Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease

European Journal of Pharmacology

Volumn 564, Issue 1-3, 2007, Pages 66-74

  Geng, Xingchao ^a   Tian, Xuefei ^a   Tu, Pengfei ^a   Pu, Xiaoping ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 3; Caspase 8; Echinacoside; MPP+; MPTP; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMANTADINE; CASPASE 3; CASPASE 8; DOPAMINE; ECHINACOSIDE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; LOW DRUG DOSE; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; CASPASE 3; CASPASE 8; CELL DEATH; CEREBELLUM; CISTANCHE; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDES; MALE; MICE; MICE, INBRED C57BL; MPTP POISONING; NEURONS; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE, SECONDARY; PLANT EXTRACTS; TYROSINE 3-MONOOXYGENASE;

EID: 34250640707     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.01.084     Document Type: Article

References (35)

1. Ankarcrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A., and Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15 (1995) 961-973
2. Atabay C., Cagnoli C.M., Kharlamov E., Ikonomovic M.D., and Manev H. Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: protection with antioxidants and glutamate receptor antagonists. J. Neurosci. Res. 43 (1996) 465-475
3. Boulares A.H., Yakovlev A.G., Ivanova V., Stoica B.A., Wang G., Iyer S., and Smulson M. Role of poly (ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J. Biol. Chem. 274 (1999) 22932-22940
4. Deng M., Zhao J.Y., Tu P.F., Jiang Y., Li Z.B., and Wang Y.H. Echinacoside rescues the SHSY5Y neuronal cells from TNFalpha-induced apoptosis. Eur. J. Pharmacol. 505 (2004) 11-18
5. Dipasquale B., Marini A.M., and Youle R.J. Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochem. Biophys. Res. Commun. 181 (1991) 1442-1448
6. Du Y., Dodel R.C., Bales K.R., Jemmerson R., Hamilton-Byrd E., and Paul S.M. Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons. J. Neurochem. 69 (1997) 1382-1388
7. Facino R.M., Carini M., Aldini G., Saibene L., Pietta P., and Mauri P. Echinacoside and caffeoyl conjugates protect collagen from free radical-induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage. Planta Med. 61 (1995) 510-514
8. Hartmann A., Troadec J.D., Hunot S., Kikly K., Faucheux B.A., Mouatt-Prigent A., Ruberg M., Agid Y., and Hirsch E.C. Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis. J. Neurosci. 21 (2001) 2247-2255
9. Heikkila R.E., Hess A., and Duvoisin R.C. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science 224 (1984) 1451-1453
10. Heilmann J., Calis I., Kirmizibekmez H., Schuhly W., Harput S., and Sticher O. Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes: structure-activity relationships. Planta Med. 66 (2000) 746-748
11. +)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. Biochem. J. 371 (2003) 151-164
12. Kitamura Y., Kosaka T., Kakimura J.I., Matsuoka Y., Kohno Y., Nomura Y., and Taniguchi T. Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells. Mol. Pharmacol. 54 (1998) 1046-1054
13. Koo K.A., Sung S.H., Park J.H., Kim S.H., Lee K.Y., and Kim Y.C. In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma. Planta Med. 71 (2005) 778-780
14. Lei L., Song Z.H., Tu P.F., Li Y.Z., Wu L.J., and Chen F.K. Metabolic regulation of phenylethanoid glycosides from Herba cistanches in dogs'gastrointestine. Yao Xue Xue Bao 36 (2001) 432-435
15. Leng A., Mura A., Hengerer B., Feldon J., and Ferger B. Effects of blocking the dopamine biosynthesis and of neurotoxic dopamine depletion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on voluntary wheel running in mice. Behav. Brain Res. 154 (2004) 375-383
16. Levi G., Aloisi F., Ciotti M.T., and Gallo V. Autoradiographic localization and depolarization-induced release of acidic amino acid in differentiating cerebellar granule cell cultures. Brain Res. 290 (1984) 77-86
17. Loucks F.A., Le S.S., Zimmermann A.K., Ryan K.R., Barth H., Aktories K., and Linseman D.A. Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. J Neurochem. 97 (2006) 957-967
18. Marini A.M., Schwartz J.P., and Kopin I.J. The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells. J. Neurosci. 9 (1989) 3665-3672
19. Miller T.M., and Johnson Jr. E.M. Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells. J. Neurosci. 16 (1996) 7487-7495
20. Nijhawan D., Honarpour N., and Wang X. Apoptosis in neural development and disease. Annu. Rev. Neurosci. 23 (2000) 73-87
21. Oertel W.H., and Ellgring H. Parkinson's disease-medical education and psychosocial aspects. Patient Educ. Couns. 26 (1995) 71-79
22. Pellati F., Benvenuti S., Magro L., Melegari M., and Soragni F. Analysis of phenolic compounds and radical scavenging activity of Echinacea spp. J. Pharm. Biomed. Anal. 35 (2004) 289-301
23. Rausch W.D., Schallauer E., Chan W.W., Riederer P., and Weiser M. Effects of l-deprenyl and amantadine in an MPTP-model of parkinsonism. J. Neural Transm., Suppl. 32 (1990) 269-275
24. Rozas G., Lopez-Martin E., Guerra M.J., and Labandeira-Garcia J.L. The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism. J. Neurosci. Methods 83 (1998) 165-175
25. Salvesen G.S., and Dixit V.M. Caspases: intracellular signaling by proteolysis. Cell 91 (1997) 443-446
26. Sanchez I., Xu C.J., Juo P., Kakizaka A., Blenis J., and Yuan J. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron 22 (1999) 623-633
27. Sastry P.S., and Rao K.S. Apoptosis and the nervous system. J. Neurochem. 74 (2000) 1-20
28. Schmidt N., and Ferger B. Neurochemical findings in the MPTP model Parkinson's disease. J. Neural Transm. 108 (2001) 1263-1282
29. Schwarting R.K., and Huston J.P. Behavioral concomitants of regional changes in the brain's biogenic amines after apomorphine and amphetamine. Pharmacol. Biochem. Behav. 41 (1992) 675-682
30. Sedelis M., Schwarting R.K., and Huston J.P. Behavioral phenotyping of the MPTP mouse model of Parkinson's disease. Behav. Brain Res. 125 (2001) 109-125
31. Shiozaki S., Ichikawa S., Nakamura J., Kitamura S., Yamada K., and Kuwana Y. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl) 147 (1999) 90-95
32. Sommer B., Barbieri S., Hofele K., Wiederhold K., Probst A., Mistl C., Danner S., Kauffmann S., Spooren W., Tolnay M., Bilbe G., van der Putten H., Kafmann S., Caromi P., and Ruegg M.A. Mouse models of alpha-synucleinopathy and Lewy pathology. Exp. Gerontol. 35 (2000) 1389-1403
33. Speroni E., Govoni P., Guizzardi S., Renzulli C., and Guerra M.C. Anti-inflammatory and cicatrizing activity of Echinacea pallida Nutt. root extract. J. Ethnopharmacol. 79 (2002) 265-272
34. Takada M., Li Z.K., and Hattori T. Dopaminergic nigrotectal projection in the rat. Brain Res. 457 (1988) 165-168
35. Velier J.J., Ellison J.A., Kikly K.K., Spera P.A., Barone F.C., and Feuerstein G.Z. Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat. J. Neurosci. 19 (1999) 5932-5941