Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 52, 2009, Pages 22445-22450

  Heller, Aaron S ^a,b   Johnstone, Tom ^c   Shackman, Alexander J ^a,b   Light, Sharee N ^a,b   Peterson, Michael J ^d   Kolden, Gregory G ^b,d   Kalin, Ned H ^b,d   Davidson, Richard J ^a,b,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF READING   (United Kingdom)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Anhedonia; Emotion regulation; Nucleus accumbens

Indexed keywords

ADULT; AFFECT; ANHEDONIA; ARTICLE; CLINICAL ARTICLE; CONTROL GROUP; CORPUS STRIATUM; EMOTION; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN EXPERIMENT; IMAGE INTENSIFIER; MAJOR DEPRESSION; MALE; MENTAL PATIENT; NERVE CELL NETWORK; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; REWARD; SELF REPORT; TASK PERFORMANCE;

ADULT; AFFECT; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; EMOTIONS; FEMALE; FRONTAL LOBE; HUMANS; MALE; MIDDLE AGED; NUCLEUS ACCUMBENS; REWARD; VISUAL CORTEX; YOUNG ADULT;

EID: 76049128458     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910651106     Document Type: Article

References (54)

1. American Psychiatric Association (2000) Diagnostic Criteria from DSM-IV-TR (Am Psychiatric Assoc, Arlington, VA), p xii.
2. Nestler EJ, Carlezon WA, Jr (2006) The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 59:1151-1159.
3. Nestler EJ, et al. (2002) Neurobiology of depression. Neuron 34:13-25.
4. Tremblay LK, et al. (2005) Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Arch Gen Psychiatry 62:1228-1236.
5. Del Arco A, Mora F (2008) Prefrontal cortex-nucleus accumbens interaction: In vivo modulation by dopamine and glutamate in the prefrontal cortex. Pharmacol Biochem Behav 90:226-235.
6. Wager TD, Davidson ML, Hughes BL, Lindquist MA, Ochsner KN (2008) Prefrontalsubcortical pathways mediating successful emotion regulation. Neuron 59:1037-1050.
7. Kim SH, Hamann S (2007) Neural correlates of positive and negative emotion regulation. J Cogn Neurosci 19:776-798.
8. Grace AA, Floresco SB, Goto Y, Lodge DJ (2007) Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci 30:220-227.
9. Myerson A (1922) Anhedonia. Am J Psychiatry 2:87-103.
10. Meehl PE (1975) Hedonic capacity: Some conjectures. Bull Menninger Clin 39:295-307.
11. Sloan DM, Bradley MM, Dimoulas E, Lang PJ (2002) Looking at facial expressions: Dysphoria and facial EMG. Biol Psychol 60:79-90.
12. Larson CL, Nitschke JB, Davidson RJ (2007) Common and distinct patterns of affective response in dimensions of anxiety and depression. Emotion 7:182-191.
13. Fiorito ER, Simons RF (1994) Emotional imageryandphysical anhedonia. Psychophysiology 31:513-521.
14. Kaviani H, et al. (2004) Affective modulation of the startle response in depression: Influence of the severity of depression, anhedonia, and anxiety. J Affect Disord 83:21-31.
15. Germans MK, Kring AM (2000) Hedonic deficit in anhedonia: Support for the role of approach motivation. Pers Individ Dif 28:14.
16. Berlin IG-S, L., Lecrubier Y, Puech AJ (1998) Measures of anhedonia and hedonic responses to sucrose in depressive and schizophrenic patients in comparison to healthy subjects. Eur Psychiatry 13:7.
17. Keedwell PA, Andrew C, Williams SC, Brammer MJ, Phillips ML(2005) The neural correlates of anhedonia in major depressive disorder. Biol Psychiatry 58:843-853.
18. Epstein J, et al. (2006) Lack of ventral striatal response to positive stimuli in depressed versus normal subjects. Am J Psychiatry 163:1784-1790.
19. Knutson B, Bhanji JP, Cooney RE, Atlas LY, Gotlib IH (2008) Neural responses to monetary incentives in major depression. Biol Psychiatry 63:686-692.
20. Schaefer HS, Putnam KM, Benca RM, Davidson RJ (2006) Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression. Biol Psychiatry 60:974-986.
21. Mitterschiffthaler MT, et al. (2003) Neural response to pleasant stimuli in anhedonia: An fMRI study. Neuroreport 14:177-182.
22. Harvey PO, Pruessner J, Czechowska Y, Lepage M (2007) Individual differences in trait anhedonia: A structural and functional magnetic resonance imaging study in non-clinical subjects. Mol Psychiatry 12:767-775.
23. Tomarken AJ, Keener AD (1998) Frontal brain asymmetry and depression: A selfregulatory perspective. Cogn Emot 12:34.
