Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation

Journal of Neuroimmunology

Volumn 148, Issue 1-2, 2004, Pages 24-31

  Li, Feng Qiao ^a,b   Lu, Xiu Zhi ^a   Liang, Xi Bin ^a   Zhou, Hui Fang ^a   Xue, Bing ^a   Liu, Xian Yu ^a   Niu, Dong Bin ^a   Han, Ji Sheng ^a   Wang, Xiao Min ^a  

^a PEKING UNIVERSITY   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Inflammation; Microglia; Neurodegeneration; Parkinson's disease; Tripterygium wilfordii Hook F; Triptolide

Indexed keywords

DOPAMINE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; TRIPTERYGIUM WILFORDII EXTRACT; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL LOSS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINE UPTAKE; DOPAMINERGIC NERVE CELL; EMBRYO; GLIA; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; INHIBITION KINETICS; MEDICINAL PLANT; MESENCEPHALON; MICROGLIA; NERVE INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; TRIPTERYGIUM WILFORDI;

EID: 1242272720     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2003.10.054     Document Type: Article

References (40)

1. Bal-Price A., Brown G.C. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J. Neurosci. 21:2001;6480-6491.
2. Bronstein D.M., Perez-Otano I., Sun V., Mullis Sawin S.B., Chan J., Wu G.C., Hudson P.M., Kong L.Y., Hong J.S., McMillian M.K. Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures. Brain Res. 704:1995;112-116.
3. Cheng X.X., Li F.Q., Huang M., Wang X.M., Han J.S. Protective effect of tripchlorolide on dopaminergic neurons in partially lesioned rat model of Parkinson's disease. Acta Pharm. Sin. 37:2002;339-342.
4. Estevez A.G., Jordan J. Nitric oxide and superoxide, a deadly cocktail. Ann. N.Y. Acad. Sci. 962:2002;207-211.
5. Floyd R.A. Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development. Free Radic. Biol. Med. 26:1999;1346-1355.
6. Gayle D.A., Ling Z., Tong C., Landers T., Lipton J.W., Carvey P.M. Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res. Dev. Brain Res. 133:2002;27-35.
7. Guo W., Ma L., Tao X. In vitro inhibitive effects of Tripterygium wilforii on NO production, iNOS activity, and iNOS-mRNA expression in chondrocyrtes of patients with rheumatoid arthritis. Zhonghua Yixue ZaZhi. 81:2001;1035-1037.
8. Hirsch E.C. Glial cells and Parkinson's disease. J. Neurol. 247(Suppl. 2):2000;II58-II62.
9. Hunot S., Brugg B., Ricard D., Michel P.P., Muriel M.P., Ruberg M., Faucheux B.A., Agid Y., Hirsch E.C. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease. Proc. Natl. Acad. Sci. U. S. A. 94:1997;7531-7536.
10. Iravani M.M., Kashefi K., Mander P., Rose S., Jenner P. Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration. Neuroscience. 110:2002;49-58.
11. Jana M., Dasgupta S., Liu X., Pahan K. Regulation of tumor necrosis factor-alpha expression by CD40 ligation in BV-2 microglial cells. J. Neurochem. 80:2002;197-206.
12. Jeohn G.H., Wilson B., Wetsel W.C., Hong J.S. The indolocarbazole Go6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. Brain Res. Mol. Brain Res. 79:2000;32-44.
13. Kim W.G., Mohney R.P., Wilson B., Jeohn G.H., Liu B., Hong J.S. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J. Neurosci. 20:2000;6309-6316.
14. Kohutnicka M., Lewandowska E., Kurkowska-Jastrzebska I., Czlonkowski A., Czlonkowska A. Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, (MPTP). Immunopharmacology. 39:1998;167-180.
15. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:1996;312-318.
16. Kupchan S.M., Court W.A., Dailey R.G. Jr., Gilmore C.J., Bryan R.F. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J. Am. Chem. Soc. 94:1972;7194-7195.
17. Langston J.W., Forno L.S., Tetrud J., Reeves A.G., Kaplan J.A., Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 46:1999;598-605.
