Neurogenetics of depression: A focus on reward processing and stress sensitivity

Neurobiology of Disease

Volumn 52, Issue , 2013, Pages 12-23

  Bogdan, Ryan ^a,b   Nikolova, Yuliya S ^b   Pizzagalli, Diego A ^c  

^a WASHINGTON UNIVERSITY   (United States)

^b DUKE UNIVERSITY   (United States)

^c MCLEAN HOSPITAL   (United States)

Author keywords

CRH; Depression; Dopamine; Fmri; Gene; HPA axis; Intermediate phenotype; Reward; Stress

Indexed keywords

CATECHOL METHYLTRANSFERASE; CORTICOTROPIN RELEASING FACTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE TRANSPORTER;

DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR DEPRESSION; MOLECULAR GENETICS; NEUROIMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; REVIEW; REWARD; SINGLE NUCLEOTIDE POLYMORPHISM; STRESS; STRESS ENSISITIVITY;

BRAIN; DEPRESSIVE DISORDER; FUNCTIONAL NEUROIMAGING; HUMANS; MAGNETIC RESONANCE IMAGING; PHENOTYPE; REWARD; STRESS, PSYCHOLOGICAL;

EID: 84873522183     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.05.007     Document Type: Review

References (218)

1. Aarts E., et al. Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging. Neuropsychopharmacology 2010, 35:1943-1951.
2. Agrawal, A., et al., in press. Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression. Arch. Gen. Psychiatry. http://dx.doi.org/10.1001/archgenpsychiatry.2011.2273.
3. Akil M., et al. Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J. Neurosci. 2003, 23:2008-2013.
4. American Psychiatric Association Diagnostic and statistical manual of mental disorders: DSM-IV-TR 2000, American Psychiatric Association, Washington, DC.
5. Anisman H., Matheson K. Stress, depression, and anhedonia: Caveats concerning animal models. Neurosci. Biobehav. Rev. 2005, 29:525-546.
6. Arinami T., et al. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum. Mol. Genet. 1997, 6:577-582.
7. Aschbacher K., et al. Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms. Brain Behav. Immun. 2012, 26:346-352.
8. Asghari V., et al. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J. Neurochem. 1995, 65:1157-1165.
9. Bakken T.E., et al. Association of genetic variants on 15q21 with cortical thickness and cognition in schizophrenia. Arch. Gen. Psychiatry 2011, 68:781-790.
10. Beckstead M.J., et al. CRF Enhancement of GIRK Channel-Mediated Transmission in Dopamine Neurons. Neuropsychopharmacology 2009, 34:1926-1935.
11. Belsky J., et al. Vulnerability genes or plasticity genes?. Mol. Psychiatry 2009, 14:746-754.
12. Berenbaum H., Connelly J. The effect of stress on hedonic capacity. J. Abnorm. Psychol. 1993, 102:474-481.
13. Berridge K.C., et al. Dissecting components of reward: 'liking', 'wanting', and learning. Curr. Opin. Pharmacol. 2009, 9:65-73.
14. Bertolino A., et al. Genetically Determined Interaction between the Dopamine Transporter and the D2 Receptor on Prefronto-Striatal Activity and Volume in Humans. J. Neurosci. 2009, 29:1224-1234.
15. Bijttebier P., et al. Responses to positive affect predict mood symptoms in children under conditions of stress: a prospective study. J. Abnorm. Child Psychol. 2011, 40:381-389.
16. Bilder R.M., et al. The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic-Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes. Neuropsychopharmacology 2004, 29:1943-1961.
17. Binder E.B. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009, 34(Suppl. 1):S186-S195.
18. Binder E.B., Nemeroff C.B. The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol. Psychiatry 2009, 15:574-588.
19. Bis J.C., et al. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat. Genet. 2012, 44:545-551.
20. Blomeyer D., et al. Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. Biol. Psychiatry 2008, 63:146-151.
21. Blood A.J., et al. Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder. PLoS One 2010, 5:e13945.
22. Bochdanovits Z., et al. Joint reanalysis of 29 correlated SNPs supports the role of PCLO/Piccolo as a causal risk factor for major depressive disorder. Mol. Psychiatry 2009, 14:650-652.
23. Bogdan, R., et al., in press. A neurogenetics approach to understanding individual differences inbrain, behavior, and risk for psychopathology. Mol. Psychiatry. http://dx.doi.org/10.1038/mp2012.35.
24. Bogdan R., Pizzagalli D. Acute Stress Reduces Reward Responsiveness: Implications for Depression. Biol. Psychiatry 2006, 60:1147-1154.
