Disruption of the klotho gene causes pulmonary emphysema in mice: Defect in maintenance of pulmonary integrity during postnatal life

American Journal of Respiratory Cell and Molecular Biology

Volumn 22, Issue 1, 2000, Pages 26-33

  Suga, Tatsuo ^a,b,c,d,e   Kurabayashi, Masahiko ^a,b,c,d,e   Sando, Yoshichika ^a,b,c,d,e   Ohyama, Yoshio ^a,b,c,d,e   Maeno, Toshitaka ^a,b,c,d,e   Maeno, Yuri ^a,b,c,d,e   Aizawa, Hiroki ^a,b,c,d,e   Matsumura, Yutaka ^a,b,c,d,e   Kuwaki, Tomoyuki ^a,b,c,d,e   Kuro O, Makoto ^a,b,c,d,e   Nabeshima, Yo ichi ^a,b,c,d,e   Nagai, Ryozo ^a,b,c,d,e  

^a GUNMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c CHIBA UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e Core Res for Evolutional S ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0034093125     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.22.1.3554     Document Type: Article

References (31)

1. 1. Snider, G. L., E. C. Lucey, and P. J. Stone. 1986. Animal models of emphysema. Am. Rev. Respir. Dis. 133:149-169.
2. 2. Snider, G. L. 1989. Chronic obstructive pulmonary disease: risk factors, pathophysiology and pathogenesis. Annu. Rev. Med. 40:411-429.
3. 3. Bascom, R. 1991. Differential susceptibility to tobacco smoke: possible mechanisms. Pharmacogenetics 1:102-106.
4. 4. Laurell, C. B., and S. Eriksson. 1963. The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency. Scand. J. Clin. Invest. 15: 132-140.
5. 5. Finlay, G. A., L. R. O'Driscoll, K. J. Russell, E. M. D'Arcy, J. B. Masterson, M. X. FitzGerald, and C. M. O'Connor. 1997. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema. Am. J. Respir. Crit. Care Med. 156:240-247.
6. 6. Hautamaki, R. D., D. K. Kobayashi, R. M. Senior, and S. D. Shapiro. 1997. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277:2002-2004.
7. 7. Smith, C. A. D., and D. J. Harrison. 1997. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Lancet 350:630-633.
8. 8. Kuro-o, M., Y. Matsumura, H. Aizawa, H. Kawaguchi, T. Suga, T. Utsugi, Y. Ohyama, M. Kurabayashi, T. Kaname, E. Kume, H. Iwasaki, A. Iida, T. Shiraki-Iida, S. Nishikawa, R. Nagai, and Y. Nabeshima. 1997. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
9. 9. Matsumura, Y., H. Aizawa, T. Shiraki-Iida, R. Nagai, M. Kuro-o, and Y. Nabeshima. 1998. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem. Biophys. Res. Commun. 242:626-630.
10. 10. Aizawa, H., Y. Saito, T, Nakamura, M. Inoue, T. Imanari, Y. Ohyama, Y. Matsumura, H. Masuda, S. Oba, N. Mise, K. Kimura, A. Hasegawa, M. Kurabayashi, M. Kuro-o, Y. Nabeshima, and R. Nagai. 1998. Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Biochem. Biophys. Res. Commun. 249:865-871.
11. 11. Saetta, M., R. J. Shiner, G. E. Angus, W. D. Kim, N. Wang, M. King, H. Ghezzo, and M. G. Cosio. 1985. Destructive index: a measurement of lung parenchymal destruction in smokers. Am. Rev. Respir. Dis. 131:764-769.
12. 12. Dunnill, M. S. 1962. Quantitative methods in the study of pulmonary pathology. Thorax 17:320-328.
13. 13. Palecek, F. 1969. Measurement of ventilatory mechanics in the rat. J. Appl. Physiol. 27:149-156.
14. 14. Onodera, M., T. Kuwaki, M. Kumada, and Y. Masuda. 1997. Determination of ventilatory volume in mice by whole body plethysmography. Jpn. J. Physiol. 47:317-326.
