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Volumn 29, Issue 7, 2011, Pages 615-624

Therapeutic targeting of the IL-12/23 pathways: Generation and characterization of ustekinumab

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL EVALUATION; CLINICAL OBSERVATION; CLINICAL STUDY; CROHN'S DISEASE; CYTOKINES; MOLECULAR ENTITIES; MONOCLONAL ANTIBODIES (MAB); PSORIATIC ARTHRITIS; THERAPEUTIC AGENTS;

EID: 79960209969     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1903     Document Type: Review
Times cited : (121)

References (84)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A. & Coffman, R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357 (1986). (Pubitemid 16136806)
    • (1986) Journal of Immunology , vol.136 , Issue.7 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3
  • 2
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • DOI 10.1038/nri1001
    • Trinchieri, G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3, 133-146 (2003). (Pubitemid 37328691)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.2 , pp. 133-146
    • Trinchieri, G.1
  • 3
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • Fiorentino, D.F., Bond, M.W. & Mosmann, T.R. Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170, 2081-2095 (1989).
    • (1989) J. Exp. Med. , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 5
    • 0030445948 scopus 로고    scopus 로고
    • A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
    • Presky, D.H. et al. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93, 14002-14007 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14002-14007
    • Presky, D.H.1
  • 6
    • 0033564323 scopus 로고    scopus 로고
    • IL-12, independently of IFN-γ, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder
    • Hong, K., Chu, A., Lúdvíksson, B.R., Berg, E.L. & Ehrhardt, R.O. IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder. J. Immunol. 162, 7480-7491 (1999). (Pubitemid 29277728)
    • (1999) Journal of Immunology , vol.162 , Issue.12 , pp. 7480-7491
    • Hong, K.1    Chu, A.2    Ludviksson, B.R.3    Berg, E.L.4    Ehrhardt, R.O.5
  • 7
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard, J.P., Waldburger, K.E. & Goldman, S.J. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181, 381-386 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 11
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • DOI 10.1016/S0016-5085(97)70128-8
    • Monteleone, G. et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112, 1169-1178 (1997). (Pubitemid 27157528)
    • (1997) Gastroenterology , vol.112 , Issue.4 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3    Morrone, G.4    Marasco, O.5    Luzza, F.6    Pallone, F.7
  • 13
    • 0028809507 scopus 로고
    • Expression of costimulatory molecules B7-1 (Crohn's disease80), B7-2 (Crohn's disease86), and interleukin 12 cytokine in multiple sclerosis lesions
    • Windhagen, A. et al. Expression of costimulatory molecules B7-1 (Crohn's disease80), B7-2 (Crohn's disease86), and interleukin 12 cytokine in multiple sclerosis lesions. J. Exp. Med. 182, 1985-1996 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 1985-1996
    • Windhagen, A.1
  • 18
    • 77957227339 scopus 로고    scopus 로고
    • Structural basis for dual recognition of IL-12 and IL-23 by ustekinumab
    • Luo, J. et al. Structural basis for dual recognition of IL-12 and IL-23 by ustekinumab. J. Mol. Biol. 402, 797-812 (2010).
    • (2010) J. Mol. Biol. , vol.402 , pp. 797-812
    • Luo, J.1
  • 19
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B. et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725 (2000).
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1
  • 21
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • DOI 10.1074/jbc.M207577200
    • Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F.J. & Gurney, A.L. Interleukin-23 promotes a distinct Crohn's disease4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278, 1910-1914 (2003). (Pubitemid 36801431)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.3 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.-H.3    De Sauvage, F.J.4    Gurney, A.L.5
  • 23
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
    • DOI 10.1038/ni1496, PII NI1496
    • Acosta-Rodriguez, E.V., Napolitani, G., Lanzavecchia, A. & Sallusto, F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8, 942-949 (2007). (Pubitemid 47300008)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 25
    • 67651171182 scopus 로고    scopus 로고
    • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
    • Trifari, S., Kaplan, C.D., Tran, E.H., Crellin, N.K. & Spits, H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat. Immunol. 10, 864-871 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 864-871
    • Trifari, S.1    Kaplan, C.D.2    Tran, E.H.3    Crellin, N.K.4    Spits, H.5
  • 26
    • 77955902281 scopus 로고    scopus 로고
    • Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
    • Staudt, V. et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33, 192-202 (2010).