25. Bogdan R., Pizzagalli D.A. The heritability of hedonic capacity and perceived stress: a twin study evaluation of candidate depressive phenotypes. Psychol. Med. 2009, 39:211-218.
26. Bogdan R., et al. The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning. Genes Brain Behav. 2010, 9:658-667.
27. Bogdan R., et al. Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. J. Neurosci. 2011, 31:13246-13254.
28. Bosker F.J., et al. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol. Psychiatry 2011, 16:516-532.
29. Bradley R.G., et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch. Gen. Psychiatry 2008, 65:190-200.
30. Brady K.T., et al. Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals. Arch. Gen. Psychiatry 2009, 66:422-430.
31. Brookes K.J., et al. Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post-mortem midbrain tissue. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007, 144B:1070-1078.
32. Brown G.W., Harris T.O. Social origins of depression: a study of psychiatric disorder in women 1978, Free Press, New York.
33. Buckholtz J.W., et al. fMRI evidence for functional epistasis between COMT and RGS4. Mol. Psychiatry 2007, 12(893-5):885.
34. Camara E., et al. The effects of COMT (Val108/158Met) and DRD4 (SNP -521) dopamine genotypes on brain activations related to valence and magnitude of rewards. Cereb. Cortex. 2010, 20:1985-1996.
35. Cannon T.D., Keller M.C. Endophenotypes in the Genetic Analyses of Mental Disorders. Annu. Rev. Clin. Psychol. 2006, 2:267-290.
36. Caspi A., et al. Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene. Science 2003, 301:386-389.
37. Caspi A., et al. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am. J. Psychiatry 2010, 167:509-527.
38. Cen X., et al. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Mol. Psychiatry 2008, 13(349):451-463.
39. Chakrabarti B., Baron-Cohen S. Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. Mol. Autism. 2011, 2:10.
40. Chakrabarti B., et al. Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces. Eur. J. Neurosci. 2006, 23:1944-1948.
41. Chen J., et al. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am. J. Hum. Genet. 2004, 75:807-821.
42. Chen M.C., et al. Serotonin transporter polymorphism predicts waking cortisol in young girls. Psychoneuroendocrinology 2009, 34:681-686.
43. Cheon K.A., et al. The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate. Eur. Neuropsychopharmacol. 2005, 15:95-101.
44. Chiang K.P., et al. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Hum. Mol. Genet. 2004, 13:2113-2119.
45. Cichon S., et al. Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Am. J. Psychiatry 2009, 166:540-556.
46. Cohen M.X., et al. Individual differences in extraversion and dopamine genetics predict neural reward responses. Brain Res. Cogn. Brain Res. 2005, 25:851-861.
47. de Kloet E.R., et al. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 2005, 6:463-475.
48. Derijk R., et al. Corticosteroid receptor-gene variants: Modulators of the stress-response and implications for mental health. Eur. J. Pharmacol. 2008, 585:492-501.
49. Deutch A.Y. The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. J. Neural. Transm. 1992, (Suppl. 36):61-89.
50. Dichter G.S., et al. The Effects of Psychotherapy on Neural Responses to Rewards in Major Depression. Biol. Psychiatry 2009, 66:886-897.
51. Diekhof E., et al. Functional neuroimaging of reward processing and decision-making: A review of aberrant motivational and affective processing in addiction and mood disorders. Brain Res. Rev. 2008, 59:164-184.
52. Dillon D.G., et al. Dissociation of neural regions associated with anticipatory versus consummatory phases of incentive processing. Psychophysiology 2008, 45:36-49.
53. Dillon D.G., et al. Childhood Adversity Is Associated with Left Basal Ganglia Dysfunction During Reward Anticipation in Adulthood. Biol. Psychiatry 2009, 66:206-213.
54. Dillon D.G., et al. Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. Hum. Brain Mapp. 2010, 31:210-221.
55. Dowd E.C., Barch D.M. Anhedonia and emotional experience in schizophrenia: neural and behavioral indicators. Biol. Psychiatry 2010, 67:902-911.
56. Dreher J.C., et al. Variation in dopamine genes influences responsivity of the human reward system. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:617-622.
