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Volumn 5, Issue 10, 2006, Pages 845-854

Novel pharmacological targets for the treatment of Parkinson's disease

(14)  Schapira, Anthony H V a,b   Bezard, Erwan c   Brotchie, Jonathan d   Calon, Frédéric e,f   Collingridge, Graham L g   Ferger, Borris h   Hengerer, Bastian h   Hirsch, Etienne i,j   Jenner, Peter k   Novère, Nicolas Le l   Obeso, José A m   Schwarzschild, Michael A n   Spampinato, Umberto c   Davidai, Giora o  

c CNRS   (France)
i INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACP 103; AMPA RECEPTOR ANTAGONIST; ANTIPARKINSON AGENT; APOMORPHINE; BUSPIRONE; CATECHOL METHYLTRANSFERASE INHIBITOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; CLOZAPINE; DONEPEZIL; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; E 2007; ENZYME INHIBITOR; GLUTAMATE RECEPTOR AGONIST; GYKI 47261; LEVODOPA; LISURIDE; MEMANTINE; METHYSERGIDE; MIRTAZAPINE; N PHENYL 7 (HYDROXYLIMINO)CYPROPA[B]CHROMEN 1A CARBOXAMIDE; QUETIAPINE; RIVASTIGMINE; ROTIGOTINE; SARIZOTAN; SEROTONIN AGONIST; SEROTONIN UPTAKE INHIBITOR; TALAMPANEL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33749247103     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2087     Document Type: Review
Times cited : (277)

References (119)
  • 1
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak, H. et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24, 197-211 (2003).
    • (2003) Neurobiol. Aging , vol.24 , pp. 197-211
    • Braak, H.1
  • 2
    • 0034682308 scopus 로고    scopus 로고
    • A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa
    • 056 Study Group
    • Rascol, O. et al. A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. 056 Study Group. N. Engl. J. Med. 34, 1484-1491 2000).
    • (2000) N. Engl. J. Med. , vol.34 , pp. 1484-1491
    • Rascol, O.1
  • 3
    • 3142733662 scopus 로고    scopus 로고
    • Pramipexole vs levodopa as initial treatment for Parkinson disease: A 4-year randomized controlled trial
    • Holloway, R. G. et al. Pramipexole vs levodopa as initial treatment for Parkinson disease: A 4-year randomized controlled trial. Arch. Neurol. 61, 1044-1053 (2004).
    • (2004) Arch. Neurol. , vol.61 , pp. 1044-1053
    • Holloway, R.G.1
  • 4
    • 20144366287 scopus 로고    scopus 로고
    • Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: A prospective study using single-dose challenges
    • Katzenschlager, R. et al. Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: A prospective study using single-dose challenges. Mov. Disord. 20, 151-157 (2005).
    • (2005) Mov. Disord. , vol.20 , pp. 151-157
    • Katzenschlager, R.1
  • 5
    • 22544437307 scopus 로고    scopus 로고
    • Clinical studies with transdermal rotigotine in early Parkinson's disease
    • Poewe, W. & Luessi, F. Clinical studies with transdermal rotigotine in early Parkinson's disease. Neurology 65, S11-S14 (2005).
    • (2005) Neurology , vol.65
    • Poewe, W.1    Luessi, F.2
  • 6
    • 0036828226 scopus 로고    scopus 로고
    • Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and α(1)/α (2)-adrenoceptor
    • Newman-Tancredi, A. et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and α(1)/α(2)-adrenoceptor. J. Pharmacol. Exp. Ther. 303, 805-814 (2002).
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , pp. 805-814
    • Newman-Tancredi, A.1
  • 7
    • 85013942102 scopus 로고    scopus 로고
    • (eds Schapira, A. H. V. & Olanow, C. W.) (Elsevier, Philadelphia)
    • Jenner, P. in Principles of Treatment in Parkinson's Disease (eds Schapira, A. H. V. & Olanow, C. W.) 33-359 (Elsevier, Philadelphia, 2005).
    • (2005) Principles of Treatment in Parkinson's Disease , pp. 333-359
    • Jenner, P.1
  • 8
    • 26444597591 scopus 로고    scopus 로고
    • Does levodopa slow or hasten the rate of progression of Parkinson's disease?
    • Fahn, S. Does levodopa slow or hasten the rate of progression of Parkinson's disease? J. Neurol. 252 (Suppl. 4), iv37-iv42 (2005).
    • (2005) J. Neurol. , vol.252 , Issue.SUPPL. 4
    • Fahn, S.1
  • 9
    • 0033695789 scopus 로고    scopus 로고
    • Continuous dopamine-receptor stimulation in early Parkinson's disease
    • Olanow, W., Schapira, A. H. & Rascol, O. Continuous dopamine-receptor stimulation in early Parkinson's disease. Trends Neurosci. 23, S117-S126 (2000).
    • (2000) Trends Neurosci. , vol.23
    • Olanow, W.1    Schapira, A.H.2    Rascol, O.3
  • 10
    • 10644250114 scopus 로고    scopus 로고
    • Dopamine-receptor stimulation: Biobehavioral and biochemical consequences
    • Calon, F. et al. Dopamine-receptor stimulation: Biobehavioral and biochemical consequences. Trends Neurosci. 23, S92-S100 (2000).
    • (2000) Trends Neurosci. , vol.23
    • Calon, F.1
  • 11
    • 0041704637 scopus 로고    scopus 로고
    • Entacapone is beneficial in both fluctuating and non-fluctuating patients with Parkinson's disease: A randomised, placebo controlled, double blind, six month study
    • Brooks, D. J. & Sagar, H. Entacapone is beneficial in both fluctuating and non-fluctuating patients with Parkinson's disease: A randomised, placebo controlled, double blind, six month study. J. Neurol. Neurosurg. Psychiatry 74, 1071-1079 (2003).
