Recent advances in herbal medicines treating Parkinson's disease

Fitoterapia

Volumn 84, Issue 1, 2013, Pages 273-285

  Li, Xu Zhao ^a   Zhang, Shuai Nan ^b   Liu, Shu Min ^a   Lu, Fang ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^b Hospital of Heilongjiang Province   (China)

Author keywords

Genera; Herbal formulation; Herbal medicines; Parkinson's disease

Indexed keywords

ANTIPARKINSON AGENT; ASTRAGALOSIDE IV; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; GINSENG EXTRACT; HERBACEOUS AGENT; PAEONIA RADIX; PAEONIFLORIN; TETRAMETHYLPYRAZINE;

ALPINIA OXYPHYLLA; ASTRAGALUS MEMBRANACEUS; CHINENSIS SIELBOLDIANA; CHRYSANTHEMUM INDICUM; CHRYSANTHEMUM MORIFOLIUM; CISTANCHE; CISTANCHE DESERTICOLA; CISTANCHE SALSA; CISTANCHE TUBULOSA; CUSCUTA AUSTRALIS; CUSCUTA CHINENSIS; DOPAMINERGIC NERVE CELL; ELEUTHEROCOCCUS SENTICOSUS; FRAXINUS; FRAXINUS RHYNCHOPHYLLA; FRAXINUS STYLOSA; FRAXINUS SZABOANA; GASTRODIA ELATA; GINKGO BILOBA; GINSENG; GYNOSTEMMA PENTAPHYLLUM; HERBAL MEDICINE; HYPERICUM PERFORATUM; LIGUSTICUM; LIGUSTICUM CHUANXIONG; NEUROPROTECTION; NONHUMAN; PAEONIA LACTIFLORA; PANAX NOTOGINSENG; PARKINSON DISEASE; POLYGALA TENUIFOLIA; POLYGONUM CUSPIDATUM; PRIORITY JOURNAL; PUERARIA LOBATA; REVIEW; SALVIA MILTIORRHIZA; SCUTELLARIA BAICALENSIS; SENNA OBTUSIFOLIA; SENNA TORA; TEA;

HERBAL MEDICINE; HUMANS; PARKINSON DISEASE; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 84873380786     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2012.12.009     Document Type: Review

References (154)

1. S.M. Liu, X.Z. Li, Y. Huo, and F. Lu Protective effect of extract of Acanthopanax senticosus Harms on dopaminergic neurons in Parkinson's disease mice Phytomedicine 19 2012 631 638
2. A.H. Schapira, E. Bezard, J. Brotchie, F. Calon, G.L. Collingridge, and B. Ferger Novel pharmacological targets for the treatment of Parkinson's disease Nat Rev Drug Discov 5 2006 845 854
3. Q. Li, D. Zhao, and E. Bezard Traditional Chinese medicine for Parkinson's disease: a review of Chinese literature Behav Pharmacol 17 2006 403 410
4. L. Zhang, and S.M. Liu Recent developments of traditional Chinese medicine in treatment of Parkinson disease Chin J Clin Rehabil 10 2006 152 154
5. Subject Database of China Plant www.plant.csdb.cn
6. M.F. Beal Experimental models of Parkinson's disease Nat Rev Neurosci 2 2001 325 334
7. D. Blum, S. Torch, N. Lambeng, M. Nissou, A.L. Benabid, and R. Sadoul Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease Prog Neurobiol 65 2001 135 172
8. S. Singh, and M. Dikshit Apoptotic neuronal death in Parkinson's disease: involvement of nitric oxide Brain Res Rev 54 2007 233 250
9. T. Fujikawa, S. Miguchi, N. Kanada, N. Nakai, M. Ogata, and I. Suzuki Acanthopanax senticosus Harms as a prophylactic for MPTP-induced Parkinson's disease in rats J Ethnopharmacol 97 2005 375 381
10. T. Fujikawa, H. Soya, H. Hibasami, H. Kawashima, H. Takeda, and S. Nishibe Effect of Acanthopanax senticosus Harms on biogenic monoamine levels in the rat brain Phytother Res 16 2002 474 478
11. T. Fujikawa, N. Kanada, A. Shimada, M. Ogata, I. Suzuki, and I. Hayashi Effect of sesamin in Acanthopanax senticosus HARMS on behavioral dysfunction in rotenone-induced parkinsonian rats Biol Pharm Bull 28 2005 169 172
12. V. Lahaie-Collins, J. Bournival, M. Plouffe, J. Carange, and M.G. Martinoli Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP +-induced oxidative stress Oxid Med Cell Longev 1 2008 54 62
13. Y.L. Dong, S.M. Liu, L.F. AN, F. Lu, B. Tang, and S.H. Zhou The effect of eleutheroside B on ERK1/2 of MPP +-induced PC12 cells J Mol Diagn Ther 3 2011 155 158
14. Z.J. Zhang, L.C. Cheang, M.W. Wang, G.H. Li, I.K. Chu, and Z.X. Lin Ethanolic extract of fructus Alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish Cell Mol Neurobiol 32 2012 27 40
15. H.N. Zhang, C.N. An, and X.P. Pu Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo Neurosci Lett 474 2010 99 103
16. H.N. Zhang, C.N. An, M. Xu, D.A. Guo, M. Li, and X.P. Pu Protocatechuic acid inhibits rat pheochromocytoma cell damage induced by a dopaminergic neurotoxin Biol Pharm Bull 32 2009 1866 1869
17. S. Guan, B. Jiang, Y.M. Bao, and L.J. An Protocatechuic acid suppresses MPP +-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells Food Chem Toxicol 44 2006 1659 1666
18. L.J. An, S. Guan, G.F. Shi, Y.M. Bao, Y.L. Duan, and B. Jiang Protocatechuic acid from Alpinia oxyphylla against MPP +-induced neurotoxicity in PC12 cells Food Chem Toxicol 44 2006 436 443
19. Z.G. Zhang, L. Wu, J.L. Wang, J.D. Yang, J. Zhang, and L.H. Li Astragaloside IV prevents MPP(+)-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production Mol Cell Biochem 364 2012 209 216
20. W.S. Chan, S.S. Durairajan, J.H. Lu, Y. Wang, L.X. Xie, and W.F. Kum Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture Neurochem Int 55 2009 414 422
21. W.X. LI, S.G. Sun, H. Yuan, H.T. Wang, Y.B. Zhang, and B.L. Sun Time dependency of astragalus polysaccharides against systemic injury of free radical in astrocyte culture medium Chin J Clin Rehabil 10 2006 56 61
22. K. Tanaka, Y. Miyake, W. Fukushima, S. Sasaki, C. Kiyohara, and Y. Tsuboi Intake of Japanese and Chinese teas reduces risk of Parkinson's disease Parkinsonism Relat Disord 17 2011 446 450
23. Y. Levites, M.B. Youdim, G. Maor, and S. Mandel Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures Biochem Pharmacol 63 2002 21 29
24. S. Guo, E. Bezard, and B. Zhao Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway Free Radic Biol Med 39 2005 682 695
25. S. Guo, J. Yan, T. Yang, X. Yang, E. Bezard, and B. Zhao Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway Biol Psychiatry 62 2007 1353 1362
26. G. Nie, C. Jin, Y. Cao, S. Shen, and B. Zhao Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells Arch Biochem Biophys 397 2002 84 90
27. R. Li, N. Peng, X.P. Li, and W.D. Le (-)-Epigallocatechin gallate regulates dopamine transporter internalization via protein kinase C-dependent pathway Brain Res 1097 2006 85 89
28. K.K. Tai, and D.D. Truong (-)-Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, reduces dichlorodiphenyl-trichloroethane (DDT)-induced cell death in dopaminergic SHSY-5Y cells Neurosci Lett 482 2010 183 187
29. J.Y. Choi, C.S. Park, D.J. Kim, M.H. Cho, B.K. Jin, and J.E. Pie Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate Neurotoxicology 23 2002 367 374
30. J.S. Kim, J.M. Kim, J.J. O, and B.S. Jeon Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease J Clin Neurosci 17 2010 1165 1168
31. M.S. Ju, H.G. Kim, J.G. Choi, J.H. Ryu, J. Hur, and Y.J. Kim Cassiae semen, a seed of Cassia obtusifolia, has neuroprotective effects in Parkinson's disease models Food Chem Toxicol 48 2010 2037 2044
32. T.H. Park, D.H. Kim, C.H. Kim, H.A. Jung, J.S. Choi, and J.W. Lee Peroxynitrite scavenging mode of alaternin isolated from Cassia tora J Pharm Pharmacol 56 2004 1315 1321
33. B.Y. Shin, D.H. Kim, S.K. Hyun, H.A. Jung, J.M. Kim, and S.J. Park Alaternin attenuates delayed neuronal cell death induced by transient cerebral hypoperfusion in mice Food Chem Toxicol 48 2010 1528 1536
34. I.S. Kim, S. Koppula, P.J. Park, E.H. Kim, C.G. Kim, and W.S. Choi Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP +-induced cytotoxicity J Ethnopharmacol 126 2009 447 454