57. Duval F., et al. Cortisol hypersecretion in unipolar major depression with melancholic and psychotic features: dopaminergic, noradrenergic and thyroid correlates. Psychoneuroendocrinology 2006, 31:876-888.
58. Ege M.J., et al. Gene-environment interaction for childhood asthma and exposure to farming in Central Europe. J. Allergy Clin. Immunol. 2011, 127:138-144. (144 e1-4).
59. Egerton A., et al. The dopaminergic basis of human behaviors: A review of molecular imaging studies. Neurosci. Biobehav. Rev. 2009, 33:1109-1132.
60. Epstein J., et al. Lack of ventral striatal response to positive stimuli in depressed versus normal subjects. Am. J. Psychiatry 2006, 163:1784-1790.
61. Fawcett J., et al. Assessing anhedonia in psychiatric patients. Arch. Gen. Psychiatry 1983, 40:79-84.
62. Filbey F.M., et al. Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology 2010, 35:967-975.
63. Fliessbach K., et al. Retest reliability of reward-related BOLD signals. NeuroImage 2010, 50:1168-1176.
64. Flint J., Munafo M.R. The endophenotype concept in psychiatric genetics. Psychol. Med. 2007, 37:163-180.
65. Forbes E.E., et al. Reward-related decision-making in pediatric major depressive disorder: an fMRI study. J. Child Psychol. Psychiatry 2006, 47:1031-1040.
66. Forbes E.E., et al. Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. Mol. Psychiatry 2009, 14:60-70.
67. Fox H.C., et al. Reliability of salivary cortisol assessments in cocaine dependent individuals. J. Psychopharmacol. 2006, 20:650-655.
68. Fox E., et al. The Serotonin Transporter Gene Alters Sensitivity to Attention Bias Modification: Evidence for a Plasticity Gene. Biol. Psychiatry 2011, 70:1049-1054.
69. Garcia J.R., et al. Associations between dopamine D4 receptor gene variation with both infidelity and sexual promiscuity. PLoS One 2010, 5:e14162.
70. George S.A., et al. CRH-stimulated cortisol release and food intake in healthy, non-obese adults. Psychoneuroendocrinology 2010, 35:607-612.
71. Gerfen C.R., et al. D1 and D2 dopamine receptor function in the striatum: coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons. J. Neurosci. 1995, 15:8167-8176.
72. Gibbons J.L., Mc H.P. Plasma cortisol in depressive illness. J. Psychiatr. Res. 1962, 1:162-171.
73. Gold P.W., Chrousos G.P. The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences. Proc. Assoc. Am. Physicians 1999, 111:22-34.
74. Gold P.W., et al. Divergent endocrine abnormalities in melancholic and atypical depression: clinical and pathophysiologic implications. Endocrinol. Metab. Clin. North Am. 2002, 31:37-62. (vi).
75. Goldman D., Ducci F. Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes. ScientificWorldJournal 2007, 7:124-130.
76. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 2003, 160:636-645.
77. Grace A.A. Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia. J. Neural. Trans. 1993, 91:111-134.
78. Haber S.N., Knutson B. The Reward Circuit: Linking Primate Anatomy and Human Imaging. Neuropsychopharmacology 2009, 35:4-26.
79. Haenisch B., et al. Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009, 150B:1013-1016.
80. Hammen C. Stress and depression. Annu. Rev. Clin. Psychol. 2005, 1:293-319.
81. Hankin B.L., et al. Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'. Transl. Psychiatry 2011, 1:e44.
82. Hariri A.R. The Neurobiology of Individual Differences in Complex Behavioral Traits. Annu. Rev. Neurosci. 2009, 32:225-247.
83. Hariri A.R., et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002, 297:400-403.
84. Hariri A.R., et al. Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. J. Neurosci. 2006, 26:13213-13217.
85. Hariri A.R., et al. Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. Biol. Psychiatry 2009, 66:9-16.
86. Hasler G., Northoff G. Discovering imaging endophenotypes for major depression. Mol. Psychiatry 2011, 16:604-619.
87. Hasler G., et al. Discovering Endophenotypes for Major Depression. Neuropsychopharmacology 2004, 29:1765-1781.
88. Hauger R.L., et al. Corticotropin releasing factor (CRF) receptor signalling in the central nervous system: New molecular targets. CNS Neurol. Disord. Drug Targets 2006, 5:453-479.
89. Heils A., et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 1996, 66:2621-2624.
