Role of Cathepsin d in u18666a-induced neuronal cell death potential implication in Niemann-Pick type c disease pathogenesis

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 3136-3152

  Amritraj, Asha ^a   Wang, Yanlin ^a   Revett, Timothy J ^a   Vergote, David ^a   Westaway, David ^a   Kar, Satyabrata ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN D; CYTOSOLIC; DIFFERENT MECHANISMS; EXTRACELLULAR LEVELS; INTRACELLULAR CHOLESTEROL; NEURONAL CELL; NEURONAL DEATH; NIEMANN-PICK TYPE C;

CELL DEATH; ENZYME ACTIVITY; PATHOLOGY;

NEURONS;

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; CASPASE 3; CATHEPSIN D; CHOLESTEROL; CYTOCHROME C; MESSENGER RNA; PEPSTATIN; PEPTIDE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BRAIN NERVE CELL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; LIPID STORAGE; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NIEMANN PICK DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANDROSTENES; ANIMALS; BIOLOGICAL MARKERS; CASPASE 3; CATHEPSIN D; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CHOLESTEROL; CYTOCHROMES C; EXTRACELLULAR SPACE; FIBROBLASTS; HIPPOCAMPUS; HUMANS; MICE; MICE, INBRED BALB C; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; NIEMANN-PICK DISEASE, TYPE C; PROTEASE INHIBITORS; STAUROSPORINE;

EID: 84873290004     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.412460     Document Type: Article

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