35. I.S. Kim, H.M. Ko, S. Koppula, B.W. Kim, and D.K. Choi Protective effect of Chrysanthemum indicum Linne against 1-methyl-4-phenylpridinium ion and lipopolysaccharide-induced cytotoxicity in cellular model of Parkinson's disease Food Chem Toxicol 49 2011 963 973
36. W.W. Li, R. Yang, and D.F. Cai Protective effects of Cistanche total glycosides on dopaminergic neuron in substantia nigra of model mice of Parkinson's disease Zhongguo Zhong Xi Yi Jie He Za Zhi 28 2008 248 251
37. H. Chen, F.C. Jing, C.L. Li, P.F. Tu, Q.S. Zheng, and Z.H. Wang Echinacoside prevents the striatal extracellular levels of monoamine neurotransmitters from diminution in 6-hydroxydopamine lesion rats J Ethnopharmacol 114 2007 285 289
38. X. Geng, X. Tian, P. Tu, and X. Pu Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease Eur J Pharmacol 564 2007 66 74
39. Q. Zhao, J. Gao, W. Li, and D. Cai Neurotrophic and neurorescue effects of echinacoside in the subacute MPTP mouse model of Parkinson's disease Brain Res 1346 2010 224 236
40. Y. Gao, and X.P. Pu Neuroprotective effect of acteoside against rotenone-induced damage of SH-SY5Y cells and its possible mechanism Chin Pharmacol Bull 23 2007 161 165
41. L. Zhao, and X.P. Pu Neuroprotective effect of acteoside against MPTP-induced mouse model of Parkinson's disease Chin Pharmacol Bull 23 2007 42 46
42. Z.G. Li, B. Jiang, Y.M. Bao, and L.J. An Protection of Semen Cuscuta extracts from apoptosis PC12 cell of induced by1-methyl-4-phenylpyridinium Chin Tradit Pat Med 28 2006 219 221
43. M.F. Molina-Jimenez, M.I. Sanchez-Reus, and J. Benedi Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine Eur J Pharmacol 472 2003 81 87
44. M.F. Molina-Jimenez, M.I. Sanchez-Reus, D. Andres, M. Cascales, and J. Benedi Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells Brain Res 1009 2004 9 16
45. M.F. Molina-Jimenez, M.I. Sanchez-Reus, M. Cascales, D. Andres, and J. Benedi Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine Toxicol Appl Pharmacol 209 2005 214 225
46. M.I. Sanchez-Reus, I.I. Peinado, M.F. Molina-Jimenez, and J. Benedi Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells Neurosci Res 53 2005 48 56
47. D.L. Zhao, L.B. Zou, S. Lin, J.G. Shi, and H.B. Zhu Anti-apoptotic effect of esculin on dopamine-induced cytotoxicity in the human neuroblastoma SH-SY5Y cell line Neuropharmacology 53 2007 724 732
48. D.L. Zhao, L. Shi, K.G. Zhai, L.B. Zou, S. Lin, and J.G. Shi Esculin, an extract from Fraxinus sielboldiana blume, protects SH-SY5Y cells from MPP +-induced cytotoxicity Acad J PLA Postgrad Med Sch 29 2008 112 114
49. D.L. Zhao, L.B. Zou, S. Lin, J.G. Shi, and H.B. Zhu 6,7-di-O- glucopyranosyl-esculetin protects SH-SY5Y cells from dopamine-induced cytotoxicity Eur J Pharmacol 580 2008 329 338
50. D.L. Zhao, D.W. Shen, Y.T. Chi, F. Liu, L.B. Zou, and H.B. Zhu Liriodendrin protects SH-SY5Y cells from dopamine-induced cytotoxicity J Chin Pharm Sci 16 2007 294 299
51. H. An, I.S. Kim, S. Koppula, B.W. Kim, P.J. Park, and B.O. Lim Protective effects of Gastrodia elata Blume on MPP +-induced cytotoxicity in human dopaminergic SH-SY5Y cells J Ethnopharmacol 130 2010 290 298
52. I.S. Kim, D.K. Choi, and H.J. Jung Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells Molecules 16 2011 5349 5361
53. E. Jeschke, T. Ostermann, H.C. Vollmar, M. Tabali, F. Schad, and H. Matthes Prescribing patterns in dementia: a multicentre observational study in a German network of CAM physicians BMC Neurol 11 2011 99