90. Heinz A., et al. Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology 2000, 22:133-139.
91. Hek K., et al. The PCLO gene and depressive disorders: replication in a population-based study. Hum. Mol. Genet. 2010, 19:731-734.
92. Heller A.S., et al. Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:22445-22450.
93. Heurteaux C., et al. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype. Nat. Neurosci. 2006, 9:1134-1141.
94. Hodgkinson C.A., et al. Genome-wide association identifies candidate genes that influence the human electroencephalogram. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:8695-8700.
95. Hoogman M., et al. Nitric oxide synthase genotype modulation of impulsivity and ventral striatal activity in adult ADHD patients and healthy comparison subjects. Am. J. Psychiatry 2011, 168:1099-1106.
96. Hyman S.E. Can neuroscience be integrated into the DSM-V?. Nat. Rev. Neurosci. 2007, 8:725-732.
97. Ibi D., et al. Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region. Neurochem. Int. 2010, 56:77-83.
98. Insel T.R., Cuthbert B.N. Endophenotypes: bridging genomic complexity and disorder heterogeneity. Biol. Psychiatry 2009, 66:988-989.
99. Insel T., et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am. J. Psychiatry 2010, 167:748-751.
100. Jahn A.L., et al. Subgenual Prefrontal Cortex Activity Predicts Individual Differences in Hypothalamic-Pituitary-Adrenal Activity Across Different Contexts. Biol. Psychiatry 2010, 67:175-181.
101. Jonsson E.G., et al. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol. Psychiatry 1999, 4:290-296.
102. Karg K., et al. The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited: Evidence of Genetic Moderation. Arch. Gen. Psychiatry 2011, 68:444-454.
103. Kasch K.L., et al. Behavioral activation and inhibition systems and the severity and course of depression. J. Abnorm. Psychol. 2002, 111:589-597.
104. Keedwell P., et al. A Double Dissociation of Ventromedial Prefrontal Cortical Responses to Sad and Happy Stimuli in Depressed and Healthy Individuals. Biol. Psychiatry 2005, 58:495-503.
105. Keedwell P., et al. The Neural Correlates of Anhedonia in Major Depressive Disorder. Biol. Psychiatry 2005, 58:843-853.
106. Kendler K.S., Gardner C.O. Boundaries of major depression: an evaluation of DSM-IV criteria. Am. J. Psychiatry 1998, 155:172-177.
107. Kendler K.S., Neale M.C. Endophenotype: a conceptual analysis. Mol. Psychiatry 2010, 15:789-797.
108. Kendler K.S., et al. Causal relationship between stressful life events and the onset of major depression. Am. J. Psychiatry 1999, 156:837-841.
109. Kendler K.S., et al. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch. Gen. Psychiatry 2005, 62:529-535.
110. Klein D.F. Depression and anhedonia. Anhedonia and affect deficit states 1987, PMA Publishing Corporation, NY. D.C. Clark, J. Fawcett (Eds.).
111. Knutson B., Gibbs S.E.B. Linking nucleus accumbens dopamine and blood oxygenation. Psychopharmacology 2007, 191:813-822.
112. Knutson B., et al. FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task. NeuroImage 2000, 12:20-27.
113. Knutson B., et al. Neural Responses to Monetary Incentives in Major Depression. Biol. Psychiatry 2008, 63:686-692.
114. Koks S., et al. Analysis of SNP profiles in patients with major depressive disorder. Int. J. Neuropsychopharmacol. 2006, 9:167-174.
115. Krugel L.K., et al. Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:17951-17956.
116. Kudielka B., et al. Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge. Psychoneuroendocrinology 2009, 34:2-18.
117. Kuehner C., et al. PCLO rs 2522833 impacts HPA system activity in healthy young adults. Transl. Psychiatry 2011, 1:e10.
118. Kumar P., et al. Abnormal temporal difference reward-learning signals in major depression. Brain 2008, 131:2084-2093.
119. Kuningas M., et al. Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology 2007, 32:1295-1301.
120. Lee M.R., et al. Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. PLoS One 2011, 6:e24203.
121. Lesch K.P., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531.
122. Levinson D.F. The genetics of depression: a review. Biol. Psychiatry 2006, 60:84-92.
123. Lewis C.M., et al. Genome-wide association study of major recurrent depression in the U.K. population. Am. J. Psychiatry 2010, 167:949-957.
