The serotonin transporter gene alters sensitivity to attention bias modification: Evidence for a plasticity gene

Biological Psychiatry

Volumn 70, Issue 11, 2011, Pages 1049-1054

  Fox, Elaine ^a   Zougkou, Konstantina ^a   Ridgewell, Anna ^b   Garner, Kelly ^c  

^a UNIVERSITY OF ESSEX   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Anxiety; attention bias modification; cognitive bias; genetics; GxE interaction; serotonin transporter gene

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALLELE; ANXIETY DISORDER; ARTICLE; ATTENTION DISTURBANCE; AUDIOVISUAL EQUIPMENT; COGNITION; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN TISSUE; MALE; MEDICAL RESEARCH; NORMAL HUMAN; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROMOTER REGION; SELECTIVE ATTENTION; SENSITIVITY ANALYSIS;

ADULT; ATTENTION; BIAS (EPIDEMIOLOGY); EMOTIONS; ENVIRONMENT; FEMALE; GENOTYPE; HUMANS; MALE; PAIN MEASUREMENT; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; REACTION TIME; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 80155208643     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.07.004     Document Type: Article

References (40)

1. A. Caspi, and T.E. Moffitt Gene environment interactions in psychiatry: Joining forces with neuroscience Nat Rev Neurosci 7 2006 583 590 (Pubitemid 43995433)
2. R. Uher The role of genetic variation in the causation of mental illness: An evolution-informed framework Mol Psychiatry 14 2009 1072 1082
3. A.R. Hariri The neurobiology of individual differences in complex behavioural traits Ann Rev Neurosci 32 2009 225 247
4. A. Caspi, A.R. Hariri, A. Holmes, R. Uher, and T.E. Moffitt Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits Am J Psychiatry 167 2010 509 527
5. R. Uher, and P. McGuffin The moderation by the serotonin transporter gene of environmental adversity in the etiology of mental illness: Review and methodological analysis Mol Psychiatry 13 2008 131 146
6. R. Uher, and P. McGuffin The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update Mol Psychiatry 15 2010 18 22
7. K. Karg, M. Burmeister, K. Shedden, and S. Sen The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation Arch Gen Psychiatry 68 2011 444 454
8. T. Canli, and K.P. Lesch Long story short: The serotonin transporter in emotion regulation and social cognition Nat Neurosci 10 2007 1103 1109 (Pubitemid 47339957)
9. A.R. Hariri, and A. Holmes Genetics of emotion regulation: The role of the serotonin transporter in neural function Trends Cogn Sci 10 2006 182 191
10. K.P. Lesch, D. Bengel, A. Heils, S.Z. Sabol, B.D. Greenberg, and S. Petri Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1996 1527 1531 (Pubitemid 26403928)
11. A. Caspi, K. Sugden, T.E. Moffitt, A. Taylor, I.W. Craig, and H. Harrington Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene Science 301 2003 386 389 (Pubitemid 36877077)
12. N. Risch, R. Herrell, T. Lehner, K.Y. Liang, I. Eaves, and J. Hoh Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis JAMA 301 2009 2462 2471
13. J. Belsky, C. Jonassaint, M. Pleuss, M. Stanton, B. Brummett, and R. Williams Vulnerability genes or plasticity genes? Mol Psychiatry 14 2009 746 754
14. J. Belsky, and M. Pluess Beyond diasthesis stress: Differential susceptibility to environmental influences Psychol Bull 135 2009 895 908
15. J.R. Homberg, and K.P. Lesch Looking on the bright side of serotonin transporter gene variation Biol Psychiatry 69 2011 513 519
16. C.J. Harmer Serotonin and emotional processing: Does it help explain antidepressant drug action? Neuropharmacology 55 2008 1023 1028
17. E. Fox, V. Lester, R. Russo, R.J. Bowles, A. Pichler, and K. Dutton Facial expressions of emotion: Are angry faces detected more efficiently? Cogn Emot 14 2000 61 92 (Pubitemid 30350146)
18. E. Fox, S. Cahill, and K. Zougkou Preconscious processing biases predict emotional reactivity to stress Biol Psychiatry 67 2010 371 377
