Associations between dopamine d4 receptor gene variation with both infidelity and sexual promiscuity

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Garcia, Justin R ^a   Mackillop, James ^b,c   Aller, Edward L ^a   Merriwether, Ann M ^a   Wilson, David Sloan ^a   Lum, J Koji ^a  

^a BINGHAMTON UNIVERSITY   (United States)

^b University of Georgia ^*  (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 4 RECEPTOR;

ADULT; ALLELE; ARTICLE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEALTH SURVEY; HUMAN; MALE; SEXUAL BEHAVIOR; SEXUAL INFIDELITY; SEXUAL PROMISCUITY; SEXUALITY; VARIABLE NUMBER OF TANDEM REPEAT; GENETICS; MOTIVATION; NONPARAMETRIC TEST; QUESTIONNAIRE; REWARD; SEX DIFFERENCE; SMOKING; STATISTICAL MODEL;

FEMALE; GENOTYPE; HUMANS; LINEAR MODELS; MALE; MINISATELLITE REPEATS; MOTIVATION; POLYMORPHISM, GENETIC; QUESTIONNAIRES; RECEPTORS, DOPAMINE D4; REWARD; SEX FACTORS; SEXUAL BEHAVIOR; SMOKING; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 78649765797     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014162     Document Type: Article

References (46)