    • (2010) Immunity , vol.33 , pp. 192-202
    • Staudt, V.1
  • 27
    • 77954948735 scopus 로고    scopus 로고
    • Effector T cell plasticity: Flexibility in the face of changing circumstances
    • Murphy, K.M. & Stockinger, B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat. Immunol. 11, 674-680 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 674-680
    • Murphy, K.M.1    Stockinger, B.2
  • 28
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of Crohn's disease4+ T cell lineage differentiation
    • Zhou, L., Chong, M.M. & Littman, D.R. Plasticity of Crohn's disease4+ T cell lineage differentiation. Immunity 30, 646-655 (2009).
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1    Chong, M.M.2    Littman, D.R.3
  • 29
    • 68949143060 scopus 로고    scopus 로고
    • IL-23 promotes production of IL-17 by antigen-specific CD8 by CD T cells in the absence of IL-12 and type-I interferons
    • Curtis, M.M., Way, S.S. & Wilson, C.B. IL-23 promotes production of IL-17 by antigen-specific CD8 by CD T cells in the absence of IL-12 and type-I interferons. J. Immunol. 183, 381-387 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 381-387
    • Curtis, M.M.1    Way, S.S.2    Wilson, C.B.3
  • 30
    • 79960204446 scopus 로고    scopus 로고
    • IL-23 modulates Crohn's disease56+/Crohn's disease3-NK cell and Crohn's disease56+/Crohn's disease3+ NK-like T cell function differentially from IL-12
    • van de Wetering, D., de Paus, R.A. & van Dissel, J.T. & van de Vosse, E. IL-23 modulates Crohn's disease56+/Crohn's disease3-NK cell and Crohn's disease56+/Crohn's disease3+ NK-like T cell function differentially from IL-12. Int. Immunol. 21, 145-153 (2008).
    • (2008) Int. Immunol. , vol.21 , pp. 145-153
    • Van De Wetering, D.1    De Paus, R.A.2    Van Dissel, J.T.3    Van De Vosse, E.4
  • 32
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran, B. et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169, 7104-7110 (2002). (Pubitemid 36899299)
    • (2002) Journal of Immunology , vol.169 , Issue.12 , pp. 7104-7110
    • Gran, B.1    Zhang, G.-X.2    Yu, S.3    Li, J.4    Chen, X.-H.5    Ventura, E.S.6    Kamoun, M.7    Rostami, A.8
  • 34
    • 36049052516 scopus 로고    scopus 로고
    • Interleukin-12 interleukin-23, and psoriasis: Current prospects
    • comment and author reply. 58, 1083
    • Torti, D.C. & Feldman, S.R. Interleukin-12, interleukin-23, and psoriasis: current prospects. J. Am. Acad. Dermatol. 57, 1059-1068; comment and author reply. 58, 1083 (2007).
    • (2007) J. Am. Acad. Dermatol. , vol.57 , pp. 1059-1068
    • Torti, D.C.1    Feldman, S.R.2
  • 38
    • 79952066088 scopus 로고    scopus 로고
    • The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector responses in humans
    • Di Meglio, P. et al. The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector responses in humans. PLoS ONE 6, e17160 (2011).
    • (2011) PLoS ONE , vol.6
    • Di Meglio, P.1
  • 39
    • 84873085258 scopus 로고    scopus 로고
    • Characterization of immune and asthmatic responses in cynomolgus macaques following antagonism of IL-12/23 activity with ustekinumab (CNTO 1275)
    • Sachs, C. et al. Characterization of immune and asthmatic responses in cynomolgus macaques following antagonism of IL-12/23 activity with ustekinumab (CNTO 1275). The Toxicologist 102, Abstract 2141 (2008).
