 28:959-966.
18. Koh M.T., Haberman R.P., Foti S., McCown T.J., Gallagher M. Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology 2010, 35:1016-1025.
19. Lacy J.W., Yassa M.A., Stark S.M., Muftuler L.T., Stark C.E. Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn. Mem. 2011, 18:15-18.
20. Leutgeb S., Leutgeb J.K. Pattern separation, pattern completion, and new neuronal codes within a continuous CA3 map. Learn. Mem. 2007, 14:745-757.
21. Leutgeb S., Leutgeb J.K., Treves A., Moser M.B., Moser E.I. Distinct ensemble codes in hippocampal areas CA3 and CA1. Science 2004, 305:1295-1298.
22. Lyseng-Williamson K.A. Levetiracetam: a review of its use in epilepsy. Drugs 2011, 71:489-514.
23. McHugh T.J., Jones M.W., Quinn J.J., Balthasar N., Coppari R., Elmquist J.K., Lowell B.B., Fanselow M.S., Wilson M.A., Tonegawa S. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 2007, 317:94-99.
24. Miller S.L., Fenstermacher E., Bates J., Blacker D., Sperling R.A., Dickerson B.C. Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. J. Neurol. Neurosurg. Psychiatry 2008, 79:630-635.
25. Morris J.C. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993, 43:2412-2414.
26. O'Brien J.L., O'Keefe K.M., LaViolette P.S., DeLuca A.N., Blacker D., Dickerson B.C., Sperling R.A. Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline. Neurology 2010, 74:1969-1976.
27. Palop J.J., Chin J., Roberson E.D., Wang J., Thwin M.T., Bien-Ly N., Yoo J., Ho K.O., Yu G.Q., Kreitzer A., et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007, 55:697-711.
28. Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Tangalos E.G., Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol. 1999, 56:303-308.
29. Putcha D., Brickhouse M., O'Keefe K., Sullivan C., Rentz D., Marshall G., Dickerson B., Sperling R. Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults. J. Neurosci. 2011, 31:17680-17688.
30. Quiroz Y.T., Budson A.E., Celone K., Ruiz A., Newmark R., Castrillón G., Lopera F., Stern C.E. Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease. Ann. Neurol. 2010, 68:865-875.
31. Stark S.M., Yassa M.A., Stark C.E.L. Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learn. Mem. 2010, 17:284-288.
32. Toner C.K., Pirogovsky E., Kirwan C.B., Gilbert P.E. Visual object pattern separation deficits in nondemented older adults. Learn. Mem. 2009, 16:338-342.
33. Trivedi M.A., Schmitz T.W., Ries M.L., Hess T.M., Fitzgerald M.E., Atwood C.S., Rowley H.A., Asthana S., Sager M.A., Johnson S.C. fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's disease. Neuropsychologia 2008, 46:1667-1678.
34. Wechsler D. Wechsler Adult Intelligence Scale, Third Edition (WAIS-III) 1997, The Psychological Corporation, San Antonio, TX.
35. Wilson I.A., Ikonen S., McMahan R.W., Gallagher M., Eichenbaum H., Tanila H. Place cell rigidity correlates with impaired spatial learning in aged rats. Neurobiol. Aging 2003, 24:297-305.
36. Wilson I.A., Ikonen S., Gallagher M., Eichenbaum H., Tanila H. Age-associated alterations of hippocampal place cells are subregion specific. J. Neurosci. 2005, 25:6877-6886.
37. Wilson I.A., Gallagher M., Eichenbaum H., Tanila H. Neurocognitive aging: prior memories hinder new hippocampal encoding. Trends Neurosci. 2006, 29:662-670.
38. Yassa M.A., Stark C.E. A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe. Neuroimage 2009, 44:319-327.
39. Yassa M.A., Stark S.M., Bakker A., Albert M.S., Gallagher M., Stark C.E. High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment. Neuroimage 2010, 51:1242-1252.