    • (2003) J. Neurol. Neurosurg. Psychiatry , vol.74 , pp. 1071-1079
    • Brooks, D.J.1    Sagar, H.2
  • 12
    • 20544476874 scopus 로고    scopus 로고
    • The 'magic' of L-dopa: Why is it the gold standard Parkinson's disease therapy?
    • Mercuri, N. B. & Bernardi, G. The 'magic' of L-dopa: Why is it the gold standard Parkinson's disease therapy? Trends Pharmacol. Sci. 26, 341-344 (2005).
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 341-344
    • Mercuri, N.B.1    Bernardi, G.2
  • 13
    • 0025009227 scopus 로고
    • Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types
    • Perry, E. K. et al. Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types. J. Neurol. Transm. Park. Dis. Dement. Sect. 2, 149-158 (1990).
    • (1990) J. Neurol. Transm. Park. Dis. Dement. Sect. , vol.2 , pp. 149-158
    • Perry, E.K.1
  • 14
    • 0029010288 scopus 로고
    • Hypersensitivity of cortical muscarinic receptors in Parkinson's disease demonstrated by PET
    • Asahina, M. et al. Hypersensitivity of cortical muscarinic receptors in Parkinson's disease demonstrated by PET. Acta Neurol. Scand. 91, 437-443 (1995).
    • (1995) Acta Neurol. Scand. , vol.91 , pp. 437-443
    • Asahina, M.1
  • 15
    • 4344698859 scopus 로고    scopus 로고
    • Smoking, nicotine and Parkinson's disease
    • Quik, M. Smoking, nicotine and Parkinson's disease. Trends Neurosci. 27, 561-568 (2004).
    • (2004) Trends Neurosci. , vol.27 , pp. 561-568
    • Quik, M.1
  • 16
    • 0028082156 scopus 로고
    • Cholinergic markers in degenerative parkinsonism: Autoradiographic demonstration of high-affinity choline uptake carrier hyperactivity
    • Rodriguez-Puertas, R., Pazos, A. & Pascual, J. Cholinergic markers in degenerative parkinsonism: Autoradiographic demonstration of high-affinity choline uptake carrier hyperactivity. Brain Res. 636, 327-332 (1994).
    • (1994) Brain Res. , vol.636 , pp. 327-332
    • Rodriguez-Puertas, R.1    Pazos, A.2    Pascual, J.3
  • 17
    • 18344398824 scopus 로고    scopus 로고
    • Anticholinergics for symptomatic management of Parkinson's disease
    • CD003735
    • Katzenschlager, R. et al. Anticholinergics for symptomatic management of Parkinson's disease. Cochrane Database Syst Rev. CD003735 (2003).
    • (2003) Cochrane Database Syst Rev.
    • Katzenschlager, R.1
  • 18
    • 0842325101 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of donepezil in cognitive impairment in Parkinson's disease
    • Leroi, I. et al. Randomized placebo-controlled trial of donepezil in cognitive impairment in Parkinson's disease. Int. J. Geriatr. Psychiatry 19, 1-8 (2004).
    • (2004) Int. J. Geriatr. Psychiatry , vol.19 , pp. 1-8
    • Leroi, I.1
  • 19
    • 0036265213 scopus 로고    scopus 로고
    • Donepezil for cognitive impairment in Parkinson's disease: A randomised controlled study
    • Aarsland, D. et al. Donepezil for cognitive impairment in Parkinson's disease: A randomised controlled study. J. Neurol. Neurosurg. Psychiatry 72, 708-712 (2002).
    • (2002) J. Neurol. Neurosurg. Psychiatry , vol.72 , pp. 708-712
    • Aarsland, D.1
  • 20
    • 10044283107 scopus 로고    scopus 로고
    • Rivastigmine for dementia associated with Parkinson's disease
    • Emre, M. et al. Rivastigmine for dementia associated with Parkinson's disease. N. Engl. J. Med. 351, 2509-2518 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2509-2518
    • Emre, M.1
  • 21
    • 0035207628 scopus 로고    scopus 로고
    • The beneficial effect of cholinesterase inhibitors on patients suffering from Parkinson's disease and dementia
    • Werber, E. A. & Rabey, J. M. The beneficial effect of cholinesterase inhibitors on patients suffering from Parkinson's disease and dementia. J. Neural Transm. 108, 1319-1325 (2001).
    • (2001) J. Neural Transm. , vol.108 , pp. 1319-1325
    • Werber, E.A.1    Rabey, J.M.2
  • 22
    • 0036276359 scopus 로고    scopus 로고
    • Donepezil in the treatment of hallucinations and delusions in Parkinson's disease
    • Fabbrini, G. et al. Donepezil in the treatment of hallucinations and delusions in Parkinson's disease. Neurol. Sci. 23, 41-43 (2002).
    • (2002) Neurol. Sci. , vol.23 , pp. 41-43
    • Fabbrini, G.1
  • 23
    • 0029908722 scopus 로고    scopus 로고
    • Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain
    • Le Novere, N., Zoli, M. & Changeux, J. P. Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. Eur. J. Neurosci. 8, 2428-2439 (1996).
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 2428-2439
    • Le Novere, N.1    Zoli, M.2    Changeux, J.P.3
  • 24
    • 0035847204 scopus 로고    scopus 로고
    • Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra
    • Costa, G., Abin-Carriquiry, J. A. & Dajas, F. Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. Brain Res. 888, 336-342 (2001).
    • (2001) Brain Res. , vol.888 , pp. 336-342
    • Costa, G.1    Abin-Carriquiry, J.A.2    Dajas, F.3
  • 25
    • 0037185083 scopus 로고    scopus 로고
    • Stimulation of non-α7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture
    • Jeyarasasingam, G., Tompkins, L. & Quik, M. Stimulation of non-α7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture. Neuroscience 109, 275-285 (2002).
