Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo

Kidney International

Volumn 80, Issue 5, 2011, Pages 475-482

  López, Ignacio ^a   Rodríguez Ortiz, M Encarnación ^b   Almadén, Yolanda ^b   Guerrero, Fátima ^b   Oca, A Montes De ^a   Pineda, Carmen ^a   Shalhoub, Vicky ^c   Rodríguez, Mariano ^b   Aguilera Tejero, Escolástico ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^c Department of Metabolic Disorders ^*  (United States)

Author keywords

Calcitriol; FGF23; Parathyroidectomy; PTH; Rat

Indexed keywords

CALCITRIOL; CALCIUM; FIBROBLAST GROWTH FACTOR 23; KLOTHO PROTEIN; PARATHYROID HORMONE; PHOSPHORUS; FGF23 PROTEIN, RAT; FIBROBLAST GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; HORMONE RELEASE; HYPERPHOSPHATEMIA; IN VIVO STUDY; INFUSION PUMP; KIDNEY; MALE; NONHUMAN; PARATHYROIDECTOMY; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; BLOOD; DRUG EFFECT;

ANIMALS; CALCITRIOL; CALCIUM; FIBROBLAST GROWTH FACTORS; PARATHYROID HORMONE; PARATHYROIDECTOMY; PHOSPHORUS; RATS;

EID: 84857067427     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.107     Document Type: Article

References (32)

1. Shimada T, Hasegawa H, Yamazaki Y et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 2004; 19: 429-435. (Pubitemid 38787398)
2. Shimada T, Kakitani M, Yamazaki Y et al. Targeted ablation of FgF23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 2004; 113: 561-568. (Pubitemid 38542505)
3. Liu S, Tang W, Zhou J et al. Fibroblast growth factor 23 is a counterregulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol 2006; 17: 1305-1315. (Pubitemid 43673410)
4. Barthel TK, Mathern DR, Whitfield GK et al. 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol 2007; 103: 381-388. (Pubitemid 46415670)
5. Komaba H, Fukagawa M. FGF23-parathyroid interaction: implications in chronic kidney disease. Kidney Int 2010; 77: 292-298.
6. Shigematsu T, Kazama JJ, Yamashita T et al. Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency. Am J Kid Dis 2004; 44: 250-256. (Pubitemid 38962552)
7. Gutierrez OM, Isakova T, Rhee E et al. Fibroblast growth factor 23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol 2005; 16: 2205-22015.
8. Gutierrez OM, Mannstadt M, Isakova T et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 2008; 359: 584-592.
9. Fukagawa M, Kazama JJ. FGF23: its role in renal bone disease. Pediatr Nephrol 2006; 21: 1802-1806. (Pubitemid 44741156)
10. Felsenfeld AJ, Rodriguez M, Aguilera-Tejero E. Dynamics of parathyroid hormone secretion in health and secondary hyperparathyroidism. Clin J Am Soc Nephrol 2007; 2: 1283-1305.
11. Rix M, Andreassen H, Eskildsen P et al. Bone mineral density and biochemical markers of bone turnover in patients with predialysis chronic renal failure. Kidney Int 1999; 56: 1084-1093. (Pubitemid 29411737)
12. Liu S, Zhou J, Tang W et al. Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab 2006; 291: E38-E49. (Pubitemid 44035308)
13. Kurosu H, Ogawa Y, Miyoshi M et al. Regulation of fibroblast growth factor-23 signaling by Klotho. J Biol Chem 2006; 281: 6120-6123. (Pubitemid 43847540)
14. Urakawa I, Yamazaki Y, Shimada T et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006; 444: 770-774. (Pubitemid 44949607)
15. Bai X, Dinghong Q, Miao D et al. Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype. Am J Physiol Endocrinol Metab 2009; 296: E79-E88.
16. Nakatani Y, Ohnishi M, Razzaque M S et al. Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model. FASEB J 2009; 23: 3702-3711.
17. Ben Dov IZ, Galitzer H, Lavi-Moshayoff V et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 2007; 117: 4003-4008. (Pubitemid 350224109)
18. Krajisnik T, Bjorklund P, Marsell R et al. Fibroblast growth factor-23 regulates parathyoid hormone and 1alpha-hydroxylase expression in culture bovine parathyroid cells. J Endocrinol 2007; 195: 125-131. (Pubitemid 350056006)
19. Canalejo R, Canalejo A, Martinez-Moreno JM et al. FGF23 fails to inhibit uremic parathyroid glands. J Am Soc Nephrol 2010; 21: 1125-1135.
20. Shigematsu T, Caverzasio J, Bonjour JP. Parathyroid removal prevents the progression of chronic renal failure induced by high protein diet. Kidney Int 1993; 44: 173-181. (Pubitemid 23198041)
21. Lempert UG, Scharla SH, Minne HW et al. Influence of parathyroidectomy, 1,25-dihydroxyvitamin D3 and high dietary calcium intake on demineralized bone matrix powder-induced bone formation in the rat. Bone Miner 1991; 13: 103-109.
22. Berdud I, Martin-Malo A, Almaden Y et al. The PTH-calcium relationship during a range of infused PTH doses in the parathyroidectomized rat. Calcif Tissue Int 1998; 62: 457-461. (Pubitemid 28180844)
23. Inoue Y, Segawa H, Kaneko I et al. Role of vitamin D receptor on FGF23 action in phosphate metabolism. Biochem J 2005; 390: 325-331. (Pubitemid 41192259)
24. Lobaugh B, Drezner MK. Abnormal regulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the X-linked hypophosphatemic mouse. J Clin Invest 1983; 71: 400-403. (Pubitemid 13137507)
25. Armbrecht HJ, Wongsurawat N, Zenser TV et al. Differential effects of parathyroid hormone on the renal 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 production of young and adult rats. Endocrinology 1982; 111: 1339-1344.
26. Urakawa I, Yamazaki Y, Shimada T et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006; 444: 770-774. (Pubitemid 44949607)
27. Nakatani T, Sarraj B, Ohnishi M et al. In vivo genetic evidence for klothodependent, fibroblast growth factor 23 (Fgf23)-mediated regulation of systemic phosphate homeostasis. FASEB J 2009; 23: 433-441.
28. Ohnishi M, Nakatani T, Lanske B et al. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1a-hydroxylase. Kidney Int 2009; 75: 1166-1172.
29. Ito M, Sakai Y, Furumoto M et al. Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells. Am J Physiol 2005; 288: E1101-E1109. (Pubitemid 40726796)
30. Kawata T, Imanishi Y, Kobayashi K et al. Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism. J Am Soc Nephrol 2007; 18: 2683-2688. (Pubitemid 47531195)
31. Yamashita H, Yamazaki Y, Hasegawa H et al. Fibroblast growth factor-23 (FGF23) in patients with transient hypoparathyroidism: its important role in serum phosphate regulation. Endocr J 2007; 54: 465-470. (Pubitemid 47105436)
32. Rodriguez M, Felsenfeld AJ, Llach F. Aluminum administration in the rat separately affects the osteoblast and bone mineralization. J Bone Miner Res 1990; 5: 59-67. (Pubitemid 20089904)