Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture

Neurochemistry International

Volumn 55, Issue 6, 2009, Pages 414-422

  Chan, Wing Sai ^a   Durairajan, Siva Sundara Kumar ^a   Lu, Jia Hong ^a   Wang, Yan ^a   Xie, Li Xia ^a   Kum, Wan Fung ^a   Koo, Irene ^a   Yung, Ken Kin Lam ^a   Li, Min ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

6 Hydroxydopamine; Astragaloside IV; Nigral primary cell cultures; Nitric oxide synthase; Parkinson's disease; Tyrosine hydroxylase

Indexed keywords

ASTRAGALOSIDE IV; NITRIC OXIDE SYNTHASE; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL LOSS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE FIBER GROWTH; NERVE SPROUTING; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ANIMALS; ANIMALS, NEWBORN; CELL DEATH; CELL DIFFERENTIATION; CELLS, CULTURED; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; NERVE DEGENERATION; NEURITES; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE I; OXIDOPAMINE; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; SUBSTANTIA NIGRA; SYMPATHOLYTICS; TRITERPENES; TYROSINE 3-MONOOXYGENASE;

ASTRAGALUS MEMBRANACEUS;

EID: 67650064518     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.04.012     Document Type: Article

References (49)

1. Bove J., Prou D., Perier C., and Przedborski S. Toxin-induced models of Parkinson's disease. NeuroRx 2 (2005) 484-494
2. Bredt D.S., and Synder S.H. Nitric oxide, a novel neuronal messenger. Neuron 8 (1992) 3-11
3. Brewer G.J. Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J. Neurosci. Res. 42 (1995) 674-683
4. Carrillo M.C., Minami C., Kitani K., Maruyama W., Ohashi K., Yamamoto T., Naoi M., Kanai S., and Youdim M.B. Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat. Life Sci. 67 (2000) 577-585
5. Cheng C.Y., Yao C.H., Liu B.S., Liu C.J., Chen G.W., and Chen Y.S. The role of astragaloside in regeneration of the peripheral nerve system. J. Biomed. Mater. Res. A 76 (2006) 463-469
6. Choi W.S., Yoon S.Y., Oh T.H., Choi E.J., O'Malley K.L., and Oh Y.J. Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK. J. Neurosci. Res. 57 (1999) 86-94
7. Chung V., Liu L., Bian Z., Zhao Z., Leuk Fong W., Kum W.F., Gao J., and Li M. Efficacy and safety of herbal medicines for idiopathic Parkinson's disease: a systematic review. Mov. Disord. 21 (2006) 1709-1715
8. Cohen G. Oxy-radical toxicity in catecholamine neurons. Neurotoxicology 5 (1984) 77-82
9. Dawson T.M., and Dawson V.L. Nitric oxide synthase: role as a transmitter/mediator in the brain and endocrine system. Annu. Rev. Med. 47 (1996) 219-227
10. Dawson V.L., Dawson T.M., London E.D., Bredt D.S., and Snyder S.H. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 6368-6371
11. De Vente J., Markerink-van Ittersum M., van Abeelen J., Emson P.C., Axer H., and Steinbusch H.W. NO-mediated cGMP synthesis in cholinergic neurons in the rat forebrain: effects of lesioning dopaminergic or serotonergic pathways on nNOS and cGMP synthesis. Eur. J. Neurosci. 12 (2000) 507-519
12. Ding Y.M., Jaumotte J.D., Signore A.P., and Zigmond M.J. Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor. J. Neurochem. 89 (2004) 776-787
13. Durairajan S.S.K., Yuan Q., Xie L., Chan W.S., Kum W.F., Koo I., Liu C., Song Y., Huang J.D., Klein W.L., and Li M. Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty. Neurochem. Int. 52 (2008) 741-750
14. Filbin M.T. Axon regeneration: vaccinating against spinal cord injury. Curr. Biol. 10 (2000) R100-R103
15. Fournier A.E., and Strittmatter S.M. Repulsive factors and axon regeneration in the CNS. Curr. Opin. Neurobiol. 11 (2001) 89-94
16. Garcia de Yebenes J., Yebenes J., and Mena M.A. Neurotrophic factors in neurodegenerative disorders: model of Parkinson's disease. Neurotox. Res. 2 (2000) 115-137
17. Ha K.S., Kim K.M., Kwon Y.G., and Bai S.K. Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation. FASEB J. 17 (2003) 1036-1047
18. Heneka M.T., Loschmann P.A., Gleichmann M., and Weller M. Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide. J. Neurochem. 71 (1998) 88-94
19. Henze C., Earl C., Sautter J., Schmidt N., Themann C., Hartmann A., and Oertel W.H. Reactive oxidative and nitrogen species in the nigrostriatal system following striatal 6-hydroxydopamine lesion in rats. Brain Res. 1052 (2005) 97-104
20. Jia R.R., Gou Y.L., Ho L.S., and Ng C.P. Anti-apoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells. Cell Biol. Int. 29 (2005) 835-842