    • (2002) Neuroscience , vol.109 , pp. 275-285
    • Jeyarasasingam, G.1    Tompkins, L.2    Quik, M.3
  • 26
    • 4444230502 scopus 로고    scopus 로고
    • Smoking and Parkinson's disease: Systematic review of prospective studies
    • Allam, M. F. et al. Smoking and Parkinson's disease: Systematic review of prospective studies. Mov. Disord. 19, 614-621 (2004).
    • (2004) Mov. Disord. , vol.19 , pp. 614-621
    • Allam, M.F.1
  • 27
    • 0030906167 scopus 로고    scopus 로고
    • 8-OH-DPAT, a 5-HT1A agonist and ritanserin, a 5-HT2A/C antagonist, reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release
    • Lucas, G., Bonhomme, N., De Deurwaerdère, P., Le Moal, M. & Spampinato, U. 8-OH-DPAT, a 5-HT1A agonist and ritanserin, a 5-HT2A/C antagonist, reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release. Psychopharmacology 131, 57-63 (1997).
    • (1997) Psychopharmacology , vol.131 , pp. 57-63
    • Lucas, G.1    Bonhomme, N.2    De Deurwaerdère, P.3    Le Moal, M.4    Spampinato, U.5
  • 28
    • 0032817813 scopus 로고    scopus 로고
    • Role of serotonin(2A) and serotonin(2B/2C) receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation
    • De Deurwaerdère, P. & Spampinato, U. Role of serotonin(2A) and serotonin(2B/2C) receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation. J. Neurochem. 73, 1033-42 (1999).
    • (1999) J. Neurochem. , vol.73 , pp. 1033-1042
    • De Deurwaerdère, P.1    Spampinato, U.2
  • 29
    • 1842610940 scopus 로고    scopus 로고
    • Constitutive activity of the serotonin 2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens
    • De Deurwaerdère, P., Navailles, S., Berg, K. A., Clarke, W. P. & Spampinato, U. Constitutive activity of the serotonin 2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J. Neurosci. 24, 3235-3241 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 3235-3241
    • De Deurwaerdère, P.1    Navailles, S.2    Berg, K.A.3    Clarke, W.P.4    Spampinato, U.5
  • 30
    • 0036460744 scopus 로고    scopus 로고
    • 5-hydroxytryptamine (5-HT, serotonin) and Parkinson's disease-opportunities for novel therapeutics to reduce the problems of levodopa therapy
    • Nicholson, S. L. & Brotchie, J. M. 5-hydroxytryptamine (5-HT, serotonin) and Parkinson's disease-opportunities for novel therapeutics to reduce the problems of levodopa therapy. Eur. J. Neurol. 9 (Suppl. 3), 1-6 (2002).
    • (2002) Eur. J. Neurol. , vol.9 , Issue.SUPPL. 3 , pp. 1-6
    • Nicholson, S.L.1    Brotchie, J.M.2
  • 31
    • 0035869756 scopus 로고    scopus 로고
    • Serotonin 5-HT(1A) receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys
    • Frechilla, D. et al. Serotonin 5-HT(1A) receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys. Synapse 39, 288-296 (2001).
    • (2001) Synapse , vol.39 , pp. 288-296
    • Frechilla, D.1
  • 32
    • 0028986779 scopus 로고
    • Increased expression of 5HT2 receptor mRNA in rat striatum following 6-OHDA lesions of the adult nigrostriatal pathway
    • Numan, S. et al. Increased expression of 5HT2 receptor mRNA in rat striatum following 6-OHDA lesions of the adult nigrostriatal pathway. Brain Res. Mol. Brain Res 29, 391-396 (1995).
    • (1995) Brain Res. Mol. Brain Res. , vol.29 , pp. 391-396
    • Numan, S.1
  • 33
    • 0033625998 scopus 로고    scopus 로고
    • 5-HT2C receptor binding is increased in the substantia nigra pars reticulata in Parkinson's disease
    • Fox, S. H. & Brotchie, J. M. 5-HT2C receptor binding is increased in the substantia nigra pars reticulata in Parkinson's disease. Mov. Disord. 15, 1064-1069 (2000).
    • (2000) Mov. Disord. , vol.15 , pp. 1064-1069
    • Fox, S.H.1    Brotchie, J.M.2
  • 34
    • 0035960558 scopus 로고    scopus 로고
    • Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models
    • Bibbiani, F., Oh, J. D. & Chase, T. N. Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models. Neurology. 57, 1829-1834 (2001).
    • (2001) Neurology. , vol.57 , pp. 1829-1834
    • Bibbiani, F.1    Oh, J.D.2    Chase, T.N.3
  • 35
    • 26444537122 scopus 로고    scopus 로고
    • Modulation of serotonin receptors in MPTP-lesioned monkeys
    • Chassain, C. & Durif, F. M. Modulation of serotonin receptors in MPTP-lesioned monkeys. Mov. Disord. 19, 412 (2004).
    • (2004) Mov. Disord. , vol.19 , pp. 412
    • Chassain, C.1    Durif, F.M.2
  • 36
    • 2342450729 scopus 로고    scopus 로고
    • Multicenter, open-label, trial of sarizotan in Parkinson disease patients with levodopa-induced dyskinesias (the SPLENDID Study)
    • Olanow, C. W. et al. Multicenter, open-label, trial of sarizotan in Parkinson disease patients with levodopa-induced dyskinesias (the SPLENDID Study). Clin. Neuropharmacol. 27, 58-62 (2004).
    • (2004) Clin. Neuropharmacol. , vol.27 , pp. 58-62
    • Olanow, C.W.1
  • 37
    • 26444586231 scopus 로고    scopus 로고
    • Effects of serotonin 5-HT1A agonist in advanced Parkinson's disease
    • Bara-Jimenez, W. et al. Effects of serotonin 5-HT1A agonist in advanced Parkinson's disease. Mov. Disord. 20, 932-936 (2005).