54. X. Kang, J. Chen, Z. Xu, H. Li, and B. Wang Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells Toxicol In Vitro 21 2007 1003 1009
55. M.S. Kim, J.I. Lee, W.Y. Lee, and S.E. Kim Neuroprotective effect of Ginkgo biloba L. extract in a rat model of Parkinson's disease Phytother Res 18 2004 663 666
56. P. Rojas, N. Serrano-Garcia, J.J. Mares-Samano, O.N. Medina-Campos, J. Pedraza-Chaverri, and S.O. Ogren EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine- induced Parkinsonism in mice: role of oxidative stress Eur J Neurosci 28 2008 41 50
57. P. Rojas, S. Montes, N. Serrano-Garcia, and J. Rojas-Castaneda Effect of EGb761 supplementation on the content of copper in mouse brain in an animal model of Parkinson's disease Nutrition 25 2009 482 485
58. H.S. Choi, M.S. Park, S.H. Kim, B.Y. Hwang, C.K. Lee, and M.K. Lee Neuroprotective effects of herbal ethanol extracts from Gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease Molecules 15 2010 2814 2824
59. P. Wang, L. Niu, X.D. Guo, L. Gao, W.X. Li, and D. Jia Gypenosides protects dopaminergic neurons in primary culture against MPP(+)-induced oxidative injury Brain Res Bull 83 2010 266 271
60. P. Wang, L. Niu, L. Gao, W.X. Li, D. Jia, and X.L. Wang Neuroprotective effect of gypenosides against oxidative injury in the substantia nigra of a mouse model of Parkinson's disease J Int Med Res 38 2010 1084 1092
61. M. Mohanasundari, and M. Sabesan Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson's disease in mice Eur Rev Med Pharmacol Sci 11 2007 17 20
62. Y.H. Lu, C.B. Du, J.W. Liu, W. Hong, and D.Z. Wei Neuroprotective effects of Hypericum perforatum on trauma induced by hydrogen peroxide in PC12 cells Am J Chin Med 32 2004 397 405
63. M.I. Sanchez-Reus, M.A. Gomez del Rio, I. Iglesias, M. Elorza, K. Slowing, and J. Benedi Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats Neuropharmacology 52 2007 606 616
64. Y.P. Zou, Y.H. Lu, and D.Z. Wei Protective effects of a flavonoid-rich extract of Hypericum perforatum L. against hydrogen peroxide-induced apoptosis in PC12 cells Phytother Res 24 Suppl. 1 2010 S6 S10
65. Z. Liu, X. Tao, C. Zhang, Y. Lu, and D. Wei Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide Biomed Pharmacother 59 2005 481 490
66. D.Q. Wang, W. Wang, and F.C. Jing Effects of tetramethylpyrazine on brain oxidative damage induced by intracerebral perfusion of L-DOPA in rats with Parkinson's disease Zhongguo Zhong Xi Yi Jie He Za Zhi 27 2007 629 632
67. D.Q. Wang, W. Wang, F.C. Jing, and J.N. Zhao Effects of tetramethylpyrazine on the extracellular DA, its metabolites and hydroxyl radical in striatum of PD rats treated by L-DOPA Chin Pharm J 42 2007 28 32
68. M.E. Zhu, D. Shu, J.F. Chen, and J.C. He Neuroprotective effects and mechanisms of ligustrazine against MPTP-induced dopaminergic neurotoxicity in a mouse model of Parkinson's disease J Apoplexy Nerv Dis 26 2009 333 335
69. J. Du, L.C. Shan, G.X. Zhang, and Y.Q. Wang Effect of TMP on dopaminergic neuron injury induced by MPTP in vivo and vitro Lishizhen Med Mater Med Res 22 2011 1564 1565
70. B.Y. Cao, Y.P. Yang, W.F. Luo, C.J. Mao, R. Han, and X. Sun Paeoniflorin, a potent natural compound, protects PC12 cells from MPP + and acidic damage via autophagic pathway J Ethnopharmacol 131 2010 122 129
71. D.Z. Liu, J. Zhu, D.Z. Jin, L.M. Zhang, X.Q. Ji, and Y. Ye Behavioral recovery following sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson's disease J Ethnopharmacol 112 2007 327 332
72. H.Q. Liu, W.Y. Zhang, X.T. Luo, Y. Ye, and X.Z. Zhu Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor Br J Pharmacol 148 2006 314 325
