Striatal dopamine mediates the interface between motivational and cognitive control in humans: Evidence from genetic imaging

Neuropsychopharmacology

Volumn 35, Issue 9, 2010, Pages 1943-1951

  Aarts, Esther ^a,b   Roelofs, Ardi ^a   Franke, Barbara ^a,b   Rijpkema, Mark ^a   Fernández, Guillén ^a,b   Helmich, Rick C ^a,b   Cools, Roshan ^a,b  

^a RADBOUD UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

DAT polymorphism; fMRI; reward; SLC6A3; task switching; ventral striatum

Indexed keywords

DOPAMINE TRANSPORTER; DOPAMINE; MICROSATELLITE DNA; OXYGEN; SLC6A3 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ADULT; ALLELE; ANTICIPATION; ARTICLE; BASE PAIRING; COGNITION; CORPUS STRIATUM; DNA POLYMORPHISM; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE; GENETIC ANALYSIS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; MOTIVATION; NORMAL HUMAN; PRIORITY JOURNAL; REWARD; TASK PERFORMANCE; ADOLESCENT; BLOOD; BRAIN MAPPING; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; IMAGE PROCESSING; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY; PROCEDURES; VASCULARIZATION; YOUNG ADULT;

ADOLESCENT; ADULT; BRAIN MAPPING; COGNITION; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MICROSATELLITE REPEATS; MOTIVATION; OXYGEN; POLYMORPHISM, GENETIC; REWARD; YOUNG ADULT;

EID: 77954761128     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2010.68     Document Type: Article

References (51)