24. Urry HL, van Reekum CM, Johnstone T, Davidson RJ (2009) Individual differences in some (but not all) medial prefrontal regions reflect cognitive demand while regulating unpleasant emotion. NeuroImage 47:852-863.
25. Kriegeskorte N, Simmons WK, Bellgowan PS, Baker CI (2009) Circular analysis in systems neuroscience: The dangers of double dipping. Nat Neurosci 12:535-540.
26. Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: The PANAS scales. J Pers Soc Psychol 54:1063-1070.
27. Urry HL, et al. (2006) Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of cortisol secretion among older adults. J Neurosci 26:4415-4425.
28. Kahneman D, Beatty J (1966) Pupil diameter and load on memory. Science 154:1583-1585.
29. Pizzagalli DA, Iosifescu D, Hallett LA, Ratner KG, Fava M (2008) Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task. J Psychiatric Res 43:76-87.
30. Knutson B, Wimmer GE (2007) Splitting the difference: How does the brain code reward episodes? Ann NY Acad Sci 1104:54-69.
31. Wise RA (2002) Brain reward circuitry: Insights from unsensed incentives. Neuron 36:229-240.
32. Knutson B, Cooper JC (2005) Functional magnetic resonance imaging of reward prediction. Curr Opin Neurol 18:411-417.
33. Johnstone T, van Reekum CM, Urry HL, Kalin NH, Davidson RJ (2007) Failure to regulate: Counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. J Neurosci 27:8877-8884.
34. Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28:309-369.
35. Pizzagalli DA, et al. (2009) Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. Am J Psychiatry 166:702-710.
36. O'Doherty J, et al. (2004) Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science 304:452-454.
37. Tricomi EM, Delgado MR, Fiez JA (2004) Modulation of caudate activity by action contingency. Neuron 41:281-292.
38. Lewinsohn PM (1974) in The Psychology of Depression: Contemporary Theory and Research, eds Friedman RJ, Katz MM (Wiley, New York), p 30.
39. Hoberman HM, Lewinsohn, P.M (1985) in Handbook of Depression: Treatment, Assessment, and Research, eds Beckham EE, Leber WR (Dorsey, Homewood, IL), p 43.
40. Salamone JD, Correa M, Mingote S, Weber SM (2003) Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: Implications for studies of natural motivation, psychiatry, and drug abuse. J Pharmacol Exp Ther 305:1-8.
41. Salamone JD, Correa M, Farrar A, Mingote SM (2007) Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology (Berl) 191:461-482.
42. Davidson RJ (2003) Affective neuroscience and psychophysiology: Toward a synthesis. Psychophysiology 40:655-665.
43. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62.
44. Jackson DC, Malmstadt JR, Larson CL, Davidson RJ (2000) Suppression and enhancement of emotional responses to unpleasant pictures. Psychophysiology 37:515-522.
45. Schaefer SM, et al. (2002) Modulation of amygdalar activity by the conscious regulation of negative emotion. J Cognit Neurosci 14:913-921.
46. Ochsner KN, et al. (2004) For better or for worse: Neural systems supporting the cognitive down- and up-regulation of negative emotion. NeuroImage 23:483-499.
47. Lang PJ BM, Cuthbert BN (2005) International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual. Technical Report A-6 (Univ of Florida, Gainesville, FL).
48. Cox RW (1996) AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29:162-173.
49. Johnstone T, et al. (2006) Motion correction and the use of motion covariates in multiple-subject fMRI analysis. Hum Brain Mapp 27:779-788.
50. Rissman J, Gazzaley A, D'Esposito M (2004) Measuring functional connectivity during distinct stages of a cognitive task. Neuroimage 23:752-763.
51. Kalisch R (2009) The functional neuroanatomy of reappraisal: Time matters. Neurosci Biobehav Rev, 10.1016/j.neubiorev.2009.06.003.
52. Friston KJ Worsley KJ, Frackowiak RSJ, Mazziotta JC, Evans AC (1993) Assessing the significance of focal activations using their spatial extent. Hum Brain Mapp 1:210-220.
53. Forman SD, et al. (1995) Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold. Magn Reson Med 33:636-647.
54. Petersson KM, Nichols TE, Poline JB, Holmes AP (1999) Statistical limitations in functional neuroimaging. II. Signal detection and statistical inference. Philos Trans R Soc London Ser B 354:1261-1281.