124. Lighthall N.R., et al. Gender differences in reward-related decision processing under stress. Soc. Cogn. Affect. Neurosci. 2011, 7:476-484.
125. Liou Y.J., et al. Support for the involvement of the KCNK2 gene in major depressive disorder and response to antidepressant treatment. Pharmacogenet. Genomics 2009, 19:735-741.
126. Loas G. Vulnerability to depression: a model centered on anhedonia. J. Affect. Disord. 1996, 41:39-53.
127. Lohoff F.W. Overview of the genetics of major depressive disorder. Curr. Psychiatry Rep. 2010, 12:539-546.
128. Lopez-Duran N.L., et al. Hypothalamic-pituitary-adrenal axis dysregulation in depressed children and adolescents: A meta-analysis. Psychoneuroendocrinology 2009, 34:1272-1283.
129. López-León S., et al. Meta-analyses of genetic studies on major depressive disorder. Mol. Psychiatry 2007, 13:772-785.
130. Lotta T., et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995, 34:4202-4210.
131. Marquez C., et al. Responsiveness of the hypothalamic-pituitary-adrenal axis to different novel environments is a consistent individual trait in adult male outbred rats. Psychoneuroendocrinology 2005, 30:179-187.
132. Martinez D., et al. The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. Neuropsychopharmacology 2001, 24:553-560.
133. Mazella J., et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010, 13:e1000355.
134. Mazure C.M. Life stressors as risk factors in depression. Clin. Psychol. Sci. Pract. 1998, 5:291-313.
135. McEwen B.S., Gianaros P.J. Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease. Ann. N. Y. Acad. Sci. 2010, 1186:190-222.
136. Meehl P.E. Hedonic capacity: some conjectures. Bull. Menn. Clin. 1975, 39:295-307.
137. Meyer-Lindenberg A., Weinberger D.R. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 2006, 7:818-827.
138. Meyer-Lindenberg A., et al. Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat. Neurosci. 2005, 8:594-596.
139. Mill J., et al. Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1). BMC Genet. 2005, 6:3.
140. Muglia P., et al. Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol. Psychiatry 2010, 15:589-601.
141. Munafo M.R., et al. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol. Psychiatry 2008, 63:852-857.
142. Murphy D., et al. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology 2008, 55:932-960.
143. Muscatell K.A., et al. Stressful life events, chronic difficulties, and the symptoms of clinical depression. J. Nerv. Ment. Dis. 2009, 197:154-160.
144. Myerson A. Anhedonia. Am. J. Psychiatry 1922, 79:87-103.
145. Nestler E.J., Carlezon W.A. The mesolimbic dopamine reward circuit in depression. Biol. Psychiatry 2006, 59:1151-1159.
146. Nikolova, Y.S., et al., in press. Ventral striatal reactivity to reward and recent life stress interact to predict postive affect. Biol. Psychiatry. http://dx.doi.org/10.1016/j.biopsych.2012.03.014.
147. Nikolova Y.S., et al. Multilocus Genetic Profile for Dopamine Signaling Predicts Ventral Striatum Reactivity. Neuropsychopharmacology 2011, 36:1940-1947.
148. Nikolova Y.S., et al. Perception of a naturalistic stressor interacts with 5-HTTLPR genotype and gender to impact reward responsiveness. Neuropsychobiology 2012, 65:45-54.
149. Noble E.P. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am. J. Med. Genet. B 2003, 116B:103-125.
150. O'Doherty J.P., et al. Temporal difference models and reward-related learning in the human brain. Neuron 2003, 38:329-337.
151. Oei T.I., et al. Anhedonia, suicide ideation and dexamethasone nonsuppression in depressed patients. J. Psychiatr. Res. 1990, 24:25-35.
152. Opmeer E.M., et al. Depression and the role of genes involved in dopamine metabolism and signalling. Prog. Neurobiol. 2010, 92:112-133.
153. Ossewaarde L., et al. Two-week administration of the combined serotonin-noradrenaline reuptake inhibitor duloxetine augments functioning of mesolimbic incentive processing circuits. Biol. Psychiatry 2011, 70:568-574.
154. Pascucci T., et al. The Medial Prefrontal Cortex Determines the Accumbens Dopamine Response to Stress through the Opposing Influences of Norepinephrine and Dopamine. Cereb. Cortex. 2007, 17:2796-2804.
155. Pecina S., et al. Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?. BMC Biol. 2006, 4:8.
156. Pei L., et al. Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects. Nat. Med. 2012, 16:1393-1995.
