Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson's disease in mice

European Review for Medical and Pharmacological Sciences

Volumn 11, Issue 1, 2007, Pages 17-20

  Mohanasundari, M ^a   Sabesan, Muthukumar ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Hypericum perforatum extract; Monoamine oxidase B; MPTP; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; GLIAL FIBRILLARY ACIDIC PROTEIN; HYPERICUM PERFORATUM EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN TISSUE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE;

ANIMALS; ASTROCYTES; CORPUS STRIATUM; GLIAL FIBRILLARY ACIDIC PROTEIN; HYPERICUM; IMMUNOHISTOCHEMISTRY; MALE; MICE; MONOAMINE OXIDASE; MPTP POISONING; PLANT EXTRACTS;

EID: 33947693245     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Przedborski S, Vila M. MPTP: a review of the mechanisms of neurotoxicity. Clin Neurosci Res 2001; 1: 407-418.
2. Di Monte DA, Wu EY, De Lanney LE, Langston JW. Production and disposition of 1-methyl-4-phenylpyridinium in primary cultures of mouse astrocytes. Glia 1992; 5: 48-55.
3. Eng LF, Lee YL. Intermediate filament in astrocytes. In: Neuroglia Eds, Kettenmann H., Ransom B.R., Oxford University Press, New York 1995; 650-667.
4. Tateishi N, Mori T, Kagamiishi Y, Satoh S, Katsube N, Morikawa E. Morimoto T, Matsui T, Asano T. Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats: Part II. Suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits. J Cerebr Blood Flow Metab 2002; 22: 723-734.
5. Biffignandi PM, Bilia, AR. The growing knowledge of St. John's Wort (Hypericum perforatum L.) drug interactions and their clinical significance. Curr Therap Res 2001; 61: 389-394.
6. Silva BA, Ferreres F, Malva J, Dias ACP. Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts. Food Chem 2005; 90: 157-167.
7. Arari T, Mikami T, Tanji H, Matsubara M, Imai Y, Mizugaki M, Itoyama Y. Biochemical and immunohistological changes in the brain of 1-methyl-1,2,3,6-tetrahydropyridine (MPTP) treated mice. Eur J Pharm Sci 2001; 12: 231-238.
8. Mitra N, Mohanakumar KP, Ganguly K. Resistance of golden hamster to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: relationship with low levels of regional monoamine oxidase B. J Neurochem 1994; 62: 1906-1912.
9. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
10. Maharaj DS, Saravanan KS, Maharaj H, Mohanakumar KP, Daya S. Acetaminophen and aspirin inhibit superoxide anion generation and lipid peroxidation, and protect against 1-methyl-4-phenylpyridinium-induced dopaminergic neurotoxicity in rats. Neurochem Int 2004; 44: 355-360.
11. Thomas B, Muralikrishnan D, Mohanakumar KP. In vivo hydroxyl radical generation in the striatum following systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain Res 2000; 852: 221-224.
12. Klaidman LK, Adams Jr. JD, Leung AC, Kim SS, Cadenas E. Redox cycling of MPP+: evidence for a new mechanism in involving hydride transfer with xanthine oxidase aldehyde dehydrogenase and lipoamide dehydrogenase. Free Radical Biol Med 1993; 15: 169-179.
13. Mohanasundari M, Sethupathy S, Sabesan M. The effect of Hypericum perforatum extract against the neurochemical and behavioural changes induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. Indian J Pharmacol 2006; 38: 266-270.
14. El-Sherbiny DA, Khalifa AE, Attia AS, Eldenshary ES. Hypericum perforatum extract demonstrated antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Pharmacol Biochem Behav 2003; 76: 525-533.
15. Bladt S, Wagner H. Inhibition of MAO by fractions and constituents of Hypericum extract. J Geriatr Psychiatry Neurol 1994; 7: S57-S59.