21. Ko J.K., Lam F.Y., and Cheung A.P. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World J. Gastroenterol. 11 (2005) 5787-5794
22. Lafon-Cazal M., Fagni L., Guiraud M.J., Mary S., Lerner-Natoli M., Pin J.P., Shigemoto R., and Bockaert J. mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons. Eur J Neurosci. 11 (1999) 663-672
23. Lai S.K., Wong C.K.C., Yang M.S., and Yung K.K.L. Changes in expression of N-methyl-d-aspartate receptor subunits in the rat neostriatum after a single dose of antisense oligonucleotide specific for N-methyl-d-aspartate receptor one subunit. Neuroscience 98 (2000) 493-500
24. Langston J.W., and Tanner C.M. Etiology. In: William C. (Ed). Handbook of Parkinson's disease (1992), Marcel Dekker, Inc., New York, USA 369-390
25. Lindholm P., Voutilainen M.H., Laurén J., Peränen J., Leppänen V.M., Andressoo J.O., Lindahl M., Janhunen S., Kalkkinen N., Timmusk T., Tuominen R.K., and Saarma M. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature 44 (2007) 73-77
26. Liu C.L., Xie L.X., Li M., Durairajan S.S.K., Goto S., and Huang J.D. Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt and Bcl-2 pathways. PLoS ONE 2 (2007) e1321
27. Luo Y., Qin Z., Hong Z., Zhang X., Ding D., Fu J.H., Zhang W.D., and Chen J. Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci. Lett. 363 (2004) 218-223
28. McKerracher L. Spinal cord repair: strategies to promote axon regeneration. Neurobiol. Dis. 8 (2001) 11-18
29. Meletis C.D., and Zabriskie N. Nutritional and botanical approaches to antiaging. Altern. Complement. Ther. (2006) 269-274
30. Mink J.W. Basal ganglia. In: Zigmond M.J., Bloom F., Landis S.C., Roberts J.L., and Squire L.R. (Eds). Fundamental Neuroscience (1999), Academic Press, U.S 951-972
31. BR2 receptor immunoreactivity in neurochemically identified neurons of the rat neostriatum J. Comp. Neurol. 433 (2001) 458-470
32. Olanow C.W., and Tatton W.G. Etiology and pathogenesis of Parkinson's disease. Ann. Rev. Neurosci. 22 (1999) 123-144
33. Orth M., and Tabrizi S.J. Models of Parkinson's disease. Mov. Disord. 18 (2003) 729-737
34. Rios J.L., and Waterman P.G. A review of the pharmacology and toxicology of Astragalus. Phytother. Res. 11 (1997) 411-418
35. Ryu E.J., Harding H.P., Angelastro J.M., Vitolo O.V., Ron D., and Greene L.A. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J. neurosci. 22 (2002) 10690-10698
36. Storch A., Burkhardt K., Ludolph A.C., and Schwarz J. Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolism. J. Neurochem. 75 (2000) 2259-2269
37. Sze S.C.W., Wong C.K.C., and Yung K.K.L. Modulation of the gene expression of N-methyl-aspartate receptor NR2B subunit in the rat neostriatum by a single dose of specific antisense oligodeoxynucleotide. Neurochem. Int. 39 (2001) 319-327
38. Thomas M., and Le W.D. Minocycline: neuroprotective mechanisms in Parkinson's disease. Curr. Pharm. Des. 10 (2004) 679-686
39. Tohda C., Kuboyama T., and Komatsu K. Search for natural products related to regeneration of the neuronal network. Neurosignals 14 (2005) 34-45
40. Tohda C., Tamura T., Matsuyama S., and Komatsu K. Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus. Br. J. Pharmacol. 149 (2006) 532-541
41. Xu M., Xiao S.Z., Sun Y.H., Yang Y.O., and Zheng X.X. Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro. Acta Pharmacol. Sin. 27 (2006) 229-236
42. Yin X.X., Zhang Y.D., Wu H.W., Zhu X., Zheng X.G., and Jiang S.J. Protective effects of Astragalus saponin I on early stage of diabetic nephropathy in rats. J. Pharmacol. Sci. 95 (2004) 256-266
43. BR1 receptor immunoreactivity. Brain Res. 830 (1999) 345-352
44. Zhang C., Wang X.H., Zhong M.F., Liu R.H., Li H.L., Zhang W.D., and Chen H. Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings. Clin. Exp. Pharmacol. Physiol. 34 (2007) 387-392
45. Zhang J., Dawson V.L., Dawson T.M., and Synder S.H. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science 263 (1994) 687-689
46. Zhang W.D., Chen H., Zhang C., Liu R.H., Li H.L., and Chen H.Z. Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Med. 72 (2006) 4-8
47. Zhang Z.X., Roman G.C., Hong Z., Wu C.B., Qu Q.M., Huang J.B., Zhou B., Geng Z.P., Wu J.X., Wen H.B., Zhao H., and Zahner G.E. Parkinson's disease in China: prevalence in Beijing, Xian, and Shanghai. Lancet 5365 (2005) 595-597
48. 2+ oscillations on hippocampal neurons. Acta Pharmacol. Sin. 29 (2008) 57-64
49. Zhu X.Z., and Luo L.G. Effect of nitroprusside (nitric oxide) on endogenous dopamine release from rat striatal slices. J. Neurochem. 59 (1992) 932-935