1. Fisher HE (1992) Anatomy of Love: The natural history of monogamy, adultery, and divorce. New York: Norton and Company.
2. Buss DM (2003) The Evolution of Desire. New York: Basic Books.
3. Schmitt DP, Alcalay L, Allik J, Angleitner A, Ault L, et al. (2004) Patterns and universals of mate poaching across 53 nations: the effects of sex, culture, and personality on romantically attracting another person9s partner. J Pers Soc Psychol 86: 560-584.
4. Jankowiak WR, Fischer EF (1992) A cross-cultural perspective on romantic love. Ethnology 31: 149-155.
5. Buss DM, Schmitt DP (1993) Sexual strategies theory: An evolutionary perspective on human mating. Psychological Review 100: 204-232.
6. Griffith SC, Owens IPF, Thuman KA (2002) Extra pair paternity in birds: a review of interspecific variation and adaptive function. Mol Ecol 11: 2195-212.
7. Westneat DF, Stewart IRK (2003) Extra-pair paternity in birds: Causes, correlates, and conflict. Annu Rev Ecol Evol Syst 34: 365-396.
8. Reichard U (1995) Extra-pair copulation in a monogamous gibbon (Hylobates lar). Ethology 100: 99-112.
9. Kitchen AM, Gese EM, Walts LP, Karki SM, Schauster ER (2006) Multiple breeding strategies in the swift fox, Vulpes velox. Animal Behav 71: 1029-1038.
10. Baker RR, Bellis MA (1995) Human sperm competition: Copulation, masturbation, and infidelity. London: Chapman and Hall.
11. Anderson KG (2006) How well does paternity confidence match actual paternity? Evidence from worldwide nonpaternity rates. Current Anthropology 47: 513-520.
12. Wilson M, Daly M (1993) An evolutionary psychological perspective on male sexual proprietariness and violence against wives. Viol Vict 8: 271-294.
13. Cherkas LF, Oelsner EC, Mak YT, Valdes A, Spector TD (2004) Genetic influences on female infidelity and number of sexual partners in humans: a linkage and association study of the role of the vasopressin receptor gene (AVPR1A). Twin Res 7: 649-658.
14. Zietsch BP, Verweij KJH, Bailey JM, Wright MJ, Martin NG (2010) Genetics and environmental influences on risky sexual behaviour and its relationship with personality. Behav Genet 40: 12-21.
15. Aragona BJ, Liu Y, Yu YJ, Curtis JT, Detwiler JM, et al. (2006) Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds. Nat Neurosci 9: 133-139.
16. Fisher HE, Aron A, Mashek D, Li H, Brown LL. Defining the brain systems of lust, romantic attraction, and attachment. Arch Sex Behav 31: 413-419.
17. Melis MR, Argiolas A (1995) Dopamine and sexual behavior. Neurosci Biobehav Rev 19: 19-38.
18. Carter CS (1998) Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 23: 779-818.
19. Depue RA, Morrone-Strupinsky JVA (2005) A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. Behav Brain Sci 28: 313-395.
20. Insel TR, Young LJ (2001) The neurobiology of attachment. Nat Rev Neurosci 2: 129-136.
21. Walum H, Westberg L, Henningsson S, Neiderhiser JM, Reiss D, et al. (2008) Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proc Natl Acad Sci USA 105: 14153-14156.
22. Neuman MG (2008) The Truth about Cheating: Why Men Stray and What You Can Do to Prevent It. New Jersey: John Wiley & Sons, Inc.
23. Chen CS, Burton M, Greenberger E, Dmitrieva J (1999) Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe. Evol Hum Behav 20: 309-324.
24. Congdon E, Lesch KP, Canli T (2008) Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implication for impulsivity. Am J Med Genet B Neuropsychiatric Genet 147B: 27-32.
25. Ding Y, Chi H, Grady DL, Morishima A, Kidd JR, et al. (2002) Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci USA 99: 309-314.
26. Harpending H, Cochran G (2002) In our genes. Proc Natl Acad Sci USA 99: 10-12.
27. McGeary J (2009) The DRD4 exon 3 VNTR polymorphism and addictionrelated phenotypes: a review. Pharmacol Biochem Behav 93: 222-229.
28. Schoots O, Van Tol HHM (2003) The human dopamine D4 receptor repeat sequences modulate expression. Pharmacogenomics J 3: 343-348.
29. Wang E, Ding Y, Flodman P, Kidd JR, Kidd KK, et al. (2004) The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet 74: 931-944.
30. Peterson RL (2005) The neuroscience of investing: fMRI of the reward system. Brain Res Bull 67: 391-397.
31. Li D, Sham PC, Owen MJ, He L (2006) Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet 15: 2276-2284.
32. MacKillop J, Menges DP, McGeary JE, Lisman SA (2007) Effects of craving and DRD4 VNTR genotype on the relative value of alcohol: an initial human laboratory study. Behav Brain Funct 3: 11.
33. Ray LA, Bryan A, MacKillop J, McGeary J, Hesterberg K, et al. (2008) The dopamine D4 receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects. Addict Biol 14: 238-244.
34. Dreber A, Apicella CL, Eisenberg DTA, Garcia JR, Zamore RS, et al. (2009) The 7R polymorphism in the dopamine receptor D4 gene (DRD4) is associated with financial risk-taking in men. Evol Hum Behav 30: 85-92.
35. Eisenberg DTA, Campbell B, MacKillop J, Modi M, Dang D, et al. (2007) Polymorphisms in the dopamine D4 and D2 receptor genes and reproductive and sexual behaviors. Evol Psychol 5: 696-715.
36. Zion IZB, Tessler R, Cohen L, Lerer E, Raz Y, et al. (2006) Polymorphisms in the dopamine D4 receptor gene (DRD4) contribute to individual differences in human sexual behavior: desire, arousal and sexual function. Mol Psychiatry 11: 782-786.
37. Halpern CT, Kaestle CE, Guo G, Hallfors DD (2007) Gene-environment contributions to young adult sexual partnering. Arch Sex Behav 36: 543-554.
38. Guo G, Tong Y, Xie C, Lange LA (2007) Dopamine transporter, gender, and number of sexual partners among young adults. Euro J Hum Genet 15: 279-287.
39. Eisenberg DTA, Apicella CL, Campbell BC, Dreber A, Garcia JR, et al. (2010) Assortative human pair-bonding for partner ancestry and allelic variation of the dopamine receptor D4 (DRD4) gene. Soc Cog Affect Neurosci 5: 194-202.
40. Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO (1991) The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict 86: 1119-1127.
41. Kirby KN, Petry NM, Bickel WK (1999) Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. J Exp Psychol Gen 128: 78-87.
42. Feigelson HS, Rodriguez C, Robertson AS, Jacobs EJ, Calle EE, et al. (2001) Determinants of DNA yield and quality from buccal cell samples collected with mouthwash. Cancer Epidemiol Biomarkers Prev 10: 1005-1008.
43. Hamarman S, Fossella J, Ulger C, Brimacombe M, Dermody J (2004) Dopamine receptor 4 (DRD4) 7-repeat allele predicts methylphenidate dose response in children with attention deficit hyperactivity disorder: A pharmacogenetic study. J Child Adolesc Psychopharm 14: 564-574.
44. Hamer D, Sirota L (2000) Beware the chopsticks gene. Mol Psychiatry 5: 11-13.
45. MacArthur RH, Wilson EO (1967) The Theory of Island Biogeography. New Jersey: Princeton University Press.
46. Garcia JR, Reiber C (2008) Hook-up behavior: A biopsychosocial perspective. J Soc Evol Cult Psychol 2: 192-208.