Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma

Haematologica

Volumn 96, Issue 11, 2011, Pages 1723-1727

  Kleppe, Maria ^a,b   Tousseyn, Thomas ^c   Geissinger, Eva ^d   Atak, Zeynep Kalender ^b   Aerts, Stein ^b   Rosenwald, Andreas ^d   Wlodarska, Iwona ^b   Cools, Jan ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Mutation; Phosphatase; T cell NHL; Tumor suppressor

Indexed keywords

JANUS KINASE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; STAT PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENE SEQUENCE; HODGKIN DISEASE; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; PTPN2 GENE; T CELL LYMPHOMA; TUMOR SUPPRESSOR GENE;

CELL LINE, TUMOR; DNA MUTATIONAL ANALYSIS; FEMALE; HODGKIN DISEASE; HUMANS; JANUS KINASES; MALE; MUTATION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 80355126500     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.041921     Document Type: Article

References (18)

1. Tartaglia M, Martinelli S, Cazzaniga G, Cordeddu V, Iavarone I, Spinelli M, et al. Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia. Blood. 2004;104(2):307-13.
2. Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet. 2003;34(2):148-50.
3. Kleppe M, Lahortiga I, El Chaar T, De Keersmaecker K, Mentens N, Graux C, et al. Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nat Genet. 2010;42 (6):530-5.
4. Mosinger B Jr, Tillmann U, Westphal H, Tremblay ML. Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proc Natl Acad Sci USA. 1992;89(2):499-503.
5. Andersen JN, Jansen PG, Echwald SM, Mortensen OH, Fukada T, Del Vecchio R, et al. A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J. 2004;18(1):8-30.
6. Doody KM, Bourdeau A, Tremblay ML. Tcell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease. Immunol Rev. 2009;228(1):325-41.
7. Tiganis T, Kemp BE, Tonks NK. The proteintyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling. J Biol Chem. 1999;274(39): 27768-75.
8. Simoncic PD, Lee-Loy A, Barber DL, Tremblay ML, McGlade CJ. The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol. 2002;12(6):446-53.
9. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Fourth Edition. Lyon: World Health Organization 2008.
10. Kleppe M, Mentens N, Tousseyn T, Wlodarska I, Cools J. MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell context. Haematologica. 2011; 96(5):779-83.
11. Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009;25(14):1754-60.
12. Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics. 2009;25(16):2078-9.
13. Cool DE, Tonks NK, Charbonneau H, Walsh KA, Fischer EH, Krebs EG. cDNA isolated from a human T-cell library encodes a member of the protein-tyrosinephosphatase family. Proc Natl Acad Sci USA. 1989;86(14):5257-61.
14. Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010;116(17):3268-77.
15. Diehl V, Kirchner HH, Schaadt M, Fonatsch C, Stein H, Gerdes J, et al. Hodgkin's disease: establishment and characterization of four in vitro cell lines. J Cancer Res Clin Oncol. 1981;101(1):111-24.
16. Joos S, Kupper M, Ohl S, von Bonin F, Mechtersheimer G, Bentz M, et al. Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells. Cancer Res. 2000;60(3):549-52.
17. Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K, et al. Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho- STAT5 accumulation. Oncogene. 2006;25(18):2679-84.
18. Lu X, Chen J, Sasmono RT, Hsi ED, Sarosiek KA, Tiganis T, et al. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. Mol Cell Biol. 2007;27(6):2166-79.