18. Le W., Rowe D., Xie W., Ortiz I., He Y., Appel S.H. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J. Neurosci. 21:2001;8447-8455.
19. Li S.-Z. Compend. Mater. Med. 1578.
20. Li Q., Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2:2002;725-734.
21. Li F.Q., Cheng X.X., Liang X.B., Wang X.H., Xue B., He Q.H., Wang X.M., Han J.S. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp. Neurol. 179:2003;28-37.
22. Liberatore G.T., Jackson-Lewis V., Vukosavic S., Mandir A.S., Vila M., McAuliffe W.G., Dawson V.L., Dawson T.M., Przedborski S. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 5:1999;1403-1409.
23. Lin N., Sato T., Ito A. Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook F., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts. Arthritis Rheum. 44:2001;2193-2200.
24. Liu B., Du L., Hong J.S. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. J. Pharmacol. Exp. Ther. 293:2000;607-617.
25. Liu H., Liu Z.H., Chen Z.H., Yang J.W., Li L.S. Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes. Acta Pharmacol. Sin. 21:2000;782-786.
26. Mattson M.P., Camandola S. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 107:2001;247-254.
27. McGeer P.L., McGeer E.G. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Brain Res. Rev. 21:1995;195-218.
28. McGeer P.L., Itagaki S., Boyes B.E., McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology. 38:1988;1285-1291.
29. Merrill J.E., Ignarro L.J., Sherman M.P., Melinek J., Lane T.E. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151:1993;2132-2141.
30. Mogi M., Harada M., Riederer P., Narabayashi H., Fujita K., Nagatsu T. Tumor necrosis factor-alpha, (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci. Lett. 165:1994;208-210.
31. Panet H., Barzilai A., Daily D., Melamed E., Offen D. Activation of nuclear transcription factor kappa B, (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells. J. Neurochem. 77:2001;391-398.
32. Qiu D., Zhao G., Aoki Y., Shi L., Uyei A., Nazarian S., Ng J.C., Kao P.N. Immunosuppressant PG490, (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J. Biol. Chem. 274:1999;13443-13450.
33. Tao X.L. Mechanism of treating rheumatoid arthritis with Tripterygium wilfordii Hook: II. Effect on PGE2 secretion. Zhongguo Yixue Kexueyuan Xuebao. 11:1989;36-40.
34. Torreilles F., Salman-Tabcheh S., Guerin M., Torreilles J. Neurodegenerative disorders: the role of peroxynitrite. Brain Res. Brain Res. Rev. 30:1999;153-163.
35. Vila M., Jackson-Lewis V., Guegan C., Wu D.C., Teismann P., Choi D.K., Tieu K., Przedborski S. The role of glial cells in Parkinson's disease. Curr. Opin. Neurol. 14:2001;483-489.
36. Xie Z., Wei M., Morgan T.E., Fabrizio P., Han D., Finch C.E., Longo V.D. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42 and lipopolysaccharide-activated microglia. J. Neurosci. 22:2002;3484-3492.
37. Zhao G., Vaszar L.T., Qiu D., Shi L., Kao P.N. Anti-inflammatory effects of triptolide in human bronchial epithelial cells. Am. J. Physiol Lung Cell Mol. Physiol. 279:2000;L958-L966.
38. Zheng J. Screening of active anti-inflammatory, immunosuppressive and antifertility components of Tripterygium wilfordii: III. A comparison of the antiinflammatory and immunosuppressive activities of 7 diterpene lactone epoxide compounds in vivo. Zhongguo Yixue Kexueyuan Xuebao. 13:1991;391-397.
39. Zheng Y.L., Lin J.F., Lin C.C., Xu Y. Anti-inflammatory effect of triptolide. Zhongguo Yaoli Xuebao. 15:1994;540-543.
40. Zhou H.F., Niu D.B., Xue B., Li F.Q., Liu X.Y., He Q.H., Wang X.H., Wang X.M. Triptolide inhibits TNF-α IL-1β and NO production in primary microglial cultures. NeuroReport. 14:2003;1091-1095.