    • (2005) Mov. Disord. , vol.20 , pp. 932-936
    • Bara-Jimenez, W.1
  • 38
    • 0028057911 scopus 로고
    • Buspirone in levodopa-induced dyskinesias
    • Bonifati, V. et al. Buspirone in levodopa-induced dyskinesias. Clin. Neuropharmacol. 17, 73-82 (1994).
    • (1994) Clin. Neuropharmacol. , vol.17 , pp. 73-82
    • Bonifati, V.1
  • 39
    • 0036434679 scopus 로고    scopus 로고
    • Quetiapine attenuates levodopa-induced motor complications in rodent and primate parkinsonian models
    • Oh, J. D., Bibbiani, F. & Chase, T. N. Quetiapine attenuates levodopa-induced motor complications in rodent and primate parkinsonian models. Exp. Neurol. 177, 557-564 (2002).
    • (2002) Exp. Neurol. , vol.177 , pp. 557-564
    • Oh, J.D.1    Bibbiani, F.2    Chase, T.N.3
  • 40
    • 0032080242 scopus 로고    scopus 로고
    • Behavioral effects of 5-HT2C receptor antagonism in the substantia nigra tuna reticulata of the 6-hydroxydopamine-lesioned rat model of Parkinson's disease
    • Fox, S. H., Moser, B. & Brotchie, J. M. Behavioral effects of 5-HT2C receptor antagonism in the substantia nigra tuna reticulata of the 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Exp. Neurol. 151, 35-49 (1998).
    • (1998) Exp. Neurol. , vol.151 , pp. 35-49
    • Fox, S.H.1    Moser, B.2    Brotchie, J.M.3
  • 41
    • 0034625597 scopus 로고    scopus 로고
    • 5-HT(2C) receptor antagonists enhance the behavioural response to dopamine D(1) receptor agonists in the 6-hydroxydopamine-lesioned rat
    • Fox, S. H. & Brotchie, J. M. 5-HT(2C) receptor antagonists enhance the behavioural response to dopamine D(1) receptor agonists in the 6-hydroxydopamine-lesioned rat. Eur. J. Pharmacol. 398, 59-64 (2000).
    • (2000) Eur. J. Pharmacol. , vol.398 , pp. 59-64
    • Fox, S.H.1    Brotchie, J.M.2
  • 42
    • 0027384928 scopus 로고
    • Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys
    • Gomez-Mancilla, B. & Bedard, P. J. Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys. Clin. Neuropharmacol. 16, 418-427 (1993).
    • (1993) Clin. Neuropharmacol. , vol.16 , pp. 418-427
    • Gomez-Mancilla, B.1    Bedard, P.J.2
  • 43
    • 10544244163 scopus 로고    scopus 로고
    • Pharmacological actions of the atypical antipsychotic drug dozapine: A review
    • Ashby, C. R. Jr. & Wang, R. Y. Pharmacological actions of the atypical antipsychotic drug dozapine: A review. Synapse 24, 349-394 (1996).
    • (1996) Synapse , vol.24 , pp. 349-394
    • Ashby Jr., C.R.1    Wang, R.Y.2
  • 44
    • 0030062260 scopus 로고    scopus 로고
    • Radioreceptor binding profile of the atypical antipsychotic olanzapine
    • Bymaster, F. P. et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14, 87-96 (1996).
    • (1996) Neuropsychopharmacology , vol.14 , pp. 87-96
    • Bymaster, F.P.1
  • 45
    • 0033540728 scopus 로고    scopus 로고
    • D1 receptor blockade improves L-dopa-induced dyskinesia but worsens parkinsonism in MPTP monkeys
    • Grondin, R. et al. D1 receptor blockade improves L-dopa-induced dyskinesia but worsens parkinsonism in MPTP monkeys. Neurology 52, 771-776 (1999).
    • (1999) Neurology , vol.52 , pp. 771-776
    • Grondin, R.1
  • 46
    • 1042299831 scopus 로고    scopus 로고
    • Clozapine improves dyskinesias in Parkinson disease: A double-blind, placebo-controlled study
    • Durif, F. et al. Clozapine improves dyskinesias in Parkinson disease: A double-blind, placebo-controlled study. Neurology 62, 381-388 (2004).
    • (2004) Neurology , vol.62 , pp. 381-388
    • Durif, F.1
  • 47
    • 0842309193 scopus 로고    scopus 로고
    • Low dose quetiapine for drug induced dyskinesias in Parkinson's disease: A double blind cross over study
    • Katzenschlager, R. et al. Low dose quetiapine for drug induced dyskinesias in Parkinson's disease: A double blind cross over study. J. Neurol. Neurosurg. Psychiatry 75, 295-297 (2004).
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , pp. 295-297
    • Katzenschlager, R.1
  • 48
    • 0141919606 scopus 로고    scopus 로고
    • 3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
    • Iravani, M. M. et al. 3,4-methylenedioxymethampheta mine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. J. Neurosci. 23, 9107-9115 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 9107-9115
    • Iravani, M.M.1
  • 49
    • 18844447522 scopus 로고    scopus 로고
    • Short-term paroxetine treatment does not alter the motor response to levodopa in PD
    • Chung, K. A., Carlson, N. E. & Nutt, J. G. Short-term paroxetine treatment does not alter the motor response to levodopa in PD. Neurology 64, 1797-1798 (2005).
    • (2005) Neurology , vol.64 , pp. 1797-1798
    • Chung, K.A.1    Carlson, N.E.2    Nutt, J.G.3
  • 50
    • 0042134789 scopus 로고    scopus 로고
    • Mirtazapine in L-dopa-induced dyskinesias
    • Meco, G. et al. Mirtazapine in L-dopa-induced dyskinesias. Clin. Neuropharmacol. 26, 179-181 (2003).
