Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 24, 2010, Pages 7454-7457

  Malerich, Jeremiah P ^a   Lam, Jennifer S ^a   Hart, Barry ^b   Fine, Richard M ^c   Klebansky, Boris ^c   Tanga, Mary J ^a   D'Andrea, Annalisa ^a  

^a SRI INTERNATIONAL   (United States)

^b Innovation Pathways   (United States)

^c BioPredict Inc   (United States)

Author keywords

JAK1; JAK2; JAK3; Janus associated kinase; TYK2; Tyrosine kinase 2

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; GAMMA INTERFERON; INCB 018424; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; JANUS KINASE INHIBITOR; JNJ 7706621; TG 101348; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INTERFERON PRODUCTION;

BINDING SITES; COMPUTER SIMULATION; HUMANS; INTERLEUKIN-23; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; PROTEIN KINASE INHIBITORS; TRIAZOLES; TYK2 KINASE;

EID: 78449283839     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.026     Document Type: Article

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