15. 15. Paterson, J. F., M. D. Hammond, M. R. Montgomery, J. T. Sharp, S. E. Farrier, and J. U. Balis. 1992. Acute ozone-induced lung injury in rats: structural-functional relationships of developing alveolar edema. Toxicol. Appl. Pharmacol. 117:37-45.
16. 16. Benton, W. D., and R. W. Davis. 1977. Screening lambdagt recombinant clones by hybridization to single plaques in situ. Science 196:180-182.
17. 17. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. 18. Thurlbeck, W. M. 1975. Postnatal growth and development of the lung. Am. Rev. Respir. Dis. 111:803-844.
19. 19. Haddad, A. G., R. L. Pimmel, D. D. Scaperoth, and P. A. Bromberg. 1979. Forced oscillatory respiratory parameters following papain exposure in dogs. J. Appl. Physiol. 46:61-66.
20. 20. Hirai, T., M. Hosokawa, K. Kawakami, Y. Takubo, N. Sakai, Y. Oku, K. Chin, M. Ohi, K. Higuchi, and K. Kuno 1995. Age-related changes in the static and dynamic mechanical properties of mouse lungs. Respir. Physiol. 102:195-203.
21. 21. Lwebuga, M. J. 1991. Matrix-driven pneumocyte differentiation. Am. Rev. Respir. Dis. 144:452-457.
22. 22. Otto, V. C., H. O. A. Ten, C. Franken, J. Hermans, and J. H. Dijkman. 1992. Protective effect of pulmonary surfactant on elastase-induced emphysema in mice. Eur. Respir. J. 5:1223-1230.
23. 23. Young, P. P., and C. R. Mendelson. 1997. A GT box element is essential for basal and cyclic adenosine 3′,5′-monophosphate regulation of the human surfactant protein A2 gene in alveolar type II cells: evidence for the binding of lung nuclear factors distinct from Sp1. Mol. Endocrinol. 11:1082-1093.
24. 24. Pollner, R., G. Fischer, E. Poschl, and K. Kuhn. 1990. Regulation of divergent transcription of the genes coding for basement membrane type IV collagen. Ann. NY Acad. Sci. 580:44-54.
25. 25. Fisk, D. E., and C. Kuhn. 1976. Emphysema-like changes in the lungs of the blotchy mouse. Am. Rev. Respir. Dis. 113:787-797.
26. 26. Mechanic, G. L., R. M. Farb, M. Henmi, V. Ranga, P. A. Bromberg, and M. Yamauchi. 1987. Structural crosslinking of lung connective tissue collagen in the blotchy mouse. Exp. Lung Res. 12:109-117.
27. 27. McCartney, A. C., B. Fox, T. A. Partridge, K. D. Macrae, T. D. Tetley, G. J. Phillips, and A. Guz. 1988. Emphysema in the blotchy mouse: a morphometric study. J. Pathol. 156:77-81.
28. 28. Szapiel, S. V., J. D. Fulmer, G. W. Hunninghake, N. A. Elson, O. Kawanami, V. J. Ferrans, and R. G. Crystal. 1981. Hereditary emphysema in the tight-skin (Tsk/+) mouse. Am. Rev. Respir. Dis. 123:680-685.
29. 29. Rossi, G. A., G. W. Hunninghake, J. E. Gadek, S. V. Szapiel., O. Ka wanami, V. J. Ferrans, and R. G. Crystal. 1984. Hereditary emphysema in the tight-skin mouse: evaluation of pathogenesis. Am. Rev. Respir. Dis. 129:850-855.
30. 30. Martorana, P. A., T. Brand, C. Gardi, Van E. P., de S. M., P. Calzoni, P. Marcolongo, and G. Lungarella. 1993. The pallid mouse: a model of genetic alpha I-antitrypsin deficiency. Lab. Invest. 68:233-241.
31. 31. Bostrom, H., K. Willetts, M. Pekny, P. Leveen, P. Lindahl, H. Hedstrand, M. Pekna, M. Hellstrom, M. S. Gebre, M. Schalling, M. Nilsson, S. Kurland, J. Tornell, J. K. Heath, and C. Betsholtz. 1996. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 85:863-873.