157. Pelizza L., Ferrari A. Anhedonia in schizophrenia and major depression: state or trait?. Ann. Gen. Psychiatry 2009, 8:22.
158. Perlis R.H., et al. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: Association of TREK1 and treatment resistance in the STAR(*)D Study. Neuropsychopharmacology 2008, 33:2810-2819.
159. Piazza P.V., et al. Stress, glucocorticoids, and mesencephalic dopaminergic neurons: a pathophysiological chain determining vulnerability to psychostimulant abuse. NIDA Res. Monogr. 1996, 163:277-299.
160. Pintor L., et al. Corticotropin-releasing factor test in melancholic patients in depressed state versus recovery: A comparative study. Prog. Neuropsychopharmacol. Biol. Psychiatry 2007, 31:1027-1033.
161. Pizzagalli D.A., et al. Toward an objective characterization of an anhedonic phenotype: a signal-detection approach. Biol. Psychiatry 2005, 57:319-327.
162. Pizzagalli D.A., et al. Increased perceived stress is associated with blunted hedonic capacity: potential implications for depression research. Behav. Res. Ther. 2007, 45:2742-2753.
163. Pizzagalli D.A., et al. Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task. J. Psychiatr. Res. 2008, 43:76-87.
164. Pizzagalli D.A., et al. Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. Am. J. Psychiatry 2009, 166:702-710.
165. Pohjalainen T., et al. The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol. Psychiatry 1998, 3:256-260.
166. Polanczyk G., et al. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. Arch. Gen. Psychiatry 2009, 66:978-985.
167. Potkin S.G., et al. A. Hippocampal atrophy as a quantitative trait in genome-wide association study identifying novel susceptiility genes for Alzheimer's disease. PLoS One 2009, 4:e6501.
168. Potkin S.G., et al. B. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr. Bull. 2009, 35:96-108.
169. Pruessner J.C., et al. Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations - 2008 Curt Richter Award Winner. Psychoneuroendocrinology 2010, 35:179-191.
170. Purcell S.M., et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752.
171. Risch N., et al. Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis. JAMA 2009, 301:2462-2471.
172. Ritchie T., Noble E.P. Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochem. Res. 2003, 28:73-82.
173. Robins E., Guze S.B. Establoishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. Am. J. Psychiatry 1970, 126:983-987.
174. Rodriguez-Murillo L., et al. The genetic architecture of schizophrenia: Ne wmutations and emerging paradigms. Annu. Rev. Med. 2012, 63:63-80.
175. Roussos P., et al. Cognitive and emotional processing associated with the Season of Birth and dopamine D4 receptor gene. Neuropsychologia 2010, 48:3926-3933.
176. Rucker, J.J., et al., in press. Genome-wide association analysis of copy number variation in recurrent depressive disorder. Mol. Psychiatry. http://dx.doi.org/10.1038/mp.2011.144.
177. Salimpoor V.N., et al. Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nat. Neurosci. 2011, 14:257-262.
178. Salvadore G., et al. Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans. Biol. Psychiatry 2009, 66:804-807.
179. Sanislow C.A., et al. Developing constructs for psychopathology research: research domain criteria. J. Abnorm. Psychol. 2010, 119:631-639.
180. Schacht J.P., et al. Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approach. NeuroImage 2011, 56:61-68.
181. Schuhmacher A., et al. PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder. Int. J. Neuropsychopharmacol. 2011, 14:237-245.
182. Schultz W. Behavioral dopamine signals. Trends Neurosci. 2007, 30:203-210.
183. Schwabe L., Wolf O.T. Stress-induced modulation of instrumental behavior: from goal-directed to habitual control of action. Behav. Brain Res. 2011, 219:321-328.
184. Shen L., et al. Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. NeuroImage 2010, 53:1051-1063.
185. Shi J., et al. Genome-wide association study of recurrent early-onset major depressive disorder. Mol. Psychiatry 2011, 16:193-201.
186. Shyn S.I., et al. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol. Psychiatry 2011, 16:202-215.
187. Smeraldi E., et al. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol. Psychiatry 1998, 3:508-511.