73. S. Hu, R. Han, S. Mak, and Y. Han Protection against 1-methyl-4- phenylpyridinium ion (MPP +)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells J Ethnopharmacol 135 2011 34 42
74. J. Van Kampen, H. Robertson, T. Hagg, and R. Drobitch Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease Exp Neurol 184 2003 521 529
75. K. Radad, G. Gille, R. Moldzio, H. Saito, and W.D. Rausch Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate Brain Res 1021 2004 41 53
76. W.M. Lin, Y.M. Zhang, R. Moldzio, and W.D. Rausch Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture J Neural Transm Suppl 2007 105 112
77. B.B. Xu, C.Q. Liu, X. Gao, W.Q. Zhang, S.W. Wang, and Y.L. Cao Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson's disease mouse model J Asian Nat Prod Res 7 2005 215 224
78. X.C. Chen, Y.G. Zhu, L.A. Zhu, C. Huang, Y. Chen, and L.M. Chen Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress Eur J Pharmacol 473 2003 1 7
79. Q. Liu, J.P. Kou, and B.Y. Yu Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kappaB activation Neurochem Int 58 2011 119 125
80. H. Xu, H. Jiang, J. Wang, and J. Xie Rg1 protects iron-induced neurotoxicity through antioxidant and iron regulatory proteins in 6-OHDA-treated MES23.5 cells J Cell Biochem 111 2010 1537 1545
81. H. Xu, H. Jiang, J. Wang, and J. Xie Rg1 protects the MPP +-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake Neuropharmacology 58 2010 488 494
82. Y. Chen, and X.C. Chen Possible mechanisms of the protective effect of ginsenoside Rg1 on apoptosis in substantia nigra neurons Yao Xue Xue Bao 37 2002 249 252
83. X.C. Chen, Y. Chen, Y.G. Zhu, F. Fang, and L.M. Chen Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons Acta Pharmacol Sin 23 2002 829 834
84. J. Wang, H.M. Xu, H.D. Yang, X.X. Du, H. Jiang, and J.X. Xie Rg1 reduces nigral iron levels of MPTP-treated C57BL6 mice by regulating certain iron transport proteins Neurochem Int 54 2009 43 48
85. J.F. Hu, X.Y. Song, S.F. Chu, J. Chen, H.J. Ji, and X.Y. Chen Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice Brain Res 1374 2011 8 14
86. L. Xu, L.X. Liu, W.F. Chen, J.X. Xie, and W.X. Huang The protective effect of ginsenoside Rg1 on dopaminergic neurons of substantia in the ovariectomized rat model of Parkinson's disease Zhongguo Ying Yong Sheng Li Xue Za Zhi 24 2008 1 5
87. L. Xu, W.F. Chen, and M.S. Wong Ginsenoside Rg1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway Br J Pharmacol 158 2009 738 748
88. K.W. Leung, K.K. Yung, N.K. Mak, Y.S. Chan, T.P. Fan, and R.N. Wong Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity Neuropharmacology 52 2007 827 835
89. C.A. Beamer, and D.M. Shepherd Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng J Neuroimmune Pharmacol 7 2012 465 476
90. F.C. Luo, S.D. Wang, K. Li, H. Nakamura, J. Yodoi, and J. Bai Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity J Ethnopharmacol 127 2010 419 423
91. F.C. Luo, S.D. Wang, L. Qi, J.Y. Song, T. Lv, and J. Bai Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo J Ethnopharmacol 133 2011 448 453
92. L.-b Zhang, X.-h Liu, Y. Jiang, P. Guo, L.-j Sha, and Y. Li Effect of notoginsenoside-Rg1 on the expression of several proteins in the striatum of rat models with Parkinson's disease Chem Res Chin Univ 22 2006 139 144
93. L.B. Zhang, and G.Z. Yang The antagonistic effect of notoginsenoside-Rg1 injected in striatum on immunoin-flammatory injury in rat model of Parkinson's disease Chin J Immunol 20 2004 121 123
94. J.G. Choi, H.G. Kim, M.C. Kim, W.M. Yang, Y. Huh, and S.Y. Kim Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models J Ethnopharmacol 134 2011 414 421