    • (2003) Clin. Neuropharmacol. , vol.26 , pp. 179-181
    • Meco, G.1
  • 51
    • 0032892343 scopus 로고    scopus 로고
    • Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist-a review of preclinical data
    • Parsons, C. G., Danysz, W. & Quack, G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist-a review of preclinical data. Neuropharmacology 38, 735-767 (1999).
    • (1999) Neuropharmacology , vol.38 , pp. 735-767
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 52
    • 3042833166 scopus 로고    scopus 로고
    • The NR2B-selective NMDA receptor antagonist CP-101, 606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease
    • Nash, J. E. et al. The NR2B-selective NMDA receptor antagonist CP-101, 606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease. Exp. Neurol. 188, 471-479 (2004).
    • (2004) Exp. Neurol. , vol.188 , pp. 471-479
    • Nash, J.E.1
  • 53
    • 1542360582 scopus 로고    scopus 로고
    • Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys
    • Hadj Tahar, A. et al. Effect of a selective glutamate antagonist on L-dopa-induced dyskinesias in drug-naive parkinsonian monkeys. Neurobiol. Dis 15, 171-176 (2004).
    • (2004) Neurobiol. Dis. , vol.15 , pp. 171-176
    • Hadj Tahar, A.1
  • 54
    • 0031951010 scopus 로고    scopus 로고
    • Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: Mesencephalic dopaminergic neurons
    • Counihan, T. J. et al. Expression of N-methyl-D-aspartate receptor subunit mRNA in the human brain: Mesencephalic dopaminergic neurons. J. Comp. Neurol. 390, 91-101 (1998).
    • (1998) J. Comp. Neurol. , vol.390 , pp. 91-101
    • Counihan, T.J.1
  • 55
    • 1542269774 scopus 로고    scopus 로고
    • Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid
    • Feng, B. et al. Structure-activity analysis of a novel NR2C/ NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid. Br. J. Pharmacol. 141, 508-516 (2004).
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 508-516
    • Feng, B.1
  • 56
    • 0037407907 scopus 로고    scopus 로고
    • Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
    • Picconi, B. et al. Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia. Nature Neurosci. 6, 501-506 (2003).
    • (2003) Nature Neurosci. , vol.6 , pp. 501-506
    • Picconi, B.1
  • 57
    • 0345686620 scopus 로고    scopus 로고
    • Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment
    • Marino, M. J. et al. Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment. Proc. Natl Acad. Sci. USA 100, 13668-13673 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13668-13673
    • Marino, M.J.1
  • 58
    • 1242328682 scopus 로고    scopus 로고
    • Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease
    • O'Neill, M. J. et al. Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease. Eur. J. Pharmacol. 486, 163-174 (2004).
    • (2004) Eur. J. Pharmacol. , vol.486 , pp. 163-174
    • O'Neill, M.J.1
  • 59
    • 2542422824 scopus 로고    scopus 로고
    • Characterisation of UBP296: A novel, potent and selective kainate receptor antagonist
    • More, J. C. et al. Characterisation of UBP296: A novel, potent and selective kainate receptor antagonist. Neuropharmacology 47, 46-64 (2004).
    • (2004) Neuropharmacology , vol.47 , pp. 46-64
    • More, J.C.1
  • 60
    • 0029076807 scopus 로고
    • A receptors in the striatopallidal complex
    • A receptors in the striatopallidal complex. Brain Res. 680, 43-52 (1995).
    • (1995) Brain Res. , vol.680 , pp. 43-52
    • Calon, F.1
  • 61
    • 0037354398 scopus 로고    scopus 로고
    • Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications
    • Calon, F. et al. Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications. Mov. Disord. 18, 241-253 (2003).
    • (2003) Mov. Disord. , vol.18 , pp. 241-253
    • Calon, F.1
  • 62
    • 14544288232 scopus 로고    scopus 로고
    • Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease
    • Xu, K., Bastia, E. & Schwarzschild, M. Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease. Pharmacol. Ther. 105, 267-310 (2005).
    • (2005) Pharmacol. Ther. , vol.105 , pp. 267-310
    • Xu, K.1    Bastia, E.2    Schwarzschild, M.3
  • 63
    • 21244440664 scopus 로고    scopus 로고
    • Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease
    • Jenner, P. Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease. Expert Opin. Investig. Drugs 14, 729-738 (2005).
    • (2005) Expert Opin. Investig. Drugs , vol.14 , pp. 729-738
    • Jenner, P.1
  • 64
    • 0026763441 scopus 로고
    • Molecular cloning of the rat A2 adenosine receptor: Selective co-expression with D2 dopamine receptors in rat striatum
    • Fink, J S. et al. Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res. Mol. Brain Res. 14, 186-195 (1992).
    • (1992) Brain Res. Mol. Brain Res. , vol.14 , pp. 186-195
    • Fink, J.S.1
  • 65
    • 0344052684 scopus 로고    scopus 로고
    • Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys
    • Grondin, R.et al. Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys. Neurology 52, 1673-1637 (1999).
    • (1999) Neurology , vol.52 , pp. 1637-1673
    • Grondin, R.1
  • 66
    • 0345060918 scopus 로고    scopus 로고
    • Modulation of GABAergic transmission in the striatopallidal system by adenosine A2A receptors: A potential mechanism for the antiparkinsonian effects of A2A antagonists
    • Mori, A. & Shindou, T. Modulation of GABAergic transmission in the striatopallidal system by adenosine A2A receptors: A potential mechanism for the antiparkinsonian effects of A2A antagonists. Neurology 61, S44-S48 (2003).
    • (2003) Neurology , vol.61
    • Mori, A.1    Shindou, T.2
  • 67
    • 0042626108 scopus 로고    scopus 로고
    • Adenosine A(2A) receptor antagonist treatment of Parkinson's disease
    • Bara-Jimenez, W. et al. Adenosine A(2A) receptor antagonist treatment of Parkinson's disease. Neurology 61, 293-296 (2003).
