Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures

Biochemical Pharmacology

Volumn 63, Issue 1, 2002, Pages 21-29

  Levites, Yona ^a   Youdim, Moussa B H ^a   Maor, Gila ^a   Mandel, Silvia ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

6 hydroxydopamine; Green tea; Iron; Nuclear factor B; Oxidative Stress; Parkinson's disease

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OXIDOPAMINE; POLYPHENOL;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; CYTOPLASM; DISEASE MODEL; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LIPID PEROXIDATION; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SIGNAL TRANSDUCTION; TEA;

ACTIVE TRANSPORT, CELL NUCLEUS; ADRENERGIC AGENTS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN; CELL NUCLEUS; DRUG INTERACTIONS; HUMANS; KINETICS; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; OXIDOPAMINE; PC12 CELLS; PLANT EXTRACTS; RATS; TEA; TUMOR CELLS, CULTURED;

EID: 0036145435     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00813-9     Document Type: Article

References (54)

1. The possible role of iron in the etiopathology of Parkinson's disease
2. Altered brain metabolism of iron as a cause of neurodegenerative diseases?
3. Brain iron, and ferritin in Parkinson's, and Alzheimer's diseases
4. Oxidative stress, and the pathogenesis of Parkinson's disease
5. Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain, and in the cerebrospinal fluid from Parkinsonian patients
6. Interleukin-1 beta, interleukin-6, epidermal growth factor, and transforming growth factor-alpha are elevated in the brain from Parkinsonian patients
7. Transition metals, ferritin, glutathione, and ascorbic acid in Parkinsonian brains
8. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging, and neurodegenerative diseases
9. The role of iron in neurodegeneration: Prospects for pharmacotherapy of Parkinson's disease
10. Nuclear factor kappaB: An oxidative stress-responsive transcription factor of eukaryotic cells
11. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease
12. Role of iron in NF-kappaB activation, and cytokine gene expression by rat hepatic macrophages
13. The pivotal role of iron in NF-kappaB activation, and nigrostriatal dopaminergic neurodegeneration. Prospects for neuroprotection in Parkinson's disease with iron chelators
14. Antioxidants modulate acute solar ultraviolet radiation-induced NF-kappa-B activation in a human keratinocyte cell line
15. Activation of nuclear factor-kappaB by the peroxisome proliferator ciprofibrate in H4IIEC3 rat hepatoma cells, and its inhibition by the antioxidants N-acetylcysteine, and vitamin E
16. Neuroprotection by aspirin, and sodium salicylate through blockade of NF-kappaB activation
17. The future of neuroprotection
18. The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons
19. Apomorphine protects against MPTP-induced neurotoxicity in mice
20. Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2, and 6-hydroxydopamine
21. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein
22. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid
23. The Ginkgo biloba extract (EGb 761) protects, and rescues hippocampal cells against nitric oxide-induced toxicity: Involvement of its flavonoid constituents, and protein kinase C
24. Green tea polyphenols block endotoxin-induced tumor necrosis factor-production, and lethality in a murine model
25. (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB
26. Theaflavin-3,3′-digallate from black tea blocks the nitric oxide synthase by down-regulating the activation of NF-kappaB in macrophages
27. Suppression of lypopolysaccharide-induced nuclear factor kappaB activity by theaflavin-3,3′-digallate from black tea, and other polyphenols through down-regulation of IkappaB kinase activity in macrophages
28. Selective inhibition of NF-kappaB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways
29. Green tea polyphenol (-)- Epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
30. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents
31. Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction
32. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
33. Polyphenolic flavanols as scavengers of aqueous phase radicals, and as chain-breaking antioxidants
34. Scavenging effects of tea catechins, and their derivatives on 1,1-diphenyl-2-picrylhydrazyl radical
35. Antioxidant, and iron-chelating activities of the flavonoids catechin, quercetin, and diosmetin on iron-loaded rat hepatocyte cultures
36. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes
37. Protective effects of tea polyphenols against oxidative damage to red blood cells
38. Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue
39. 6-Hydroxydopamine releases iron from ferritin, and promotes ferritin-dependent lipid peroxidation
40. Dopamine, 6-hydroxydopamine, iron, and dioxygen-their mutual interactions, and possible implication in the development of Parkinson's disease
41. Inhibition of mitochondrial complexes I, and IV by 6-hydroxydopamine
42. Reactive oxygen species, and the central nervous system
43. Structural aspects of antioxidant activity of flavonoids
44. Vitamin C, antioxidant or pro-oxidant in vivo?
45. Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice
46. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor, and HIV-1
47. The inflammatory response system of brain: Implications for therapy of Alzheimer, and other neurodegenerative diseases
48. Drugs to prevent cell death in Parkinson's disease: Neuroprotection against oxidative stress, and inflammatory gene expressions
49. cDNA microarray to study gene expression of dopaminergic neurodegenration, and neuroprotection in MPTP, and 6-hydroxydopamine models: Implications for Parkinson's disease
50. Effects of R-apomorphine, and S-apomorphine on MPTP-induced nigro-striatal doamine neuronal loss
51. NF-kappaB is activated, and promotes cell death in focal cerebral ischemia
52. Nuclear factor-kappaB/Rel proteins: A point of convergence of signaling pathways relevant in neuronal function, and dysfunction
53. NF-kappaB in neuronal plasticity, and neurodegenerative disorders
54. NF-kappaB, a crucial transcription factor for glial, and neuronal cell function