95. Z. Liang, F. Shi, Y. Wang, L. Lu, Z. Zhang, and X. Wang Neuroprotective effects of tenuigenin in a SH-SY5Y cell model with 6-OHDA-induced injury Neurosci Lett 497 2011 104 109
96. H.L. Yuan, B. Li, J. Xu, Y. Wang, Y. He, and Y. Zheng Tenuigenin protects dopaminergic neurons from inflammation-mediated damage induced by the lipopolysaccharide CNS Neurosci Ther 18 2012 584 590
97. J.K. Jeong, M.H. Moon, B.C. Bae, Y.J. Lee, J.W. Seol, and H.S. Kang Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity Neurosci Res 73 2012 99 105
98. Y. Wu, X. Li, J.X. Zhu, W. Xie, W. Le, and Z. Fan Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease Neurosignals 19 2011 163 174
99. J. Bournival, P. Quessy, and M.G. Martinoli Protective effects of resveratrol and quercetin against MPP +-induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons Cell Mol Neurobiol 29 2009 1169 1180
100. D. Alvira, M. Yeste-Velasco, J. Folch, E. Verdaguer, A.M. Canudas, and M. Pallas Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons Neuroscience 147 2007 746 756
101. M. Okawara, H. Katsuki, E. Kurimoto, H. Shibata, T. Kume, and A. Akaike Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults Biochem Pharmacol 73 2007 550 560
102. K.T. Lu, M.C. Ko, B.Y. Chen, J.C. Huang, C.W. Hsieh, and M.C. Lee Neuroprotective effects of resveratrol on MPTP-induced neuron loss mediated by free radical scavenging J Agric Food Chem 56 2008 6910 6913
103. G. Srivastava, A. Dixit, S. Yadav, D.K. Patel, O. Prakash, and M.P. Singh Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced Parkinsonism in the mouse Free Radic Biol Med 52 2012 1294 1306
104. F. Jin, Q. Wu, Y.F. Lu, Q.H. Gong, and J.S. Shi Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats Eur J Pharmacol 600 2008 78 82
105. M.M. Khan, A. Ahmad, T. Ishrat, M.B. Khan, M.N. Hoda, and G. Khuwaja Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease Brain Res 1328 2010 139 151
106. Y. Wang, H. Xu, Q. Fu, R. Ma, and J. Xiang Protective effect of resveratrol derived from Polygonum cuspidatum and its liposomal form on nigral cells in parkinsonian rats J Neurol Sci 304 2011 29 34
107. J. Chao, H. Li, K.W. Cheng, M.S. Yu, R.C. Chang, and M. Wang Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells J Nutr Biochem 21 2010 482 489
108. G. Zhao, S. Li, G.W. Qin, J. Fei, and L.H. Guo Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter J Ethnopharmacol 112 2007 498 506
109. G. Zhao, X.W. Zheng, G.W. Qin, Y. Gai, Z.H. Jiang, and L.H. Guo In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of delta 3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.) Cell Mol Life Sci 66 2009 1617 1629
110. G. Zhao, S.Y. Zang, X.W. Zheng, X.H. Zhang, and L.H. Guo Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions Biochem Pharmacol 75 2008 1835 1847
111. G. Zhu, X. Wang, S. Wu, and Q. Li Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP +-induced human neuroblastoma SH-SY5Y cell death Neurochem Int 60 2012 400 408
112. Y.F. Cheng, G.Q. Zhu, M. Wang, H. Cheng, A. Zhou, and N. Wang Involvement of ubiquitin proteasome system in protective mechanisms of puerarin to MPP(+)-elicited apoptosis Neurosci Res 63 2009 52 58
113. G. Wang, L. Zhou, Y. Zhang, M. Dong, X. Li, and J. Liu Implication of the c-jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP +)-induced apoptosis in PC-12 cells Neurosci Lett 487 2011 88 93
114. G. Zhu, X. Wang, Y. Chen, S. Yang, H. Cheng, and N. Wang Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease Planta Med 76 2010 1820 1826