    • (2003) Neurology , vol.61 , pp. 293-296
    • Bara-Jimenez, W.1
  • 68
    • 0043126954 scopus 로고    scopus 로고
    • Randomized trial of the adenosine A(2A) receptor antagonist istradefylline in advanced PD
    • Hauser, R. A., Hubble, J. P. & Truong, D. D. Randomized trial of the adenosine A(2A) receptor antagonist istradefylline in advanced PD. Neurology 61, 297-303 (2003).
    • (2003) Neurology , vol.61 , pp. 297-303
    • Hauser, R.A.1    Hubble, J.P.2    Truong, D.D.3
  • 69
    • 0345492465 scopus 로고    scopus 로고
    • Caffeinated clues from epidemiology of Parkinson's disease
    • Ascherio, A. & Chen, H. Caffeinated clues from epidemiology of Parkinson's disease. Neurology 61, S51-S54 (2003).
    • (2003) Neurology , vol.61
    • Ascherio, A.1    Chen, H.2
  • 70
    • 0035874345 scopus 로고    scopus 로고
    • Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease
    • Chen, J. F. et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J. Neurosci. 21, RC143 (2001).
    • (2001) J. Neurosci. , vol.21
    • Chen, J.F.1
  • 71
    • 0036470494 scopus 로고    scopus 로고
    • Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors
    • Fredduzzi, S. et al. Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors. J. Neurosci. 22, 1054-1062 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 1054-1062
    • Fredduzzi, S.1
  • 72
    • 0042141599 scopus 로고    scopus 로고
    • A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson's disease
    • Bibbiani, F. et al. A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson's disease. Exp. Neurol. 184, 285-294 (2003).
    • (2003) Exp. Neurol. , vol.184 , pp. 285-294
    • Bibbiani, F.1
  • 73
    • 10744224952 scopus 로고    scopus 로고
    • Receptor heteromerization in adenosine A2A receptor signaling: Relevance for striatal function and Parkinson's disease
    • Fuxe, K. et al. Receptor heteromerization in adenosine A2A receptor signaling: Relevance for striatal function and Parkinson's disease. Neurology 61, S19-S23 (2003).
    • (2003) Neurology , vol.61
    • Fuxe, K.1
  • 74
    • 27744450594 scopus 로고    scopus 로고
    • Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice
    • Kachroo, A. et al. Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. J. Neurosci. 25, 10414-10419 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 10414-10419
    • Kachroo, A.1
  • 75
    • 3242765264 scopus 로고    scopus 로고
    • 2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats
    • 2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats. Neuropsychopharmacology 29, 1451-161 (2004).
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1451-1461
    • Coccurello, R.1    Breysse, N.2    Amalric, M.3
  • 76
    • 0035434121 scopus 로고    scopus 로고
    • Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies
    • Bezard, E., Brotchie, J. M. & Gross, C. E. Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies. Nature Rev. Neurosci. 2, 577-588 (2001).
    • (2001) Nature Rev. Neurosci. , vol.2 , pp. 577-588
    • Bezard, E.1    Brotchie, J.M.2    Gross, C.E.3
  • 77
    • 0036159502 scopus 로고    scopus 로고
    • Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias
    • Calon, F. et al. Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias. J. Neuropathol. Exp. Neurol. 61, 186-196 (2002).
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , pp. 186-196
    • Calon, F.1
  • 78
    • 0034851915 scopus 로고    scopus 로고
    • μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease
    • Henry, B. et al. μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease Exp. Neurol. 171, 139-146 (2001).
    • (2001) Exp. Neurol. , vol.171 , pp. 139-146
    • Henry, B.1
  • 79
    • 0142122419 scopus 로고    scopus 로고
    • Opioid antagonists increase the dyskinetic response to dopaminergic agents in parkinsonian monkeys: Interaction between dopamine and opioid systems
    • Samadi, P., Gregoire, L. & Bedard, P. J. Opioid antagonists increase the dyskinetic response to dopaminergic agents in parkinsonian monkeys: interaction between dopamine and opioid systems. Neuropharmacology 45, 954-963 (2003).
    • (2003) Neuropharmacology , vol.45 , pp. 954-963
    • Samadi, P.1    Gregoire, L.2    Bedard, P.J.3
  • 80
    • 4544255049 scopus 로고    scopus 로고
    • Non-subtype-selective opioid receptor antagonism in treatment of levodopa-induced motor complications in Parkinson's disease
    • Fox, S. et al. Non-subtype-selective opioid receptor antagonism in treatment of levodopa-induced motor complications in Parkinson's disease. Mov. Disord. 19, 554-560 (2004).
    • (2004) Mov. Disord. , vol.19 , pp. 554-560
    • Fox, S.1
  • 81
    • 0027958852 scopus 로고
    • Naltrexone, an opiate antagonist, fails to modify motor symptoms in patients with Parkinson's disease
    • Rascol, O. et al. Naltrexone, an opiate antagonist, fails to modify motor symptoms in patients with Parkinson's disease. Mov. Disord. 9, 437-440 (1994).
    • (1994) Mov. Disord. , vol.9 , pp. 437-440
    • Rascol, O.1
  • 82
    • 0022555431 scopus 로고
    • Opioid peptide processing and receptor selectivity
    • Hollt, V. Opioid peptide processing and receptor selectivity. Annu. Rev. Pharmacol. Toxicol. 26, 59-77 (1986).
    • (1986) Annu. Rev. Pharmacol. Toxicol. , vol.26 , pp. 59-77
    • Hollt, V.1
  • 83
    • 12844281159 scopus 로고    scopus 로고
    • Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities
    • Sadee, W., Wang, D. & Bilsky, E. J. Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities. Life Sci. 76, 1427-1437 (2005).