    • (2008) The Toxicologist , vol.102 , pp. 2141
    • Sachs, C.1
  • 40
    • 72049101867 scopus 로고    scopus 로고
    • Comorbidities in patients with psoriasis
    • Gottlieb, A.B. & Dann, F. Comorbidities in patients with psoriasis. Am. J. Med. 122, 1150e1-1150e9 (2008).
    • (2008) Am. J. Med. , vol.122
    • Gottlieb, A.B.1    Dann, F.2
  • 41
    • 84873094286 scopus 로고    scopus 로고
    • Development in the cynomolgus macaque following administration of ustekinumab, a human anti-IL-12/23p40 monoclonal antibody, during pregnancy and lactation
    • Martin, P.L. et al. Development in the cynomolgus macaque following administration of ustekinumab, a human anti-IL-12/23p40 monoclonal antibody, during pregnancy and lactation. Birth Defects Res. 83, 1-13 (2010).
    • (2010) Birth Defects Res. , vol.83 , pp. 1-13
    • Martin, P.L.1
  • 42
    • 0031779387 scopus 로고    scopus 로고
    • Presence and modulation of interleukin-12 in seminal plasma of fertile and infertile men
    • Naz, R.K. & Evans, L. Presence and modulation of interleukin-12 in seminal plasma of fertile and infertile men. J. Androl. 19, 302-307 (1998). (Pubitemid 28265106)
    • (1998) Journal of Andrology , vol.19 , Issue.3 , pp. 302-307
    • Naz, R.K.1    Evans, L.2
  • 43
    • 0037393035 scopus 로고    scopus 로고
    • Reproductive/developmental toxicity and immunotoxicity assessment in the nonhuman primate model
    • DOI 10.1016/S0300-483X(02)00614-5, PII S0300483X02006145
    • Buse, E., Habermann, G., Osterburg, I., Korte, R. & Weinbauer, G.F. Reproductive/developmental toxicity and immunogenicity assessment in the nonhuman primate model. Toxicology 221, 221-227 (2003). (Pubitemid 36173739)
    • (2003) Toxicology , vol.185 , Issue.3 , pp. 221-227
    • Buse, E.1    Habermann, G.2    Osterburg, I.3    Korte, R.4    Weinbauer, G.F.5
  • 46
    • 0018099294 scopus 로고
    • Severe psoriasis - oral therapy with a new retinoid
    • Fredriksson, T. & Pettersson, U. Severe psoriasis-oral therapy with a new retinoid. Dermatologica 157, 238-244 (1978). (Pubitemid 8387357)
    • (1978) Dermatologica , vol.157 , Issue.4 , pp. 238-244
    • Fredriksson, T.1    Pettersson, U.2
  • 48
    • 58849146355 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic (PK/PD) modeling and simulation of CNTO 1275 in subjects with moderate to severe psoriasis vulgaris
    • Abstract 90
    • Zhu, Y. et al. Pharmacokinetic/pharmacodynamic (PK/PD) modeling and simulation of CNTO 1275 in subjects with moderate to severe psoriasis vulgaris. J. Clin. Pharmacol. 47, 1203, Abstract 90 (2007).
    • (2007) J. Clin. Pharmacol. , vol.47 , pp. 1203
    • Zhu, Y.1
  • 49
    • 77649209264 scopus 로고    scopus 로고
    • Population-based exposure-efficacy modeling of ustekinumab in patients with moderate to severe plaque psoriasis
    • Zhou, H. et al. Population-based exposure-efficacy modeling of ustekinumab in patients with moderate to severe plaque psoriasis. J. Clin. Pharmacol. 50, 257-267 (2010).