115. C.M. Lin, R.D. Lin, S.T. Chen, Y.P. Lin, W.T. Chiu, and J.W. Lin Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells Phytochemistry 71 2010 2147 2156
116. X. Li, X. Ye, X. Sun, Q. Liang, L. Tao, and X. Kang Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway Brain Res 1382 2011 9 18
117. L. Zhang, W. Ding, H. Sun, Q. Zhou, J. Huang, and X. Li Salidroside protects PC12 cells from MPP(+)-induced apoptosis via activation of the PI3K/Akt pathway Food Chem Toxicol 50 2012 2591 2597
118. Y.H. Zhang, M. Ye, X.J. Wang, G. Wang, H.Q. Yang, and J.F. Ma Effect of salidroside on PI3K/protein kinase B signaling in Parkinson's disease model mice J Clin Neurol 21 2008 133 135
119. X.J. Wang, and J.X. Xu Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity Neurosci Res 51 2005 129 138
120. H.A. Zhang, M. Gao, L. Zhang, Y. Zhao, L.L. Shi, and B.N. Chen Salvianolic acid A protects human SH-SY5Y neuroblastoma cells against H(2)O(2)-induced injury by increasing stress tolerance ability Biochem Biophys Res Commun 421 2012 479 483
121. L.L. Tian, X.J. Wang, Y.N. Sun, C.R. Li, Y.L. Xing, and H.B. Zhao Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents 6-hydroxydopamine induced apoptosis in SH-SY5Y cells Int J Biochem Cell Biol 40 2008 409 422
122. G. Zeng, T. Tang, H.J. Wu, W.H. You, J.K. Luo, and Y. Lin Salvianolic acid B protects SH-SY5Y neuroblastoma cells from 1-methyl-4-phenylpyridinium- induced apoptosis Biol Pharm Bull 33 2010 1337 1342
123. C.S. Liu, N.H. Chen, and J.T. Zhang Protection of PC12 cells from hydrogen peroxide-induced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae Phytomedicine 14 2007 492 497
124. X. Mu, G. He, Y. Cheng, X. Li, B. Xu, and G. Du Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental Parkinsonism in vivo and in vitro Pharmacol Biochem Behav 92 2009 642 648
125. X. Yu, G.R. He, L. Sun, X. Lan, L.L. Shi, and Z.H. Xuan Assessment of the treatment effect of baicalein on a model of Parkinsonian tremor and elucidation of the mechanism Life Sci 91 2012 5 13
126. X.X. Li, G.R. He, X. Mu, B. Xu, S. Tian, and X. Yu Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria Eur J Pharmacol 674 2012 227 233
127. J.H. Choi, A.Y. Choi, H. Yoon, W. Choe, K.S. Yoon, and J. Ha Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction Exp Mol Med 42 2010 811 822
128. F.Q. Li, T. Wang, Z. Pei, B. Liu, and J.S. Hong Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons J Neural Transm 112 2005 331 347
129. M. Zhu, S. Rajamani, J. Kaylor, S. Han, F. Zhou, and A.L. Fink The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils J Biol Chem 279 2004 26846 26857
130. J.H. Lu, M.T. Ardah, S.S. Durairajan, L.F. Liu, L.X. Xie, and W.F. Fong Baicalein inhibits formation of alpha-synuclein oligomers within living cells and prevents Abeta peptide fibrillation and oligomerisation Chembiochem 12 2011 615 624
131. Y. Cheng, G. He, X. Mu, T. Zhang, X. Li, and J. Hu Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile Neurosci Lett 441 2008 16 20
132. X. Mu, G.R. He, X. Yuan, X.X. Li, and G.H. Du Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice Pharmacol Biochem Behav 98 2011 286 291
133. Y. Liu, H.L. Chen, and G. Yang Extract of Tripterygium wilfordii Hook F protect dopaminergic neurons against lipopolysaccharide-induced inflammatory damage Am J Chin Med 38 2010 801 814
134. F.Q. Li, X.X. Cheng, X.B. Liang, X.H. Wang, B. Xue, and Q.H. He Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons Exp Neurol 179 2003 28 37
135. X. Ren, T. Zhang, J. Hu, W. Ding, and X. Wang Triptolide T10 enhances AAV-mediated gene transfer in mice striatum Neurosci Lett 479 2010 187 191
