Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophophorylation

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2526-2533

  Sandberg, Eric M ^a   Ma, Xianyue ^a   He, Kai ^b   Frank, Stuart J ^b   Ostrov, David A ^a   Sayeski, Peter P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,5,6 HEXABROMOCYCLOHEXANE; BROMINE DERIVATIVE; CYCLOHEXANE; EPIDERMAL GROWTH FACTOR RECEPTOR; JANUS KINASE 2; JANUS KINASE INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROPIDIUM IODIDE; SOLVENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; HIGH THROUGHPUT SCREENING; MODEL; MOLECULAR SIZE; MOUSE; NONHUMAN; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CELL LINE; CYCLOHEXANES; DATABASES, FACTUAL; HAPLORHINI; JANUS KINASE 2; LIGANDS; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17144369135     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049470k     Document Type: Article

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