    • (2010) J. Clin. Pharmacol. , vol.50 , pp. 257-267
    • Zhou, H.1
  • 50
    • 54249138516 scopus 로고    scopus 로고
    • Monoclonal antibody pharmacokinetics and pharmacodynamics
    • Wang, W., Wang, E.Q. & Balthasar, J.P. Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin. Pharmacol. Ther. 84, 548-558 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 548-558
    • Wang, W.1    Wang, E.Q.2    Balthasar, J.P.3
  • 51
    • 0036201914 scopus 로고    scopus 로고
    • Transcytosis and catabolism of antibody
    • Ghetie, V. & Ward, E.S. Transcytosis and catabolism of antibody. Immunol. Res. 25, 97-113 (2002). (Pubitemid 34264097)
    • (2002) Immunologic Research , vol.25 , Issue.2 , pp. 97-113
    • Ghetie, V.1    Ward, E.S.2
  • 52
    • 78650802869 scopus 로고    scopus 로고
    • Population pharmacokinetics of ustekinumab in patients with active psoriatic arthritis
    • Zhu, Y., Mendelsohn, A., Pendley, C., Davis, H.M. & Zhou, H. Population pharmacokinetics of ustekinumab in patients with active psoriatic arthritis. Int. J. Clin. Pharmacol. Ther. 48, 830-846 (2010).
    • (2010) Int. J. Clin. Pharmacol. Ther. , vol.48 , pp. 830-846
    • Zhu, Y.1    Mendelsohn, A.2    Pendley, C.3    Davis, H.M.4    Zhou, H.5
  • 53
    • 58849118867 scopus 로고    scopus 로고
    • Population pharmacokinetic modeling of ustekinumab, a human monoclonal antibody targeting IL-12/23p40, in patients with moderate to severe plaque psoriasis
    • Zhu, Y. et al. Population pharmacokinetic modeling of ustekinumab, a human monoclonal antibody targeting IL-12/23p40, in patients with moderate to severe plaque psoriasis. J. Clin. Pharmacol. 49, 162-175 (2009).
    • (2009) J. Clin. Pharmacol. , vol.49 , pp. 162-175
    • Zhu, Y.1
  • 54
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
    • Sandborn, W.J. et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 135, 1130-1141 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1
  • 55
    • 60249084148 scopus 로고    scopus 로고
    • Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: Randomised, double-blind, placebo-controlled, crossover trial
    • errata in 373, 1340 (2009) and 376, 1542, 2010
    • Gottlieb, A. et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet 373, 633-640 (2009); errata in 373, 1340 (2009) and 376, 1542 (2010).
    • (2009) Lancet , vol.373 , pp. 633-640
    • Gottlieb, A.1
  • 56
    • 48849087125 scopus 로고    scopus 로고
    • Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: A phase II, double-blind, placebo-controlled, randomised, dose-ranging study
    • Segal, B.M. et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol. 7, 796-804 (2008).
    • (2008) Lancet Neurol. , vol.7 , pp. 796-804
    • Segal, B.M.1
  • 57
    • 33749845902 scopus 로고    scopus 로고
    • Population-based assessments of clinical drug-drug interactions: Qualitative indices or quantitative measures?
    • DOI 10.1177/0091270006294278
    • Zhou, H. Population-based assessments of clinical drug-drug interactions: qualitative indices or quantitative measures? J. Clin. Pharmacol. 46, 1268-1289 (2006). (Pubitemid 44564356)
    • (2006) Journal of Clinical Pharmacology , vol.46 , Issue.11 , pp. 1268-1289
    • Zhou, H.1
  • 58
    • 69749119482 scopus 로고    scopus 로고
    • Risk-based strategy for the assessment of pharmacokinetic drug-drug interactions for therapeutic monoclonal antibodies
    • Zhou, H. & Davis, H.M. Risk-based strategy for the assessment of pharmacokinetic drug-drug interactions for therapeutic monoclonal antibodies. Drug Discov. Today 14, 891-898 (2009).