136. B. Xue, J. Jiao, L. Zhang, K.R. Li, Y.T. Gong, and J.X. Xie Triptolide upregulates NGF synthesis in rat astrocyte cultures Neurochem Res 32 2007 1113 1119
137. J.P. Gao, S. Sun, W.W. Li, Y.P. Chen, and D.F. Cai Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats: implication for immunosuppressive therapy in Parkinson's disease Neurosci Bull 24 2008 133 142
138. H.F. Zhou, X.Y. Liu, D.B. Niu, F.Q. Li, Q.H. He, and X.M. Wang Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection Neurobiol Dis 18 2005 441 449
139. F.Q. Li, X.Z. Lu, X.B. Liang, H.F. Zhou, B. Xue, and X.Y. Liu Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation J Neuroimmunol 148 2004 24 31
140. K. Iwasaki, Q. Wang, H. Seki, K. Satoh, A. Takeda, and H. Arai The effects of the traditional Chinese medicine, "Banxia Houpo Tang (Hange-Koboku To)" on the swallowing reflex in Parkinson's disease Phytomedicine 7 2000 259 263
141. Z.Y. Lu, H. Zhao, T. Wang, J. Chen, Q.J. Zhang, and H. Jin Effects of Bushen Yanggan Xifeng Decoction on neurotransmitters and dopamine receptors in the striatum of Parkinson's disease model mice J Tradit Chin Med 52 2011 1217 1220
142. D. Shu, J.C. He, and J.F. Chen Neuroprotective effects and mechanisms of Chuanxiong Chatiao pulvis against MPTP-induced dopaminergic neurotoxicity in mice model of Parkinson's disease China J Chin Mater Med 34 2009 2494 2497
143. J. Jin, L.X. Duan, J. Sun, W.J. Zhao, and Q.L. Zhou Protective effect of Huanglian Jiedu Deeoetion on the injury of PC12 cells induced by MPP + Chin Pharm J 43 2008 344 348
144. T. Ishikawa, T. Funahashi, and J. Kudo Effectiveness of the Kampo kami-shoyo-san (TJ-24) for tremor of antipsychotic-induced parkinsonism Psychiatry Clin Neurosci 54 2000 579 582
145. M.J. Dong, H.Y. Qian, S.F. Zhou, W.W. Liu, and Z.B. Wu Protective effects of Liuwei Dihuang Pill against oxidative stress reaction in PD mice model J Zhejiang Univ Trad Chin Med 33 2009 756 757
146. S.F. Zhou, and H.Y. Qian Effects of Liuwei Dihuang Pill on dopaminergic neurons in MPTP-induced PD mice Hubei J TCM 31 2009 6 7
147. Y.C. Lo, Y.T. Shih, Y.T. Tseng, and H.T. Hsu Neuroprotective effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP models of Parkinson's disease in vitro and in vivo Evid Based Complement Alternat Med 2012 2012 501032
148. J.C. He, and W.W. Wang Effect of Tianma Gouteng Yin on apoptosis of dopaminergic neurons in Parkinson's disease model rats J Tradit Chin Med 51 2010 1024 1027
149. W.W. Wang, J.C. He, and H.J. Ding Effect of tianma gouteng drink on the behavioural and oxidation stress response of Parkinson's disease rat Chin J Gerontol 30 2010 1657 1659
150. N. Bae, T. Ahn, S. Chung, M.S. Oh, H. Ko, and H. Oh The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease J Ethnopharmacol 134 2011 313 322
151. X.M. Li, H.B. Ma, Z.Q. Ma, L.F. Li, C.L. Xu, and R. Qu Ameliorative and neuroprotective effect in MPTP model of Parkinson's disease by Zhen-Wu-Tang (ZWT), a traditional Chinese medicine J Ethnopharmacol 130 2010 19 27
152. X.M. Li, C.L. Xu, J.M. Deng, L.F. Li, S.P. Ma, and R. Qu Protective effect of Zhen-Wu-Tang (ZWT) through keeping DA stable and VMAT 2/DAT mRNA in balance in rats with striatal lesions induced by MPTP J Ethnopharmacol 134 2011 768 774
153. L. Wentao, L. Rukui, W. Yang, S. Huifen, and L. Yu Inducing effects of Zhichan Soup on neuron stem cell differentiation World Sci Technol 11 2009 371 374
154. L. Wentao, S. Huifen, W. Yang, L. Rukui, L. Yi, and L. Yu Effect of Zhichan Decoction on neural stem cell differentiation in Parkinson's disease model rats World Sci Technol 13 2011 475 479