Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: A new concept in the antidepressant drug design

PLoS Biology

Volumn 8, Issue 4, 2010, Pages

  Mazella, Jean ^a   Pétrault, Olivier ^a   Lucas, Guillaume ^b   Deval, Emmanuel ^a   Béraud Dufour, Sophie ^a   Gandin, Carine ^a   El Yacoubi, Malika ^c   Widmann, Catherine ^a   Guyon, Alice ^a   Chevet, Eric ^d   Taouji, Said ^d   Conductier, Grégory ^a   Corinus, Alain ^a   Coppola, Thierry ^a   Gobbi, Gabriella ^e   Nahon, Jean Louis ^a   Heurteaux, Catherine ^a   Borsotto, Marc ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b CENTRE DE RECHERCHE FERNAND SEGUIN   (Canada)

^c UNIVERSITÉ LYON 1   (France)

^d INSERM   (France)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FLUOXETINE; SORTILIN; SPADIN; TANDEM PORE DOMAIN POTASSIUM CHANNEL; TANDEM PORE DOMAIN POTASSIUM CHANNEL TREK 1; UNCLASSIFIED DRUG; PEPTIDE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL PROTEIN TREK 1; POTASSIUM CHANNEL PROTEIN TREK-1; SEROTONIN; SPADIN PEPTIDE; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEPRESSION; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ELECTROPHYSIOLOGY; EMBRYO; GENE DELETION; HIPPOCAMPUS; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; VALIDATION STUDY; ANIMAL; C57BL MOUSE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; MALE; METABOLISM; MOTOR ACTIVITY; PATCH CLAMP; RAPHE NUCLEUS; SYNAPTIC TRANSMISSION;

MUS; RODENTIA;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIDEPRESSIVE AGENTS; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEPRESSIVE DISORDER; DRUG DESIGN; HUMANS; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RAPHE NUCLEI; SEROTONIN; SYNAPTIC TRANSMISSION;

EID: 77951710955     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000355     Document Type: Article

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