Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons

Experimental Neurology

Volumn 179, Issue 1, 2003, Pages 28-37

  Li, Feng Qiao ^a   Cheng, Xiao Xin ^a,b   Liang, Xi Bin ^a   Wang, Xin Hong ^a   Xue, Bing ^a   He, Qi Hua ^a   Wang, Xiao Min ^a   Han, Ji Sheng ^a  

^a PEKING UNIVERSITY   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Brain derived neurotrophic factor; Chinese herb; Immunosuppressant; Neurotrophic; Parkinson's disease; Tripchlorolide; Tripterygium wilfordii Hook F

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; DEXAMPHETAMINE; MESSENGER RNA; NEUROTROPHIC FACTOR; TACROLIMUS; TRIPCHLORIDE; TRIPTERYGIUM WILFORDII EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG EFFICACY; DRUG TARGETING; EMBRYO; FOREBRAIN; IN SITU HYBRIDIZATION; NERVE CELL; NERVE FIBER GROWTH; NERVE TRANSECTION; NEUROPROTECTION; NEUROTOXICITY; NEUROTROPISM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBSTANTIA NIGRA; TRIPTERYGIUM;

TRIPTERYGIUM WILFORDII;

EID: 0037226964     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.8049     Document Type: Article

References (32)

1. Beck, K. D., J. Valverde, T. Alexi, K. Poulsen, B. Moffat, R. A. Vandlen, A. Rosenthal, and F. Hefti. 1995. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373: 339-341.
2. Brecknell, J. E., S. B. Dunnett, and J. W. Fawcett. 1995. A quantitative study of cell death in the substantia nigra following a mechanical lesion of the medial forebrain bundle. Neuroscience 64: 219-227.
3. Costantini, L. C., P. Chaturvedi, D. M. Armistead, P. G. McCaffrey, T. W. Deacon, and O. Isacson. 1998. A novel immunophilin ligand: Distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease. Neurobiol. Dis. 5: 97-106.
4. Ding, W., D. Liu, and W. Wen. 1999. Effect of Tripterygium wilfordii hook on nerve regeneration after heterografting. Acta Anatom. Sin. 30: 31-34.
5. Friedman, W. J., P. Ernfors, and H. Persson. 1991. Transient and persistent expression of NT-3/BDNF mRNA in the rat brain during postnatal development. J. Neurosci. 11: 1577-1584.
6. Harper, S., J. Bilsland, L. Young, L. Bristow, S. Boyce, G. Mason, M. Rigby, L. Hewson, D. Smith, R. O'Donnell, D. O'Connor, R. G. Hill, D. Evans, C. Swain, B. Williams, and F. Hefti. 1999. Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo. Neuroscience 88: 257-267.
7. Hefti, F. 1997. Pharmacology of neurotrophic factors. Annu. Rev. Pharmacol. Toxicol. 37: 239-267.
8. Herdegan, T., G. Fischer, and B. G. Bold. 2000. Immunophilin ligands as a novel treatment of neurological disorders. Trends Pharmacol. Sci. 21: 3-5.
9. Hofer, M., S. R. Pagliusi, A. Hohn, J. Leibrock, and Y. A. Barde. 1990. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J. 9: 2459-2464.
10. Miranda, R. C., F. Sohrabji, and C. D. Toran-Allerand. 1993. Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions. Proc. Natl. Acad. Sci. USA 90: 6439-6443.
11. Mogi, M., M. Harada, T. Kondo, P. Riederer, H. Inagaki, M. Minami, and T. Nagatsu. 1994. Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180: 147-150.
12. Mogi, M., M. Harada, P. Riederer, H. Narabayashi, K. Fujita, and T. Nagatsu. 1994. Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci. Lett. 165: 208-210.
13. Mogi, M., A. Togari, T. Kondo, Y. Mizuno, O. Komure, S. Kuno, H. Ichinose, and T. Nagatsu. 1999. Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease. Neurosci. Lett. 270: 45-48.
14. Mogi, M., A. Togari, M. Ogawa, K. Ikeguchi, N. Shizuma, D. Fan, I. Nakano, and T. Nagatsu. 1998. Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum. Neurosci. Lett. 250: 25-28.