1. Aarts E, Roelofs A, van Turennout M (2008). Anticipatory activity in anterior cingulate cortex can be independent of conflict and error likelihood. J Neurosci 28: 4671-4678.
2. Aarts E, Roelofs A, van Turennout M (2009). Attentional control of task and response in lateral and medial frontal cortex: brain activity and reaction time distributions. Neuropsychologia 47: 2089-2099.
3. Adcock RA, Thangavel A, Whitfield-Gabrieli S, Knutson B, Gabrieli JD (2006). Reward-motivated learning: mesolimbic activation precedes memory formation. Neuron 50: 507-517.
4. Bakshi VP, Kelley AE (1991). Dopaminergic regulation of feeding behavior: II. Differential effects of amphetamine microinfusion into three striatal subregions. Psychobiology 19: 233-242.
5. Baldo BA, Kelley AE (2007). Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding. Psychopharmacology (Berl) 191: 439-459.
6. Berridge KC, Robinson TE (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28: 309-369.
7. Brett M, Anton JL, Valabregue R, Poline JB (eds) (2002). Region of interest analysis using an SPM toolbox. 8th International Conference on Functional Mapping of the Human Brain. Neurolmage: Sendai, Japan.
8. Chakos MH, Lieberman JA, Alvir J, Bilder R, Ashtari M (1995). Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine. Lancet 345: 456-457.
9. Cohen MX, Krohn-Grimberghe A, Elger CE, Weber B (2007). Dopamine gene predicts the brain's response to dopaminergic drug. Eur J Neurosci 26: 3652-3660.
10. Cools AR (1980). Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: facilitation of processes involved in selecting the best strategy in a stressful situation. Behav Brain Res 1: 361-378.
11. Cools R, Clark L, Robbins TW (2004). Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance. J Neurosci 24: 1129-1135.
12. Cooper JC, Bloom FE, Roth RH (2003). The Biochemical Basis of Neuropharmacology, 8th edn. Oxford University Press: Oxford.
13. Craig W (1918). Appetites and aversions as constituents of instincts. Biol Bull 34: 91-107.
14. Daw ND, Niv Y, Dayan P (2005). Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control. Nat Neurosci 8: 1704-1711.
15. Dayan P (2008). The role of value systems in decision making. In: Engel C, Singer W (eds). Better Than Conscious? Decision Making, the Human Mind, and Implications for Institutions. MIT Press: Cambridge, MA, pp 51-70.
16. Dickinson A, Balleine BW (2002). The role of learning in motivation. In: Gallistel CR (ed). Stevens' Handbook of Experimental Psychology Vol. 3: Learning, Motivation and Emotion, 3rd edn. Wiley: New York. Vol 3, pp 497-533.
17. Dreher JC, Kohn P, Kolachana B, Weinberger DR, Berman KF (2009). Variation in dopamine genes influences responsivity of the human reward system. Proc Natl Acad Sci USA 106: 617-622.
18. Forbes EE, Brown SM, Kimak M, Ferrell RE, Manuck SB, Hariri AR (2009). Genetic variation in components of dopamine neuro- transmission impacts ventral striatal reactivity associated with impulsivity. Mol Psychiatry 14: 60-70.
19. Frank MJ, Loughry B, O'Reilly RC (2001). Interactions between frontal cortex and basal ganglia in working memory: a computational model. Cogn Affect Behav Neurosci 1: 137-160.
20. Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S (2001). The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J 1: 152-156.
21. Haber SN (2003). The primate basal ganglia: parallel and integrative networks. J Chem Neuroanat 26: 317-330.
22. Haber SN, Fudge JL, McFarland NR (2000). Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci 20: 2369-2382.
23. Heinz A, Goldman D, Jones DW, Palmour R, Hommer D, Gorey JG et al (2000). Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology 22: 133-139.
24. Ikemoto S, Panksepp J (1999). The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking. Brain Res Brain Res Rev 31: 6-41.
25. Kelley AE, Gauthier AM, Lang CG (1989). Amphetamine micro- injections into distinct striatal subregions cause dissociable effects on motor and ingestive behavior. Behav Brain Res 35: 27-39.
26. Kirsch P, Reuter M, Mier D, Lonsdorf T, Stark R, Gallhofer B et al (2006). Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromo- criptine on the brain activation during the anticipation of reward. Neurosci Lett 405: 196-201.
27. Klein TA, Neumann J, Reuter M, Hennig J, von Cramon DY, Ullsperger M (2007). Genetically determined differences in learning from errors. Science 318: 1642-1645.
28. Koob GF, Riley SJ, Smith SC, Robbins TW (1978). Effects of 6- hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat. J Comp Physiol Psychol 92: 917-927.
29. Kouneiher F, Charron S, Koechlin E (2009). Motivation and cognitive control in the human prefrontal cortex. Nat Neurosci 12: 939-945.
30. Krawczyk DC, Gazzaley A, D'Esposito M (2007). Reward modulation of prefrontal and visual association cortex during an incentive working memory task. Brain Res 1141: 168-177.
31. Leber AB, Turk-Browne NB, Chun MM (2008). Neural predictors of moment-to-moment fluctuations in cognitive flexibility. Proc Natl Acad Sci USA 105: 13592-13597.
32. Logan GD, Bundesen C (2003). Clever homunculus: is there an endogenous act of control in the explicit task-cuing procedure? J Exp Psychol Hum Percept Perform 29: 575-599.
33. Lyon M, Robbins TW (1975). The action of central nervous system drugs: a general theory concerning amphetamine effects. In: Essman W (ed). Current Developments in Psychopharmacology. Spectrum publications: New York. Vol 2, pp 80-163.
34. Mill J, Asherson P, Browes C, D'Souza U, Craig I (2002). Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet 114: 975-979.
35. Mink JW (1996). The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol 50: 381-425.
36. Mogenson GJ, Jones DL, Yim CY (1980). From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 14: 69-97.
37. Monsell S (2003). Task switching. Trends Cogn Sci 7: 134-140.
38. Nauta WJ, Smith GP, Faull RL, Domesick VB (1978). Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. Neuroscience 3: 385-401.
39. Oades RD (1985). The role of noradrenaline in tuning and dopamine in switching between signals in the CNS. Neurosci Biobehav Rev 9: 261-282.
40. Robbins TW, Everitt BJ (1992). Functions of dopamine in the dorsal and ventral striatum. Semin Neurosci 4: 119-127.
41. Roelofs A, van Turennout M, Coles MG (2006). Anterior cingulate cortex activity can be independent of response conflict in stroop-like tasks. Proc Natl Acad Sci USA 103: 13884-13889.
42. Sakai K (2008). Task set and prefrontal cortex. Annu Rev Neurosci 31: 219-245.
43. Salamone JD, Correa M, Farrar A, Mingote SM (2007). Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology (Berl) 191: 461-482.
44. Schultz W (2002). Getting formal with dopamine and reward. Neuron 36: 241-263.
45. Selemon LD, Lidow MS, Goldman-Rakic PS (1999). Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure. Biol Psychiatry 46: 161-172.
46. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N et al (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15: 273-289.
47. van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M et al (2005). Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. J Nucl Med 46: 745-751.
48. VanNess SH, Owens MJ, Kilts CD (2005). The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC Genet 6: 55.
49. Voorn P, Vanderschuren LJ, Groenewegen HJ, Robbins TW, Pennartz CM (2004). Putting a spin on the dorsal-ventral divide of the striatum. Trends Neurosci 27: 468-474.
50. Wittmann BC, Schott BH, Guderian S, Frey JU, Heinze HJ, Duzel E (2005). Reward-related FMRI activation of dopaminergic mid- brain is associated with enhanced hippocampus-dependent long-term memory formation. Neuron 45: 459-467.
51. Yacubian J, Sommer T, Schroeder K, Glascher J, Kalisch R, Leuenberger B et al (2007). Gene-gene interaction associated with neural reward sensitivity. Proc Natl Acad Sci USA 104: 8125-8130.