PCLO rs2522833 impacts HPA system activity in healthy young adults

Translational Psychiatry

Volumn 1, Issue , 2011, Pages

  Kuehner, C ^a   Huffziger, S ^a   Witt, S H ^a   Rietschel, M ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cortisol awakening response; HPA axis; Neuroticism; PCLO gene

Indexed keywords

CYTOSKELETON PROTEIN; HYDROCORTISONE; NEUROPEPTIDE; PCLO PROTEIN, HUMAN;

ADOLESCENT; ADULT; ALLELE; AREA UNDER THE CURVE; ARTICLE; FEMALE; GENETICS; GENOTYPE; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; PATHOPHYSIOLOGY; PERSONALITY; PERSONALITY TEST; PSYCHOLOGICAL RATING SCALE; RISK; SALIVA; SECRETION (PROCESS); SINGLE NUCLEOTIDE POLYMORPHISM; TIME;

ADOLESCENT; ADULT; ALLELES; AREA UNDER CURVE; CYTOSKELETAL PROTEINS; FEMALE; GENOTYPE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; NEUROPEPTIDES; PERSONALITY; PERSONALITY INVENTORY; PITUITARY-ADRENAL SYSTEM; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; RISK; SALIVA; TIME FACTORS; YOUNG ADULT;

EID: 79958173289     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2011.11     Document Type: Article

References (12)

1. Sullivan PF, de Geus E J C, Willemsen G, James MR, Smit JH, Zandbelt T et al. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 2009;14:359-375.
2. Hek K, Mulder CL, Luijendijk HJ, van Duijn CM, Hofman A, Uitterlinden AG et al. The PCLO gene and depressive disorders: replication in a population-based study. Hum Mol Genet 2010;19:731-734.
3. Bochdanovits Z, Verhage M, Smit AB, de Geus EJ, Posthuma D, Boomsma DI et al. Joint reanalysis of 29 correlated SNPs supports the role of PCLO/Piccolo as a causal risk factor for major depressive disorder. Mol Psychiatry 2009;14:650-652.
4. Choi KH, Higgs BW, Wendland JR, Song J, McMahon FJ, Webster MJ. Gene expression and genetic variation data implicate PCLO in bipolar disorder. Biol Psychiatry 2011;69:353-359.
5. Schuhmacher A, Mössner R, Höfels S, Pfeiffer U, Guttenthaler V, Wagner M et al. PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder. Int J Neuropsychopharmacol 2011;14:237-245.
6. Dedovic K, Engert V, Duchesne A, Lue SD, Andrews J, Efanov SI et al. Cortisol awakening response and hippocampal volume: vulnerability for major depressive disorder? Biol Psychiatry 2010;68:847-853.
7. Chida Y, Steptoe A. Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychology 2009;80:265-278.
8. Kuehner C, Holzhauer S, Huffziger S. Decreased cortisol response to awakening is associated with cognitive vulnerability to depression in a nonclinical sample of young adults. PNEC 2007;32:199-209. (Pubitemid 46274022)
9. Klein DN, Kotov R, Bufferd SJ. Personality and Depression: Explanatory Models and Review of the Evidence. Annu Rev Clin Psychol 2011;7:269-295.
10. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. PNEC 2003;29:563-564.
11. Hautzinger M, Keller F, Kuehner C. BDI-II Beck Depression Inventory II, German version. Pearson Assessment: Frankfurt, Germany, 2006.
12. Costa PT, McCrae RR. Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) professional manual. Psychological Assessment Resources: Odessa, USA, 1992.