Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 2, 2011, Pages 968-977

  Yang, Su Hui ^a   Khadka, Daulat Bikram ^a   Cho, Suk Hee ^a   Ju, Hye Kyung ^b   Lee, Kwang Youl ^a   Han, Ho Jae ^a   Lee, Kyung Tae ^b   Cho, Won Jea ^a  

^a Chonnam National University   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

AG490; Apoptosis; JAK2; Quinazolines; Stem cell; SurflexDock; Virtual screening

Indexed keywords

(2,3 DICHLOROPHENYL)(6,7 DIMETHOXYQUINAZOLIN 4 YL)AMINE HYDROCHLORIDE; (4 BROMOPHENYL)(6,7 DIMETHOXYQUINAZOLIN 4 YL)AMINE HYDROCHLORIDE; (4 CHLOROBENZOTHIAZOL 2 YL)(6,7 DIMETHOXYQUINAZOLIN 4 YL)AMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN 4 YL) 4 TOLYLAMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)(2 METHOXYETHYL)AMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)(2 METHOXYPHENYL)AMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)(2 MORPHOLIN 4 YLETHYL)AMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)(4 METHOXYPHENYL)AMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)(4 METHYLPIPERAZIN1 YL)AMINE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)MORPHOLIN 4 YLAMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)NAPHTHALEN 1 YLAMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)PYRIDIN 2 YLMETHYLAMINE; (6,7 DIMETHOXYQUINAZOLIN 4 YL)TOLYLAMINE HYDROCHLORIDE; (6,7 DIMETHOXYQUINAZOLIN-4-YL)NAPHTHALEN 1 YLAMINE; 3 (6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO)PHENOL HYDROCHLORIDE; 4 (6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO)BENZONITRILE HYDROCHLORIDE; 4 (6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO)PHENOL HYDROCHLORIDE; 5 (6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO) 2 METHYLBENZONITRILE HYDROCHLORIDE; 6,7 DIMETHOXY 3H QUINAZOLIN 4 ONE; [2 (3,4 DIMETHOXYPHENYL)ETHYL](6,7 DIMETHOXYQUINAZOLIN 4 YL)AMINE HYDROCHLORIDE; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; QUINAZOLINE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; COMPUTER SIMULATION; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; JANUS KINASE 2; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; QUINAZOLINES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 78651503800     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.057     Document Type: Article

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