    • (2005) Life Sci. , vol.76 , pp. 1427-1437
    • Sadee, W.1    Wang, D.2    Bilsky, E.J.3
  • 84
    • 0024009898 scopus 로고
    • The molecular basis of opioid receptor function
    • Simonds, W. F. The molecular basis of opioid receptor function. Endocr Rev. 9, 200-212 (1988).
    • (1988) Endocr Rev. , vol.9 , pp. 200-212
    • Simonds, W.F.1
  • 85
    • 0028887626 scopus 로고
    • Opioid-receptor mRNA expression in the rat CNS: Anatomical and functional implications
    • Mansour, A. et al. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 18, 22-29 (1995).
    • (1995) Trends Neurosci. , vol.18 , pp. 22-29
    • Mansour, A.1
  • 86
    • 33744982893 scopus 로고    scopus 로고
    • Etiology of Parkinson's disease
    • Schapira, A. H. Etiology of Parkinson's disease. Neurology 66, S10-S23 (2006).
    • (2006) Neurology , vol.66
    • Schapira, A.H.1
  • 87
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • Dawson, T. M. & Dawson, V. L. Molecular pathways of neurodegeneration in Parkinson's disease. Science. 302, 819-822 (2003).
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 88
    • 0036771852 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 in early Parkinson disease: Evidence of slowing of the functional decline
    • Shults, C. W. et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch. Neurol. 59, 1541-1550 (2002).
    • (2002) Arch. Neurol. , vol.59 , pp. 1541-1550
    • Shults, C.W.1
  • 89
    • 0035805523 scopus 로고    scopus 로고
    • Apoptosis. Death of a monopoly?
    • Hunot, S. & Flavell, R. A. Apoptosis. Death of a monopoly? Science 292, 865-866 (2001).
    • (2001) Science , vol.292 , pp. 865-866
    • Hunot, S.1    Flavell, R.A.2
  • 90
    • 0041653249 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
    • Chen, H. et al. Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease. Arch. Neurol. 60, 1059-1064 (2003).
    • (2003) Arch. Neurol. , vol.60 , pp. 1059-1064
    • Chen, H.1
  • 91
    • 2442570592 scopus 로고    scopus 로고
    • Disease modification in Parkinson's disease
    • Schapira, A. H. Disease modification in Parkinson's disease. Lancet Neurol. 3, 362-368 (2004).
    • (2004) Lancet Neurol. , vol.3 , pp. 362-368
    • Schapira, A.H.1
  • 93
    • 9744276661 scopus 로고    scopus 로고
    • Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms
    • Gu, M. et al. Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms. J. Neurochem. 91, 1075-1081 (2004).
    • (2004) J. Neurochem. , vol.91 , pp. 1075-1081
    • Gu, M.1
  • 94
    • 0037785449 scopus 로고    scopus 로고
    • Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study
    • Whone, A. L. et al. Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Ann. Neurol. 54, 93-101 (2003).
    • (2003) Ann. Neurol. , vol.54 , pp. 93-101
    • Whone, A.L.1
  • 95
    • 0037012478 scopus 로고    scopus 로고
    • Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression
    • Parkinson Study Group
    • Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA 287, 1653-1661 (2002).
    • (2002) JAMA , vol.287 , pp. 1653-1661
  • 96
    • 0347133331 scopus 로고    scopus 로고
    • Neuroprotection in Parkinson disease: Mysteries, myths, and misconceptions
    • Schapira, A. H. & Olanow, C. W. Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions. JAMA 291, 358-364 (2004).
    • (2004) JAMA , vol.291 , pp. 358-364
    • Schapira, A.H.1    Olanow, C.W.2
  • 97
    • 0022394212 scopus 로고
    • Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion
    • Mytilineou, C. & Cohen, G. Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion. J. Neurochem. 45, 1951-1953 (1985).
    • (1985) J. Neurochem. , vol.45 , pp. 1951-1953
    • Mytilineou, C.1    Cohen, G.2
  • 98
    • 0026353406 scopus 로고
    • Rescue of dying neurons: A new action for deprenyl in MPTP parkinsonism
    • Tatton, W. G. & Greenwood, C. E. Rescue of dying neurons: A new action for deprenyl in MPTP parkinsonism. J. Neurosci. Res. 30, 666-672 (1991).
    • (1991) J. Neurosci. Res. , vol.30 , pp. 666-672
    • Tatton, W.G.1    Greenwood, C.E.2
  • 99
    • 0026683140 scopus 로고
    • Enhanced hydroxyl radical generation by 2′-methyl analog of MPTP: Suppression by clorgyline and deprenyl
    • Chiueh, C. C., Huang, S. J. & Murphy, D. L. Enhanced hydroxyl radical generation by 2′-methyl analog of MPTP: Suppression by clorgyline and deprenyl. Synapse 11, 346-348 (1992).
    • (1992) Synapse , vol.11 , pp. 346-348
    • Chiueh, C.C.1    Huang, S.J.2    Murphy, D.L.3
  • 100
    • 0027517052 scopus 로고
    • Apparent antioxidant effect of L-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo
    • Wu RM, Chiueh CC, Pert A, Murphy DL. Apparent antioxidant effect of L-deprenyl on hydroxyl radical formation and nigral injury elicited by MPP+ in vivo. Eur. J. Pharmacol. 243, 241-247 (1993).
    • (1993) Eur. J. Pharmacol. , vol.243 , pp. 241-247
    • Wu, R.M.1    Chiueh, C.C.2    Pert, A.3    Murphy, D.L.4
  • 101
    • 0034113209 scopus 로고    scopus 로고
    • Effect of MAO-B inhibitors on MPP+ toxicity in vivo
    • Wu, R. M., Chen, R. C. & Chiueh, C. C. Effect of MAO-B inhibitors on MPP+ toxicity in vivo. Ann. NY Acad. Sci. 899, 255-261 (2000).
