Alaternin attenuates delayed neuronal cell death induced by transient cerebral hypoperfusion in mice

Food and Chemical Toxicology

Volumn 48, Issue 6, 2010, Pages 1528-1536

  Shin, Bum Young ^a   Kim, Dong Hyun ^a   Hyun, Sook Kyung ^b   Jung, Hyun Ah ^b   Kim, Jong Min ^a   Park, Se Jin ^a   Kim, Seong Yun ^c   Cheong, Jae Hoon ^d   Choi, Jae Sue ^b   Ryu, Jong Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Pukyong National University   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d Sahmyook University   (South Korea)

Author keywords

Alaternin; Inducible nitric oxide synthase; Memory; Microglia; Nitrotyrosine; Transient cerebral hypoperfusion

Indexed keywords

3 NITROTYROSINE; ALATERNIN; DIZOCILPINE; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; COGNITIVE DEFECT; CONTROLLED STUDY; LIPID PEROXIDATION; MALE; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PASSIVE AVOIDANCE; PRIMARY PREVENTION; PROTEIN EXPRESSION;

ANIMALS; AVOIDANCE LEARNING; BLOTTING, WESTERN; CAROTID ARTERIES; CELL DEATH; CEREBROVASCULAR CIRCULATION; EMODIN; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; NEURONS;

MUS;

EID: 77952878983     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.03.020     Document Type: Article

References (31)

1. Adams H., Adams R., Del Zoppo G., Goldstein L.B. Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Stroke 2005, 36:916-923.
2. Alderton W.K., Cooper C.E., Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 2001, 357:593-615.
3. Brown G.C., Borutaite V. Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species. Biochem. Soc. Trans. 2006, 34:953-956.
4. Cho K.O., Kim S.K., Cho Y.J., Sung K.W., Kim S.Y. Regional differences in the neuroprotective effect of minocycline in a mouse model of global forebrain ischemia. Life Sci. 2007, 80:2030-2035.
5. Cuzzocrea S., Costantino G., Gitto E., Mazzon E., Fulia F., Serraino I., Cordaro S., Barberi I., De Sarro A., Caputi A.P. Protective effects of melatonin in ischemic brain injury. J. Pineal Res. 2000, 29:217-227.
6. del Zoppo G., Ginis I., Hallenbeck J.M., Iadecola C., Wang X., Feuerstein G.Z. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol. 2000, 10:95-112.
7. Giulian D., Vaca K. Inflammatory glia mediate delayed neuronal damage after ischemia in the central nervous system. Stroke 1993, 24:I84-90.
8. Halliwell B., Zhao K., Whiteman M. Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies. Free Radical Res. 1999, 31:651-669.
9. Hashiguchi A., Kawano T., Yano S., Morioka M., Hamada J., Sato T., Shirasaki Y., Ushio Y., Fukunaga K. The neuroprotective effect of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4- imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, in transient forebrain ischemia. Neuroscience 2003, 121:379-386.
10. Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 1994, 265:1883-1885.
11. Huang J., Agus D.B., Winfree C.J., Kiss S., Mack W.J., McTaggart R.A., Choudhri T.F., Kim L.J., Mocco J., Pinsky D.J., Fox W.D., Israel R.J., Boyd T.A., Golde D.W., Connolly E.S. Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc. Natl. Acad. Sci. USA 2001, 98:11720-11724.
12. Iadecola C., Zhang F., Casey R., Nagayama M., Ross M.E. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J. Neurosci. 1997, 17:9157-9164.
13. Ischiropoulos H. Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species. Arch. Biochem. Biophys. 1998, 356:1-11.
14. Jung H.A., Chung H.Y., Yokozawa T., Kim Y.C., Hyun S.K., Choi J.S. Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells. Arch. Pharm. Res. 2004, 27:947-953.
15. Khan M., Sekhon B., Jatana M., Giri S., Gilg A.G., Sekhon C., Singh I., Singh A.K. Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J. Neurosci. Res. 2004, 76:519-527.
16. Kim D.H., Yoon B.H., Kim Y.W., Lee S., Shin B.Y., Jung J.W., Kim H.J., Lee Y.S., Choi J.S., Kim S.Y., Lee K.T., Ryu J.H. The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice. J. Pharmacol. Sci. 2007, 105:82-93.
17. Kim D.H., Kim S., Jung W.Y., Park S.J., Park D.H., Kim J.M., Cheong J.H., Ryu J.H. The neuroprotective effects of the seeds of Cassia obtusifolia on transient cerebral global ischemia in mice. Food Chem. Toxicol. 2009, 47:1473-1479.
18. Laude K., Thuillez C., Richard V. Peroxynitrite triggers a delayed resistance of coronary endothelial cells against ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 2002, 283:H1418-1423.
19. Lei B., Adachi N., Nagaro T., Arai T., Koehler R.C. Nitric oxide production in the CA1 field of the gerbil hippocampus after transient forebrain ischemia: effects of 7-nitroindazole and NG-nitro-l-arginine methyl ester. Stroke 1999, 30:669-677.
20. Murphy S., Gibson C.L. Nitric oxide, ischaemia and brain inflammation. Biochem. Soc. Trans. 2007, 35:1133-1137.
21. Park T.H., Kim D.H., Kim C.H., Jung H.A., Choi J.S., Lee J.W., Chung H.Y. Peroxynitrite scavenging mode of alaternin isolated from Cassia tora. J. Pharm. Pharmacol. 2004, 56:1315-1321.
22. Pu F., Mishima K., Egashira N., Iwasaki K., Kaneko T., Uchida T., Irie K., Ishibashi D., Fujii H., Kosuna K., Fujiwara M. Protective effect of buckwheat polyphenols against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia. J. Pharmacol. Sci. 2004, 94:393-402.
23. Rodrigo J., Fernandez A.P., Serrano J., Peinado M.A., Martinez A. The role of free radicals in cerebral hypoxia and ischemia. Free Radical Biol. Med. 2005, 39:26-50.
24. Samdani A.F., Dawson T.M., Dawson V.L. Nitric oxide synthase in models of focal ischemia. Stroke 1997, 28:1283-1288.
25. Slemmer J.E., Shacka J.J., Sweeney M.I., Weber J.T. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr. Med. Chem. 2008, 15:404-414.
26. Streit W.J. Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res. Brain Res. Rev. 2005, 48:234-239.
27. Takizawa S., Aratani Y., Fukuyama N., Maeda N., Hirabayashi H., Koyama H., Shinohara Y., Nakazawa H. Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain. J. Cereb. Blood Flow Metab. 2002, 22:50-54.
28. Willmot M., Gibson C., Gray L., Murphy S., Bath P. Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review. Free Radical Biol. Med. 2005, 39:412-425.
29. Yokozawa T., Rhyu D.Y., Cho E.J. (-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors. J. Pharm. Pharmacol. 2004, 56:231-239.
30. Yoshida T., Waeber C., Huang Z., Moskowitz M.A. Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion. Neurosci. Lett. 1995, 194:214-218.
31. Yrjanheikki J., Tikka T., Keinanen R., Goldsteins G., Chan P.H., Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc. Natl. Acad. Sci. USA 1999, 96:13496-13500.