19. C.G. Beevers, B.E. Gibb, J.E. McGeary, and I.W. Miller Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients J Abnorm Psychol 116 2007 208 212 (Pubitemid 46328611)
20. R. Osinsky, M. Reuter, Y. Kpper, A. Schmitz, E. Kozyra, N. Alexander, and J. Hennig Variation in the serotonin transporter gene modulates selective attention to threat Emotion 8 2008 584 588
21. C.G. Beevers, T.T. Wells, A.J. Ellis, and J.E. McGeary Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli J Abnorm Psychol 118 2009 670 681
22. E. Fox, A. Ridgewell, and C. Ashwin Looking on the bright side: Biased attention and the human serotonin transporter gene Proc Biol Sci 276 2009 1747 1751
23. C.G. Beevers, A.J. Ellis, T.T. Wells, and J.E. McGeary Serotonin transporter gene promoter region polymorphism and selective processing of emotional images Biol Psychol 83 2010 260 2655
24. T. Kwang, T.T. Wells, J.E. McGeary, W.B. Swann, and C.G. Beevers Association of the serotonin transporter promoter region polymorphism with biased attention for negative word stimuli Depress Anxiety 27 2010 746 751
25. K. Pérez-Edgar, Y. Bar-Haim, J.M. McDermott, E. Gorodetsky, C.A. Hodgkinson, and D. Goldman Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces Biol Psychol 83 2010 269 271
26. C.G. Beevers, C.N. Marti, H.J. Lee, D.L. Stote, R.E. Ferrell, A.R. Hariri, and M.J. Telch Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information J Abnorm Psychol 120 2011 187 197
27. A.R. Hariri, V.S. Mattay, A. Tessitore, B. Kolachana, F. Fera, and D. Goldman Serotonin transporter genetic variation and the response of the human amygdala Science 297 2002 400 403 (Pubitemid 34790769)
28. M.R. Munafo, S.M. Brown, and A.R. Hariri Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis Biol Psychiatry 63 2008 852 857 (Pubitemid 351458448)
29. T.B. Lonsdorf, A.I. Weike, P. Nikamo, M. Schalling, A.O. Hamm, and A. Ohman Genetic gating of human fear learning and extinction Psychol Sci 20 2009 198 206
30. L.K. Pischek-Simpson, M.J. Boschen, D.L. Neumann, and A.M. Waters The development of an attentional bias for angry faces following Pavlovian fear conditioning Behav Res Ther 47 2009 322 330
31. A. Yates, C. Ashwin, and E. Fox Does emotion processing require attention? The effects of fear conditioning and perceptual load Emotion 10 2010 822 830
32. C. MacLeod, E. Rutherford, L. Campbell, G. Ebsworthy, and L. Holker Selective attention and emotional vulnerability: Assessing the causal basis of their association through the experimental manipulation of attentional bias J Abnorm Psychol 111 2002 107 123 (Pubitemid 34150828)
33. Y. Bar-Haim Attention bias modification (ABM): A novel treatment for anxiety disorders J Child Psychol Psychiatry 51 2010 859 870
34. M. Browning, E.A. Holmes, and C. Harmer The modification of attentional bias to emotional information: A review of techniques, mechanisms and relevance to emotional disorders Cogn Affect Behav Neurosci 10 2010 8 20
35. Y. Hakamata, S. Lissek, Y. Bar-Haim, J.C. Britton, N.A. Fox, and E. Leibenluft Attention bias modification treatment: A meta-analysis toward the establishment of novel treatment for anxiety Biol Psychiatry 68 2010 982 990
36. C.D. Spielberger, R.L. Gorsuch, R.E. Lushene, P. Vagg, and G.A. Jacobs Manual for the State-Trait Anxiety Inventory STAI (Form Y) 1983 Consulting Psychologists Press Palo Alto, CA
37. A. Beck, R. Steer, and G. Brown Manual for Beck Depression Inventory-II 1996 Psychological Corporation San Antonio, TX
38. D. Derryberry, and M.A. Reed Anxiety related attentional biases and their regulation by attentional control J Abnorm Psychol 111 2002 225 236 (Pubitemid 34441201)
39. P.J. Lang, M.M. Bradley, and B.N. Cuthbert International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual. Technical Report A-6 2005 University of Florida Gainesville, FL
40. R.A. Bryant, K.L. Felmingham, E.M. Falconer, L. Pe Benito, C. Dobson-Stone, K.D. Pierce, and P.R. Schofield Preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in posttraumatic stress disorder Biol Psychiatry 67 2010 1217 1219