    • (2009) Drug Discov. Today , vol.14 , pp. 891-898
    • Zhou, H.1    Davis, H.M.2
  • 59
    • 77951838972 scopus 로고    scopus 로고
    • Positive treatment effects of ustekinumab in psoriasis: Analysis of lesional and systemic parameters
    • Reddy, M. et al. Positive treatment effects of ustekinumab in psoriasis: analysis of lesional and systemic parameters. J. Dermatol. 37, 413-425 (2010).
    • (2010) J. Dermatol. , vol.37 , pp. 413-425
    • Reddy, M.1
  • 60
    • 68049131637 scopus 로고    scopus 로고
    • Psoriasis
    • Nestle, F.O. et al. Psoriasis. N. Engl. J. Med. 361, 496-509 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 496-509
    • Nestle, F.O.1
  • 62
    • 77955862769 scopus 로고    scopus 로고
    • Effects of ustekinumab administration on primate/human antigen-recall and humoral immune response functions
    • Brodmerkel, C. et al. Effects of ustekinumab administration on primate/human antigen-recall and humoral immune response functions. J. Drugs Dermatol. 9, 677-683 (2010).
    • (2010) J. Drugs Dermatol. , vol.9 , pp. 677-683
    • Brodmerkel, C.1
  • 63
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • DOI 10.1016/S0140-6736(08)60725-4, PII S0140673608607254
    • Leonardi, C.L. et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371, 1665-1674 (2008); erratum in: 1838 (2008). (Pubitemid 351671883)
    • (2008) The Lancet , vol.371 , Issue.9625 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3    Yeilding, N.4    Guzzo, C.5    Wang, Y.6    Li, S.7    Dooley, L.T.8    Gordon, K.B.9
  • 64
    • 74249094930 scopus 로고    scopus 로고
    • Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis
    • Griffiths, C.E. et al. Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N. Engl. J. Med. 362, 118-128 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 118-128
    • Griffiths, C.E.1
  • 65
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • DOI 10.1016/S0140-6736(08)60726-6, PII S0140673608607266
    • Papp, K.A. et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 371, 1675-1684 (2008). (Pubitemid 351671884)
    • (2008) The Lancet , vol.371 , Issue.9625 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3    Krueger, G.G.4    Szapary, P.5    Yeilding, N.6    Guzzo, C.7    Hsu, M.-C.8    Wang, Y.9    Li, S.10    Dooley, L.T.11    Reich, K.12
  • 66
    • 0036861899 scopus 로고    scopus 로고
    • Immunogenicity of therapeutic proteins: Clinical implications and future prospects
    • DOI 10.1016/S0149-2918(02)80075-3
    • Schellekens, H. Immunogenicity of therapeutic proteins: clinical implications and future prospects. Clin. Ther. 24, 1720-1740 (2002); discussion 1719 (2002). (Pubitemid 35440946)
    • (2002) Clinical Therapeutics , vol.24 , Issue.11 , pp. 1720-1740
    • Schellekens, H.1
  • 67
    • 33847279025 scopus 로고    scopus 로고
    • Pathogenesis and therapy of psoriasis
    • Lowes, M.A. et al. Pathogenesis and therapy of psoriasis. Nature 445, 866-873 (2007).
    • (2007) Nature , vol.445 , pp. 866-873
    • Lowes, M.A.1
  • 69
    • 84873099012 scopus 로고    scopus 로고
    • Molecular profiling and gene expression analysis in cutaneous sarcoidosis: The role of IL-12 IL-23, and the Th17 pathways
    • in the press
    • Judson, M. et al. Molecular profiling and gene expression analysis in cutaneous sarcoidosis: the role of IL-12, IL-23, and the Th17 pathways. J. Amer. Acad. Derm. (in the press).
    • J. Amer. Acad. Derm.
