Neuroprotective effect of Ginkgo biloba L. extract in a rat model of parkinson's disease

Phytotherapy Research

Volumn 18, Issue 8, 2004, Pages 663-666

  Kim, M S ^a   Lee, J I ^b,c   Lee, W Y ^b   Kim, S E ^b  

^a The Catholic University of Korea   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Samsung Medical Center   (South Korea)

Author keywords

6 hydroxydopamine; Ginkgo biloba extract; Parkinson's disease

Indexed keywords

DOPAMINE; GINKGO BILOBA EXTRACT; OXIDOPAMINE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG MEGADOSE; FOREFOOT; LOW DRUG DOSE; MALE; MOTOR DYSFUNCTION; NEUROPROTECTION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; RAT; SUBSTANTIA NIGRA;

ANIMALS; BRAIN DISEASES; DISEASE MODELS, ANIMAL; GAIT; GINKGO BILOBA; MALE; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PARKINSON DISEASE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

GINKGO BILOBA;

EID: 4944263826     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1486     Document Type: Article

References (17)

1. Bastianetto S, Ramassamy C, Dore S, Christen Y, Poirier J, Quirion R. 2000. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur J Neurosci 12: 1882-1890.
2. Blum D, Torch S, Lambeng N, et al. 2001. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Progr Neurobiol 65: 135-172.
3. Chandrasekaran K, Mehrabian Z, Spinnewyn B, Drieu K, Fiskum G. 2001. Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb761), in gerbil global brain ischemia. Brain Res 922: 282-292.
4. Chang JW, Wachtel SR, Young D, Kang UJ. 1999. Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: Studies on medial forebrain bundle and striatal lesions. Neuroscience 88: 617-628.
5. Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT. 2001. Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. Neuroreport 12: 3871-3875.
6. Dongen M, van Rossum E, Kessels A, Sielhorst H, Knipchild P. 2003. Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial. J Clin Epidem 56: 367-376.
7. Levites Y, Weinreb O, Maor G, Youdim MBH, Mandel S. 2001. Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 78: 1073-1082.
8. Levivier M, Przedborski S, Bencsics C, Kang UJ. 1995. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J Neurosci 15: 7810-7820.
9. Ni Y, Zhao B, Hou J, Xin W. 1996. Preventive effect of Ginkgo biloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals. Neurosci Lett 214: 115-118.
10. Olsson M, Nikkhah G, Bentlage C, Bjorklund A. 1995. Forelimb akinesia in the rat Parkinsonian model: differential effect of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15: 3863-3875.
11. Oyama Y, Chikahisa L, Ueha T, Kanemaru K, Noda K. 1996. Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide Brain Res 712: 349-352.
12. Przedborski S, Levivier M, Jiang H, et al. 1995. Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine. Neuroscience 67: 631-647.
13. Sharma HS, Drieu K, Alm P, Westman J. 1999. Upregulation of nitric oxide synthase, edema and cell injury following heat stress are reduced by pretreatment with EGB-761 in the rat. J Therm Biol 24: 439-445.
14. Shim IS, Javaid JI, Kim SE. 2000. Effect of ginseng total saponin on extracellular dopamine release elicited by local infusion of nicotine into the striatum of freely moving rats. Planta Med 66: 705-708.
15. Ünal I, Gürsoy-Özdemir Y, Bolay H, Söylemezoǧ lu F, Saribaş O, Dalkara T. 2001. Chronic daily administration of selegeline and EGb 761 increases brain's resistance to ischemia in mice. Brain Res 917: 174-181.
16. Watanabe CMH, Wolffram S, Ader P, et al. 2001. The in vivo neuromodulatory effects of the herbal medicine Ginkgo biloba. Proc Natl Acad Sci USA 92: 9368-9372.
17. Wu WR, Zhu XZ. 1999. Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice. Life Sci 65: 157-164.