    • (2000) Ann. NY Acad. Sci. , vol.899 , pp. 255-261
    • Wu, R.M.1    Chen, R.C.2    Chiueh, C.C.3
  • 102
    • 0027941312 scopus 로고
    • (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis
    • Tatton, W. G., Ju, W. Y., Holland, D. P., Tai, C. & Kwan, M. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J. Neurochem. 63, 1572-1575 (1994).
    • (1994) J. Neurochem. , vol.63 , pp. 1572-1575
    • Tatton, W.G.1    Ju, W.Y.2    Holland, D.P.3    Tai, C.4    Kwan, M.5
  • 103
    • 0031890109 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: Time course and modification by (-)-deprenyl
    • Wadia, J. S. et al. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: Time course and modification by (-)-deprenyl. J. Neurosci. 18, 932-947 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 932-947
    • Wadia, J.S.1
  • 104
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • Parkinson Disease Study Group
    • Parkinson Disease Study Group Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N. Engl. J. Med. 328, 176-183 (1993).
    • (1993) N. Engl. J. Med. , vol.328 , pp. 176-183
  • 105
    • 0037189081 scopus 로고    scopus 로고
    • An anti-Parkinson's disease drug, N-propargyl-1 (R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells
    • Akao, Y. et al. An anti-Parkinson's disease drug, N-propargyl-1 (R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells. Neurosci. Lett. 326, 105-108 (2002).
    • (2002) Neurosci. Lett. , vol.326 , pp. 105-108
    • Akao, Y.1
  • 106
    • 1542317394 scopus 로고    scopus 로고
    • Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline
    • Am, O. B., Amit, T. & Youdim, M. B. Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline. Neurosci. Lett. 355, 169-172 (2004).
    • (2004) Neurosci. Lett. , vol.355 , pp. 169-172
    • Am, O.B.1    Amit, T.2    Youdim, M.B.3
  • 107
    • 0036206323 scopus 로고    scopus 로고
    • The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells
    • Maruyama, W., Takahashi, T., Youdim, M. & Naoi, M. The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells. J. Neural Transm. 109, 467-481 (2002).
    • (2002) J. Neural Transm. , vol.109 , pp. 467-481
    • Maruyama, W.1    Takahashi, T.2    Youdim, M.3    Naoi, M.4
  • 108
    • 5144228935 scopus 로고    scopus 로고
    • Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease
    • Jenner, P. Preclinical evidence for neuroprotection with monoamine oxidase-B inhibitors in Parkinson's disease. Neurology 63 (Suppl. 2), S13-S22 (2004).
    • (2004) Neurology , vol.63 , Issue.SUPPL. 2
    • Jenner, P.1
  • 109
    • 2342655732 scopus 로고    scopus 로고
    • A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease
    • Parkinson Study Group
    • Parkinson Study Group. A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch. Neurol. 61, 561-566 (2004).
    • (2004) Arch. Neurol. , vol.61 , pp. 561-566
  • 110
    • 0036787532 scopus 로고    scopus 로고
    • Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys
    • Grondin, R. et al. Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys. Brain 125, 2191-2201 (2002).
    • (2002) Brain , vol.125 , pp. 2191-2201
    • Grondin, R.1
  • 111
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower, J. H. et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290, 767-773 (2000).
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1
  • 112
    • 0032850453 scopus 로고    scopus 로고
    • Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
    • Kordower, J. H. et al. Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann. Neurol. 46, 419-424 (1999).
    • (1999) Ann. Neurol. , vol.46 , pp. 419-424
    • Kordower, J.H.1
  • 113
    • 0037435511 scopus 로고    scopus 로고
    • Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    • Nutt, J. G. et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60, 69-73 (2003).
    • (2003) Neurology , vol.60 , pp. 69-73
    • Nutt, J.G.1
  • 114
    • 0038249170 scopus 로고    scopus 로고
    • Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
    • Gill, S. S. et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nature Med. 9, 589-595 (2003).
    • (2003) Nature Med. , vol.9 , pp. 589-595
    • Gill, S.S.1
  • 115
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    • Lang, A. E. et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann. Neurol. 59, 459-466 (2006).
    • (2006) Ann. Neurol. , vol.59 , pp. 459-466
    • Lang, A.E.1
  • 116
    • 33644976376 scopus 로고    scopus 로고
    • Continuing trials of GDNF in Parkinson's disease
    • Barker, R. A. Continuing trials of GDNF in Parkinson's disease. Lancet Neurol. 5, 285-286 (2006).
    • (2006) Lancet Neurol. , vol.5 , pp. 285-286
    • Barker, R.A.1
  • 117
    • 33644824423 scopus 로고    scopus 로고
    • Timing of treatment initiation in Parkinson's disease: A need for reappraisal?
    • Schapira, A. H. & Obeso, J. Timing of treatment initiation in Parkinson's disease: A need for reappraisal? Ann. Neurol. 59, 559-562 (2006).
    • (2006) Ann. Neurol. , vol.59 , pp. 559-562
    • Schapira, A.H.1    Obeso, J.2
  • 118
    • 32544432029 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Diagnosis and management
    • Chaudhuri, K. R., Healy, D. G. & Schapira, A. H. Non-motor symptoms of Parkinson's disease: Diagnosis and management. Lancet Neurol. 5, 235-245 (2006).
    • (2006) Lancet Neurol. , vol.5 , pp. 235-245
    • Chaudhuri, K.R.1    Healy, D.G.2    Schapira, A.H.3
  • 119
    • 1942520420 scopus 로고    scopus 로고
    • Challenges in Parkinson's disease: Restoration of the nigrostriatal dopamine system is not enough
    • Lang, A. E. & Obeso, J. A. Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol. 3, 309-316 (2004).
    • (2004) Lancet Neurol. , vol.3 , pp. 309-316
    • Lang, A.E.1    Obeso, J.A.2


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