188. Stein J.L., et al. Identification of common variants associated with human hippocampal and intracranial volumes. Nat. Genet. 2012, 44:552-561.
189. Stetler C., Miller G.E. Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom. Med. 2011, 73:114-126.
190. Stice E., et al. Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele. Science 2008, 322:449-452.
191. Stoy M., et al. Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram. J. Psychopharmacol. 2011, 26:677-688.
192. Sullivan P.F., et al. Genetic epidemiology of major depression: review and meta-analysis. Am. J. Psychiatry 2000, 157:1552-1562.
193. Sullivan P.F., et al. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol. Psychiatry 2009, 14:359-375.
194. Taber M.T., et al. Cortical regulation of subcortical dopamine release: mediation via the ventral tegmental area. J. Neurochem. 1995, 65:1407-1410.
195. Thode K., et al. Functional effects of polymorphisms in the human corticotropin-releasing hormone receptor 1 (CRHR1) gene. Poster presented at the Annua Meeting of the American Psychiatric Association 2009.
196. Trantham-Davidson H., et al. Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex. J. Neurosci. 2004, 24:10652-10659.
197. Treadway M.T., Zald D.H. Reconsidering anhedonia in depression: Lessons from translational neuroscience. Neurosci. Biobehav. Rev. 2011, 35:537-555.
198. Trivedi M.H., et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: Implications for clinical practice. Am. J. Psychiatry 2006, 163:28-40.
199. Tyrka A.R., et al. Interaction of Childhood Maltreatment with the Corticotropin-Releasing Hormone Receptor Gene: Effects on Hypothalamic-Pituitary-Adrenal Axis Reactivity. Biol. Psychiatry 2009, 66:681-685.
200. Ulrich-Lai Y.M., Herman J.P. Neural regulation of endocrine and autonomic stress responses. Nat. Rev. Neurosci. 2009, 10:397-409.
201. Ulrich-Lai Y.M., et al. Pleasurable behaviors reduce stress via brain reward pathways. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:20529-20534.
202. Urry H.L., et al. Amygdala and Ventromedial Prefrontal Cortex Are Inversely Coupled during Regulation of Negative Affect and Predict the Diurnal Pattern of Cortisol Secretion among Older Adults. J. Neurosci. 2006, 26:4415-4425.
203. Ursini G., et al. Stress-Related Methylation of the Catechol-O-Methyltransferase Val158 Allele Predicts Human Prefrontal Cognition and Activity. J. Neurosci. 2011, 31:6692-6698.
204. van Praag H.M., et al. Stress, the brain and depression 2004, xii. Cambridge University Press, Cambridge, UK ; New York, 283 pp.
205. Villafuerte S., et al. Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. Mol. Psychiatry 2011, 17:511-519.
206. Watson D., et al. Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples. J. Abnorm. Psychol. 1995, 104:15-25.
207. Watson K.K., et al. Serotonin transporter genotype modulates social reward and punishment in rhesus macaques. PLoS One 2009, 4:e4156.
208. Williams G.V., Millar J. Concentration-dependent actions of stimulated dopamine release on neuronal activity in rat striatum. Neuroscience 1990, 39:1-16.
209. Willner P. Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS. Neuropsychobiology 2005, 52:90-110.
210. Willner O. Anhedonia. Symptoms of depression 1993, John Wiley & Sons, Inc., NY. C.G. Costello (Ed.).
211. Wise R.A. Catecholamine theories of reward: a critical review. Brain Res. 1978, 152:215-247.
212. Wise R.A. Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotox. Res. 2008, 14:169-183.
213. World Health Organization. International statistical classification of diseases and related health problems 2004, World Health Organization, Geneva.
214. Yacubian J., et al. Gene-gene interaction associated with neural reward sensitivity. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:8125-8130.
215. Yehuda R. Post-traumatic stress disorder. N. Engl. J. Med. 2002, 346:108-114.
216. Zhang T.Y., Meaney M.J. Epigenetics and the environmental regulation of the genome and its function. Annu. Rev. Psychol. 2010, 61(439-66):C1-C3.
217. Zieba B., et al. The behavioural and electrophysiological effects of CRF in rat frontal cortex. Neuropeptides 2008, 42:513-523.
218. Zimmermann P., et al. Interaction of FKBP5 Gene Variants and Adverse Life Events in Predicting Depression Onset: Results From a 10-Year Prospective Community Study. Am. J. Psychiatry 2011, 168:1107-1116.