    • Judson, M.1
  • 70
    • 33646695671 scopus 로고    scopus 로고
    • Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy
    • DOI 10.1191/0309133306pp482pr, PII 0000143220060600000005
    • Bowman, E.P., Chackerian, A.A. & Cua, D.J. Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy. Curr. Opin. Infect. Dis. 19, 245-252 (2006). (Pubitemid 43740362)
    • (2006) Current Opinion in Infectious Diseases , vol.19 , Issue.3 , pp. 245-252
    • Bowman, E.P.1    Chackerian, A.A.2    Cua, D.J.3
  • 71
    • 36049052516 scopus 로고    scopus 로고
    • Interleukin-12 interleukin-23, and psoriasis: Current prospects
    • Torti, D.C. & Feldman, S.R. Interleukin-12, interleukin-23, and psoriasis: current prospects. J. Am. Acad. Dermatol. 57, 1059-1068 (2007).
    • (2007) J. Am. Acad. Dermatol. , vol.57 , pp. 1059-1068
    • Torti, D.C.1    Feldman, S.R.2
  • 73
    • 0036645530 scopus 로고    scopus 로고
    • Suppression of lymphoma and epithelial malignancies effected by interferon γ
    • DOI 10.1084/jem.20020063
    • Street, S.E., Trapani, J.A., MacGregor, D. & Smyth, M.J. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J. Exp. Med. 196, 129-134 (2002). (Pubitemid 34747318)
    • (2002) Journal of Experimental Medicine , vol.196 , Issue.1 , pp. 129-134
    • Street, S.E.A.1    Trapani, J.A.2    MacGregor, D.3    Smyth, M.J.4
  • 76
    • 33846966636 scopus 로고    scopus 로고
    • A brief history of T(H) 17, the first major revision in the T(H)1/T(H)2 hypothesis of T-cell-mediated tissue damage
    • Steinman, L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T-cell-mediated tissue damage. Nat. Med. 13, 139-145 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 139-145
    • Steinman, L.1
  • 77
    • 34548125310 scopus 로고    scopus 로고
    • T(H)-17 differentiation: Of mice and men
    • Laurence, A. & O'Shea, J.J. T(H)-17 differentiation: of mice and men. Nat. Immunol. 8, 903-905 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 903-905
    • Laurence, A.1    O'Shea, J.J.2
  • 78
    • 4344610517 scopus 로고    scopus 로고
    • The role of IL-12, IL-23 and IFN-γ in immunity to viruses
    • DOI 10.1016/j.cytogfr.2004.03.009, PII S1359610104000188
    • Novelli, F. & Casanova, J.L. The role of IL-12, IL-23 and IFN-gamma in immunity to viruses. Cytokine Growth Factor Rev. 15, 367-377 (2004). (Pubitemid 39140700)
    • (2004) Cytokine and Growth Factor Reviews , vol.15 , Issue.5 , pp. 367-377
    • Novelli, F.1    Casanova, J.-L.2
  • 79
    • 0038759100 scopus 로고    scopus 로고
    • The role of interleukin-12 in human infectious diseases: Only a faint signature
    • DOI 10.1002/eji.200324038
    • Fieschi, C. & Casanova, J.L. The role of interleukin-12 in human infectious diseases: only a faint signature. Eur. J. Immunol. 33, 1461-1464 (2003). (Pubitemid 36790405)
    • (2003) European Journal of Immunology , vol.33 , Issue.6 , pp. 1461-1464
    • Fieschi, C.1    Casanova, J.-L.2
  • 81
    • 77956130043 scopus 로고    scopus 로고
    • Oesophageal squamous cell carcinoma in a young adult with Il-12Rβ1 deficiency
    • Cárdenes, M. et al. Oesophageal squamous cell carcinoma in a young adult with Il-12Rβ1 deficiency. J. Med. Genet. 47, 635-637 (2010).
    • (2010) J. Med. Genet. , vol.47 , pp. 635-637
    • Cárdenes, M.1
  • 84
    • 78049257495 scopus 로고    scopus 로고
    • New mechanisms and expanded indications for biologic therapies: A perspective on immunology research and development
    • Dillon, S.R. New mechanisms and expanded indications for biologic therapies: a perspective on immunology research and development. Drug Disc. World Fall, 87-93 (2010).
    • (2010) Drug Disc. World Fall , pp. 87-93
    • Dillon, S.R.1


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