메뉴 건너뛰기




Volumn 8, Issue 4, 2009, Pages 273-274

Tocilizumab

Author keywords

[No Author keywords available]

Indexed keywords

ATLIZUMAB; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; METHOTREXATE; PLACEBO;

EID: 64049108915     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2863     Document Type: Article
Times cited : (49)

References (17)
  • 1
    • 35648988128 scopus 로고    scopus 로고
    • New therapies for the treatment of rheumatoid arthritis
    • Smolen, J. S. et al. New therapies for the treatment of rheumatoid arthritis. Lancet 370, 1861-1874 (2007).
    • (2007) Lancet , vol.370 , pp. 1861-1874
    • Smolen, J.S.1
  • 3
    • 0027305079 scopus 로고
    • Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis
    • Sack, U. et al. Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis. Rheumatol. Int. 13, 45-51 (1993).
    • (1993) Rheumatol. Int , vol.13 , pp. 45-51
    • Sack, U.1
  • 4
    • 0027518860 scopus 로고
    • Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
    • Madhok, R. et al. Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity. Ann. Rheum. Dis. 52, 232-234 (1993).
    • (1993) Ann. Rheum. Dis , vol.52 , pp. 232-234
    • Madhok, R.1
  • 5
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • Alonzi, T. et al. Interleukin 6 is required for the development of collagen-induced arthritis. J. Exp. Med. 187, 461-468 (1998).
    • (1998) J. Exp. Med , vol.187 , pp. 461-468
    • Alonzi, T.1
  • 6
    • 0032429668 scopus 로고    scopus 로고
    • Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
    • Takagi N. et al. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum. 41, 2117-2121 (1998).
    • (1998) Arthritis Rheum , vol.41 , pp. 2117-2121
    • Takagi, N.1
  • 7
    • 0027502201 scopus 로고
    • Reshaping a human antibody to inhibit the interleukin-6-dependent tumor cell growth
    • Sato, K. et al. Reshaping a human antibody to inhibit the interleukin-6-dependent tumor cell growth. Cancer Res. 53, 851-856 (1993).
    • (1993) Cancer Res , vol.53 , pp. 851-856
    • Sato, K.1
  • 8
    • 64049116349 scopus 로고    scopus 로고
    • RoActemra. EMEA website [online]
    • European Medicines Agency (EMEA). European Public Assessment Report - RoActemra. EMEA website [online], http://www.emea.europa.eu/humandocs/ PDFs/EPAR/RoActemra/H-955-PI-en.pdf (2008).
    • (2008) European Public Assessment Report
  • 9
    • 52149090600 scopus 로고    scopus 로고
    • Tocilizumab monotherapy is superior to methotrexate monotherapy in reducing disease activity in patients with rheumatoid arthritis: The AMBITION study
    • Jones, G. et al. Tocilizumab monotherapy is superior to methotrexate monotherapy in reducing disease activity in patients with rheumatoid arthritis: The AMBITION study. Ann. Rheum. Dis. 67 (Suppl. II), 89 (2008).
    • (2008) Ann. Rheum. Dis , vol.67 , Issue.SUPPL. II , pp. 89
    • Jones, G.1
  • 10
    • 64049115766 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with an inadequate response to methotrexate: The LITHE Study
    • Kremer, J. M. et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with an inadequate response to methotrexate: The LITHE Study. Arthritis Rheum. 58, 4031 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 4031
    • Kremer, J.M.1
  • 11
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen, J. S. et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet 371 987-997 (2008).
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1
  • 12
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese, M. C. et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 58, 2968-2980 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 2968-2980
    • Genovese, M.C.1
  • 13
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
    • Emery, P. et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial. Ann. Rheum. Dis. 67, 1516-1523 (2008).
    • (2008) Ann. Rheum. Dis , vol.67 , pp. 1516-1523
    • Emery, P.1
  • 14
    • 34447343764 scopus 로고    scopus 로고
    • Assessing remission in clinical practice
    • Mierau, M. et al. Assessing remission in clinical practice. Rheumatology 46, 975-979 (2007).
    • (2007) Rheumatology , vol.46 , pp. 975-979
    • Mierau, M.1
  • 15
    • 67449124635 scopus 로고    scopus 로고
    • Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: The impacts of remission and TNF-blockade
    • 7 Jul, doi:10.1136/ ard.2008.090019
    • Smolen, J. S. et al. Radiographic changes in rheumatoid arthritis patients attaining different disease activity states with methotrexate monotherapy and infliximab plus methotrexate: The impacts of remission and TNF-blockade. Ann. Rheum. Dis. 7 Jul 2008 (doi:10.1136/ ard.2008.090019).
    • (2008) Ann. Rheum. Dis
    • Smolen, J.S.1
  • 16
    • 64049106604 scopus 로고    scopus 로고
    • IMS MIDAS 2009
    • IMS MIDAS (2009).
  • 17
    • 64049083596 scopus 로고    scopus 로고
    • Therapeutic categories outlook: Arthritis & inflammation (Cowen and Company, 2008).
    • Therapeutic categories outlook: Arthritis & inflammation (Cowen and Company, 2008).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.