15. Mogi, M., A. Togari, K. Tanaka, N. Ogawa, H. Ichinose, and T. Nagatsu. 2000. Increase in level of tumor necrosis factor-alpha in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506. Neurosci. Lett. 289: 165-168.
16. Park, T. H., and C. Mytilineou. 1992. Protection from 1-methyl-4-phenylpyridinium (MPP+) toxicity and stimulation of re-growth of MPP(+)-damaged dopaminergic fibers by treatment of mesencephalic cultures with EGF and basic FGF. Brain Res. 599: 83-97.
17. Paxinos, G., and Watson, C. 1982. The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
18. Qiu, D., G. Zhao, Y. Aoki, L. Shi, A. Uyei, S. Nazarian, J. C. Ng, and P. N. Kao. 1999. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J. Biol. Chem. 274: 13443-13450.
19. Rabacchi, S. A., B. Kruk, J. Hamilton, C. Carney, J. R. Hoffman, S. L. Meyer, J. E. Springer, and D. H. Baird. 1999. BDNF and NT4/5 promote survival and neurite outgrowth of ponto-cerebellar mossy fiber neurons. J. Neurobiol. 40: 254-269.
20. Revuelta, M., J. L. Venero, A. Machado, and J. Cano. 1999. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial fore-brain bundle: Correlation with reactive microglial and astroglial populations. Neuroscience 91: 567-577.
21. Shults, C. W., T. Kimber, and C. A. Altar. 1995. BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine. NeuroReport 6: 1109-1112.
22. Snyder, S. H., D. M. Sabatini, M. M. Lai, J. P. Steiner, G. S. Hamilton, and P. D. Suzdak. 1998. Neural actions of immunophilin ligands. Trends Pharmacol. Sci. 19: 21-26.
23. Son, J. H., H. S. Chun, T. H. Joh, S. Cho, B. Conti, and J. W. Lee. 1999. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos. J. Neurosci. 19: 10-20.
24. Steiner, J. P., G. S. Hamilton, D. T. Ross, H. L. Valentine, H. Guo, M. A. Connolly, S. Liang, C. Ramsey, J. H. Li, W. Huang, P. Howorth, R. Soni, M. Fuller, H. Sauer, A. C. Nowotnik, and P. D. Suzdak. 1997. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc. Natl. Acad. Sci. USA 94: 2019-2024.
25. Streit, W. J., S. A. Walter, and N. A. Pennell, 1999. Reactive microgliosis. Prog. Neurobiol. 57: 563-581.
26. Tao, X. L. 1989. [Mechanism of treating rheumatoid arthritis with Tripterygium wilfordii hook. II. Effect on PGE2 secretion.] Zhongguo Yi Xue Ke Xue Yuan Xue Bao 11: 36-40.
27. Tseng, J. L., E. E. Baetge, A. D. Zurn, and P. Aebischer. 1997. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. J. Neurosci. 17: 325-333.
28. Venero, J. L., M. Revuelta, J. Cano, and A. Machado. 1997. Time course changes in the dopaminergic nigrostriatal system following transection of the medial forebrain bundle: Detection of oxidatively modified proteins in substantia nigra. J. Neurochem. 68: 2458-2468.
29. Ventimiglia, R., P. E. Mather, B. E. Jones, and R. M. Lindsay. 1995. The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro. Eur. J. Neurosci. 7: 213-222.
30. Winter, C., J. Schenkel, E. Burger, C. Eickmeier, M. Zimmermann, and T. Herdegen. 2000. The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle. Neuroscience 95: 753-762.
31. Yao, Q. P., and N. Z. Zhang. 1994. [Effects of tripchlorolide (T4) of Tripterygium wilfordii hook on the production of prostaglandin E2 by synovial cells of rheumatoid arthritis.] Yao Xue Xue Bao 29: 790-792.
32. Zhang, L., Z. Bi, and X. Li. 1994. [Inhibitory effects of monomer T4 from Tripterygium wilfordii hook on cultured mesangial cells proliferation and IL-1 production.] Zhongguo Yi Xue Ke Xue Yuan Xue Bao 16: 270-274.