Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2

Journal of Biological Chemistry

Volumn 283, Issue 47, 2008, Pages 32334-32343

  Gozgit, Joseph M ^a   Bebernitz, Geraldine ^a   Patil, Pankaj ^a   Ye, Minwei ^a   Parmentier, Julie ^a   Wu, Jiaquan ^a   Su, Nancy ^a   Wang, Tao ^a   Ioannidis, Stephanos ^a   Davies, Audrey ^a   Huszar, Dennis ^a   Zinda, Michael ^a,b  

^a ASTRAZENECA   (United Kingdom)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELLS; CHEMICAL REACTIONS; ELECTRIC LOAD MANAGEMENT; NUCLEIC ACIDS; PHOSPHORYLATION; RNA; TRANSIENTS;

ANTIAPOPTOTIC PROTEINS; APOPTOSIS; APOPTOTIC CELL DEATHS; CELL LINES; IN VITRO; KINASE FAMILIES; POLYCYTHEMIA VERA; PROMOTES CELLS; PROTEIN LEVELS; SMALL MOLECULES; SURVIVAL SIGNALING;

CYTOLOGY;

5 FLUORO 2 [1 (4 FLUOROPHENYL)ETHYLAMINO] 6 (5 METHYL 1H PYRAZOL 3 YLAMINO)NICOTINONITRILE; AZ 960; JANUS KINASE 2; JANUS KINASE INHIBITOR; MESSENGER RNA; PROTEIN BAD; PROTEIN BCL XL; PROTEIN KINASE; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; SERINE; SMALL INTERFERING RNA; STAT3 PROTEIN; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ALLELE; APOPTOSIS; ARTICLE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HETEROZYGOSITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; MEGAKARYOBLAST; MITOSIS INHIBITION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINOPYRIDINES; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; JANUS KINASE 2; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-PIM-1; PYRAZOLES; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 57749084579     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803813200     Document Type: Article

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