The molecular machinery for lysosome biogenesis

BioEssays

Volumn 23, Issue 4, 2001, Pages 333-343

  Mullins, Chris ^a   Bonifacino, Juan S ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ALKALINE PHOSPHATASE; ALPHA ADAPTIN; CARRIER PROTEIN; GGA ADAPTOR PROTEINS; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL; RAS PROTEIN; SNARE PROTEIN; VESICULAR TRANSPORT ADAPTOR PROTEIN; VESICULAR TRANSPORT PROTEIN;

ANIMAL; CELL VACUOLE; EUKARYOTIC CELL; GENETICS; HUMAN; LYSOSOME; METABOLISM; PHYSIOLOGY; REVIEW; SACCHAROMYCES CEREVISIAE; TRANS GOLGI NETWORK; TRANSPORT AT THE CELLULAR LEVEL;

ADAPTOR PROTEIN COMPLEX ALPHA SUBUNITS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADP-RIBOSYLATION FACTORS; ALKALINE PHOSPHATASE; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; EUKARYOTIC CELLS; HUMANS; LYSOSOMES; MEMBRANE PROTEINS; PHOSPHATIDYLINOSITOLS; RAS PROTEINS; SACCHAROMYCES CEREVISIAE; SNARE PROTEINS; TRANS-GOLGI NETWORK; VACUOLES; VESICULAR TRANSPORT PROTEINS;

ANIMALIA; EUKARYOTA; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0035074341     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.1048     Document Type: Review

References (98)

1. Lysosome-related organelles
2. Maturation models for endosome and lysosome biogenesis
3. The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?
4. Lysosome-endosome fusion and lysosome biogenesis
5. The mannose 6-phosphate receptor and the biogenesis of lysosomes
6. Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts
7. Intracellular trafficking of lysosomal membrane proteins
8. Molecular bases for the recognition of tyrosine-based sorting signals
9. Adaptors for clathrin-mediated traffic
10. Mannose 6-phosphate receptors and ADP-ribosylation factors cooperate for high affinity interaction of the AP-1 Golgi assembly proteins with membranes
11. The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles
12. mu1A-adaptin-deficient mice: Lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
13. TIP47: A cargo selection device for mannose 6-phosphate receptor trafficking
14. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
15. Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles
16. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor
17. The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins
18. Cytoplasmic coat proteins involved in endosome function
19. A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi
20. GGAs: A family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex
21. A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome
22. Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains
23. Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin
24. Association of the AP-3 adaptor complex with clathrin
25. Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
26. Mutant Rab7 causes the accumulation of cathepsin D and cation- independent mannose 6-phosphate receptor in an early endocytic compartment
27. Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network
28. Rab7: A key to lysosome biogenesis
29. Transport-vesicle targeting: Tethers before SNAREs
30. Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages
31. Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking
32. SNARE interactions are not selective. Implications for membrane fusion specificity
33. Compartmental specificity of cellular membrane fusion encoded in SNARE protiens
34. Protein traffic in the yeast endocytic and vacuolar protein sorting pathways
35. Transport of proteins to the yeast vacuole: Autophagy, cytoplasm-to- vacuole targeting, and role of the vacuole in degradation
36. Divide and multiply: Organelle partitioning in yeast
37. Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast
38. The VPS1 protein, a homolog of dynamin required for vacuolar protein sorting in Saccharomyces cerevisiae, is a GTPase with two functionally separable domains
39. VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins
40. Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport
41. A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast
42. Yeast Vps45p is a Sec 1p-like protein required for the consumption of vacuole-targeted, post-Golgi transport vesicles
43. Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast
44. The yeast v-SNARE Vti1p mediates two vesicle transport pathways through interactions with the t-SNAREs Sed5p and Pep12p
45. Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant
46. Vesicle-mediated protein transport: Regulatory interactions between the Vps15 protein kinase and the Vps34 Ptdlns 3-kinase essential for protein sorting to the vacuole in yeast
47. A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast
48. Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae
49. Induction of autophagy and inhibition of tumorigenesis by beclin 1
50. Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi
51. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae
52. Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant
53. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function
54. Fab1p Ptdlns(3)P 5-kinase function essential for protein sorting in the multivesicular body
55. A novel RING finger protein complex essential for a late step in protein transport to the yeast vacuole
56. Vam2/Vps41p and Vam6/ Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae
57. The yeast AP-3 complex is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole
58. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole
59. Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE
60. Formation of AP-3 transport intermediates requires Vps41 function
61. The docking stage of yeast vacuole fusion requires the transfer of proteins from a cis-SNARE complex to a Rab/Ypt protein
62. Morphological classification of the yeast vacuolar protein sorting mutants: Evidence for a prevacuolar compartment in class E vps mutants
63. Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast
64. Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet
65. Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine
66. Distinct requirements for the AP-3 complex in pigment granule and synaptic vesicle biogenesis in Drosophila melanogaster
67. Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP-3beta adaptin gene ruby
68. The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness
69. Molecular characterization of the deep orange (dor) gene of Drosophila melanogaster
70. A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila
71. The light gene of Drosophila melanogaster encodes a homologue of VPS41, a yeast gene involved in cellular-protein trafficking
72. The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells
73. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking
74. Enhanced degradation of EGF receptors by a sorting nexin, SNX1
75. Identification of a family of sorting nexin molecules and characterization of their association with receptors
76. Sorting nexins (SNX)I and 2: Interaction domains involved in self association and associations with human retromer proteins
77. Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p
78. The Saccharomyces cerevisiae MVP1 gene interacts with VPS1 and is required for vacuolar protein sorting
79. Phosphoinositide signaling and the regulation of membrane trafficking in yeast
80. Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p
81. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
82. The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting
83. Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome
84. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
85. Fab1p is essential for Ptdlns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis
86. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
87. Characterization of p150, an adaptor protein for the human phosphatidylinositol (Ptdlns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150, Ptdins 3-kinase complex
88. A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes
89. Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes
90. Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin
91. Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis
92. Selective membrane recruitment of EEA1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes
93. Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes
94. Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis
95. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
96. Genetic dissection of endocytic trafficking in Drosophila using a horseradish peroxidase-bride of sevenless chimera: Hook is required for normal maturation of multivesicular endosomes
97. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila
98. The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency